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Scandinavian Journal of Gastroenterology Volume 35, 2000 - Issue 8
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Research Article

Is the Increase in Serum Cystathionine Levels in Patients with Liver Cirrhosis a Consequence of Impaired Homocysteine Transsulfuration at the Level of ?-Cystathionase?

M. P. Look, R. Riezler, C. Reichel, K. A. Brensing, J. K. Rockstroh, S. P. Stabler, U. Spengler, H. K. Berthold, T. Sauerbruch Dept. of Internal Medicine I, University of Bonn, Sigmund-Freud-Strasse 25, 53105 Bonn, Germany
Pages 866-872 | Published online: 08 Jul 2009

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Uwe Pöge, M. Look, T. Gerhardt, H. U. Klehr, T. Sauerbruch & R. P. Woitas. (2004) Intravenous Treatment of Hyperhomocysteinemia in Patients on Chronic Hemodialysis—A Pilot Study. Renal Failure 26:6, pages 703-708.
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Indu Dhar, Vegard Lysne, Gard F T Svingen, Per M Ueland, Jesse F Gregory, Kaare H Bønaa & Ottar K Nygård. (2019) Elevated plasma cystathionine is associated with increased risk of mortality among patients with suspected or established coronary heart disease. The American Journal of Clinical Nutrition 109:6, pages 1546-1554.
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Andrea D. Belalcázar, John G. Ball, Leslie M. Frost, Monica A. Valentovic & John Wilkinson. (2013) Transsulfuration Is a Significant Source of Sulfur for Glutathione Production in Human Mammary Epithelial Cells. ISRN Biochemistry 2013, pages 1-7.
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Charles Halsted, Valentina Medici & Farah Esfandiari. 2009. Folate in Health and Disease, Second Edition. Folate in Health and Disease, Second Edition 429 448 .
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Diana R Mager, Margaret Marcon, Paul Wales & Paul B Pencharz. (2008) Use of N-Acetyl Cysteine for the Treatment of Parenteral Nutrition–induced Liver Disease in Children Receiving Home Parenteral Nutrition. Journal of Pediatric Gastroenterology & Nutrition 46:2, pages 220-223.
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Jesus A. Villanueva, Farah Esfandiari, Donna H. Wong, Iram Ahmad, Stepan Melnyk, S. Jill James & Charles H. Halsted. (2006) Abnormal Transsulfuration and Glutathione Metabolism in the Micropig Model of Alcoholic Liver Disease. Alcoholism: Clinical and Experimental Research 30:7, pages 1262-1270.
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S. H. Chui, K. Chan, A. K. K. Chui, L. S. L. Shek & R. N. S. Wong. (2005) The effects of a Chinese medicinal suppository (Vitalliver) on insulin-like growth factor 1 and homocysteine in patients with hepatitis B infection. Phytotherapy Research 19:8, pages 674-678.
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Kimihito FujiiTadayuki SakuragawaMisato KashibaYasoo SugiuraMieko KondoKayo MaruyamaNobuhito GodaYuji NimuraMakoto Suematsu. (2005) Hydrogen Sulfide as an Endogenous Modulator of Biliary Bicarbonate Excretion in the Rat Liver. Antioxidants & Redox Signaling 7:5-6, pages 788-794.
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Karine Robert, Johnny Nehmé, Emmanuel Bourdon, Gérard Pivert, Bertrand Friguet, Claude Delcayre, Jean–Maurice Delabar & Nathalie Janel. (2005) Cystathionine β Synthase Deficiency Promotes Oxidative Stress, Fibrosis, and Steatosis in Mice Liver. Gastroenterology 128:5, pages 1405-1415.
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Young C. Kim, Young S. Jung & Sang K. Kim. (2005) Effect of betaine supplementation on changes in hepatic metabolism of sulfur-containing amino acids and experimental cholestasis induced by α-naphthylisothiocyanate. Food and Chemical Toxicology 43:5, pages 663-670.
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Paolo Ventura, Maria Cristina Rosa, Gianluca Abbati, Stefano Marchini, Elvira Grandone, Patrizia Vergura, Silvia Tremosini & Maria Luisa Zeneroli. (2005) Hyperhomocysteinaemia in chronic liver diseases: role of disease stage, vitamin status and methylenetetrahydrofolate reductase genetics. Liver International 25:1, pages 49-56.
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Lucio Amitrano, Maria Anna Guardascione, Vincenzo Brancaccio, Maurizio Margaglione, Francesco Manguso, Luigi Iannaccone, Elvira Grandone & Antonio Balzano. (2004) Risk factors and clinical presentation of portal vein thrombosis in patients with liver cirrhosis. Journal of Hepatology 40:5, pages 736-741.
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Anne B Guttormsen, Einar Solheim & Helga Refsum. (2004) Variation in plasma cystathionine and its relation to changes in plasma concentrations of homocysteine and methionine in healthy subjects during a 24-h observation period. The American Journal of Clinical Nutrition 79:1, pages 76-79.
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Anja Bosy-Westphal, Martina Ruschmeyer, Norbert Czech, Gerd Oehler, Holger Hinrichsen, Matthias Plauth, Erich Lotterer, Wolfgang Fleig & Manfred James Müller. (2003) Determinants of hyperhomocysteinemia in patients with chronic liver disease and after orthotopic liver transplantation,,. The American Journal of Clinical Nutrition 77:5, pages 1269-1277.
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James D Finkelstein. (2003) Methionine metabolism in liver diseases. The American Journal of Clinical Nutrition 77:5, pages 1094-1095.
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Stefan Russmann, Edith Junker & Bernhard H. Lauterburg. (2002) Remethylation and transsulfuration of methionine in cirrhosis: Studies with L -[ 2 H 3 -methyl-1- 13 C]methionine . Hepatology 36:5, pages 1190-1196.
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L. John Hoffer. (2002) Methods for measuring sulfur amino acid metabolism. Current Opinion in Clinical Nutrition and Metabolic Care 5:5, pages 511-517.
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Rainer P Woitas, Birgit Stoffel-Wagner, Uwe Poege & Tilman Sauerbruch. (2002) Increased Homocysteine in Liver Cirrhosis: A Result of Renal Impairment?. Clinical Chemistry 48:5, pages 796-797.
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Wolfgang Herrmann, Heike Schorr, Jürgen Geisel & Werner Riegel. (2001) Homocysteine, Cystathionine, Methylmalonic Acid and B-Vitamins in Patients with Renal Disease. Clinical Chemistry and Laboratory Medicine 39:8.
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