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Current Eye Research Volume 23, 2001 - Issue 1
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Research Article

Rod outer segments mediate mitochondrial DNA damage and apoptosis in human retinal pigment epithelium

Gui-Feng Jin Department of Ophthalmology and Visual Sciences, University of Texas Medical Branch, Galveston, USA
,
John S. Hurst Department of Ophthalmology and Visual Sciences, University of Texas Medical Branch, Galveston, USA
&
Bernard F. Godley Department of Ophthalmology and Visual Sciences, University of Texas Medical Branch, Galveston, USA
Pages 11-19 | Published online: 02 Jul 2009

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Sarah Catherine Borrie, James Duggan & M Francesca Cordeiro. (2009) Retinal cell apoptosis. Expert Review of Ophthalmology 4:1, pages 27-45.
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Stuart G. Jarrett, Julie Albon & Mike Boulton. (2006) The contribution of DNA repair and antioxidants in determining cell type-specific resistance to oxidative stress. Free Radical Research 40:11, pages 1155-1165.
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Articles from other publishers (42)

Teodora Piskova, Aleksandra N. Kozyrina & Jacopo Di Russo. (2023) Mechanobiological implications of age-related remodelling in the outer retina. Biomaterials Advances 147, pages 213343.
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Mohana Devi Subramaniam, Mahalaxmi Iyer, Aswathy P. Nair, Dhivya Venkatesan, Sinnakaruppan Mathavan, Nimmisha Eruppakotte, Soumya Kizhakkillach, Manoj kumar Chandran, Ayan Roy, Abilash Valsala Gopalakrishnan & Balachandar Vellingiri. (2022) Oxidative stress and mitochondrial transfer: A new dimension towards ocular diseases. Genes & Diseases 9:3, pages 610-637.
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Kai Kaarniranta, Hannu Uusitalo, Janusz Blasiak, Szabolcs Felszeghy, Ram Kannan, Anu Kauppinen, Antero Salminen, Debasish Sinha & Deborah Ferrington. (2020) Mechanisms of mitochondrial dysfunction and their impact on age-related macular degeneration. Progress in Retinal and Eye Research 79, pages 100858.
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Eszter Szalai, John M. Nickerson & Hans E. Grossniklaus. 2020. Retinal Pigment Epithelium in Health and Disease. Retinal Pigment Epithelium in Health and Disease 3 17 .
Viktoriia Baksheeva, Veronika Tiulina, Natalia Tikhomirova, Olga Gancharova, Sergey Komarov, Pavel Philippov, Andrey ZamyatninJr.Jr., Ivan Senin & Evgeni Zernii. (2018) Suppression of Light-Induced Oxidative Stress in the Retina by Mitochondria-Targeted Antioxidant. Antioxidants 8:1, pages 3.
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Daniela Calzia, Paolo Degan, Federico Caicci, Maurizio Bruschi, Lucia Manni, Luca A. Ramenghi, Giovanni Candiano, Carlo Enrico Traverso & Isabella Panfoli. (2018) Modulation of the rod outer segment aerobic metabolism diminishes the production of radicals due to light absorption. Free Radical Biology and Medicine 117, pages 110-118.
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Wayne Liu, Shorong-Shii Liou, Tang-Yao Hong & I-Min Liu. (2017) The Benefits of the Citrus Flavonoid Diosmin on Human Retinal Pigment Epithelial Cells under High-Glucose Conditions. Molecules 22:12, pages 2251.
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Wayne Liu, Shorong-Shii Liou, Tang-Yao Hong & I-Min Liu. (2017) Protective Effects of Hesperidin (Citrus Flavonone) on High Glucose Induced Oxidative Stress and Apoptosis in a Cellular Model for Diabetic Retinopathy. Nutrients 9:12, pages 1312.
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Almudena Crooke, Fernando Huete-Toral, Basilio Colligris & Jesús Pintor. (2017) The role and therapeutic potential of melatonin in age-related ocular diseases. Journal of Pineal Research 63:2, pages e12430.
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Khalid Kamel, Michael Farrell & Colm O'Brien. (2017) Mitochondrial dysfunction in ocular disease: Focus on glaucoma. Mitochondrion 35, pages 44-53.
