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Abstract
Human herpes viruses have latency and lytic replication phases in their lifecycle. Proper regulation of herpes viral lifecycle is essential for the evasion of host immune surveillance and development of their related diseases. Recent advancements indicate a role of a novel class of viral non-coding RNAs, microRNAs (miRNAs), in the fine-tuning of herpes viral lifecycle. So far, herpes viral miRNAs have been shown to promote viral latency by inhibiting viral lytic replication either through direct targeting of key viral replication genes or through manipulation of host pathways that regulate viral lifecycle. The oncogenic Kaposi's sarcoma-associated herpes virus (KSHV) has adapted both strategies to control viral latency. Our recent study has identified a KSHV miRNA that inhibits viral lytic replication by upregulating the NF-κB pathway.
Acknowledgements
This work was supported by grants from American Cancer Society (#RSG-04-195) and National Institute of Health (CA096512, CA124332, CA132637 and DE017333) to S.J.G. and the National Science Foundation (CCF-0546345) to Y.F.H.
Figures and Tables
Figure 1 Multiple KSHV miRNAs regulate viral latency and lytic replication by either directly targeting key viral lytic protein RTA or indirectly targeting cellular regulatory pathways.
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