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GUEST REVIEW

NMR Methods for Optical Purity Determination of Pharmaceuticals

Pages 2155-2163 | Received 27 Jun 1988, Accepted 06 Sep 1988, Published online: 05 Dec 2006

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Sahar Al Akoum-Ebrik, Mohamed Ansar, Rahima Mouhoub, Claude Vaccher, Marie-Pierre Vaccher & Nathalie Flouquet. (1998) 1H and 13C NMR Determination of the Enantiomeric Purity of Substituted 4-Amino-3- (thien-2-Yl)-Butyric Acids and 4-Amino-3-(Benzo[b]Furan-2-yl)-Butyric Acids, Ligands of the GabaB Receptor.. Spectroscopy Letters 31:5, pages 925-944.
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FrederickJ. Troendle, KunisiS. Venkatasubban & Robert Rothchildb. (1997) NMR Studies of Drugs. Applications of Achiral and Chiral Lanthanide Shift Reagents to Citiolone.. Spectroscopy Letters 30:3, pages 435-450.
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MarcieV. Brown, KunisiS. Venkatasubban, Helen Lee & Robert Rothchild. (1995) NMR Studies of Agricultural Compounds. Applications of Achiral and Chiral Lanthanide Shift Reagents to the Herbicide, Fenoxaprop-Ethyl. Spectroscopy Letters 28:6, pages 957-981.
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Michael DeArment, Michelle Eastabrooks, KunisiS. Venkatasubban, Ronnie Benshafrut, Robert Rothchild & Helen Wyss. (1994) NMR Studies of Drugs. Applications of a Chiral Lanthanide Shift Reagent to Methoxamine in Chloroform-d or Acetonitrile-d 3.. Spectroscopy Letters 27:4, pages 533-555.
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Diana Shields, Han Tran, KunisiS. Venkatasubban, Robert Rothchild & Helen Wyss. (1994) NMR Studies of Drugs. Applications of Achiral and Chiral Lanthanide Shift Reagents to the Anticonvulsant, Methetoin, 5-Ethyl-1-Methyl-5-Phenyl-2, 4-Imidazolidinedione. Spectroscopy Letters 27:1, pages 23-39.
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Robert Rothchild, Kerry Sanders & KunisiS. Venkatasubban. (1993) NMR Studies of Drugs. Phensuximide. 1H and 13C NMR Methods with Chiral Solvating Agents and Lanthanide Shift Reagents. Spectroscopy Letters 26:10, pages 1997-2015.
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Katherine Roberts, Robert Rothchild & Helen Wyss. (1993) NMR Studies of Drugs. Applications of Achiral and Chiral Lanthanide Shift Reagents to a 5-Substituted-4-thiazolidinone. Spectroscopy Letters 26:10, pages 1901-1921.
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Robert Rothchild & Helen Wyss. (1993) NMR Studies of Drugs. Sulindac Methyl Ester. Applications of Achiral and Chiral Lanthanide Shift Reagents. Spectroscopy Letters 26:7, pages 1269-1285.
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Robert Rothchild, KunisiS. Venkatasubban, Shari Braddock, Kerry Sanders & Stacey Traviglia. (1993) NMR Studies of Drugs. Achiral and Chiral Lanthanide Shift Reagents with Mephenoxalone, a Substituted 2-Oxazolidinone. Spectroscopy Letters 26:2, pages 271-291.
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Lorraine Keller & Robert Rothchild. (1992) NMR Studies of Drugs. Application of Achiral and Chiral Lanthanide Shift Reagents to α-Ethyl-α-Phenylsuccinimide. Spectroscopy Letters 25:8, pages 1177-1197.
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Ronnie Benshafrut & Robert Rothchild. (1992) NMR Studies of Drugs. Enantiomeric Excess Determination of N-acetylcathinone with Eu(HFC)3 . Spectroscopy Letters 25:7, pages 1097-1120.
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HassanY. Aboul-Enein, Simonique Médonné & Robert Rothchild. (1991) 1H NMR Spectral Simplification with Achiral and Chiral Lanthanide Shift Reagents. Mexiletine. Spectroscopy Letters 24:6, pages 909-930.
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John Avolio, Carol Myers, Robert Rothchild & Iraida Valentin. (1990) 1H NMR Spectral Simplification with Achiral and Chiral Lanthanide Shift Reagents. Paramethadione, 5-Ethyl-3,5-Dimethyl-2,4-Oxazolidinedione. Spectroscopy Letters 23:4, pages 459-479.
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Articles from other publishers (7)

Maryam Shahrajabian, Forough Ghasemi & M. Reza Hormozi-Nezhad. (2018) Nanoparticle-based Chemiluminescence for Chiral Discrimination of Thiol-Containing Amino Acids. Scientific Reports 8:1.
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Gloria Uccello-Barretta & Federica Balzano. 2013. Differentiation of Enantiomers II. Differentiation of Enantiomers II 69 131 .
Ulrich Schmitt, Sarah K. Branch & Ulrike Holzgrabe. (2002) Chiral separations by cyclodextrin-modified capillary electrophoresis - Determination of the enantiomeric excess. Journal of Separation Science 25:15-17, pages 959-974.
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Kyeong Ho Kim, Hyun Ju Kim, Jeong-Hwan Kim, Joo Hyun Lee & Sang Cheal Lee. (2001) Determination of the optical purity of (R)-terbutaline by 1H-NMR and RP-LC using chiral derivatizing agent, (S)-(−)-α-methylbenzyl isocyanate. Journal of Pharmaceutical and Biomedical Analysis 25:5-6, pages 947-956.
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B.W.K. Diehl & U. Holzgrabe. 1999. NMR Spectroscopy in Drug Development and Analysis. NMR Spectroscopy in Drug Development and Analysis 82 101 .
Ulrike Holzgrabe, Bernd W.K. Diehl & Iwona Wawer. (1998) NMR spectroscopy in pharmacy. Journal of Pharmaceutical and Biomedical Analysis 17:4-5, pages 557-616.
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Pauline M. Lacroix, Brian A. Dawson, Roger W. Sears & D. Bruce Black. (2004) HPLC and NMR methods for the quantitation of the (R)‐enantiomer in (−)‐(S)‐timolol maleate drug raw materials. Chirality 6:6, pages 484-491.
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