Abstract
NMR spectra of the racemic anticonvulsant, phensuximide, 1, in CDCl3 solution, have been studied with additives to explore methods for potential direct determination of enantiomeric excess (% ee). Proton studies at 200 MHz with the chiral solvating agent (CSA) (-)-2,2,2-trifluoro-1- (9-recommended for ee analysis due to uncertainties of contributions to the NCH3 from the CH2 proton absorptions.