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Original Article

Lactose intolerance: Lactose tolerance test versus genotyping

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Pages 822-826 | Received 07 Sep 2004, Published online: 08 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (9)

Símun Niclasen, Stig Andersen, Nadja Albertsen & Henrik Bygum Krarup. (2023) The influence of Scandinavian presence on Greenlandic lactase persistence. Scandinavian Journal of Gastroenterology 58:4, pages 349-353.
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Morten Mørk, Stine Linding Andersen, Inge Søkilde Pedersen, Anja Ernst, Simon Lykkeboe & Henrik Bygum Krarup. (2020) Use of genetic testing for hypolactasia trait in the North Denmark Region. Scandinavian Journal of Gastroenterology 55:9, pages 1012-1018.
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Claus Lohman Brasen, Lone Frischknecht, Dorthe Ørnskov, Lotte Andreasen & Jonna Skov Madsen. (2017) Combination of real-time PCR and sequencing to detect multiple clinically relevant genetic variations in the lactase gene. Scandinavian Journal of Clinical and Laboratory Investigation 77:1, pages 60-65.
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Shruti V. Baadkar, Manjari S. Mukherjee & Smita S. Lele. (2014) Study on influence of age, gender and genetic variants on lactose intolerance and its impact on milk intake in adult Asian Indians. Annals of Human Biology 41:6, pages 548-553.
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Licínio Manco, Sara Pires, Ana Isabel Lopes, Ima Figueiredo, David Albuquerque, Manuela Alvarez, Jorge Rocha & Augusto Abade. (2013) Distribution of the − 13910C>T polymorphism in the general population of Portugal and in subjects with gastrointestinal complaints associated with milk consumption. Annals of Human Biology 40:2, pages 205-208.
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Andrew Szilagyi, Henry Leighton, Barry Burstein & Ian Shrier. (2011) Significant Positive Correlation Between Sunshine and Lactase Nonpersistence in Europe May Implicate Both in Similarly Altering Risks for Some Diseases. Nutrition and Cancer 63:7, pages 991-999.
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Qayyum Husain. (2010) β Galactosidases and their potential applications: a review. Critical Reviews in Biotechnology 30:1, pages 41-62.
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Irma Järvelä, Suvi Torniainen & Kaija-Leena Kolho. (2009) Molecular genetics of human lactase deficiencies. Annals of Medicine 41:8, pages 568-575.
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Leena Seppo, Tuula Tuure, Riitta Korpela, Irma Järvelä, Heli Rasinperä & Timo Sahi. (2008) Can primary hypolactasia manifest itself after the age of 20 years? A two-decade follow-up study. Scandinavian Journal of Gastroenterology 43:9, pages 1082-1087.
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Articles from other publishers (35)

Marcia Wehba Esteves CAVICHIO, Caio Robledo D’Angioli Costa QUAIO, Wagner Antonio da Rosa BARATELA, Patrícia Marinho Costa de OLIVEIRA & Soraia TAHAN. (2024) EVALUATION OF AGREEMENT BETWEEN C/T-13910 POLYMORPHISM GENOTYPING RESULTS AND LACTOSE TOLERANCE TEST RESULTS: A RETROSPECTIVE POPULATION-BASED STUDY IN BRAZIL. Arquivos de Gastroenterologia 61.
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Magdalena Kowalówka, Grzegorz Kosewski, Daniel Lipiński & Juliusz Przysławski. (2023) A Comprehensive Look at the -13910 C>T LCT Gene Polymorphism as a Molecular Marker for Vitamin D and Calcium Levels in Young Adults in Central and Eastern Europe: A Preliminary Study. International Journal of Molecular Sciences 24:12, pages 10191.
