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Re-evaluation of the classical dietary arginine:lysine interaction for modern poultry diets: a review

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Pages 275-289 | Published online: 23 Sep 2019

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (5)

Hiep Thi Dao & Robert A. Swick. (2021) New insights into arginine and arginine-sparing effects of guanidinoacetic acid and citrulline in broiler diets. World's Poultry Science Journal 77:4, pages 753-773.
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E.A. Awad, I. Zulkifli, A.F. Soleimani, F.L. Law, S.K. Ramiah, I.M. Mohamed-Yousif, E.A. Hussein & E.S. Khalil. (2019) Response of broilers to reduced-protein diets under heat stress conditions. World's Poultry Science Journal 75:4, pages 583-598.
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Youssef A. Attia, Fulvia Bovera, Abd-El-Hamid E. Abd-El-Hamid, Abd-Elrazk E. Tag EL-Din, Mohammed A. Al-Harthi, Antonino Nizza & Raesa M. Elharidy. (2017) Effect of dietary protein concentrations, amino acids and conjugated linoleic acid supplementations on productive performance and lipid metabolism of broiler chicks. Italian Journal of Animal Science 16:4, pages 563-572.
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F. Khajali & R.F. Wideman. (2010) Dietary arginine: metabolic, environmental, immunological and physiological interrelationships. World's Poultry Science Journal 66:4, pages 751-766.
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R. Gonzalez-Esquerra & S. Leeson. (2006) Physiological and metabolic responses of broilers to heat stress - implications for protein and amino acid nutrition. World's Poultry Science Journal 62:2, pages 282-295.
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Articles from other publishers (38)

Guanchen Liu & Woo Kyun Kim. (2023) The Functional Roles of Methionine and Arginine in Intestinal and Bone Health of Poultry: Review. Animals 13:18, pages 2949.
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Shemil P. Macelline, Peter V. Chrystal, Chanon Inanan, Mehdi Toghyani, Peter H. Selle & Sonia Yun Liu. (2023) The influence of dietary crude protein concentrations, grain types and arginine:lysine ratios on the performance of broiler chickens. Animal Nutrition 14, pages 259-268.
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Marcos Vinícius Martins Morais, Heder José D'Avila Lima, Fernanda Nunes Albernaz Silva & Marcus Vinicius Figueiredo Campos Gomes. (2023) Indicators of thermal comfort and nitrogen digestibility as a function of digestible arginine: lysine ratios in the diet of laying Japanese quails raised in hot weather. Journal of Thermal Biology 115, pages 103597.
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Michael Fruci, Munene Kithama, Elijah G. Kiarie, Suqin Shao, Huaizhi Liu, Edward Topp & Moussa S. Diarra. (2023) Effects of partial or complete replacement of soybean meal with commercial black soldier fly larvae (Hermetia illucens) meal on growth performance, cecal short chain fatty acids, and excreta metabolome of broiler chickens. Poultry Science 102:4, pages 102463.
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Giorgio Brugaletta, Luca Laghi, Marco Zampiga, Chiara Oliveri, Valentina Indio, Raffaela Piscitelli, Stefano Pignata, Massimiliano Petracci, Alessandra De Cesare & Federico Sirri. (2023) Metabolic and microbiota response to arginine supplementation and cyclic heat stress in broiler chickens. Frontiers in Physiology 14.
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Hannah Facey, Munene Kithama, Mohsen Mohammadigheisar, Lee-Anne Huber, Anna K. Shoveller & Elijah G. Kiarie. (2023) Complete replacement of soybean meal with black soldier fly larvae meal in feeding program for broiler chickens from placement through to 49 days of age reduced growth performance and altered organs morphology. Poultry Science 102:1, pages 102293.
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Shemil P. Macelline, Mehdi Toghyani, Peter V. Chrystal, Juliano C. de Paula Dorigam, Shiva Greenhalgh, Peter H Selle & Sonia Y. Liu. (2022) Essential amino acid recommendations for Isa Brown layers during peak and post peak production. Poultry Science 101:12, pages 102171.
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Magdalena Krauze, Katarzyna Ognik, Dariusz Mikulski & Jan Jankowski. (2022) Assessment of Neurodegenerative Changes in Turkeys Fed Diets with Different Proportions of Arginine and Methionine Relative to Lysine. Animals 12:12, pages 1535.
