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Original Articles

The Effect of Particle Size on the Regional Deposition of Inhaled Aerosols in the Human Respiratory Tract

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Pages 257-275 | Published online: 27 Dec 2007

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Yasmin M. Madney, Hadeer S. Harb, Thierry Porée, Myriam Eckes, Marina E. Boules & Mohamed E. A. Abdelrahim. (2022) Preliminary bronchodilator dose effect on aerosol-delivery through different nebulizers in noninvasively ventilated COPD patients. Experimental Lung Research 48:2, pages 77-85.
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Conor A. Ruzycki, Michael Yang, Hak-Kim Chan & Warren H. Finlay. (2017) Improved prediction of intersubject variability in extrathoracic aerosol deposition using algebraic correlations. Aerosol Science and Technology 51:6, pages 667-673.
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Morton Lippmann, Mitchell D. Cohen & Lung-Chi Chen. (2015) Health effects of World Trade Center (WTC) Dust: An unprecedented disaster with inadequate risk management. Critical Reviews in Toxicology 45:6, pages 492-530.
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Fadi Eskandar, Morgane Lejeune & Stephen Edge. (2011) Low powder mass filling of dry powder inhalation formulations. Drug Development and Industrial Pharmacy 37:1, pages 24-32.
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Ahmed Fadl, Jinbo Wang & Zongqin Zhang. (2010) Metered-dose inhaler efficiency enhancement: A case study and novel design. Inhalation Toxicology 22:7, pages 601-609.
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Ahmed Fadl, Jinbo Wang, Pao Yang, Zongqin Zhang & Yung Sung Cheng. (2007) Balloon-Based In Vitro MDI Aerosol Deposition Experiments on the Effects of Mouthpiece Diameter. Inhalation Toxicology 19:6-7, pages 505-515.
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StephenW. Stein & PaulB. Myrdal. (2006) The Relative Influence of Atomization and Evaporation on Metered Dose Inhaler Drug Delivery Efficiency. Aerosol Science and Technology 40:5, pages 335-347.
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Gary L. Ginsberg, Brenda Perkovich Foos & Michael P. Firestone. (2005) Review and Analysis of Inhalation Dosimetry Methods for Application to Children’s Risk Assessment. Journal of Toxicology and Environmental Health, Part A 68:8, pages 573-615.
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Yung Sung Cheng. (2003) Aerosol Deposition in the Extrathoracic Region. Aerosol Science and Technology 37:8, pages 659-671.
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Mark A. Higuchi, Paul H. Ayres, James E. Swauger, Walter T. Morgan, Arnold T. Mosberg. (2000) Quantative Analysis of Potential Transfer of Continuous Glass Filament From Eclipse Prototype 9-014 Cigarettes. Inhalation Toxicology 12:11, pages 1055-1070.
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Mark A. Higuchi, Paul H. Ayres, James E. Swauger, Walter T. Morgan, Arnold T. Mosberg. (2000) ANALYSIS OF POTENTIAL TRANSFER OF CONTINUOUS GLASS FILAMENT FROM ECLIPSE CIGARETTES. Inhalation Toxicology 12:7, pages 617-640.
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I.W. Lugton, P.R. Wilson, R.S. Morris & G. Nugent. (1998) Epidemiology and pathogenesis of Mycobacferium bowis infection of red deer (Cervus elaphus) in New Zealand. New Zealand Veterinary Journal 46:4, pages 147-156.
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JIAN ZHENG, HENRY MA, CHAKK. CHAN & LI CHENG. (1997) PARTICULATE MATTER EXPOSURES TO COMMUTERS IN HONG KONG. Particulate Science and Technology 15:3-4, pages 341-360.
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M. G. Ménache, O. G. Raabe & F. J. Miller. (1996) An Empirical Dosimetry Model of Aerodynamic Particle Deposition in the Rat Respiratory Tract. Inhalation Toxicology 8:6, pages 539-578.
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Brian J. Day, Kathy S. Evans, Bor-Hwang Kang, Ling-Yi Chang, Craig D. Wegner & James D. Crapo. (1995) Immunolocalization of Inhaled Recombinant Human Manganese Superoxide Dismutase Reveals a Prolonged Retention in Lung Surface Lining Fluids. Inhalation Toxicology 7:7, pages 1109-1120.
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I. Ping Chung, RobertF. Phalen & Derek Dunn-Rankin. (1993) Predicted Aerosol Aspiration Efficiency for Infants, Children, and Adults. Applied Occupational and Environmental Hygiene 8:7, pages 639-644.
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JonathanS. Ilowite, GeraldC. Smaldone, RobertJ. Perry, WilliamD. Bennett & W. Michael Foster. (1989) Relationship between Tracheobronchial Particle Clearance Rates and Sites of Initial Deposition in Man. Archives of Environmental Health: An International Journal 44:4, pages 267-273.
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Morris B. Snipes. (1989) Long-Term Retention and Clearance of Particles Inhaled by Mammalian Species. Critical Reviews in Toxicology 20:3, pages 175-211.