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Daniela Calzia, Isabella Panfoli, Nora Heinig, Ulrike Schumann, Marius Ader, Carlo Enrico Traverso, Richard H.W. Funk & Cora Roehlecke. (2016) Impairment of extramitochondrial oxidative phosphorylation in mouse rod outer segments by blue light irradiation. Biochimie 125, pages 171-178.
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Yuan Tao, Pengfei Jiang, Yuhua Wei, Ping Wang, Xiaoling Sun & Hong Wang. (2016) <i>?</i>-Lipoic Acid Treatment Improves Vision-Related Quality of Life in Patients with Dry Age-Related Macular Degeneration. The Tohoku Journal of Experimental Medicine 240:3, pages 209-214.
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Mohammad J Hosen, Paul J Coucke, Olivier Le Saux, Anne De Paepe & Olivier M Vanakker. (2014) Perturbation of specific pro-mineralizing signalling pathways in human and murine pseudoxanthoma elasticum. Orphanet Journal of Rare Diseases 9:1.
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Yun LiHongwei ShenJingming ShiLuosheng Tang. (2014) The effects of alpha lipoic acid in preventing oxidative stress-induced retinal pigment epithelial cell injury. Canadian Journal of Physiology and Pharmacology 92:9, pages 765-772.
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Daniela Calzia, Greta Garbarino, Federico Caicci, Lucia Manni, Simona Candiani, Silvia Ravera, Alessandro Morelli, Carlo Enrico Traverso & Isabella Panfoli. (2014) Functional expression of electron transport chain complexes in mouse rod outer segments. Biochimie 102, pages 78-82.
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Paulina Tokarz, Kai Kaarniranta & Janusz Blasiak. (2013) Role of antioxidant enzymes and small molecular weight antioxidants in the pathogenesis of age-related macular degeneration (AMD). Biogerontology 14:5, pages 461-482.
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ENRICA BIANCHI, FABIO SCARINCI, GUIDO RIPANDELLI, JANOS FEHER, ELENA PACELLA, GIUSEPPE MAGLIULO, CORRADO BALACCO GABRIELI, ROCCO PLATEROTI, PASQUALE PLATEROTI, FIORENZO MIGNINI & MARCO ARTICO. (2012) Retinal pigment epithelium, age-related macular degeneration and neurotrophic keratouveitis. International Journal of Molecular Medicine 31:1, pages 232-242.
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Milam A. BrantleyJrJr & Paul SternbergJrJr. 2013. Retina. Retina 517 528 .
Stuart G. Jarrett & Michael E. Boulton. (2012) Consequences of oxidative stress in age-related macular degeneration. Molecular Aspects of Medicine 33:4, pages 399-417.
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Stuart G. Jarrett, Alfred S. Lewin & Michael E. Boulton. 2012. Studies on Retinal and Choroidal Disorders. Studies on Retinal and Choroidal Disorders 203 239 .
Marco A. Zarbin & Philip J. Rosenfeld. 2012. Studies on Retinal and Choroidal Disorders. Studies on Retinal and Choroidal Disorders 1 46 .
Yuan He, Jian Ge, Janice M. Burke, Roland L. Myers, Zhi Z. Dong & Joyce Tombran-Tink. (2011) Mitochondria impairment correlates with increased sensitivity of aging RPE cells to oxidative stress. Journal of Ocular Biology, Diseases, and Informatics 3:3, pages 92-108.
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Guillermo GeronaDamián LópezMercedes PalmeroVictoria Maneu. (2010) Antioxidant N -Acetyl-Cysteine Protects Retinal Pigmented Epithelial Cells from Long-Term Hypoxia Changes in Gene Expression . Journal of Ocular Pharmacology and Therapeutics 26:4, pages 309-314.
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J. Alexander Fraser, Valérie Biousse & Nancy J. Newman. (2010) The Neuro-ophthalmology of Mitochondrial Disease. Survey of Ophthalmology 55:4, pages 299-334.
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Xiaoguang Cao, Melissa Liu, Jingsheng Tuo, Defen Shen & Chi-Chao Chan. (2010) The effects of quercetin in cultured human RPE cells under oxidative stress and in Ccl2/Cx3cr1 double deficient mice. Experimental Eye Research 91:1, pages 15-25.
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Yuan He & Joyce Tombran-Tink. 2010. Retinal Degenerative Diseases. Retinal Degenerative Diseases 165 183 .
