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Research Article

Mutations of the APC Gene in Human Sporadic Colorectal Cancers

Pages 1048-1053 | Published online: 08 Jul 2009

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Xiaorong Liu, Xiangnian Shan, Waltraut Friedl, Siegfried Uhlhaas, Peter Propping, Jintian Li & Yaping Wang. (2007) May the APC gene somatic mutations in tumor tissues influence the clinical features of Chinese sporadic colorectal cancers?. Acta Oncologica 46:6, pages 757-762.
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Lu Ping Tan, Ban Kim Ng, Pauline Balraj, Patricia Kim Chooi Lim & Suat Cheng Peh. (2007) No difference in the occurrence of mismatch repair defects and APC and CTNNB1 genes mutation in a multi‐racial colorectal carcinoma patient cohort. Pathology 39:2, pages 228-234.
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Articles from other publishers (17)

Constantin Stefani, Daniela Miricescu, Iulia-Ioana Stanescu-Spinu, Remus Iulian Nica, Maria Greabu, Alexandra Ripszky Totan & Mariana Jinga. (2021) Growth Factors, PI3K/AKT/mTOR and MAPK Signaling Pathways in Colorectal Cancer Pathogenesis: Where Are We Now?. International Journal of Molecular Sciences 22:19, pages 10260.
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Jinrong Chang, Hoileong Wong Xavier, Dongfeng Chen, Yamei Liu, Hui Li & Zhaoxiang Bian. (2021) Potential Role of Traditional Chinese Medicines by Wnt/β-Catenin Pathway Compared With Targeted Small Molecules in Colorectal Cancer Therapy. Frontiers in Pharmacology 12.
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Andreas W Berger, Katja Raedler, Cord Langner, Leopold Ludwig, Nektarios Dikopoulos, Karl F Becker, Julia Slotta‐Huspenina, Michael Quante, Daniel Schwerdel, Lukas Perkhofer, Alexander Kleger, Eugen Zizer, Franz Oswald, Thomas Seufferlein & Alexander Meining. (2018) Genetic Biopsy for Prediction of Surveillance Intervals after Endoscopic Resection of Colonic Polyps: Results of the GENESIS Study. United European Gastroenterology Journal 6:2, pages 290-299.
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Ju-Hee Kang, Jeong-Eun Jang, Siddhartha Kumar Mishra, Hee-Ju Lee, Chu Won Nho, Dongyun Shin, Mirim Jin, Mi Kyung Kim, Changsun Choi & Seung Hyun Oh. (2015) Ergosterol peroxide from Chaga mushroom (Inonotus obliquus) exhibits anti-cancer activity by down-regulation of the β-catenin pathway in colorectal cancer. Journal of Ethnopharmacology 173, pages 303-312.
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Shakir M. Saud, Weidong Li, Nicole L. Morris, Matthias S. Matter, Nancy H. Colburn, Young S. Kim & Matthew R. Young. (2014) Resveratrol prevents tumorigenesis in mouse model of Kras activated sporadic colorectal cancer by suppressing oncogenic Kras expression. Carcinogenesis 35:12, pages 2778-2786.
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Ana Sebio & Heinz-Josef Lenz. (2014) Clinical importance of recently discovered gene variants in colon cancer recurrence and prognosis. Colorectal Cancer 3:2, pages 147-162.
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Madhuri Hegde, Mathew Ferber, Rong Mao, Wade Samowitz & Arupa Ganguly. (2013) ACMG technical standards and guidelines for genetic testing for inherited colorectal cancer (Lynch syndrome, familial adenomatous polyposis, and MYH-associated polyposis). Genetics in Medicine 16:1, pages 101-116.
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Jenifer R. Prosperi, Hue H. Luu & Kathleen H. Goss. 2011. Targeting the Wnt Pathway in Cancer. Targeting the Wnt Pathway in Cancer 81 128 .
Ja-Lok Ku, Young-Kyoung Shin, Duck-Woo Kim, Kyung-Hee Kim, Jin-Sung Choi, Sung-Hye Hong, You-Kyung Jeon, Sung-Hee Kim, Hong-Sun Kim, Jae-Hyun Park, Il-Jin Kim & Jae-Gahb Park. (2010) Establishment and characterization of 13 human colorectal carcinoma cell lines: mutations of genes and expressions of drug-sensitivity genes and cancer stem cell markers. Carcinogenesis 31:6, pages 1003-1009.
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Shaokun Shu & Jin Q. Cheng. 2010. Mechanisms of Oncogenesis. Mechanisms of Oncogenesis 269 277 .
A.J. Quyn, R.J.C. Steele, F.A. Carey & I.S. Näthke. (2008) Prognostic and therapeutic implications of APC mutations in colorectal cancer. The Surgeon 6:6, pages 350-356.
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Enikő Kámory, Judit Olasz & Orsolya Csuka. (2008) Somatic APC Inactivation Mechanisms in Sporadic Colorectal Cancer Cases in Hungary. Pathology & Oncology Research 14:1, pages 51-56.
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Tetsuji Takayama, Koji Miyanishi, Tsuyoshi Hayashi, Yasushi Sato & Yoshiro Niitsu. (2006) Colorectal cancer: genetics of development and metastasis. Journal of Gastroenterology 41:3, pages 185-192.
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Margreet Lüchtenborg, Matty P Weijenberg, Petra A Wark, A Merdan Saritas, Guido MJM Roemen, Goos NP van Muijen, Adriaan P de Bruïne, Piet A van den Brandt & Anton FPM de Goeij. (2005) Mutations in APC, CTNNB1 and K-ras genes and expression of hMLH1 in sporadic colorectal carcinomas from the Netherlands Cohort Study. BMC Cancer 5:1.
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Margreet Lüchtenborg, Matty P. Weijenberg, Anton F. P. M. de Goeij, Petra A. Wark, Mirian Brink, Guido M. J. M. Roemen, Marjolein H. F. M. Lentjes, Adriaan P. de Bruïne, R. Alexandra Goldbohm, Pieter van ‘t Veer & Piet A. van den Brandt. (2005) Meat and Fish Consumption, APCGene Mutations and hMLH1 Expression in Colon and Rectal Cancer: a Prospective Cohort Study (The Netherlands). Cancer Causes & Control 16:9, pages 1041-1054.
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Jan-Sing Hsieh, Shiu-Ru Lin, Mei-Yin Chang, Fang-Ming Chen, Chien-Yu Lu, Tsung-Jen Huang, Yu-Sheng Huang, Che-Jen Huang & Jaw-Yuan Wang. (2020) APC, K-ras, and p53 Gene Mutations in Colorectal Cancer Patients: Correlation to Clinicopathologic Features and Postoperative Surveillance. The American Surgeon 71:4, pages 336-343.
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B. Lustig & J. Behrens. (2003) The Wnt signaling pathway and its role in tumor development. Journal of Cancer Research and Clinical Oncology 129:4, pages 199-221.
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