438
Views
46
CrossRef citations to date
0
Altmetric
Original

Human intestinal P‐glycoprotein activity estimated by the model substrate digoxin

, , , , , , & show all
Pages 123-134 | Received 05 Apr 2006, Accepted 31 Aug 2006, Published online: 08 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Natalia A. Jungmann, Dieter Lang, Soundos Saleh, Dorina Van Der Mey & Michael Gerisch. (2019) In vitro–in vivo correlation of the drug–drug interaction potential of antiretroviral HIV treatment regimens on CYP1A1 substrate riociguat. Expert Opinion on Drug Metabolism & Toxicology 15:11, pages 975-984.
Read now
Stephen Drain, Mark A. Catherwood & H. Denis Alexander. (2010) Multidrug resistance in the chronic lymphoproliferative disorders. Leukemia & Lymphoma 51:10, pages 1793-1804.
Read now
Mette Østergaard, Anja Ernst, Rodrigo Labouriau, Enrika Dagiliené, Henrik B. Krarup, Mariann Christensen, Niels Thorsgaard, Bent A. Jacobsen, Ulrik Tage-Jensen, Kim Overvad, Herman Autrup & Vibeke Andersen. (2009) Cyclooxygenase-2, multidrug resistance 1, and breast cancer resistance protein gene polymorphisms and inflammatory bowel disease in the Danish population. Scandinavian Journal of Gastroenterology 44:1, pages 65-73.
Read now

Articles from other publishers (43)

Satoshi Kondo & Masateru Miyake. (2023) Simultaneous Prediction Method for Intestinal Absorption and Metabolism Using the Mini-Ussing Chamber System. Pharmaceutics 15:12, pages 2732.
Crossref
Mary P. Choules, Peiying Zuo, Yukio Otsuka, Amit Garg, Mei Tang & Peter Bonate. (2023) Physiologically based pharmacokinetic model to predict drug–drug interactions with the antibody–drug conjugate enfortumab vedotin. Journal of Pharmacokinetics and Pharmacodynamics.
Crossref
Cordula Stillhart, Adam Asteriadis, Ekaterina Bocharova, Gabriel Eksteen, Fritz Harder, Jonas Kusch, Theodora Tzakri, Patrick Augustijns, Christophe Matthys, Maria Vertzoni, Werner Weitschies & Christos Reppas. (2023) The impact of advanced age on gastrointestinal characteristics that are relevant to oral drug absorption: An AGePOP review. European Journal of Pharmaceutical Sciences 187, pages 106452.
Crossref
Fatima Zahra Marok, Jan-Georg Wojtyniak, Laura Maria Fuhr, Dominik Selzer, Matthias Schwab, Johanna Weiss, Walter Emil Haefeli & Thorsten Lehr. (2023) A Physiologically Based Pharmacokinetic Model of Ketoconazole and Its Metabolites as Drug–Drug Interaction Perpetrators. Pharmaceutics 15:2, pages 679.
Crossref
Christopher M. Arian, Tomoki Imaoka, Jade Yang, Edward J. Kelly & Kenneth E. Thummel. (2022) Gutsy science: In vitro systems of the human intestine to model oral drug disposition. Pharmacology & Therapeutics 230, pages 107962.
Crossref
Liam M. Koehn. 2022. The ADME Encyclopedia. The ADME Encyclopedia 18 25 .
Mariana Babayeva, Brigitte Azzi & Zvi G. Loewy. 2022. Pharmacogenomics in Drug Discovery and Development. Pharmacogenomics in Drug Discovery and Development 201 240 .
Punyabhorn Rattanacheeworn, Stephen J Kerr, Wonngarm Kittanamongkolchai, Natavudh Townamchai, Suwasin Udomkarnjananun, Kearkiat Praditpornsilpa, Thanundorn Thanusuwannasak, Udomsak Udomnilobol, Suree Jianmongkol, Boonsri Ongpipattanakul, Thomayant Prueksaritanont, Yingyos Avihingsanon & Pajaree Chariyavilaskul. (2021) Quantification of CYP3A and Drug Transporters Activity in Healthy Young, Healthy Elderly and Chronic Kidney Disease Elderly Patients by a Microdose Cocktail Approach. Frontiers in Pharmacology 12.
