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Scandinavian Journal of Gastroenterology Volume 40, 2005 - Issue 4
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Original Article: Inflammatory Bowel Disease

Effects of 6-mercaptopurine treatment on sperm production and reproductive performance: A study in male mice

Moshe Ligumsky Gastroenterology Unit, Division of Internal Medicine, Hadassah-Hebrew University Medical Center, Jerusalem, Israel
,
Shadi Badaan Research Laboratory, Hadassah-Hebrew University Medical Center, Jerusalem, Israel
,
Hadassa Lewis Research Laboratory, Hadassah-Hebrew University Medical Center, Jerusalem, Israel
&
Dror Meirow IVF Unit, Division of Obstetrics and Gynecology, Sheba Medical Center, Tel-Hashomer, IsraelCorrespondence[email protected]
Pages 444-449 | Received 13 Jul 2004, Accepted 15 Sep 2004, Published online: 08 Jul 2009

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Eyyüp Rencüzoğulları & Muhsin Aydın. (2019) Genotoxic and mutagenic studies of teratogens in developing rat and mouse. Drug and Chemical Toxicology 42:4, pages 409-429.
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Yoshihiro Yokota, Takayuki Imai, Masahiro Kawahara, Osamu Inatomi, Atsushi Nishida, Yoichi Kakuta, Atsushi Masamune & Akira Andoh. (2023) Thiopurines exert harmful effects on spermatogenesis in Nudt15R138C knock-in mice. Journal of Gastroenterology 59:2, pages 109-118.
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Archna Panghal & Gopabandhu Jena. (2023) Single versus intermittent cycle exposure effect of 6-mercaptopurine in juvenile Sprague–Dawley rat: a germ cell-specific mechanistic study. Naunyn-Schmiedeberg's Archives of Pharmacology.
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Claudia Massarotti, Elvira Sbragia, Irene Gazzo, Sara Stigliani, Matilde Inglese & Paola Anserini. (2021) Effect of Multiple Sclerosis and Its Treatments on Male Fertility: Cues for Future Research. Journal of Clinical Medicine 10:22, pages 5401.
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Joseph Meserve, Jiyu Luo, Wenhong Zhu, Nina Veeravalli, Gretchen Bandoli, Christina D. Chambers, Abha G. Singh, Brigid S. Boland, William J. Sandborn, Uma Mahadevan & Siddharth Singh. (2021) Paternal Exposure to Immunosuppressive and/or Biologic Agents and Birth Outcomes in Patients With Immune-Mediated Inflammatory Diseases. Gastroenterology 161:1, pages 107-115.e3.
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Renata Finelli, Kristian Leisegang, Federica Finocchi, Salvatore De Masi, Ashok Agarwal & Giovanni Damiani. (2021) The impact of autoimmune systemic inflammation and associated medications on male reproductive health in patients with chronic rheumatological, dermatological, and gastroenterological diseases: A systematic review. American Journal of Reproductive Immunology 85:5.
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Mirjam Schuchardt, Jaqueline Herrmann, Cornelia Henkel, Milen Babic, Markus van der Giet & Markus Tölle. (2021) Long-Term Treatment of Azathioprine in Rats Induces Vessel Mineralization. Biomedicines 9:3, pages 327.
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Muhammad B. HammamiUma Mahadevan. (2020) Men With Inflammatory Bowel Disease: Sexual Function, Fertility, Medication Safety, and Prostate Cancer. American Journal of Gastroenterology 115:4, pages 526-534.
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Yang Mao-Draayer, Sandra Thiel, Elizabeth A. Mills, Tanuja Chitnis, Michelle Fabian, Ilana Katz Sand, M. Isabel Leite, Sven Jarius & Kerstin Hellwig. (2020) Neuromyelitis optica spectrum disorders and pregnancy: therapeutic considerations. Nature Reviews Neurology 16:3, pages 154-170.
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Yong Eun Park & Tae Oh Kim. (2020) Sexual Dysfunction and Fertility Problems in Men with Inflammatory Bowel Disease. The World Journal of Men's Health 38:3, pages 285.
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Mariangela Allocca, Daniela Gilardi, Gionata Fiorino, Federica Furfaro, Laurent Peyrin-Biroulet & Silvio Danese. (2018) Sexual and reproductive issues and inflammatory bowel disease: a neglected topic in men. European Journal of Gastroenterology & Hepatology 30:3, pages 316-322.
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Melek Simsek, Cornelis B Lambalk, Janneke A Wilschut, Chris J J Mulder & Nanne K H de Boer. (2018) The associations of thiopurines with male fertility and paternally exposed offspring: a systematic review and meta-analysis. Human Reproduction Update 24:2, pages 192-206.
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Piyush Kumar, Anupam Das, NiharikaRanjan Lal, Sourabh Jain & Anupama Ghosh. (2018) Safety of important dermatological drugs (retinoids, immune suppressants, anti androgens and thalidomide) in reproductively active males with respect to pregnancy outcome: A brief review of literature. Indian Journal of Dermatology, Venereology and Leprology 84:5, pages 539.