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Charles Venirius Lisnahan, Oktovianus R. Nahak, Welsiliana Welsiliana & Lukas Pardosi. (2022) Effect of L-arginine and L-Lysine HCl ratio on growth performance and ileum morphology of native chickens aged 2-14 weeks. Veterinary World, pages 1365-1372.
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Zuzanna Całyniuk, Dariusz Mikulski, Magdalena Krauze, Katarzyna Ognik & Jan Jankowski. (2022) Selected metabolic, epigenetic, nitration and redox parameters in turkeys fed diets with different levels of arginine and methionine. Annals of Animal Science 22:2, pages 601-612.
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Marzena Zając, Krzysztof Zając & Jakub Dybaś. (2022) The effect of nitric oxide synthase and arginine on the color of cooked meat. Food Chemistry 373, pages 131503.
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Hiep Thi Dao, Nishchal K. Sharma, Emma J. Bradbury & Robert A. Swick. (2021) Effects of L-arginine and L-citrulline supplementation in reduced protein diets for broilers under normal and cyclic warm temperature. Animal Nutrition 7:4, pages 927-938.
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Paweł Konieczka, Dariusz Mikulski, Katarzyna Ognik, Jerzy Juśkiewicz, Zenon Zduńczyk & Jan Jankowski. (2021) Increased Dietary Inclusion Levels of Lysine Are More Effective than Arginine in Supporting the Functional Status of the Gut in Growing Turkeys. Animals 11:8, pages 2351.
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Katarzyna Ognik, Dariusz Mikulski, Paweł Konieczka, Bartłomiej Tykałowski, Magdalena Krauze, Anna Stępniowska, Anna Nynca & Jan Jankowski. (2021) The immune status, oxidative and epigenetic changes in tissues of turkeys fed diets with different ratios of arginine and lysine. Scientific Reports 11:1.
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Hiep Thi Dao, Nishchal K. Sharma, Emma J. Bradbury & Robert A. Swick. (2021) Response of laying hens to L-arginine, L-citrulline and guanidinoacetic acid supplementation in reduced protein diet. Animal Nutrition 7:2, pages 460-471.
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J. Jankowski, K. Ognik, Z. Całyniuk, A. Stępniowska, P. Konieczka & D. Mikulski. (2021) The effect of different dietary ratios of lysine, arginine and methionine on protein nitration and oxidation reactions in turkey tissues and DNA. Animal 15:4, pages 100183.
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W. L. Bryden, X. Li, I. Ruhnke, D. Zhang & S. Shini. (2021) Nutrition, feeding and laying hen welfare. Animal Production Science 61:10, pages 893-914.
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Mehran Mehri, Shokoufeh Hasanvand & Hossein Bazzi. (2021) Nutritional requirement of meat-type Japanese quail: Threonine. Animal Feed Science and Technology 271, pages 114774.
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Jan Jankowski, Katarzyna Ognik, Paweł Konieczka & Dariusz Mikulski. (2020) Effects of different levels of arginine and methionine in a high-lysine diet on the immune status, performance, and carcass traits of turkeys. Poultry Science 99:10, pages 4730-4740.
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Marco Zampiga, Luca Laghi, Massimiliano Petracci, Chenglin Zhu, Adele Meluzzi, Sami Dridi & Federico Sirri. (2018) Effect of dietary arginine to lysine ratios on productive performance, meat quality, plasma and muscle metabolomics profile in fast-growing broiler chickens. Journal of Animal Science and Biotechnology 9:1.
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S.J. Rochell, C.M. Parsons & R.N. Dilger. (2016) Effects of Eimeria acervulina infection severity on growth performance, apparent ileal amino acid digestibility, and plasma concentrations of amino acids, carotenoids, and α1-acid glycoprotein in broilers. Poultry Science 95:7, pages 1573-1581.
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Shiqun Han, Qing Zhou, Yudi Xu, Floris Vanogtrop, Qijin Guo, Guofeng Liu & Shaohua Yan. (2015) Valuable ingredients and feed toxicity evaluation of Microcystis aeruginosa acidolysis product in mice . Experimental Biology and Medicine 240:10, pages 1333-1339.
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G. U. Manju, B. S. V. Reddy, Gideon Gloridoss, T. M. Prabhu, K. S. Giridhar & N. Suma. (2015) Effect of supplementation of lysine producing microbes vis-a-vis source and level of dietary protein on performance and egg quality characteristics of post-peak layers. Veterinary World 8:4, pages 453-460.