Crossref
David M. Stresser, Jun Sun & Sarah S. Wilson. (2021) Evaluation of Tissue Stem Cell–Derived Human Intestinal Organoids, a Physiologically Relevant Model to Evaluate Cytochrome P450 Induction in Gut. Drug Metabolism and Disposition 49:3, pages 245-253.
Crossref
Simran Kaur, Nupur Angrish, Kajal Gupta, Anil K. Tyagi & Garima Khare. (2021) Inhibition of ABCG2 efflux pumps renders the Mycobacterium tuberculosis hiding in mesenchymal stem cells responsive to antibiotic treatment. Infection, Genetics and Evolution 87, pages 104662.
Crossref
Liam M. Koehn. 2021. The ADME Encyclopedia. The ADME Encyclopedia 1 8 .
Chih-hsuan Hsin, Marc S. Stoffel, Malaz Gazzaz, Elke Schaeffeler, Matthias Schwab, Uwe Fuhr & Max Taubert. (2020) Combinations of common SNPs of the transporter gene ABCB1 influence apparent bioavailability, but not renal elimination of oral digoxin. Scientific Reports 10:1.
Crossref
Izna Ali, Daniel Guidone, Joseph A. Nicolazzo & Kim L.R. Brouwer. (2019) Impact of reduced P‐glycoprotein function on digoxin concentrations in patients with dementia. British Journal of Clinical Pharmacology 85:10, pages 2351-2359.
Crossref
Nina Hanke, Sebastian Frechen, Daniel Moj, Hannah Britz, Thomas Eissing, Thomas Wendl & Thorsten Lehr. (2018) PBPK Models for CYP3A4 and P-gp DDI Prediction: A Modeling Network of Rifampicin, Itraconazole, Clarithromycin, Midazolam, Alfentanil, and Digoxin. CPT: Pharmacometrics & Systems Pharmacology 7:10, pages 647-659.
Crossref
Ana Vavlukis, Aleksandra Kapedanovska Nestorovska, Zoran Sterjev, Aleksandra Grozdanova, Marija Vavlukis & Zorica Naumovska. (2017) Influence of ABCB1 C3435T Genotype on Clinical Cardiovascular Outcomes in Coronary Artery Disease Patients on Clopidogrel Treatment. MOJ Drug Design Development & Therapy 1:2.
Crossref
Marie Lund, Tonny Studsgaard Petersen & Kim Peder Dalhoff. (2017) Clinical Implications of P-Glycoprotein Modulation in Drug–Drug Interactions. Drugs 77:8, pages 859-883.
Crossref
Janko Samardzic, Dubravka Svob Strac & John N. van den Anker. 2017. Total Intravenous Anesthesia and Target Controlled Infusions. Total Intravenous Anesthesia and Target Controlled Infusions 697 711 .
Hamid A. Merchant, Fang Liu, Mine Orlu Gul & Abdul W. Basit. (2016) Age-mediated changes in the gastrointestinal tract. International Journal of Pharmaceutics 512:2, pages 382-395.
Crossref
Célia Lloret-Linares, Eisuke Miyauchi, Huilong Luo, Laurence Labat, Jean-Luc Bouillot, Christine Poitou, Jean-Michel Oppert, Jean-Louis Laplanche, Stéphane Mouly, Jean-Michel Scherrmann, Yasuo Uchida, Masanori Tachikawa, Tetsuya Terasaki, Jean-François Bergmann & Xavier Declèves. (2016) Oral Morphine Pharmacokinetic in Obesity: The Role of P-Glycoprotein, MRP2, MRP3, UGT2B7, and CYP3A4 Jejunal Contents and Obesity-Associated Biomarkers. Molecular Pharmaceutics 13:3, pages 766-773.
