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Research Article

Rod outer segments mediate mitochondrial DNA damage and apoptosis in human retinal pigment epithelium

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Pages 11-19 | Published online: 02 Jul 2009

Reference

  • Bressler NM, Bressler SB, Fine SL. Age-related macular degeneration. Surv Ophthalmol. 1988;32:375–413.
  • Snodderly DM. Evidence for protection against age-related macular degeneration by carotenoids and antioxidant vita-mins. Am J Clin Nutr. 1995;62:1448S–14615.
  • van der Hagen AM, Yolton DP, Kaminski MS, Yolton RL. Free radicals and antioxidant supplementation: A review of their roles in age-related macular degeneration. J Am Optom Assoc. 1993;64:871–878.
  • Winkler BS, Boulton ME, Gottsch JD, Sternberg P. Oxida-tive damage and age-related macular degeneration. Mo/ Vis. 1999;5:32.
  • Rose RC, Richer SP, Bode AM. Ocular oxidants and antioxidant protection. Proc Soc Exp Biol Med. 1998;217:397–407.
  • Young RW. The renewal of photoreceptor cell outer seg-ments. J Cell BioL 1967;33:61–72.
  • Dorey CK, Khouri GG, Syniuta LA, Curran SA, Weiter JJ. Superoxide production by porcine retinal pigment epithe-1Mm in vitro. Invest Ophthalmol Vis Sci. 1989;30: 1047–1054.
  • Tate DJ, Jr., Miceli MV, Newsome DA. Phagocytosis and 11202 induce catalase and metallothionein gene expression in human retinal pigment epithelial cells. Invest Ophthal-mol Vis Sci. 1995;36:1271–1279.
  • Dorey CK, Wu G, Ebenstein D, Garsd A, Weiter JJ. Cell loss in the aging retina. Relationship to lipofuscin accu-mulation and macular degeneration. Invest Ophthalmol Vis Sci. 1989;30:1691–1699.
  • Ballinger SW, Van Houten B, Jin GF, Conklin CA, Godley BF. Hydrogen peroxide causes significant mitochondrial DNA damage in human RPE cells. Exp Eye Res. 1999;68:765–772.
  • Adelman R, Saul RL, Ames BN. Oxidative damage to DNA: Relation to species metabolic rate and life span. Proc Nall Acad Sci USA. 1988;85:2706–2708.
  • Ames BN, Saul RL. In: Iversen OH, ed. Theories of Carcinogenesis. Washington, DC, Hemisphere Publishing Corp; 1988:203–220.
  • Richter C, Park J-W, Ames BN. Normal oxidative damage to mitochondrial and nuclear DNA is extensive. Proc Natl Acad Sci USA. 1988;85:6465–6467.
  • Porn-Ares MI, Samali A, Orrenius S. Cleavage of the calpain inhibitor, calpastatin, during apoptosis. Cell Death Dijièr. 1998;5:1028–1033.
  • Wei YH. Oxidative stress and mitochondrial DNA muta-tions in human aging. Proc Soc Exp Biol Med. 1998; 217:53–63.
  • Wei YH. Mitochondrial DNA mutations and oxidative damage in aging and diseases: An emerging paradigm of gerontology and medicine. Proc Natl Sci Council, Rep China - Part B, Life Sciences. 1998;22:55–67.
  • Ramana CV, Boldogh I, Izumi T, Mitra S. Activation of apurinic/apyrimidinic endonuclease in human cells by reac-tive oxygen species and its correlation with their adaptive response to genotoxicity of free radicals. Proc Natl Acad Sci USA. 1998;95:5061–5066.
  • Chen KH, Yakes FM, Srivastava DK, Singhal RK, Sobol RW, Horton JK, Van Houten B, Wilson SH. Up-regulation of base excision repair correlates with enhanced protection against a DNA damaging agent in mouse cell lines. Nucleic Acids Res. 1998;26:2001–2007.
  • Bennett RA, Wilson DM, III, Wong D, Demple B. Interac-tion of human apurinic endonuclease and DNA polymerase beta in the base excision repair pathway. Proc Natl Acad Sci USA. 1997;94:7166–7169.
  • Kerendian J, Enomoto H, Wong CG. Induction of stress proteins in SV-40 transformed human RPE-derived cells by organic oxidants. Curr Eye Res. 1992;11: 385–396.
  • Kvanta A. Expression and secretion of transforming growth factor-beta in transformed and nontransformed retinal pigment epithelial cells. Ophthalmic Res. 1994;26:361–367.
  • Sippy BD, Hofman FM, He S, Osusky R, Sheu SJ, Walker SM, Ryan SJ, Hinton DR. 5V40-immortalized and primary cultured human retinal pigment epithelial cells share similar patterns of cytokine-receptor expression and cyto-kine responsiveness. Curr Eye Res. 1995;14:495–503.