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Marc-Alexander Lieboldt, Ingrid Halle, Jana Frahm, Lars Schrader, Steffen Weigend, Rudolf Preisinger & Sven Dänicke. (2015) Effects of Long-term Graded L-arginine Supply on Growth Development, Egg Laying and Egg Quality in Four Genetically Diverse Purebred Layer Lines. The Journal of Poultry Science 53:1, pages 8-21.
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W. Zhu, W. Jiang & L. Y. Wu. (2014) Dietary L‐arginine supplement alleviates hepatic heat stress and improves feed conversion ratio of Pekin ducks exposed to high environmental temperature. Journal of Animal Physiology and Animal Nutrition 98:6, pages 1124-1131.
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Mehran Mehri. (2014) Optimization of response surface and neural network models in conjugation with desirability function for estimation of nutritional needs of methionine, lysine, and threonine in broiler chickens. Poultry Science 93:7, pages 1862-1867.
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Christian Wecke & Frank Liebert. (2013) Improving the Reliability of Optimal In-Feed Amino Acid Ratios Based on Individual Amino Acid Efficiency Data from N Balance Studies in Growing Chicken. Animals 3:3, pages 558-573.
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LMGS Silva, AE Murakami, JIM Fernandes, D Dalla Rosa & JF Urgnani. (2012) Effects of dietary arginine supplementation on broiler breeder egg production and hatchability. Revista Brasileira de Ciência Avícola 14:4, pages 267-273.
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L. Mejia, C.D. Zumwalt, P.B. Tillman, R.B. Shirley & A. Corzo. (2012) Ratio needs of arginine relative to lysine of male broilers from 28 to 42 days of age during a constant, elevated environmental temperature regimen. Journal of Applied Poultry Research 21:2, pages 305-310.
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M. Mehri, A.A. Davarpanah & H.R. Mirzaei. (2012) Estimation of ideal ratios of methionine and threonine to lysine in starting broiler chicks using response surface methodology. Poultry Science 91:3, pages 771-777.
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Alice E. Murakami, Jovanir I. M. Fernandes, Luzmarina Hernandes & Tatiana C. Santos. (2012) Effects of starter diet supplementation with arginine on broiler production performance and on small intestine morphometry. Pesquisa Veterinária Brasileira 32:3, pages 259-266.
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Y. A. Attia, R. A. Hassan, A. E. Tag El‐Din & B. M. Abou‐Shehema. (2010) Effect of ascorbic acid or increasing metabolizable energy level with or without supplementation of some essential amino acids on productive and physiological traits of slow‐growing chicks exposed to chronic heat stress. Journal of Animal Physiology and Animal Nutrition 95:6, pages 744-755.
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K. MASAGOUNDER, R.S. HAYWARD & J.D. FIRMAN. (2011) Comparison of dietary essential amino acid requirements determined from group-housed versus individually-housed juvenile bluegill, Lepomis macrochirus. Aquaculture Nutrition 17:2, pages e559-e571.
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Christine Laganá, Andréa Machado Leal Ribeiro, Félix Hilario Diaz González, Luciana de Almeida Lacerda, Lílian Ribeiro Kratz & Patrícia Rick Barbosa. (2007) Níveis dietéticos de proteína e gordura e parâmetros bioquímicos, hematológicos e empenamento em frangos de corte estressados pelo calor. Revista Brasileira de Zootecnia 36:6, pages 1783-1790.
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R. Gonzalez-Esquerra & S. Leeson. (2006) Concentrations of Putrescine, Spermidine, and Spermine in Duodenum and Pancreas as Affected by the Ratio of Arginine to Lysine and Source of Methionine in Broilers Under Heat Stress. Poultry Science 85:8, pages 1398-1408.
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J. Chen, X. Li, D. Balnave & J Brake. (2005) The influence of dietary sodium chloride, arginine:lysine ratio, and methionine source on apparent ileal digestibility of arginine and lysine in acutely heat-stressed broilers. Poultry Science 84:2, pages 294-297.
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D. Balnave & J. Brake. (2004) Evidence Supporting the Hypothesis that Ambient Temperature and Dietary Composition Influence the Relative Efficacy of Methionine and Its Hydroxy Analogues for Broilers: A Review. Journal of Applied Poultry Research 13:4, pages 693-700.
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D. Balnave. (2004) Challenges of Accurately Defining the Nutrient Requirements of Heat-Stressed Poultry. Poultry Science 83:1, pages 5-14.
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