Crossref
David Dahlgren, Carl Roos, Erik Sjögren & Hans Lennernäs. (2015) Direct In Vivo Human Intestinal Permeability (Peff) Determined with Different Clinical Perfusion and Intubation Methods. Journal of Pharmaceutical Sciences 104:9, pages 2702-2726.
Crossref
Amir Jalali, Sepideh Ghasemian, Hossein Najafzadeh, Hamid Galehdari, Masoud Reza Seifi, Fateme Zangene & Shaiesteh Dehdardargahi. (2014) Verapamil and Rifampin Effect on P-Glycoprotein Expression in Hepatocellular Carcinoma. Jundishapur Journal of Natural Pharmaceutical Products 9:4.
Crossref
Dan-Dan Wu, Ji-Xiang Zhang, Jiao Li & Wei-Guo Dong. (2014) Lack of Association of the MDR1 C3435T Polymorphism with Susceptibility to Gastric Cancer and Peptic Ulcer: a Systemic Review and Meta-analysis. Asian Pacific Journal of Cancer Prevention 15:7, pages 3021-3027.
Crossref
LIANG XU, HUA LI, YUBIN WANG, FANG DONG, HUANGBING WANG & SHUTONG ZHANG. (2014) Enhanced activity of doxorubicin in drug resistant A549 tumor cells by encapsulation of P-glycoprotein inhibitor in PLGA-based nanovectors. Oncology Letters 7:2, pages 387-392.
Crossref
Suda Vannaprasaht, Sirirat Reungjui, Darika Supanya, Dhavee Sirivongs, Cholatip Pongskul, Yingyos Avihingsanon & Wichittra Tassaneeyakul. (2013) Personalized Tacrolimus Doses Determined by CYP3A5 Genotype for Induction and Maintenance Phases of Kidney Transplantation. Clinical Therapeutics 35:11, pages 1762-1769.
Crossref
Vibeke Andersen, Ulla Vogel, Sine Godiksen, Franz B. Frenzel, Mona Sæbø, Julian Hamfjord, Elin Kure & Lotte K. Vogel. (2013) Low ABCB1 Gene Expression Is an Early Event in Colorectal Carcinogenesis. PLoS ONE 8:8, pages e72119.
Crossref
Jörg König, Fabian Müller & Martin F. Fromm. (2013) Transporters and Drug-Drug Interactions: Important Determinants of Drug Disposition and Effects. Pharmacological Reviews 65:3, pages 944-966.
Crossref
Xavier Lucas, Silke Simon, Rolf Schubert & Stefan Günther. (2013) Discovery of the Inhibitory Effect of a Phosphatidylinositol Derivative on P-Glycoprotein by Virtual Screening Followed by In Vitro Cellular Studies. PLoS ONE 8:4, pages e60679.
Crossref
Sara Van der Heyden, Siska Croubels, Caroline Gadeyne, Richard Ducatelle, Sylvie Daminet, Hugo Murua Escobar, Katharina Sterenczak, Ingeborgh Polis, Stijn Schauvliege, Myriam Hesta & Koen Chiers. (2012) Influence of P-glycoprotein modulation on plasma concentrations and pharmacokinetics of orally administered prednisolone in dogs. American Journal of Veterinary Research 73:6, pages 900-907.
Crossref
Jasmine A. Talameh & David E. Lanfear. (2011) Pharmacogenetics in Chronic Heart Failure: New Developments and Current Challenges. Current Heart Failure Reports 9:1, pages 23-32.
Crossref
Sam Rebello, Séverine Compain, Aimin Feng, Sam Hariry, Hans-Armin Dieterich & Venkateswar Jarugula. (2011) Effect of Cyclosporine on the Pharmacokinetics of Aliskiren in Healthy Subjects. The Journal of Clinical Pharmacology 51:11, pages 1549-1560.
