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Annals of Tropical Medicine & Parasitology Volume 90, 1996 - Issue 5
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Original Articles

Onchocerca volvulus and O. lienalis: the microfilaricidal activity of moxidectin compared with that of ivermectin in vitro and in vivo

S. K. TagbotoInternational Institute of Parasitology, 395a Hatfield Road, St AlbansAL4 OXU, U.K.
&
S. TownsonInternational Institute of Parasitology, 395a Hatfield Road, St AlbansAL4 OXU, U.K.
Pages 497-505 | Received 06 Mar 1996, Accepted 25 Apr 1996, Published online: 15 Nov 2016

Citations (35)

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Jianxia Dong, Xu Song, Xianghong Lian, Yao Fu & Tao Gong. (2016) Subcutaneously injected ivermectin-loaded mixed micelles: formulation, pharmacokinetics and local irritation study. Drug Delivery 23:7, pages 2220-2227.
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Prashant Kumar Singh, Arya Ajay, Susheela Kushwaha, Rama Pati Tripathi & Shailja Misra-Bhattacharya. (2010) Towards Novel Antifilarial Drugs: Challenges and Recent Developments. Future Medicinal Chemistry 2:2, pages 251-283.
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Erwin van den Enden. (2009) Pharmacotherapy of helminth infection. Expert Opinion on Pharmacotherapy 10:3, pages 435-451.
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Simon Townson, Bernadette Ramirez, Foluke Fakorede, Marie-Annick Mouries & Solomon Nwaka. (2007) Challenges in drug discovery for novel antifilarials. Expert Opinion on Drug Discovery 2:sup1, pages S63-S73.
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Articles from other publishers (31)

