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Original Articles

Tolerance Mechanisms

Determinants of Lung Responses to Injurious Agents

Pages 111-126 | Received 13 Apr 1966, Accepted 27 May 1966, Published online: 30 Apr 2013

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (26)

Raymond F. Hamilton Jr, Andrij Holian. (2000) PROTECTION AGAINST OZONE-INDUCED PULMONARY INFLAMMATION AND CELL DEATH BY ENDOTOXIN PRETREATMENT IN MICE: ROLE OF HO-1. Inhalation Toxicology 12:12, pages 1225-1238.
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Toyoshi Umezu, Takashi Miura & Hirokazu Tsubone. (1994) Development of Tolerance Against Ozone Effects on Drinking and Eating Behaviors in Rats by Intermittent Exposures. Inhalation Toxicology 6:3, pages 289-302.
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H. W. Balfoort, H. J. Th. Bloemen, L. van Bree, J. A. M. A. Dormans & P. J. A. Rombout. (1989) Tolerance to Ozone Induced in Rats by Preexposure to Cadmium Chloride Aerosol. Inhalation Toxicology 1:2, pages 139-152.
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RichardB. Schlesinger. (1987) Intermittent inhalation of nitrogen dioxide: Effects on rabbit alveolar macrophages. Journal of Toxicology and Environmental Health 21:1-2, pages 127-139.
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A. A. Horton, Steven Fairhurst & James S. Bus. (1987) Lipid Peroxidation and Mechanisms of Toxicity. CRC Critical Reviews in Toxicology 18:1, pages 27-79.
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ThomasA. Vollmuth, KevinE. Driscoll & RichardB. Schlesinger. (1986) Changes in early alveolar particle clearance due to single and repeated nitrogen dioxide exposures in the rabbit. Journal of Toxicology and Environmental Health 19:2, pages 255-266.
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Toshiko Imamura, J. Gandy & L. Hasegawa. (1985) Development of tolerance to a pneumotoxic impurity of malathion. Journal of Toxicology and Environmental Health 15:2, pages 279-291.
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JamesJ. McGrath$suffix/text()$suffix/text() & DavidL. Smith. (1984) Respiratory responses to nitrogen dioxide inhalation subtitle: Nitrogen dioxide. Journal of Environmental Science and Health . Part A: Environmental Science and Engineering 19:4, pages 417-431.
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Saburo Sone, LindaM. Brennan & DonaldA. Creasia. (1983) In vivo and in vitro no2 exposures enhance phagocytic and tumoricidal activities of rat alveolar macrophages. Journal of Toxicology and Environmental Health 11:1, pages 151-163.
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Michael R. Boyd & H. P. Witschi. (1980) Biochemical Mechanisms in Chemical-Induced Lung Injury: Roles of Metabolic Activation. CRC Critical Reviews in Toxicology 7:2, pages 103-176.
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D. A. Creasia. (1978) Stimulation of DNA synthesis in lungs of hamsters tolerant to nitrogen dioxide. Journal of Toxicology and Environmental Health 4:5-6, pages 755-762.
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D. A. Creasia, P. Nettesheim & J. C. S. Kim. (1977) Stimulation of DNA synthesis in the lungs of hamsters exposed intermittently to nitrogen dioxide. Journal of Toxicology and Environmental Health 2:5, pages 1173-1181.
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George K. York, Thomas H. Peirce, Lester W. Schwartz & Carroll E. Cross. (1976) Stimulation by Cigarette Smoke of Glutathione Peroxidase System Enzyme Activities in Rat Lung. Archives of Environmental Health: An International Journal 31:6, pages 286-290.
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Onkar S. Atwal & Thursa Wilson. (1974) Parathyroid Gland Changes Following Ozone Inhalation. Archives of Environmental Health: An International Journal 28:2, pages 91-100.
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Yves Alarie. (1973) Sensory Irritation by Airborne Chemicals. CRC Critical Reviews in Toxicology 2:3, pages 299-363.
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Donald E. Gardner, Trent R. Lewis, Stephen M. Alpert, Daniel J. Hurst & David L. Coffin. (1972) The Role of Tolerance in Pulmonary Defense Mechanisms. Archives of Environmental Health: An International Journal 25:6, pages 432-438.
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Bernard D. Goldstein, Maura R. Levine, Richard Cuzzi-Spada, Ramon Cardenas, Ramon D. Buckley & Oscar J. Balchum. (1972) p-Amminobenzoic Acid as a Protective Agent in Ozone Toxicity. Archives of Environmental Health: An International Journal 24:4, pages 243-247.
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Michael J. Evans, Robert J. Stephens, Linda J. Cabral & Gustave Freeman. (1972) Cell Renewal in the Lungs of Rats Exposed to Low Levels of NO2 . Archives of Environmental Health: An International Journal 24:3, pages 180-188.
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Robert J. Stephens, Gustave Freeman & Michael J. Evans. (1972) Early Response of Lungs to Low Levels of Nitrogen Dioxide. Archives of Environmental Health: An International Journal 24:3, pages 160-179.
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Alice Y. S. P’an & Zygmunt Jegier. (1971) The Serum Trypsin Inhibitor Capacity During Ozone Exposure. Archives of Environmental Health: An International Journal 23:3, pages 215-219.
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Murray B. Gardner, Clayton G. Loosli, Bernard Hanes, William Blackmore & Dixie Teebken. (1970) Pulmonary Changes in 7,000 Mice Following Prolonged Exposure to Ambient and Filtered Los Angeles Air. Archives of Environmental Health: An International Journal 20:3, pages 310-317.
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Murray B. Gardner, Clayton G. Loosli, Bernard Hanes, William Blackmore & Dixie Teebken. (1969) Histopathologic Findings in Rats Exposed to Ambient and Filtered Air. Archives of Environmental Health: An International Journal 19:5, pages 637-647.
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Bernard D. Goldstein, Charlotte Lodi, Charlotte Cóllinson & Oscar J. Balchum. (1969) Ozone and Lipid Peroxidation. Archives of Environmental Health: An International Journal 18:4, pages 631-635.
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William H. Becker, Fred J. Schilling & Mahadeo P. Verma. (1968) The Effect on Health of the 1966 Eastern Seaboard Air Pollution Episode. Archives of Environmental Health: An International Journal 16:3, pages 414-419.
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Louis S. Jaffe. (1968) Photochemical Air Pollutants and Their Effects on Men and Animals. Archives of Environmental Health: An International Journal 16:2, pages 241-255.
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ArthurR. Gregory, LymanA. Ripperton & Bradford Miller. (1967) Effect of Neonatal Thymectomy on the Development of Ozone Tolerance in Mice. American Industrial Hygiene Association Journal 28:3, pages 278-282.
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Articles from other publishers (39)

