71
Views
27
CrossRef citations to date
0
Altmetric
Research Article

Homozygous Disruption of the mdr1a P-glycoprotein Gene Affects Blood-Nerve Barrier Function in Mice Administered with Neurotoxic Drugs

Pages 735-742 | Published online: 08 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (1)

Ulrich Hoffmann & Heyo K. Kroemer. (2004) The ABC Transporters MDR1 and MRP2: Multiple Functions in Disposition of Xenobiotics and Drug Resistance. Drug Metabolism Reviews 36:3-4, pages 669-701.
Read now

Articles from other publishers (26)

Tore B. Stage, Christina Mortensen, Sehbar Khalaf, Vivien Steffensen, Helen S. Hammer, Chenling Xiong, Flemming Nielsen, Oliver Poetz, Åsa Fex Svenningsen, Cristina Rodriguez‐Antona & Deanna L. Kroetz. (2020) P‐Glycoprotein Inhibition Exacerbates Paclitaxel Neurotoxicity in Neurons and Patients With Cancer. Clinical Pharmacology & Therapeutics 108:3, pages 671-680.
Crossref
Jessica Maiuolo, Micaela Gliozzi, Vincenzo Musolino, Cristina Carresi, Saverio Nucera, Roberta Macrì, Miriam Scicchitano, Francesca Bosco, Federica Scarano, Stefano Ruga, Maria Caterina Zito, Francesca Oppedisano, Rocco Mollace, Sara Paone, Ernesto Palma, Carolina Muscoli & Vincenzo Mollace. (2019) The Role of Endothelial Dysfunction in Peripheral Blood Nerve Barrier: Molecular Mechanisms and Pathophysiological Implications. International Journal of Molecular Sciences 20:12, pages 3022.
Crossref
Houfu Liu, Yan Chen, Liang Huang, Xueying Sun, Tingting Fu, Shengqian Wu, Xiaoyan Zhu, Wei Zhen, Jihong Liu, Gang Lu, Wei Cai, Ting Yang, Wandong Zhang, Xiaohong Yu, Zehong Wan, Jianfei Wang, Scott G. Summerfield, Kelly Dong & Georg C. Terstappen. (2018) Drug Distribution into Peripheral Nerve. Journal of Pharmacology and Experimental Therapeutics 365:2, pages 336-345.
Crossref
Maurits de Vries, Olaf van Tellingen, Andel. G.L. van der Mey, Antonius M.G. Bunt, Inge Briaire-de Bruijn & Pancras C.W. Hogendoorn. (2017) BCRP expression in schwannoma, plexiform neurofibroma and MPNST. Oncotarget 8:51, pages 88751-88759.
Crossref
Yoo-Seong Jeong, Chang-Soon Yim, Heon-Min Ryu, Chi-Kyoung Noh, Yoo-Kyung Song & Suk-Jae Chung. (2017) Estimation of the minimum permeability coefficient in rats for perfusion-limited tissue distribution in whole-body physiologically-based pharmacokinetics. European Journal of Pharmaceutics and Biopharmaceutics 115, pages 1-17.
Crossref
Chang-Soon Yim, Yoo-Seong Jeong, Song-Yi Lee, Wonji Pyeon, Heon-Min Ryu, Jong-Hwa Lee, Kyeong-Ryoon Lee, Han-Joo Maeng & Suk-Jae Chung. (2017) Specific Inhibition of the Distribution of Lobeglitazone to the Liver by Atorvastatin in Rats: Evidence for a Rat Organic Anion Transporting Polypeptide 1B2–Mediated Interaction in Hepatic Transport. Drug Metabolism and Disposition 45:3, pages 246-259.
Crossref
Wei Jiao, Zhongmin Wan, Shuang Chen, Runhua Lu, Xiaozhen Chen, Dongmei Fang, Jiufeng Wang, Shengcai Pu, Xin Huang, Haixiang Gao & Huawu Shao. (2015) Lathyrol Diterpenes as Modulators of P-Glycoprotein Dependent Multidrug Resistance: Structure–Activity Relationship Studies on Euphorbia Factor L 3 Derivatives . Journal of Medicinal Chemistry 58:9, pages 3720-3738.
Crossref
Tristan M. Sissung, Andrew K. L. Goey, Ariel M. Ley, Jonathan D. Strope & William D. Figg. 2014. Pharmacogenomics in Drug Discovery and Development. Pharmacogenomics in Drug Discovery and Development 91 120 .
Soobitha Subenthiran, Noor Rain Abdullah, Joyce Pauline Joseph, Prem Kumar Muniandy, Boon Teck Mok, Chee Cheong Kee, Zakiah Ismail & Zahurin Mohamed. (2013) Linkage Disequilibrium between Polymorphisms of ABCB1 and ABCC2 to Predict the Treatment Outcome of Malaysians with Complex Partial Seizures on Treatment with Carbamazepine Mono-Therapy at the Kuala Lumpur Hospital. PLoS ONE 8:5, pages e64827.
Crossref
