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Acta Chirurgica Belgica Volume 113, 2013 - Issue 6
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Review Article

Mucinous Differentiation in Colorectal Cancer: Molecular, Histological and Clinical Aspects

H. DebunneDepartment of Surgery, Ghent University Hospital, Ghent, Belgium
&
W. CeelenDepartment of Surgery, Ghent University Hospital, Ghent, BelgiumView further author information
Pages 385-390 | Published online: 11 Mar 2016

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Yeqian Huang, Nayef A. Alzahrani, Winston Liauw, Arief Arrowaili & David L. Morris. (2018) Survival difference between mucinous vs. non-mucinous colorectal cancer following cytoreductive surgery and intraperitoneal chemotherapy. International Journal of Hyperthermia 35:1, pages 298-304.
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Articles from other publishers (39)

Theo Guitton, Pierre Allaume, Noémie Rabilloud, Nathalie Rioux-Leclercq, Sébastien Henno, Bruno Turlin, Marie-Dominique Galibert-Anne, Astrid Lièvre, Alexandra Lespagnol, Thierry Pécot & Solène-Florence Kammerer-Jacquet. (2023) Artificial Intelligence in Predicting Microsatellite Instability and KRAS, BRAF Mutations from Whole-Slide Images in Colorectal Cancer: A Systematic Review. Diagnostics 14:1, pages 99.
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Chaolin Deng, Min-Er Zhong, Yanyu Chen, Meng Pan, Lai Xu, Yi Xiao, Yanpan Gao & Bin Wu. (2023) Proteomic profiling and functional characterization of serum-derived extracellular vesicles in the mucinous and non-mucinous colon adenocarcinoma. Journal of Cancer Research and Clinical Oncology 149:11, pages 9285-9300.
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Arka Saha, Nancy Gavert, Thomas Brabletz & Avri Ben-Ze’ev. (2023) An Increase in Mucin2 Expression Is Required for Colon Cancer Progression Mediated by L1. International Journal of Molecular Sciences 24:17, pages 13418.
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Murali R. Kuracha, Venkatesh Govindarajan, Brian W. Loggie, Martin Tobi & Benita L. McVicker. (2023) Pictilisib-Induced Resistance Is Mediated through FOXO1-Dependent Activation of Receptor Tyrosine Kinases in Mucinous Colorectal Adenocarcinoma Cells. International Journal of Molecular Sciences 24:15, pages 12331.
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William P. Duggan, Manuela Salvucci, Batuhan Kisakol, Andreas U. Lindner, Ian S. Reynolds, Heiko Dussmann, Joanna Fay, Tony O’Grady, Daniel B. Longley, Fiona Ginty, Elizabeth Mc Donough, Daniel J. Slade, John P. Burke & Jochen H. M. Prehn. (2023) Increased Fusobacterium tumoural abundance affects immunogenicity in mucinous colorectal cancer and may be associated with improved clinical outcome. Journal of Molecular Medicine 101:7, pages 829-841.
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Ian S. Reynolds, Paul M. Cromwell, Éanna J. Ryan, Erinn McGrath, Rory Kennelly, Ronan Ryan, Niall Swan, Kieran Sheahan, Des C. Winter & Emir Hoti. (2022) An Analysis of Clinicopathological Outcomes and the Utility of Preoperative MRI for Patients Undergoing Resection of Mucinous and Non-Mucinous Colorectal Cancer Liver Metastases. Frontiers in Oncology 12.
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Junqin Zhang, Yuxi Ge, Heng Zhang, Zi Wang, Weiqiang Dou & Shudong Hu. (2022) Quantitative T2 Mapping to Discriminate Mucinous from Nonmucinous Adenocarcinoma in Rectal Cancer: Comparison with Diffusion-weighted Imaging. Magnetic Resonance in Medical Sciences 21:4, pages 593-598.
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Emer O’Connell, Manuela Salvucci, Ian S. Reynolds, Deborah A. McNamara, John P. Burke & Jochen H. M. Prehn. (2021) Mucinous Colorectal Cancer is Associated With Expression of the TIM-3 Immune Checkpoint Independently of Microsatellite Instability (MSI) Status. Annals of Surgical Oncology 28:12, pages 7999-8006.
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E. O’Connell, I. S. Reynolds, M. Salvucci, D. A. McNamara, J. P. Burke & J. H. M. Prehn. (2021) Mucinous and non-mucinous colorectal cancers show differential expression of chemotherapy metabolism and resistance genes. The Pharmacogenomics Journal 21:4, pages 510-519.
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Emer O’Connell, Ian S. Reynolds, Deborah A. McNamara, John P. Burke & Jochen H. M. Prehn. (2021) Resistance to Cell Death in Mucinous Colorectal Cancer—A Review. Cancers 13:6, pages 1389.
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Ian S. Reynolds, Paul M. Cromwell & Emir Hoti. (2021) Clinicopathological characteristics and survival outcomes for patients with mucinous colorectal cancer liver metastases undergoing hepatic resection: A systematic review and meta-analysis. The American Journal of Surgery.