Willie J. McKinney, Richard H. Jaskot, Judy H. Richards, Daniel L. Costa & Kevin L. Dreher. (1998) Cytokine Mediation of Ozone-induced Pulmonary Adaptation. American Journal of Respiratory Cell and Molecular Biology 18:5, pages 696-705.
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P.J. Barth, S. Uhlarik, A. Bittinger, U. Wagner & J.Rüschoff. (1994) Diffuse alveolar damage in the rat lung after short and long term exposure to nitrogen dioxide. Pathology - Research and Practice 190:1, pages 33-41.
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TOYOSHI UMEZU, AKIRA K. SUZUKI, TAKASHI MIURA & AKIRA KOIZUMI. 1994. Neurobehavioral Methods and Effects in Occupational and Environmental Health. Neurobehavioral Methods and Effects in Occupational and Environmental Health 949 965 .
U. Winkler. 1992. HNO Praxis Heute. HNO Praxis Heute 141 168 .
David H. Wegman & Ellen A. Eisen. (1990) Acute Irritants. Chest 97:4, pages 773-775.
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Duane L. Peavy & Edward J. Fairchild. (1987) Toxicologic interactions between ozone and bacterial endotoxin. Environmental Research 42:1, pages 63-71.
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Myron A. Mehlman & Carmia Borek. (1987) Toxicity and biochemical mechanisms of ozone. Environmental Research 42:1, pages 36-53.
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Allen D. Hacker, Mohammad G. Mustafa, Jean J. Ospital, Nabil M. Elsayed & Si Duk Lee. (1986) Relationship of age to rat lung collagen synthesis in response to ozone exposure. AGE 9:1, pages 1-5.
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Michael J. Evans, Nusi P. Dekker, Linda J. Cabral-Anderson & Susan G. Shami. (1985) Morphological basis of tolerance to ozone. Experimental and Molecular Pathology 42:3, pages 366-376.
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David A. Penney, Kerstin Hogberg, George J. Traiger & Robert P. Hanzlik. (1985) The acute toxicity of cyclopentadienyl manganese tricarbonyl in the rat. Toxicology 34:4, pages 341-347.
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N. Konno, T.R. Fukuto & T. Imamura. (1984) Lung injury and delayed toxicity produced by O,S,S-trimethyl phosphorodithioate, an impurity of malathion. Toxicology and Applied Pharmacology 75:2, pages 219-228.
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Nabil M. Elsayed, Mohammad G. Mustafa, Allen D. Hacker, Klaus Kuehn & Gerhard N. Schrauzer. (1984) Dietary antioxidants and the biochemical response to oxidant inhalation. Biological Trace Element Research 6:3, pages 249-261.
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Ziro Nambu & Eiji Yokoyama. (1983) Antioxidant system and ozone tolerance. Environmental Research 32:1, pages 111-117.
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Deepak K. Agarwal. (1983) Biochemical assessment of the bioreactivity of intratracheally administered polyvinyl chloride dust in rat lung. Chemico-Biological Interactions 44:1-2, pages 195-201.
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Ping C. Hu, Frederick J. Miller, Mary J. Daniels, Gary E. Hatch, Judith A. Graham, Donald E. Gardner & Maryjane K. Selgrade. (1982) Protein accumulation in lung lavage fluid following ozone exposure. Environmental Research 29:2, pages 377-388.
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Ziro Nambu & Eiji Yokoyama. (1982) Experimental suppression of tolerance to ozone and of cross-tolerance (NO2O3) in rats by actinomycin D and colchicine. Environmental Research 29:1, pages 62-69.
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Michael R. Boyd, Leo T. Burka, Benjamin J. Wilson & B.V. Rama Sastry. (1981) Development of tolerance to the pulmonary toxin, 4-ipomeanol. Toxicology 19:2, pages 85-100.