Nejla Yosef & Eroboghene E. Ubogu. (2012) An Immortalized Human Blood-Nerve Barrier Endothelial Cell Line for In Vitro Permeability Studies. Cellular and Molecular Neurobiology 33:2, pages 175-186.
Crossref
Eroboghene E. Ubogu. (2013) The Molecular and Biophysical Characterization of the Human Blood-Nerve Barrier: Current Concepts. Journal of Vascular Research 50:4, pages 289-303.
Crossref
Alfred H. Schinkel & Johan W. Jonker. (2012) Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview. Advanced Drug Delivery Reviews 64, pages 138-153.
Crossref
B.I. Khalefa, M. Shaqura, M. Al‐Khrasani, S. Fürst, S.A. Mousa & M. Schäfer. (2011) Relative contributions of peripheral versus supraspinal or spinal opioid receptors to the antinociception of systemic opioids. European Journal of Pain 16:5, pages 690-705.
Crossref
Andrew P. Mizisin & Ananda Weerasuriya. (2010) Homeostatic regulation of the endoneurial microenvironment during development, aging and in response to trauma, disease and toxic insult. Acta Neuropathologica 121:3, pages 291-312.
Crossref
Tristan M. Sissung, Erin R. Gardner, Richard L. Piekarz, Reuben Howden, Xiaohong Chen, Sukyung Woo, Ryan Franke, James A. Clark, Laura Miller-DeGraff, Seth M. Steinberg, David Venzon, David Liewehr, Steven R. Kleeberger, Susan E. Bates, Douglas K. Price, Douglas R. Rosing, Christopher Cabell, Alex Sparreboom & William D. Figg. (2011) Impact of ABCB1 Allelic Variants on QTc Interval Prolongation . Clinical Cancer Research 17:4, pages 937-946.
Crossref
A. Hartman, R.H.N. van Schaik, I.P. van der Heiden, M.J.C. Broekhuis, M. Meier, M.L. den Boer & R. Pieters. (2010) Polymorphisms in genes involved in vincristine pharmacokinetics or pharmacodynamics are not related to impaired motor performance in children with leukemia. Leukemia Research 34:2, pages 154-159.
Crossref
Tristan M. Sissung, Caitlin E. Baum, C. Tyler Kirkland, Rui Gao, Erin R. Gardner & William D. Figg. (2009) Pharmacogenetics of Membrane Transporters: An Update on Current Approaches. Molecular Biotechnology 44:2, pages 152-167.
Crossref
Nejla Yosef, Robin H. Xia & Eroboghene E. Ubogu. (2010) Development and Characterization of a Novel Human In Vitro Blood-Nerve Barrier Model Using Primary Endoneurial Endothelial Cells. Journal of Neuropathology & Experimental Neurology 69:1, pages 82-97.
Crossref
Tristan M. Sissung & William D. Figg. 2010. Drug Management of Prostate Cancer. Drug Management of Prostate Cancer 163 177 .
Paul D. W. Eckford & Frances J. Sharom. (2009) ABC Efflux Pump-Based Resistance to Chemotherapy Drugs. Chemical Reviews 109:7, pages 2989-3011.
Crossref
Tristan M. Sissung, Caitlin E. Baum, John Deeken, Douglas K. Price, Jeanny Aragon-Ching, Seth M. Steinberg, William Dahut, Alex Sparreboom & William D. Figg. (2008) ABCB1 Genetic Variation Influences the Toxicity and Clinical Outcome of Patients with Androgen-Independent Prostate Cancer Treated with Docetaxel . Clinical Cancer Research 14:14, pages 4543-4549.
Crossref
C. B. Clifford & J. Watson. (2008) Old Enemies, Still with Us after All These Years. ILAR Journal 49:3, pages 291-302.
Crossref
Tristan M. Sissung, Erin R. Gardner, Rui Gao & William D. Figg. 2008. Pharmacogenomics in Drug Discovery and Development. Pharmacogenomics in Drug Discovery and Development 41 62 .
Roohangiz Safaei & Stephen B. Howell. 2006. Cancer Drug Resistance. Cancer Drug Resistance 309 327 .
Yan Zhang, Corbin Bachmeier & Donald W Miller. (2003) In vitro and in vivo models for assessing drug efflux transporter activity. Advanced Drug Delivery Reviews 55:1, pages 31-51.
Crossref
Alfred H Schinkel & Johan W Jonker. (2003) Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview. Advanced Drug Delivery Reviews 55:1, pages 3-29.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.