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Ian S. Reynolds, Valentina Thomas, Emer O’Connell, Michael Fichtner, Deborah A. McNamara, Elaine W. Kay, Jochen H. M. Prehn, John P. Burke & Simon J. Furney. (2020) Mucinous Adenocarcinoma of the Rectum: A Whole Genome Sequencing Study. Frontiers in Oncology 10.
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Gulsum S. Yalcin, Mehmet A. Gonultas, Sema Hucumenoglu, Gulcin Simsek & Mevlut R. Pekcici. (2020) SATB1 Expression of Colorectal Adenomatous Polyps is Higher than that of Colorectal Carcinomas. Applied Immunohistochemistry & Molecular Morphology 28:7, pages 532-537.
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Ian S. Reynolds, Emer O’Connell, Michael Fichtner, Deborah A. McNamara, Elaine W. Kay, Jochen H. M. Prehn, Simon J. Furney & John P. Burke. (2019) Mucinous adenocarcinoma is a pharmacogenomically distinct subtype of colorectal cancer. The Pharmacogenomics Journal 20:3, pages 524-532.
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Ramesh Pothuraju, Shiv Ram Krishn, Shailendra K. Gautam, Priya Pai, Koelina Ganguly, Sanjib Chaudhary, Satyanarayana Rachagani, Sukhwinder Kaur & Surinder K. Batra. (2020) Mechanistic and Functional Shades of Mucins and Associated Glycans in Colon Cancer. Cancers 12:3, pages 649.
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Cong Luo, Shuyi Cen, Guojun Ding & Wei Wu. (2019) Mucinous colorectal adenocarcinoma: clinical pathology and treatment options. Cancer Communications 39:1, pages 1-13.
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Sare Hosseini, NamPhong Nguyen, Mohammad Mohammadianpanah, Sepideh Mirzaei & Ali Mohammad Bananzadeh. (2018) Predictive Significance of Mucinous Histology on Pathologic Complete Response Rate Following Capecitabine-Based Neoadjuvant Chemoradiation in Rectal Cancer: a Comparative Study. Journal of Gastrointestinal Cancer 50:4, pages 716-722.
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Ian S. Reynolds, Emer O'Connell, Michael Fichtner, Deborah A. McNamara, Elaine W. Kay, Jochen H. M. Prehn, Simon J. Furney & John P. Burke. (2019) Mucinous adenocarcinoma of the colon and rectum: A genomic analysis. Journal of Surgical Oncology 120:8, pages 1427-1435.
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Tatsuya Morinishi, Yasunori Tokuhara, Hiroyuki Ohsaki, Emi Ibuki, Kyuichi Kadota & Eiichiro Hirakawa. (2019) Activation and Expression of Peroxisome Proliferator-Activated Receptor Alpha Are Associated with Tumorigenesis in Colorectal Carcinoma. PPAR Research 2019, pages 1-9.
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I S Reynolds, S J Furney, E W Kay, D A McNamara, J H M Prehn & J P Burke. (2019) Meta-analysis of the molecular associations of mucinous colorectal cancer. British Journal of Surgery 106:6, pages 682-691.
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Aldona Kasprzak, Elżbieta Siodła, Małgorzata Andrzejewska, Jacek Szmeja, Agnieszka Seraszek-Jaros, Szczepan Cofta & Witold Szaflarski. (2018) Differential expression of mucin 1 and mucin 2 in colorectal cancer. World Journal of Gastroenterology 24:36, pages 4164-4177.
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Christian Galata, Daniela Hirsch, Wolfgang Reindl, Stefan Post, Peter Kienle, Michael Boutros, Timo Gaiser & Karoline Horisberger. (2018) Clinical and Histopathologic Features of Colorectal Adenocarcinoma in Crohn’s Disease. Journal of Clinical Gastroenterology 52:7, pages 635-640.
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Ping Shen, Shu Yang, Haimei Sun, Guilan Li, Bo Wu, Fengqing Ji, Tingyi Sun & Deshan Zhou. (2018) SCF/c-KIT Signaling Increased Mucin2 Production by Maintaining Atoh1 Expression in Mucinous Colorectal Adenocarcinoma. International Journal of Molecular Sciences 19:5, pages 1541.
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Basem G. Soliman, Georgios Karagkounis, James M. Church, Thomas Plesec & Matthew F. Kalady. (2018) Mucinous Histology Signifies Poor Oncologic Outcome in Young Patients With Colorectal Cancer. Diseases of the Colon & Rectum 61:5, pages 547-553.
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Yalin Jiang, Yunfeng Zhou, Yufeng Zheng, Hong Guo, Lei Gao, Pan Chen, Dandan Feng, Ran Qi, Xiaozhen Li, Yongchao Chang, Fong-Fong Chu & Qiang Gao. (2017) Expression of inositol-requiring enzyme 1β is downregulated in colorectal cancer. Oncology Letters 13:3, pages 1109-1118.