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Olga Maria Nardone, Francesco Manfellotto, Caterina D’Onofrio, Alba Rocco, Giovanni Annona, Francesca Sasso, Pasquale De Luca, Nicola Imperatore, Anna Testa, Roberto de Sire, Elio Biffali & Fabiana Castiglione. (2021) Lactose Intolerance Assessed by Analysis of Genetic Polymorphism, Breath Test and Symptoms in Patients with Inflammatory Bowel Disease. Nutrients 13:4, pages 1290.
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Teresa Sendino, Amaia Sandúa, Sofía Calleja, Álvaro González & Estibaliz Alegre. (2020) Lactose tolerance test as an alternative to hydrogen breath test in the study of lactose malabsorption. Advances in Laboratory Medicine / Avances en Medicina de Laboratorio 1:4.
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Teresa Sendino, Amaia Sandúa, Sofía Calleja, Álvaro González & Estibaliz Alegre. (2020) Estudio del test de tolerancia a lactosa como alternativa a test de hidrógeno espirado en el estudio de la malabsorción de lactosa. Advances in Laboratory Medicine / Avances en Medicina de Laboratorio 1:4.
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Imelda de Jesús Loera-Hernández & Gerardo Espinosa-Garza. (2019) Dehydration and Sieving to 150 Microns Process of Melon Seed. Defect and Diffusion Forum 394, pages 39-46.
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Edilene Maria Araujo, Luama dos Santos, Radamés Coutinho, Viviane Assis, Najara Brandão, Daniela Almeida, Gildásio Conceição, Camila Figueredo, Hellen Fonseca, Maria de Lourdes Lima, Denise Lemaire & Domingos Rios. (2019) Genetic and Oral Tests for the Diagnosis of Lactose Intolerance in Mixed-Ancestry Brazilians with Metabolic Syndrome. Lifestyle Genomics 12:1-6, pages 1-9.
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André Castagna Wortmann, Daniel Simon, Luiz Edmundo Mazzoleni, Guilherme Becker Sander, Carlos Fernando de Magalhães Francesconi, Débora Dreher Nabinger, Camila Schultz Grott, Tássia Flores Rech, Felipe Mazzoleni, Vagner Ricardo Lunge, Laura Renata de Bona, Tobias Cancian Milbradt & Themis Reverbel da Silveira. (2018) The association between adult-type hypolactasia and symptoms of functional dyspepsia. Genetics and Molecular Biology 41:1, pages 92-97.
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Yosra Ben Halima, Rym Kefi, Marco Sazzini, Cristina Giuliani, Sara De Fanti, Chokri Nouali, Majdi Nagara, Giacomo Mengozzi, Sahar Elouej, Abdelmajid Abid, Henda Jamoussi, Lotfi Chouchane, Giovanni Romeo, Sonia Abdelhak & Donata Luiselli. (2017) Lactase persistence in Tunisia as a result of admixture with other Mediterranean populations. Genes & Nutrition 12:1.
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Paulo Roberto Lins Ponte, Pedro Henrique Quintela Soares de Medeiros, Alexandre Havt, Joselany Afio Caetano, David A C Cid, Mara de Moura Gondim Prata, Alberto Melo Soares, Richard L Guerrant, Josyf Mychaleckyj & Aldo Ângelo Moreira Lima. (2016) Clinical evaluation, biochemistry and genetic polymorphism analysis for the diagnosis of lactose intolerance in a population from northeastern Brazil. Clinics 71:2, pages 82-89.
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Zbigniew Dzialanski, Michael Barany, Peter Engfeldt, Anders Magnuson, Lovisa A. Olsson & Torbjörn K. Nilsson. (2016) Lactase persistence versus lactose intolerance: Is there an intermediate phenotype?. Clinical Biochemistry 49:3, pages 248-252.
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Yanyong Deng, Benjamin Misselwitz, Ning Dai & Mark Fox. (2015) Lactose Intolerance in Adults: Biological Mechanism and Dietary Management. Nutrients 7:9, pages 8020-8035.
