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ORIGINAL ARTICLE

Changes in the mucus barrier of the rat during 5-fluorouracil-induced gastrointestinal mucositis

, , , , , , , & , PhD show all
Pages 59-65 | Received 10 Apr 2007, Published online: 08 Jul 2009

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Junhua Huang, Alan Yaw Min Hwang, Yuting Jia, Brian Kim, Melania Iskandar, Ali Ibrahim Mohammed & Nicola Cirillo. (2022) Experimental Chemotherapy-Induced Mucositis: A Scoping Review Guiding the Design of Suitable Preclinical Models. International Journal of Molecular Sciences 23:23, pages 15434.
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Xing Huang, Mao Li, Shengzhong Hou & Bole Tian. (2021) Role of the microbiome in systemic therapy for pancreatic ductal adenocarcinoma (Review). International Journal of Oncology 59:6.
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Jiazhen Wu, Yuxuan Gan, Muxia Li, Liping Chen, Jiali Liang, Jianyi Zhuo, Huijuan Luo, Nan Xu, Xue Wu, Qiduan Wu, Zhixiu Lin, Ziren Su & Yuhong Liu. (2020) Patchouli alcohol attenuates 5-fluorouracil-induced intestinal mucositis via TLR2/MyD88/NF-kB pathway and regulation of microbiota. Biomedicine & Pharmacotherapy 124, pages 109883.
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Daniel Thorpe, Ross Butler, Masooma Sultani, Barbara Vanhoecke & Andrea Stringer. (2019) Irinotecan-Induced Mucositis Is Associated with Goblet Cell Dysregulation and Neural Cell Damage in a Tumour Bearing DA Rat Model. Pathology & Oncology Research 26:2, pages 955-965.
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Daniel Thorpe. (2019) The role of mucins in mucositis. Current Opinion in Supportive & Palliative Care 13:2, pages 114-118.
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Daniel Thorpe, Masooma Sultani & Andrea Stringer. (2019) Irinotecan induces enterocyte cell death and changes to muc2 and muc4 composition during mucositis in a tumour-bearing DA rat model. Cancer Chemotherapy and Pharmacology 83:5, pages 893-904.
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Aldo da Cunha Medeiros, Ítalo Medeiros Azevedo, Marília Leite Lima, Irami Araújo Filho & Marília Daniela Moreira. (2018) Efeitos da sinvastatina na mucosite gastrointestinal induzida por 5-fluorouracil em ratos.. Revista do Colégio Brasileiro de Cirurgiões 45:5.
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João C. Campos, João D. Cunha, Domingos C. Ferreira, Salette Reis & Paulo J. Costa. (2018) Challenges in the local delivery of peptides and proteins for oral mucositis management. European Journal of Pharmaceutics and Biopharmaceutics 128, pages 131-146.
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Kazunari Tsujii, Tomoki Hattori, Ayuko Imaoka, Takeshi Akiyoshi & Hisakazu Ohtani. (2018) 5-Fluororacil–Induced Gastrointestinal Damage Impairs the Absorption and Anticoagulant Effects of Dabigatran Etexilate. Journal of Pharmaceutical Sciences 107:5, pages 1430-1433.
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J. A. Uranga, J. M. García‐Martínez, C. García‐Jiménez, G. Vera, M. I. Martín‐Fontelles & R. Abalo. (2017) Alterations in the small intestinal wall and motor function after repeated cisplatin in rat. Neurogastroenterology & Motility 29:7.
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U Jain, C A Midgen, T M Woodruff, W J Schwaeble, C M Stover & A W Stadnyk. (2017) Properdin deficiency protects from 5-fluorouracil-induced small intestinal mucositis in a complement activation-independent, interleukin-10-dependent mechanism. Clinical and Experimental Immunology 188:1, pages 36-44.
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Rei Kawashima, Mio Fujimaki, Yuka Ikenoue, Keiko Danjo, Wasaburo Koizumi & Takafumi Ichikawa. (2015) Influence of an elemental diet on 5-fluorouracil-induced morphological changes in the mouse salivary gland and colon. Supportive Care in Cancer 24:4, pages 1609-1616.
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JUNHUA XIAO, ZHANJUN LU, JIAQING SHENG, YUNNA SONG, WEILIANG JIANG, FEI LIU & PING ZHENG. (2016) 5-Fluorouracil attenuates dextran sodium sulfate-induced acute colitis in mice. Molecular Medicine Reports 13:3, pages 2821-2828.