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Veronika Vymetalkova, Barbara Pardini, Fabio Rosa, Katerina Jiraskova, Cornelia Di Gaetano, Petra Bendova, Miloslav Levy, Veronika Veskrnova, Tomas Buchler, Ludmila Vodickova, Alessio Naccarati & Pavel Vodicka. (2017) Polymorphisms in microRNA binding sites of mucin genes as predictors of clinical outcome in colorectal cancer patients. Carcinogenesis 38:1, pages 28-39.
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Annette Eyking, Henning Reis, Magdalena Frank, Guido Gerken, Kurt W. Schmid & Elke Cario. (2016) MiR-205 and MiR-373 Are Associated with Aggressive Human Mucinous Colorectal Cancer. PLOS ONE 11:6, pages e0156871.
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Ignazio Tarantino, Felix J. Hüttner, Rene Warschkow, Bruno M. Schmied, Markus K. Diener & Alexis Ulrich. (2015) Prognostic Relevance of Mucinous Subtype in a Population-based Propensity Score Analysis of 40,083 Rectal Cancer Patients. Annals of Surgical Oncology 23:5, pages 1576-1586.
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M. Ramos, J. Monta?o, M. Esteva, A. Barcel?P. Franch. (2016) Colorectal cancer survival by stage of cases diagnosed in Mallorca, Spain, between 2006 and 2011 and factors associated with survival. Cancer Epidemiology 41, pages 63-70.
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Sare Hosseini, Shadi Zohourinia, Mohammad Zare-Bandamiri, Maral Mokhtari, Soudabeh Pourhashemi, Massood Hosseinzadeh & Mohammad Mohammadianpanah. (2016) Clinical and Pathological Characteristics of Mucinous Colorectal Adenocarcinoma: A Comparative Study. Annals of Colorectal Research 4:1.
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Priya Pai, Satyanarayana Rachagani, Punita Dhawan & Surinder K. Batra. (2016) Mucins and Wnt/β-catenin signaling in gastrointestinal cancers: an unholy nexus. Carcinogenesis 37:3, pages 223-232.
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Xin Wang, Fei Yan, Run Shi, Xing Huang, Shiming Lu, Lin Xu & Binhui Ren. (2016) Hyper Expression of Mucin 5ac Indicates Poor Cancer Prognoses. Medicine 95:1, pages e2396.
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A. Martirosyan, M. J. Olesen, R. A. Fenton, J. Kjems & K. A. Howard. (2016) Mucin-mediated nanocarrier disassembly for triggered uptake of oligonucleotides as a delivery strategy for the potential treatment of mucosal tumours. Nanoscale 8:25, pages 12599-12607.
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Zoltan Farkas Kispal, Daniel Kardos, Tamas Jilling, Laszlo Kereskai, Marla Isaacs, Daniel L. Balogh, Andrew B. Pinter, Holger Till & Peter Vajda. (2015) Long-term histological and mucin alterations in the neobladder mucosa following urinary bladder augmentation or substitution with gastrointestinal segment. Journal of Pediatric Urology 11:6, pages 349.e1-349.e6.
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Jun Tan, Shu Yang, Ping Shen, Haimei Sun, Jie Xiao, Yaxi Wang, Bo Wu, Fengqing Ji, Jihong Yan, Hong Xue & Deshan Zhou. (2015) C-kit signaling promotes proliferation and invasion of colorectal mucinous adenocarcinoma in a murine model. Oncotarget 6:29, pages 27037-27048.
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Giuseppe S. Sica, Cristina Fiorani, Carmine Stolfi, Giovanni Monteleone, Eleonora Candi, Ivano Amelio, Valeria Catani, Simone Sibio, Andrea Divizia, Giorgia Tema, Edoardo Iaculli & Achille L. Gaspari. (2015) Peritoneal expression of matrilysin helps identify early post-operative recurrence of colorectal cancer. Oncotarget 6:15, pages 13402-13415.
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JUN-PEI XIE, XIAO-SAN ZHU, YI-CHEN DAI, CUI YU, TAO XIE & ZHANG-XING CHEN. (2014) Expression of enoyl coenzyme A hydratase, short chain, 1, in colorectal cancer and its association with clinicopathological characteristics. Molecular and Clinical Oncology 2:6, pages 1081-1084.
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Juliana Santos, Alexandre Funck, Isabelle Silva-Fernandes, Silvia Rabenhorst, Carlos Martinez & Marcelo Ribeiro. (2014) Effect of APE1 T2197G (Asp148Glu) Polymorphism on APE1, XRCC1, PARP1 and OGG1 Expression in Patients with Colorectal Cancer. International Journal of Molecular Sciences 15:10, pages 17333-17343.
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Carmelo Tuscano, Elvio Grazioso Russi, Said Al Sayyad & Stefano Pergolizzi. (2014) An Incidental Finding of Mucinous Colon Cancer by 18 F-Choline PET/CT Determining a Change in Clinical Management of a Patient with Recurrent Prostate Adenocarcinoma . Case Reports in Oncological Medicine 2014, pages 1-4.
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