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X. Zheng, H. Chu, Y. Cong, Y. Deng, Y. Long, Y. Zhu, D. Pohl, M. Fried, N. Dai & M. Fox. (2015) Self‐reported lactose intolerance in clinic patients with functional gastrointestinal symptoms: prevalence, risk factors, and impact on food choices. Neurogastroenterology & Motility 27:8, pages 1138-1146.
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Nana Yaa Baffour‐Awuah, Sarah Fleet, Robert K. Montgomery, Susan S. Baker, Johannah L. Butler, Catarina Campbell, Samuel Tischfield, Paul D. Mitchell, Sophie Allende‐Richter, Jennifer E. Moon, Laurie Fishman, Athos Bousvaros, Victor Fox, Mikko Kuokkanen, Richard J. Grand & Joel N. Hirschhorn. (2015) Functional Significance of Single Nucleotide Polymorphisms in the Lactase Gene in Diverse US Patients and Evidence for a Novel Lactase Persistence Allele at −13909 in Those of European Ancestry. Journal of Pediatric Gastroenterology and Nutrition 60:2, pages 182-191.
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Concetta Santonocito, Margherita Scapaticci, Donatella Guarino, Eleonora Brigida Annicchiarico, Rosalia Lisci, Romina Penitente, Antonio Gasbarrini, Cecilia Zuppi & Ettore Capoluongo. (2015) Lactose intolerance genetic testing: Is it useful as routine screening? Results on 1426 south–central Italy patients. Clinica Chimica Acta 439, pages 14-17.
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Martin Raithel, Michael Weidenhiller, Alexander Fritz-Karl Hagel, Urban Hetterich, Markus Friedrich Neurath & Peter Christopher Konturek. (2013) The Malabsorption of Commonly Occurring Mono and Disaccharides. Deutsches Ärzteblatt international.
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David Albuquerque, Clévio Nóbrega & Licínio Manco. (2013) The lactase persistence ‐13910C>T polymorphism shows indication of association with abdominal obesity among Portuguese children. Acta Paediatrica 102:4.
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Raja A. H. Kuchay, Mumtaz Anwar, Babu R. Thapa, Akhtar Mahmood & Safrun Mahmood. (2012) Correlation of G/A -22018 single-nucleotide polymorphism with lactase activity and its usefulness in improving the diagnosis of adult-type hypolactasia among North Indian children. Genes & Nutrition 8:1, pages 145-151.
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Sunil Kumar, Prabhat Ranjan, Balraj Mittal, Rajan Singh & Uday C Ghoshal. (2012) Lactase persistence/non‐persistence genetic variants in irritable bowel syndrome in an endemic area for lactose malabsorption. Journal of Gastroenterology and Hepatology 27:12, pages 1825-1830.
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Shruti V. BaadkarManjari S. MukherjeeSmita S. Lele. (2012) A Study on Genetic Test of Lactase Persistence in Relation to Milk Consumption in Regional Groups of India. Genetic Testing and Molecular Biomarkers 16:12, pages 1413-1418.
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Evelyn Mendoza Torres, Lourdes Luz Varela Prieto, José Luis Villarreal Camacho & Daniel Antonio Villanueva Torregroza. (2012) Diagnosis of adult-type hypolactasia/lactase persistence: genotyping of single nucleotide polymorphism (SNP C/T-13910) is not consistent with breath test in Colombian Caribbean population. Arquivos de Gastroenterologia 49:1, pages 5-8.
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Loren Cordain, Matthew S. Hickey & Kami Kim. 2012. Biodiversity in Agriculture. Biodiversity in Agriculture 299 308 .
A. Marton, X. Xue & A. Szilagyi. (2011) Meta‐analysis: the diagnostic accuracy of lactose breath hydrogen or lactose tolerance tests for predicting the North European lactase polymorphism C/T‐13910. Alimentary Pharmacology & Therapeutics 35:4, pages 429-440.
