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Article Addendum

Beyond ergosterol: Linking pH to antifungal mechanisms

Pages 551-554 | Received 07 Sep 2010, Accepted 29 Sep 2010, Published online: 01 Nov 2010
 

Abstract

Many antifungal drugs including the highly successful azoles target the fungal-specific sterol, ergosterol, yet the molecular identity of cellular pathways mediating antifungal activity remained obscure. A recent study on the requirement of ergosterol in vacuolar H+-ATPase (V-ATPase) function uncovered a critical role for ion homeostasis downstream of azole inhibition of ergosterol biosynthesis. Here we review the functional link between regulation of V-ATPase by fungal membrane lipid components and discuss contributions of V-ATPase function to pathogenicity. The importance of pH homeostasis in virulence highlights its potential as target in antifungal chemotherapy.