Olga A. Kovalenko & Janine H. Santos. (2009) Analysis of Oxidative Damage by Gene‐Specific Quantitative PCR. Current Protocols in Human Genetics 62:1.
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Suofu Qin. (2007) Oxidative damage of retinal pigment epithelial cells and age‐related macular degeneration. Drug Development Research 68:5, pages 213-225.
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Stuart G. Jarrett & Michael E. Boulton. (2007) Poly(ADP-Ribose) Polymerase Offers Protection against Oxidative and Alkylation Damage to the Nuclear and Mitochondrial Genomes of the Retinal Pigment Epithelium. Ophthalmic Research 39:4, pages 213-223.
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Janos Feher, Illes Kovacs, Marco Artico, Carlo Cavallotti, Antonio Papale & Corrado Balacco Gabrieli. (2006) Mitochondrial alterations of retinal pigment epithelium in age-related macular degeneration. Neurobiology of Aging 27:7, pages 983-993.
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Peep V. Algvere, John Marshall & Stefan Seregard. (2006) Age‐related maculopathy and the impact of blue light hazard. Acta Ophthalmologica Scandinavica 84:1, pages 4-15.
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Gulden Baskol, Sarper Karakucuk, Ayse Ozturk Oner, Mevlut Baskol, Derya Kocer, Ertugrul Mirza, Recep Saraymen & Muzaffer Üstdal. (2006) Serum Paraoxonase 1 Activity and Lipid Peroxidation Levels in Patients with Age-Related Macular Degeneration. Ophthalmologica 220:1, pages 12-16.
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Xiaorui Yu, Yuhong Tang, Feng Li, Mark Barton Frank, Hu Huang, Igor Dozmorov, Yanping Zhu, Michael Centola & Wei Cao. (2005) Protection against hydrogen peroxide-induced cell death in cultured human retinal pigment epithelial cells by 17β-estradiol: A differential gene expression profile. Mechanisms of Ageing and Development 126:11, pages 1135-1145.
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Stuart G. Jarrett & Mike E. Boulton. (2005) Antioxidant up-regulation and increased nuclear DNA protection play key roles in adaptation to oxidative stress in epithelial cells. Free Radical Biology and Medicine 38:10, pages 1382-1391.
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Fong-Qi Liang, Rajiha Alssadi, Preston Morehead, Yogesh C. Awasthi & Bernard F. Godley. (2005) Enhanced expression of glutathione-S-transferase A1-1 protects against oxidative stress in human retinal pigment epithelial cells. Experimental Eye Research 80:1, pages 113-119.
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Fong-Qi Liang, Lori Green, Cindy Wang, Rajiha Alssadi & Bernard F. Godley. (2004) Melatonin protects human retinal pigment epithelial (RPE) cells against oxidative stress. Experimental Eye Research 78:6, pages 1069-1075.
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Fong-Qi Liang & Bernard F Godley. (2003) Oxidative stress-induced mitochondrial DNA damage in human retinal pigment epithelial cells: a possible mechanism for RPE aging and age-related macular degeneration. Experimental Eye Research 76:4, pages 397-403.
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Dexi ChenManabu MinamiDavid C. HenshallRobert MellerGlen KisbyRoger P. Simon. (2016) Upregulation of Mitochondrial Base-Excision Repair Capability within Rat Brain after Brief Ischemia. Journal of Cerebral Blood Flow & Metabolism 23:1, pages 88-98.
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Dexi Chen, Manabu Minami, David C. Henshall, Robert Meller, Glen Kisby & Roger P. Simon. (2003) Upregulation of Mitochondrial Base-Excision Repair Capability Within Rat Brain After Brief Ischemia. Journal of Cerebral Blood Flow & Metabolism, pages 88-98.
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Bhaskar S Mandavilli, Janine H Santos & Bennett Van Houten. (2002) Mitochondrial DNA repair and aging. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 509:1-2, pages 127-151.
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Bernard F. Godley, Gui-Fang Jin, Yan-Shi Guo & John S. Hurst. (2002) Bcl-2 Overexpression Increases Survival in Human Retinal Pigment Epithelial Cells Exposed to H2O2. Experimental Eye Research 74:6, pages 663-669.
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Peep V. Algvere & Stefan Seregard. (2003) Age‐related maculopathy: pathogenetic features and new treatment modalities. Acta Ophthalmologica Scandinavica 80:2, pages 136-143.
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