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Brigitte C.M. Haberkorn, Anton A.M. Ermens, Ankie Koeken, Christa M. Cobbaert & Coen van Guldener. (2012) Improving diagnosis of adult-type hypolactasia in patients with abdominal complaints. Clinical Chemistry and Laboratory Medicine 50:1.
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Peter Born. (2011) The clinical impact of carbohydrate malabsorption. Arab Journal of Gastroenterology 12:1, pages 1-4.
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Deborah J Nolan, Dug Yeo Han, Wen Jiun Lam, Angharad R Morgan, Alan G Fraser, Linda C Tapsell & Lynnette R Ferguson. (2010) Genetic adult lactase persistence is associated with risk of Crohn's Disease in a New Zealand population. BMC Research Notes 3:1.
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Oner Ozdemir, Emin Mete, Ferhat Catal & Duygu Ozol. (2008) Food Intolerances and Eosinophilic Esophagitis in Childhood. Digestive Diseases and Sciences 54:1, pages 8-14.
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Fabiana Castiglione, Elena Di Girolamo, Carolina Ciacci, Nicola Caporaso, Luigi Pasquale, Antonio Cozzolino, Raffaella Tortora, Anna Testa & Antonio Rispo. (2008) Lactose malabsorption: Clinical or breath test diagnosis?. e-SPEN, the European e-Journal of Clinical Nutrition and Metabolism 3:6, pages e316-e320.
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Rejane Mattar, Maria do Socorro Monteiro, Cibele Aparecida Villares, Aníbal Ferreira dos Santos & Flair José Carrilho. (2008) Single nucleotide polymorphism C/T-13910, located upstream of the lactase gene, associated with adult-type hypolactasia: Validation for clinical practice. Clinical Biochemistry 41:7-8, pages 628-630.
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Torbjörn K. Nilsson & Lovisa A. Olsson. (2008) Simultaneous genotyping of the three lactose tolerance-linked polymorphisms LCT –13907C>G, LCT –13910C>T and LCT –13915T>G with Pyrosequencing™ technology. Clinical Chemistry and Laboratory Medicine 46:1.
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Jonathan P Waud, Stephanie B Matthews & Anthony K Campbell. (2008) Measurement of breath hydrogen and methane, together with lactase genotype, defines the current best practice for investigation of lactose sensitivity. Annals of Clinical Biochemistry: International Journal of Laboratory Medicine 45:1, pages 50-58.
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Carlos Felipe Bernardes-Silva, Alexandre C. Pereira, Glória de Fátima Alves da Mota, José Eduardo Krieger & Antonio Atílio Laudanna. (2007) Lactase persistence/non-persistence variants, C/T_13910 and G/A_22018, as a diagnostic tool for lactose intolerance in IBS patients. Clinica Chimica Acta 386:1-2, pages 7-11.
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B. M. Obermayer-Pietsch, M. Gugatschka, S. Reitter, W. Plank, A. Strele, D. Walter, C. Bonelli, W. Goessler, H. Dobnig, C. Högenauer, W. Renner & A. Fahrleitner-Pammer. (2006) Adult-type hypolactasia and calcium availability: decreased calcium intake or impaired calcium absorption?. Osteoporosis International 18:4, pages 445-451.
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Sarah A Tishkoff, Floyd A Reed, Alessia Ranciaro, Benjamin F Voight, Courtney C Babbitt, Jesse S Silverman, Kweli Powell, Holly M Mortensen, Jibril B Hirbo, Maha Osman, Muntaser Ibrahim, Sabah A Omar, Godfrey Lema, Thomas B Nyambo, Jilur Ghori, Suzannah Bumpstead, Jonathan K Pritchard, Gregory A Wray & Panos Deloukas. (2006) Convergent adaptation of human lactase persistence in Africa and Europe. Nature Genetics 39:1, pages 31-40.
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Gregory Miller, Judith Jarvis & Lois McBean. 2006. Handbook of Dairy Foods and Nutrition, Third Edition. Handbook of Dairy Foods and Nutrition, Third Edition 299 338 .

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