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Rei Kawashima, Fumitaka Kawakami, Tatsunori Maekawa, Hajime Yamamoto, Wasaburo Koizumi & Takafumi Ichikawa. (2015) Elemental diet moderates 5-fluorouracil-induced gastrointestinal mucositis through mucus barrier alteration. Cancer Chemotherapy and Pharmacology 76:2, pages 269-277.
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Daigo Tsubokawa, Kenji Ishiwata, Yukinobu Goso, Takuya Yokoyama, Hirotaka Kanuka, Kazuhiko Ishihara, Takeshi Nakamura & Naotoshi Tsuji. (2015) Induction of Sda-sialomucin and sulfated H-sulfomucin in mouse small intestinal mucosa by infection with parasitic helminth. Experimental Parasitology 153, pages 165-173.
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Daniel Thorpe, Andrea Stringer & Ross Butler. (2013) Chemotherapy-induced mucositis: The role of mucin secretion and regulation, and the enteric nervous system. NeuroToxicology 38, pages 101-105.
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Tarek K. Motawi, Hanan M. Abd-Elgawad & Nancy N. Shahin. (2013) Effect of protein malnutrition on the metabolism and toxicity of cisplatin, 5-fluorouracil and mitomycin C in rat stomach. Food and Chemical Toxicology 56, pages 467-482.
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Andrea Stringer. (2013) Interaction between Host Cells and Microbes in Chemotherapy-Induced Mucositis. Nutrients 5:5, pages 1488-1499.
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Zhenze Liu, Jun Xi, Sven Schröder, Weigang Wang, Tianpei Xie, Zhugang Wang, Shisan Bao & Jian Fei. (2013) Chimonanthus nitens var. salicifolius Aqueous Extract Protects against 5-Fluorouracil Induced Gastrointestinal Mucositis in a Mouse Model . Evidence-Based Complementary and Alternative Medicine 2013, pages 1-12.
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Hajime Yamamoto, Kazuhiko Ishihara, Yuko Takeda, Wasaburo Koizumi & Takafumi Ichikawa. (2013) Changes in the Mucus Barrier during Cisplatin-Induced Intestinal Mucositis in Rats. BioMed Research International 2013, pages 1-8.
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Hannelouise Kissow, Niels-Erik Viby, Bolette Hartmann, Jens Juul Holst, Michael Timm, Lars Thim & Steen Seier Poulsen. (2012) Exogenous glucagon-like peptide-2 (GLP-2) prevents chemotherapy-induced mucositis in rat small intestine. Cancer Chemotherapy and Pharmacology 70:1, pages 39-48.
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Daigo Tsubokawa, Yukinobu Goso, Rei Kawashima, Hiroyoshi Ota, Takeshi Nakamura, Kazuo Nakamura, Noriko Sato, Makoto Kurihara, Taeko Dohi, Yuki I. Kawamura, Takafumi Ichikawa & Kazuhiko Ishihara. (2012) The monoclonal antibody HCM31 specifically recognises the Sd a tetrasaccharide in goblet cell mucin . FEBS Open Bio 2:1, pages 223-233.
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Daigo Tsubokawa, Takeshi Nakamura, Yukinobu Goso, Yuko Takano, Makoto Kurihara & Kazuhiko Ishihara. (2009) Nippostrongylus brasiliensis: Increase of sialomucins reacting with anti-mucin monoclonal antibody HCM31 in rat small intestinal mucosa with primary infection and reinfection. Experimental Parasitology 123:4, pages 319-325.
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Andrea M. Stringer, Rachel J. Gibson, Richard M. Logan, Joanne M. Bowen, Ann S. J. Yeoh, Juliette Hamilton & Dorothy M. K. Keefe. (2009) Gastrointestinal Microflora and Mucins May Play a Critical Role in the Development of 5-Fluorouracil-Induced Gastrointestinal Mucositis. Experimental Biology and Medicine 234:4, pages 430-441.
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Tomohisa Iwai, Takafumi Ichikawa, Yukinobu Goso, Tomoaki Ikezawa, Yoichi Saegusa, Isao Okayasu, Katsunori Saigenji & Kazuhiko Ishihara. (2009) Effects of indomethacin on the rat small intestinal mucosa: immunohistochemical and biochemical studies using anti-mucin monoclonal antibodies. Journal of Gastroenterology 44:4, pages 277-284.
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