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Research Article

Applicability of the Ussing Chamber Technique to Permeability Determinations in Functionally Distinct Regions of the Gastrointestinal Tract in the Rat

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Pages 732-741 | Published online: 08 Jul 2009

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Jianling Wang & Suzanne Skolnik. (2010) Mitigating permeability-mediated risks in drug discovery. Expert Opinion on Drug Metabolism & Toxicology 6:2, pages 171-187.
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Andreia S. Barros & Rute Nunes. 2024. Concepts and Models for Drug Permeability Studies. Concepts and Models for Drug Permeability Studies 309 346 .
Dong Tian, Yingxin Yang, Huiying Zhang, Hongwen Du, Hongyu Zhou & Tao Wang. (2023) Comparison of Ussing Chamber and Caco-2 Model in Evaluation of Intestinal Absorption Mechanism of Compounds from Different BCS Classifications. Drug Metabolism and Bioanalysis Letters 16:2, pages 105-112.
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Yining Xu, Neha Shrestha, Véronique Préat & Ana Beloqui. (2021) An overview of in vitro, ex vivo and in vivo models for studying the transport of drugs across intestinal barriers. Advanced Drug Delivery Reviews 175, pages 113795.
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Fiona McCartney, Vincent Jannin, Stéphanie Chevrier, Hakime Boulghobra, Delyan R. Hristov, Nicolas Ritter, Cédric Miolane, Yann Chavant, Frédéric Demarne & David J. Brayden. (2019) Labrasol® is an efficacious intestinal permeation enhancer across rat intestine: Ex vivo and in vivo rat studies. Journal of Controlled Release 310, pages 115-126.
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Vladimir Kodzhahinchev, Andrew Biancolin & Carol Bucking. (2018) Quantification of Mg2+, Ca2+ and H+ transport by the gastrointestinal tract of the goldfish, Carassius auratus, using the Scanning Ion-selective Electrode Technique (SIET). PLOS ONE 13:12, pages e0207782.
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Isabel Lozoya-Agullo, Isabel González-Álvarez, Matilde Merino-Sanjuán, Marival Bermejo & Marta González-Álvarez. (2018) Preclinical models for colonic absorption, application to controlled release formulation development. European Journal of Pharmaceutics and Biopharmaceutics 130, pages 247-259.
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Jaclyn Y. Lock, Taylor L. Carlson & Rebecca L. Carrier. (2018) Mucus models to evaluate the diffusion of drugs and particles. Advanced Drug Delivery Reviews 124, pages 34-49.
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Gianluca Picariello, Pasquale Ferranti & Francesco Addeo. (2016) Use of brush border membrane vesicles to simulate the human intestinal digestion. Food Research International 88, pages 327-335.
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Erik Sjögren, Johanna Eriksson, Charlotta Vedin, Katarina Breitholtz & Constanze Hilgendorf. (2016) Excised segments of rat small intestine in Ussing chamber studies: A comparison of native and stripped tissue viability and permeability to drugs. International Journal of Pharmaceutics 505:1-2, pages 361-368.
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Rute Nunes, Cátia Silva & Luise Chaves. 2016. Concepts and Models for Drug Permeability Studies. Concepts and Models for Drug Permeability Studies 203 236 .
Ahmad Al-Saffar, André Nogueira da Costa, Annie Delaunois, Derek J. Leishman, Louise Marks, Marie-Luce Rosseels & J.-P. Valentin. 2015. Principles of Safety Pharmacology. Principles of Safety Pharmacology 291 321 .
Masateru Miyake, Hajime Toguchi, Toru Nishibayashi, Kazutaka Higaki, Akira Sugita, Kazutaka Koganei, Nobuhiko Kamada, Mina T. Kitazume, Tadakazu Hisamatsu, Toshiro Sato, Susumu Okamoto, Takanori Kanai & Toshifumi Hibi. (2013) Establishment of Novel Prediction System of Intestinal Absorption in Humans Using Human Intestinal Tissues. Journal of Pharmaceutical Sciences 102:8, pages 2564-2571.
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E. NEIRINCKX, C. VERVAET, J. MICHIELS, S. DE SMET, W. VAN DEN BROECK, J. P. REMON, P. DE BACKER & S. CROUBELS. (2011) Feasibility of the Ussing chamber technique for the determination of in vitro jejunal permeability of passively absorbed compounds in different animal species. Journal of Veterinary Pharmacology and Therapeutics 34:3, pages 290-297.
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Iain S. Haslam, Derek A. O'Reilly, David J. Sherlock, Ambareen Kauser, Chris Womack & Tanya Coleman. (2011) Pancreatoduodenectomy as a source of human small intestine for Ussing chamber investigations and comparative studies with rat tissue. Biopharmaceutics & Drug Disposition 32:4, pages 210-221.
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Jae Woong Lee, Jung Ho Park, Dong I. L. Park, Jung-Hwan Park, Hong Joo Kim, Yong Kyun Cho, Chong I. L. Sohn, Woo Kyu Jeon & Byung Ik Kim. (2010) Subjects with Diarrhea-Predominant IBS Have Increased Rectal Permeability Responsive to Tryptase. Digestive Diseases and Sciences 55:10, pages 2922-2928.
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Nicola Antonio Colabufo, Francesco Berardi, Marialessandra Contino, Carmela Inglese, Mauro Niso & Roberto Perrone. (2008) Effect of some P-glycoprotein modulators on Rhodamine-123 absorption in guinea-pig ileum. Bioorganic & Medicinal Chemistry Letters 18:13, pages 3741-3744.
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Eman M. Hussein, Abdalla M. Hussein, Mohamed M. Eida & Maha M. Atwa. (2008) Pathophysiological variability of different genotypes of human Blastocystis hominis Egyptian isolates in experimentally infected rats. Parasitology Research 102:5, pages 853-860.
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Eiko INAGAKI-TACHIBANA, Yasuo NATORI, Hisayoshi HAYASHI & Yuichi SUZUKI. (2008) In Vitro Diffusion Barriers of the Mouse Jejunum in Ussing Chambers. Journal of Nutritional Science and Vitaminology 54:1, pages 30-38.
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Emily K.Y. Lam, Emily K.K. Tai, Marcel W.L. Koo, Helen P.S. Wong, William K.K. Wu, L. Yu, Wallace H.L. So, Patrick C.Y. Woo & C.H. Cho. (2007) Enhancement of gastric mucosal integrity by Lactobacillus rhamnosus GG. Life Sciences 80:23, pages 2128-2136.
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Blaise Corthésy, H. Rex Gaskins & Annick Mercenier. (2007) Cross-Talk between Probiotic Bacteria and the Host Immune System1,. The Journal of Nutrition 137:3, pages 781S-790S.
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Tomoo Kuge, Beverley Greenwood-Van Meerveld & Masahiro Sokabe. (2006) Stress-induced breakdown of intestinal barrier function in the rat: Reversal by wood creosote. Life Sciences 79:9, pages 913-918.
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A.P Harrison, K.H Erlwanger, V.S Elbr?nd, N.K Andersen & M.A Unmack. (2004) Gastrointestinal-tract models and techniques for use in safety pharmacology. Journal of Pharmacological and Toxicological Methods 49:3, pages 187-199.
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