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James P. Kehrer & Hanspeter Witschi. (1980) Effects of drug metabolism inhibitors on butylated hydroxytoluene-induced pulmonary toxicity in mice. Toxicology and Applied Pharmacology 53:2, pages 333-342.
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Shri N. Giri, Mannfred A. Hollinger & Mary J. Schiedt. (1980) The effects of ozone and paraquat on PGF2α and PGE2 levels in plasma and combined pleural effusion and lung lavage of rats. Environmental Research 21:2, pages 467-476.
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R. Frank, J.D. Brain, D.E. Knudson & R.A. Kronmal. (1979) Ozone exposure, adaptation, and changes in lung elasticity. Environmental Research 19:2, pages 449-459.
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Jack D. Hackney, William S. Linn, Ramon D. Buckley, Clarence R. Collier & John G. Mohler. 1978. Environmental Stress. Environmental Stress 111 124 .
Bernard D. Goldstein, Suzanne J. Hamburger, Gary W. Falk & Marie A. Amoruso. (1977) Effect of ozone and nitrogen dioxide on the agglutination of rat alveolar macrophages by concanavalin A. Life Sciences 21:11, pages 1637-1644.
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Shri N. Giri & Mannfred A. Hollinger. (1976) A possible approach to the investigation of reacting sites of ozone in rat lung. Life Sciences 19:11, pages 1693-1697.
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Carroll E. Cross, Anthony J. De Lucia, A.Krishna Reddy, M.Zamirul Hussain, Ching-Kuang Chow & Mohammad G. Mustafa. (1976) Ozone interactions with lung tissue. The American Journal of Medicine 60:7, pages 929-935.
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CHING K. CHOW. (1976) Biochemical responses in lungs of ozone-tolerant rats. Nature 260:5553, pages 721-722.
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Michael J. Evans, Lincoln V. Johnson, Robert J. Stephens & Gustave Freeman. (1976) Cell renewal in the lungs of rats exposed to low levels of ozone. Experimental and Molecular Pathology 24:1, pages 70-83.
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Lawrence Fishbein. 1976. Chemical Mutagens. Chemical Mutagens 219 319 .
Richard Parad, Geneva Simmons & Gary Huber. (1975) Impairment of Adaptive Tolerance to Oxygen Toxicity by Systemic Immunosuppression. Chest 67:2, pages 42S-43S.
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Tibor Balazs. (1974) Development of tissue resistance to toxic effects of chemicals. Toxicology 2:3, pages 247-255.
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R.J. Stephens, M.F. Sloan, M.J. Evans & G. Freeman. (1974) Alveolar type 1 cell response to exposure to 0.5 PPM O3 for short periods. Experimental and Molecular Pathology 20:1, pages 11-23.
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W.L. Castleman, D.L. Dungworth & W.S. Tyler. (1973) Histochemically detected enzymatic alterations in rat lung exposed to ozone. Experimental and Molecular Pathology 19:3, pages 402-421.
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Graham S. King. (2016) Ozone and Air Conditioning. Royal Society of Health Journal 93:2, pages 84-86.
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Alan B. Combs, Shri N. Giri & S.A. Peoples. (1971) A new method for analysis of phenylthiourea in biological fluids. Analytical Biochemistry 44:2, pages 570-575.
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R.E. Zelac, H.L. Cromroy, W.E. BolchJr.Jr., B.G. Dunavant & H.A. Bevis. (1971) Inhaled ozone as a mutagen. Environmental Research 4:3, pages 262-282.
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L. Ramazzotto, C.R. Jones & F. Cornell. (1971) Effect of nitrogen dioxide on the activities of cytochrome oxidase and succinic dehydrogenase on homogenates of some organs of the rat. Life Sciences 10:11, pages 601-604.
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