Crossref
Fabian MüllerMartin F Fromm. (2011) Transporter-mediated drug–drug interactions. Pharmacogenomics 12:7, pages 1017-1037.
Crossref
Anu M. Neuvonen, Jukka U. Palo & Antti Sajantila. (2011) Post-mortem ABCB1 genotyping reveals an elevated toxicity for female digoxin users. International Journal of Legal Medicine 125:2, pages 265-269.
Crossref
M L Reitman, X Chu, X Cai, J Yabut, R Venkatasubramanian, S Zajic, J A Stone, Y Ding, R Witter, C Gibson, K Roupe, R Evers, J A Wagner & A Stoch. (2010) Rifampin's Acute Inhibitory and Chronic Inductive Drug Interactions: Experimental and Model-Based Approaches to Drug–Drug Interaction Trial Design. Clinical Pharmacology & Therapeutics 89:2, pages 234-242.
Crossref
Hiroshi Sugimoto, Hideki Hirabayashi, Yoshiaki Kimura, Atsutoshi Furuta, Nobuyuki Amano & Toshiya Moriwaki. (2011) Quantitative Investigation of the Impact of P-Glycoprotein Inhibition on Drug Transport across Blood-Brain Barrier in Rats. Drug Metabolism and Disposition 39:1, pages 8-14.
Crossref
Stefan Oswald, Bernd Terhaag & Werner Siegmund. 2011. Drug Transporters. Drug Transporters 403 447 .
Alexander Jetter, Gerd Fätkenheuer, Dorothee Frank, Tobias Klaassen, Angela Seeringer, Oxana Doroshyenko, Julia Kirchheiner, Wolfgang Hein, Edgar Schömig, Uwe Fuhr & Christoph Wyen. (2010) Do activities of cytochrome P450 (CYP)3A, CYP2D6 and P-glycoprotein differ between healthy volunteers and HIV-infected patients?. Antiviral Therapy 15:7, pages 975-983.
Crossref
Joseph D. Ma, Shirley M. Tsunoda, Joseph S. BertinoJrJr, Meghana Trivedi, Keola K. Beale & Anne N. Nafziger. (2010) Evaluation of In Vivo P-Glycoprotein Phenotyping Probes. Clinical Pharmacokinetics 49:4, pages 223-237.
Crossref
Louis Leung & Aram Oganesian. 2010. Pharmaceutical Sciences Encyclopedia. Pharmaceutical Sciences Encyclopedia 1 38 .
Vibeke Andersen, Mette Østergaard, Jane Christensen, Kim Overvad, Anne Tjønneland & Ulla Vogel. (2009) Polymorphisms in the xenobiotic transporter Multidrug Resistance 1 (MDR1) and interaction with meat intake in relation to risk of colorectal cancer in a Danish prospective case-cohort study. BMC Cancer 9:1.
Crossref
Vibeke Andersen, Lene Agerstjerne, Dorte Jensen, Mette Østergaard, Mona Sæbø, Julian Hamfjord, Elin Kure & Ulla Vogel. (2009) The multidrug resistance 1 (MDR1) gene polymorphism G-rs3789243-A is not associated with disease susceptibility in Norwegian patients with colorectal adenoma and colorectal cancer; a case control study. BMC Medical Genetics 10:1.
Crossref
Leslie W. Chinn & Deanna L. Kroetz. 2009. ABC Transporters and Multidrug Resistance. ABC Transporters and Multidrug Resistance 411 436 .
Louis Leung & Aram Oganesian. 2009. Drug Metabolism Handbook. Drug Metabolism Handbook 89 126 .
Leposava Grbovic, Miroslav Radenkovic, Jelena Djokic, Ljiljana Gojkovic-Bukarica & Gordana DragovicJ.J.. (2007) New bearings in pharmacotherapeutic strategies: Pharmacogenetics and gene therapy. Vojnosanitetski pregled Military Medical and Pharmaceutical Journal of Serbia 64:10, pages 707-713.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.