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Research Article

Homozygous Disruption of the mdr1a P-glycoprotein Gene Affects Blood-Nerve Barrier Function in Mice Administered with Neurotoxic Drugs

Pages 735-742 | Published online: 08 Jul 2009

  • Thiebaut F, Tsuruo T, Hamada H, Gottesman MM, Pastan I. Willingham MC. Cellular localization of the multidrug-resistance gene product p-glycoprotein in normal human tissues. Proc Natl Acad Sci USA 1987: 84: 7735-8.
  • Croop JM, Raymond M, Haber D, et al. The three mouse multidrug resistance (mdr) genes are expressed in a tissue-specific manner in normal mouse tissues. Mol Cell Biol 1989: 9: 1346-50.
  • Hsu SIH, Lothstein L, Horwitz SB. Differential overexpression of three mdr gene family members in multidrug-resistant J774.2 mouse cells. J Biol Chem 1989: 264: 12053-62.
  • Devault A, Gros P. Two members of the mouse mdr gene family confer multidrug resistance with overlapping but distinct drug specificities. Mol Cell Biol 1990: 10: 1652-63.
  • Cordon-Cardo C, O'Brien JP, Casals D, et al. Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain sites. Proc Natl Acad Sei USA 1989: 86: 695-8.
  • Schinkel AH, Smit JJM, van Tellingen O, et al. Disruption of the mouse mdrIa p-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs. Cell 1994: 77: 491-502.
  • Schinkel AH, Wagenaar E, van Deemter L, Mol CAAM, Borst P. Absence of the mdrla p-glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A. J Clin Invest 1995: 96: 1698-705.
  • Lundborg G. Structure and function of the intraneurial microvessels as related to trauma, edema formation, and nerve function. J Bone Joint Surg 1975: 57A: 938-48.
  • Olsson Y. Vascular permeability in the peripheral nervous system. In: Dyck PJ, Thomas PK, Lambert EH, eds. Peripheral neuropathy. Philadelphia, PA: Saunders, 1975: 190-200.
  • Goldstein GW, Betz AL. The blood-brain barrier. Sci Am 1986; 255: 70-9.
  • Pastan I, Gottesman MM. Multidrug resistance. Annu Rev Med 1991: 42: 277-86.
  • Hegman EJ, Bauer HC, Kerbel RS. Expression and functional activity of p-glycoprotein in cultured cerebral capillary endothelial cells. Cancer Res 1992: 52: 6969-75.
  • Sikic BI. Modulation of multidrug resistance: at the threshold. J Clin Oncol 1993; 11: 1629-35.
  • Brightman MW, Klatzo I. Olsson Y, Reese TS. The blood-brain barrier to proteins under normal and pathological conditions. J Neurol Sci 1970: 10: 215-39.
  • Tatsuta T, Naito M, Oh-hara T, Sugawara I, Tsuruo T. Functional involvement of p-glycoprotein in bloodbrain barrier. J Biol Chem 1992: 267: 20383-91.
  • van Asperen J, Schinkel AH, Beijnen JH, Noojnen WJ, Borst P, van Tellingen O. Altered pharmacokinetics of vinblastine in mdrla p-glycoprotein-defkient mice. J Natl Cancer Inst 1996: 88: 94-9.
  • Schinkel AH, Wagenaar E, Mol CAAM, van Deemter L. P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs. J Clin Invest 1996; 97: 251724.
  • Meijer OC, de Lange ECM, Breimer DD, de Boer AG, Workel JO, de Kloet ER. Penetration of dexamethasone into brain glucocorticoid targets is enhanced in mdrla p-glycoprotein knockout mice. Endocrinology 1998: 139: 1789-93.
  • Bell MA, Weddell AGM. A morphometric study of intrafascicular vessels of mammalian sciatic nerve. Muscle Nerve 1984: 7: 524-34.
  • Lundborg G. Intraneural microcirculation. Orthop Clin N Am 1988; 19: 1-12.
  • Saito T, Zhang ZJ, Shibamori Y, et al. P-glycoprotein expression in capillary endothelial cells of the 7th and 8th nerves of guinea pig in relation to blood-nerve barrier sites. Neurosci Lett 1997: 232: 41-4.
  • Cho ES, Spencer PS, Jortner BS, Schaumburg HH. A single intravenous injection of doxorubicin (adriamycin®) induces sensory neuronopathy in rats. Neurotoxicology 1980; 1: 583-91.
  • Zhang ZJ, Saito T, Kimura Y, Sugimoto C, Ohtsubo T, Saito H. Disruption of nulrlu p-glycoprotein gene results in dysfunction of blood-inner ear barrier in mice. Brain Res 2000: 852: 116-26.
  • Sterman AB, Schaumburg HH. Neurotoxicity of selected drugs. In: Spencer PS, ed. Experimental and clinical neurotoxicology. Baltimore, MD: Williams & Wilkins. 1980: 593-612.
  • Weiss HD, Walker MD, Wiernik PH. Neurotoxicity of commonly antineoplastic agents. N Engl J Med 1974: 291: 127-33.

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