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Hamoun Rozati, Thomas Handley & Channa Jayasena. (2017) Process and Pitfalls of Sperm Cryopreservation. Journal of Clinical Medicine 6:9, pages 89.
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M. Semet, M. Paci, J. Saïas‐Magnan, C. Metzler‐Guillemain, R. Boissier, H. Lejeune & J. Perrin. (2017) The impact of drugs on male fertility: a review. Andrology 5:4, pages 640-663.
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Angela DautiBrigitte GerstlSerena ChongOrin ChisholmAntoinette Anazodo. (2017) Improvements in Clinical Trials Information Will Improve the Reproductive Health and Fertility of Cancer Patients. Journal of Adolescent and Young Adult Oncology 6:2, pages 235-269.
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Erma Z. Drobnis & Ajay K. NangiaErma Z. Drobnis & Ajay K. Nangia. 2017. Impacts of Medications on Male Fertility. Impacts of Medications on Male Fertility 179 210 .
Takeshi Shin & Hiroshi Okada. (2016) Infertility in men with inflammatory bowel disease. World Journal of Gastrointestinal Pharmacology and Therapeutics 7:3, pages 361.
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S. Grunewald & U. Paasch. (2015) Medikamentöse Therapie dermatologischer ErkrankungenDrug treatment of dermatological disorders. Der Hautarzt 66:12, pages 913-918.
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K. Sands, R. Jansen, S. Zaslau & D. Greenwald. (2015) Review article: the safety of therapeutic drugs in male inflammatory bowel disease patients wishing to conceive. Alimentary Pharmacology & Therapeutics 41:9, pages 821-834.
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Nitin H. Dhekale, K. Hima Bindu, K. Y. Kirankumar, Anil H. Gore, Prashant V. Anbhule & Govind B. Kolekar. (2014) Development and optimization of a multivariate RP-UPLC method for determination of telmisartan and its related substances by applying a two-level factorial design approach: application to quality control study. Analytical Methods 6:14, pages 5168.
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Jillian Wong Millsop, Misha M. Heller, Mark J. Eliason & Jenny E. Murase. (2013) Dermatological medication effects on male fertility. Dermatologic Therapy 26:4, pages 337-346.
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Deanna D. Nguyen. (2011) Thiopurines and paternity: Is it safe?. Inflammatory Bowel Diseases 17:11, pages 2402-2403.
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Prakash M. Davadra, Vivek V. Mepal, Mukul R. Jain, Chhelshanker G. Joshi & Atul H. Bapodra. (2011) A validated UPLC method for the determination of process-related impurities in Azathioprine bulk drug. Anal. Methods 3:1, pages 198-204.
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Carlos Teruel, Antonio López-San Román, Fernando Bermejo, Carlos Taxonera, José Lázaro Pérez-Calle, Javier P Gisbert, María Martín-Arranz, Ángel Ponferrada, Manuel Van Domselaar, Alicia Algaba, Jesús Estellés, Pilar López-Serrano, Pablo M Linares & Alfonso Muriel. (2010) Outcomes of Pregnancies Fathered by Inflammatory Bowel Disease Patients Exposed to Thiopurines. American Journal of Gastroenterology 105:9, pages 2003-2008.
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Elena Garrido, Manuel Van Domselaar, Sara Morales & Antonio López-Sanromán. (2010) Enfermedad inflamatoria intestinal y gestación. Gastroenterología y Hepatología 33:7, pages 517-529.
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Uma Mahadevan. 2010. Inflammatory Bowel Disease. Inflammatory Bowel Disease 568 583 .
Linda A. Feagins & Sunanda V. Kane. (2009) Sexual and Reproductive Issues for Men With Inflammatory Bowel Disease. American Journal of Gastroenterology 104:3, pages 768-773.
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Linda A Feagins & Sunanda V Kane. (2009) Sexual and Reproductive Issues for Men With Inflammatory Bowel Disease. The American Journal of Gastroenterology 104:3, pages 768-773.
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Philippe Marteau. (2008) IBD and pregnancy. Inflammatory Bowel Diseases 14:Supplement, pages S43-S44.
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Philippe Marteau. (2008) IBD and pregnancy. Inflammatory Bowel Diseases 14, pages S43-S44.
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Z. S. HEETUN, C. BYRNES, P. NEARY & C. O’MORAIN. (2007) Review article: reproduction in the patient with inflammatory bowel disease. Alimentary Pharmacology & Therapeutics 26:4, pages 513-533.
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Sonja Grunewald, Uwe Paasch & Hans‐Jürgen Glander. (2007) Systemic dermatological treatment with relevance for male fertility. JDDG: Journal der Deutschen Dermatologischen Gesellschaft 5:1, pages 15-21.
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