Paul D. E. Williams, Sudhanva S. Kashyap, Alan P. Robertson & Richard J. Martin. (2023) Diethylcarbamazine elicits Ca 2+ signals through TRP-2 channels that are potentiated by emodepside in Brugia malayi muscles . Antimicrobial Agents and Chemotherapy 67:10.
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Timothy G. Geary. (2023) New paradigms in research on Dirofilaria immitis. Parasites & Vectors 16:1.
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Roger Prichard. 2022. Human and Animal Filariases. Human and Animal Filariases 283 305 .
Shivani Choudhary, Melanie Abongwa, Sudhanva S. Kashyap, Saurabh Verma, Gunnar R. Mair, Daniel Kulke, Richard J. Martin & Alan P. Robertson. (2022) Nodulisporic acid produces direct activation and positive allosteric modulation of AVR-14B, a glutamate-gated chloride channel from adult Brugia malayi . Proceedings of the National Academy of Sciences 119:34.
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Senyo Tagboto & Verner Orish. (2022) Drug development for onchocerciasis-the past, the present and the future. Frontiers in Tropical Diseases 3.
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Marc P. Hübner, Simon Townson, Suzanne Gokool, Senyo Tagboto, Mary J. Maclean, Guilherme G. Verocai, Adrian J. Wolstenholme, Stefan J. Frohberger, Achim Hoerauf, Sabine Specht, Ivan Scandale, Achim Harder, Martin Glenschek-Sieberth, Steffen R. Hahnel & Daniel Kulke. (2021) Evaluation of the in vitro susceptibility of various filarial nematodes to emodepside. International Journal for Parasitology: Drugs and Drug Resistance 17, pages 27-35.
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Roger K. Prichard. (2021) Macrocyclic lactone resistance in Dirofilaria immitis: risks for prevention of heartworm disease. International Journal for Parasitology 51:13-14, pages 1121-1132.
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Adela Ngwewondo, Ivan Scandale & Sabine Specht. (2021) Onchocerciasis drug development: from preclinical models to humans. Parasitology Research 120:12, pages 3939-3964.
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Anastasia Diakou & Roger K. Prichard. (2021) Concern for Dirofilaria immitis and Macrocyclic Lactone Loss of Efficacy: Current Situation in the USA and Europe, and Future Scenarios. Pathogens 10:10, pages 1323.
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Carolina Horta Andrade, Bruno Junior Neves, Cleber Camilo Melo-Filho, Juliana Rodrigues, Diego Cabral Silva, Rodolpho Campos Braga & Pedro Vitor Lemos Cravo. (2019) In Silico Chemogenomics Drug Repositioning Strategies for Neglected Tropical Diseases. Current Medicinal Chemistry 26:23, pages 4355-4379.
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Roger K. Prichard & Timothy G. Geary. (2019) Perspectives on the utility of moxidectin for the control of parasitic nematodes in the face of developing anthelmintic resistance. International Journal for Parasitology: Drugs and Drug Resistance 10, pages 69-83.
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Jaiprakash N. Sangshetti, Devanand B. Shinde, Abhishek Kulkarni & Rohidas Arote. (2017) Two decades of antifilarial drug discovery: a review. RSC Advances 7:33, pages 20628-20666.
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Annette C. Kuesel. (2016) Research for new drugs for elimination of onchocerciasis in Africa. International Journal for Parasitology: Drugs and Drug Resistance 6:3, pages 272-286.
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Meenakshi Verma, Manisha Pathak, Mohd Shahab, Kavita Singh, Kalyan Mitra & Shailja Misra-Bhattacharya. (2014) Moxidectin causes adult worm mortality of human lymphatic filarial parasite Brugia malayi in rodent models. Folia Parasitologica 61:6, pages 561-570.
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Kwablah Awadzi, Nicholas O. Opoku, Simon K. Attah, Janis Lazdins-Helds & Annette C. Kuesel. (2014) A Randomized, Single-Ascending-Dose, Ivermectin-Controlled, Double-Blind Study of Moxidectin in Onchocerca volvulus Infection. PLoS Neglected Tropical Diseases 8:6, pages e2953.
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Piyanan Taweethavonsawat & Sudchit Chungpivat. (2013) Successful Treatment of Brugia pahangi in Naturally Infected Cats with Ivermectin. The Korean Journal of Parasitology 51:6, pages 759-761.
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R. A. Paveley & Q. D. Bickle. (2013) Automated Imaging and other developments in whole‐organism anthelmintic screening. Parasite Immunology 35:9-10, pages 302-313.
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Rebecca Fankhauser, Linsey R. Cozzie, Bakela Nare, Kerrie Powell, Ann E. Sluder & Lance G. Hammerland. 2012. Parasitic Helminths. Parasitic Helminths 181 199 .
Joan M. Korth‐Bradley, Virginia Parks, Alain Patat, Kyle Matschke, Philip Mayer & Lawrence Fleckenstein. (2013) Relative Bioavailability of Liquid and Tablet Formulations of the Antiparasitic Moxidectin. Clinical Pharmacology in Drug Development 1:1, pages 32-37.
Crossref
J.B. Tompkins, L.E. Stitt & B.F. Ardelli. (2010) Brugia malayi: In vitro effects of ivermectin and moxidectin on adults and microfilariae. Experimental Parasitology 124:4, pages 394-402.
Crossref
Jason P. Dufour, Frank B. Cogswell, Kathrine M. Phillippi‐Falkenstein & Rudolf P. Bohm. (2006) Comparison of efficacy of moxidectin and ivermectin in the treatment of Strongyloides fulleborni infection in rhesus macaques . Journal of Medical Primatology 35:3, pages 172-176.
Crossref
Firas Bassissi, Anne Lespine & Michel Alvinerie. (2005) Assessment of a liposomal formulation of ivermectin in rabbit after a single subcutaneous administration. Parasitology Research 98:3, pages 244-249.
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R.K. Prichard. (2005) Is anthelmintic resistance a concern for heartworm control?. Veterinary Parasitology 133:2-3, pages 243-253.
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Mark H. Bradley & V. Kumaraswami. (2004) 2.2 ESSENTIAL TOOLS—DRUGS AND CLINICAL DRUG TRIALS. The American Journal of Tropical Medicine and Hygiene 71:5_suppl, pages 7-11.
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Mohamad Firas Bassissi, Michel Alvinerie & Anne Lespine. (2004) Macrocyclic lactones: distribution in plasma lipoproteins of several animal species including humans. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 138:4, pages 437-444.
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Monette M. Cotreau, Sarah Warren, John L. Ryan, Lawrence Fleckenstein, Sreenivasa R. Vanapalli, Kenneth R. Brown, David Rock, Chieh‐Yu Chen & Ullrich S. Schwertschlag. (2013) The Antiparasitic Moxidectin: Safety, Tolerability, and Pharmacokinetics in Humans. The Journal of Clinical Pharmacology 43:10, pages 1108-1115.
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Ya-Chi Chen, Ya-Ping Hung & Lawrence Fleckenstein. (2002) Liquid chromatographic assay of moxidectin in human plasma for application to pharmacokinetic studies. Journal of Pharmaceutical and Biomedical Analysis 29:5, pages 917-926.
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William Soumbey Alley, Gerrit J van Oortmarssen, Boakye A Boatin, Nico JD Nagelkerke, Anton P Plaisier, Jan HF Remme, Janis Lazdins, Gerard JJM Borsboom & J Dik F Habbema. (2001) Macrofilaricides and onchocerciasis control, mathematical modelling of the prospects for elimination. BMC Public Health 1:1.
Crossref
J-P Paiement, C. Leger, P. Ribeiro & R.K. Prichard. (1999) Haemonchus contortus: Effects of Glutamate, Ivermectin, and Moxidectin on Inulin Uptake Activity in Unselected and Ivermectin-Selected Adults. Experimental Parasitology 92:3, pages 193-198.
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Michel Boussinesq & Jacques Gardon. (1999) La r?sistance de Onchocerca volvulus ? livermectine: une ?ventualit? ? consid?rer. Annales de l'Institut Pasteur / Actualit?s 10:1, pages 81-91.
Crossref
D.H. Molyneux & J.B. Davies. (1997) Onchocerciasis control: Moving towards the millennium. Parasitology Today 13:11, pages 418-425.
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