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StephenM. Bowes$suffix/text()$suffix/text() & DavidL. Swift. (1989) Deposition of Inhaled Particles in the Oral Airway During Oronasal Breathing. Aerosol Science and Technology 11:2, pages 157-167.
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M. B. Snipes, T. R. Olson & H. C. Yeh. (1988) Deposition and Retention Patterns for 3-, 9-, and 15-μm Latex Microspheres Inhaled by Rats and Guinea Pigs. Experimental Lung Research 14:1, pages 37-50.
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Syed A. Sattar & Mohammad Khalid Ijaz. (1987) Spread of viral infections by aerosols. Critical Reviews in Environmental Control 17:2, pages 89-131.
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RobertF. Phalen, WilliamC. Hinds, Walter John, PaulJ. Lioy, Morton Lippmann, MichaelA. McCawley, OttoG. Raabe, SidneyC. Soderholm & BruceO. Stuart. (1986) Rationale and Recommendations for Particle Size-Selective Sampling in the Workplace. Applied Industrial Hygiene 1:1, pages 3-14.
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Ki Poong Lee & Jerrold L. Abraham. (1985) Lung Response to Particulates with Emphasis on Asbestos and other Fibrous Dusts. CRC Critical Reviews in Toxicology 14:1, pages 33-86.
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RichardB. Schlesinger. (1985) Comparative deposition of inhaled aerosols in experimental animals and humans: A review. Journal of Toxicology and Environmental Health 15:2, pages 197-214.
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G.B. Xu & C.P. Yu. (1985) Theoretical Lung Deposition of Hygroscopic NaCl Aerosols. Aerosol Science and Technology 4:4, pages 455-461.
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Morton Lippmann & RichardB. Schlesinger. (1984) Interspecies comparisons of particle deposition and mucociliary clearance in tracheobronchial airways. Journal of Toxicology and Environmental Health 13:2-3, pages 441-469.
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JoshuaL. Gurman, PaulJ. Lioy, Morton Lippmann & RichardB. Schlesinger. (1984) Particle Deposition in Replicate Casts of the Human Upper Tracheobronchial Tree Under Constant and Cyclic Inspiratory Flow. II. Experimental Model. Aerosol Science and Technology 3:3, pages 253-257.
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R. B. Schlesinger, B. D. Naumann & L. C. Chen. (1983) Physiological and histological alterations in the bronchial mucociliary clearance system of rabbits following intermittent oral or nasal inhalation of sulfuric acid mist. Journal of Toxicology and Environmental Health 12:2-3, pages 441-465.
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T. B. Martonen & M. Patel. (1981) Computation of ammonium bisulfate aerosol deposition in conducting airways. Journal of Toxicology and Environmental Health 8:5-6, pages 1001-1014.
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Christopher S. Garrard, Timothy R. Gerrity, Joseph F. Schreiner & Donovan B. Yeates. (1981) Analysis of Aerosol Deposition in the Healthy Human Lung. Archives of Environmental Health: An International Journal 36:4, pages 184-193.
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ArnoldR. Brody, PhillipB. DeNee & KennethB. Adler. (1981) Biological activity of inorganic particles in the lung. C R C Critical Reviews in Environmental Control 11:3, pages 277-299.
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D. Dennis Wilkey, Peter S. Lee, Frank J. Hass, Timothy R. Gerrity, Donovan B. Yeates & Ruy V. Lourenco. (1980) Mucociliary Clearance of Deposited Particles from the Human Lung: Intra- and Inter-Subject Reproductivity, Total and Regional Lung Clearance, and Model Comparions. Archives of Environmental Health: An International Journal 35:5, pages 294-303.
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G. Patrick. (1979) The Retention of Uranium Dioxide Particles in the Trachea of the Rat. International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine 35:6, pages 571-576.
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Jack Berger, RoyE. Albert, Kevin Sanborn & Morton Lippmann. (1978) Effects of atropine and methacholine on deposition and clearance of inhaled particles in the donkey. Journal of Toxicology and Environmental Health 4:4, pages 587-604.
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Daryl E. Bohning, Roy E. Albert, Morton Lippmann & William M. Foster. (1975) Tracheobronchial Particle Deposition and Clearance. Archives of Environmental Health: An International Journal 30:9, pages 457-462.
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Maurice L. Thomson & Demetri Pavia. (1974) Particle Penetration and Clearance in the Human Lung. Archives of Environmental Health: An International Journal 29:4, pages 214-219.
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