  • Kumaki N, Anderson DM, Cosman D, Kumaki S. Expres-sion of interleukin-15 and its receptor by human fetal retinal pigment epithelial cells. Curr Eye Res. 1996;15: 876–882.
  • van Kuijk FJ, Buck P, Lewis JW, Kliger DS. Preparative scale isolation and partial purification of human rod outer segments. Exp Eye Res. 1993;57:249–252.
  • Hansen MB, Nielsen SE. Reexamination and further development of a precise and rapid dye method for mea-suring cell/growth kill. J Immunol Methods. 1989;119: 203–210.
  • Kalinowski DP, Illenye S, Van Houten B. Analysis of DNA damage and repair in murine leukemia L1210 cells using a quantitative polymerase chain reaction assay. Nucleic Acids Res. 1992;20:3485–3494.
  • Van Houten B, Chen Y, Nicklas JA, Rainville IR, O'Neill JP. Development of long PCR techniques to analyze dele-tion mutations of the human hprt gene. Mutat Res. 1998;403:171–175.
  • Rao GN. Hydrogen peroxide induces complex formation of SHC-Grb2-SOS with receptor tyrosine kinase and activates Ras and extracellular signal-regulated protein kinases group of mitogen-activated protein kinases. Oncogene. 1996;13:713–719.
  • Bradford M. A rapid and sensitive method for the quanti-ration of protein utilizing the principle of protein dye-binding. Anal Biochem. 1976;72:248–254.
  • Zhang G, Gurtu V, Kain SR, Yan G. Early detection of apop-tosis using a fluorescent conjugate of armexin V. Biotech-niques. 1997;23:525–531.
  • Cai J, Yang J, Jones DP Mitochondrial control of apopto-sis: The role of cytochrome c. Biochim Biophys Acta. 1998;1366:139–149.
  • Hinton DR, He S, Lopez PF. Apoptosis in surgically excised choroidal neovascular membranes in age-related macular degeneration. Arch OphthalmoL 1998;116:203–209.
  • Susin SA, Zamzami N, Kroemer G. Mitochondria as regu-lators of apoptosis: Doubt no more. Biochim Biophys Acta. 1998;1366:151–165.
  • LeDoux SP, Wilson GL, Beecham EJ, Stevnsner T, Wassermann K, Bohr VA. Repair of mitochondrial DNA after various types of DNA damage in Chinese hamster ovary cells. Carcinogenesis. 1992;13:1967–1973.
  • Yakes FM, Van Houten B. Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress. Proc Nall Acad Sci USA. 1997;94:514–519.
  • Grosch S, Fritz G, Kaina B. Apurinic endonuclease (Ref-1) is induced in mammalian cells by oxidative stress and involved in clastogenic adaptation. Cancer Res. 1998;58: 4410–4416.
  • Xanthoudakis S, Miao GG, Curran T. The redox and DNA-repair activities of Ref-1 are encoded by nonoverlapping domains. Proc Nall Acad Sci USA. 1994;91: 23–27.
  • Jayaraman L, Murthy KG, Zhu C, Curran T, Xanthoudakis S, Prives C. Identification of redox/repair protein Ref-1 as a potent activator of p53. Genes Dev. 1997;11:558–570.
  • Chen KH, Srivastava DK, Singhal RK, Jacob S, Ahmed AE, Wilson SH. Modulation of base excision repair by low density lipoprotein, oxidized low density lipoprotein and antioxidants in mouse monocytes. Carcinogenesis. 2000; 21:1017–1022.
  • Deng C, Zhang P, Harper JW, Elledge SJ, Leder P. Mice lacking p21CIP1IWAF1 undergo normal development, but are defective in G1 checkpoint control. Cell. 1995;82: 675–684.
  • Attardi LD, Lowe SW, Brugarolas J, Jacks T. Transcrip-tional activation by p53, but not induction of the p21 gene, is essential for oncogene-mediated apoptosis. EMBO 1996;15:3693–3701.
  • Polyak K, Xia Y, Zweier JL, Kinzler KW, Vogelstein B. A model for p53-induced apoptosis. Nature. 1997;389: 300–305.
  • Kedar PS, Lowy DR, Widen SG, Wilson SH. Transfected human beta-polymerase promoter contains a ras-responsive element. Mol Cell Biol. 1990;10:3852–3856.
  • Sandstrom PA, Pardi D, Tebbey PW, Dudek RW, Terrian DM, Folks TM, Buttke TM. Lipid hydroperoxide-induced apoptosis: Lack of inhibition by Bc1-2 over-expression. FEBS Lett. 1995;365: 66–70.
  • Vento R, d'Allesandro N, Giuliano M, Lauricella A, Carabillo M, Tesoriere G. Induction of apoptosis by arachi-donic acid in human retinoblastoma Y79 cells: Involvement of oxidative stress. Exp Eye Res. 2000;70: 503–517.
  • Kruman I, Bruce-Keller AJ, Bredesen D, Waeg G, Mattson MP. Evidence that 4-hydroxynonenal mediates oxidative stress-induced neuronal apoptosis. J Neurosci. 1997;17: 5089–5100.

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