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Inflammatory Bowel Disease

Suppression of Na+/H+ exchanger isoform-3 in human inflammatory bowel disease: Lack of reversal by 5′-aminosalicylate treatment

, & , PhD
Pages 56-64 | Received 11 Apr 2008, Published online: 08 Jul 2009

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Arivarasu N. Anbazhagan, Shubha Priyamvada, Waddah A. Alrefai & Pradeep K. Dudeja. (2018) Pathophysiology of IBD associated diarrhea. Tissue Barriers 6:2.
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Asmaa Abu-Ghefreh & Islam Khan. (2013) A Role of Intestine in Hypertension: Mechanism of Suppression of Intestinal Na-H Exchanger Isoform-3 in Spontaneously Hypertensive Rats. Clinical and Experimental Hypertension 35:7, pages 543-549.
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Amna Al-Shamali & Islam Khan. (2011) Expression of Na–H exchanger-8 isoform is suppressed in experimental colitis in adult rat: lack of reversibility by dexamethasone. Scandinavian Journal of Gastroenterology 46:1, pages 20-29.
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Martti Färkkilä. (2009) This month in Scandinavian Journal of Gastroenterology. Scandinavian Journal of Gastroenterology 44:1, pages 3-5.
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Zehong Huang, Mengjing Cao, Haoqian Fan, Yuan Sun, Tian Lan, Jingyun Ma & Qianniu Li. (2024) Porcine delta coronavirus inhibits NHE3 activity of porcine intestinal epithelial cells through miR-361–3p/NHE3 regulatory axis. Veterinary Microbiology 289, pages 109916.
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Yiran Han, Shanthi Srinivasan & C. Chris Yun. (2023) Inhibition of protein kinase C-α and activation of ezrin by Lactobacillus acidophilus restore Na + /H + exchange activity and fluid absorption in db/db mice . American Journal of Physiology-Endocrinology and Metabolism 325:3, pages E214-E226.
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Katerina Nikolovska, Ursula E. Seidler & Christian Stock. (2022) The Role of Plasma Membrane Sodium/Hydrogen Exchangers in Gastrointestinal Functions: Proliferation and Differentiation, Fluid/Electrolyte Transport and Barrier Integrity. Frontiers in Physiology 13.
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Yiran Han & C. Chris Yun. (2022) Metformin Inhibits Na+/H+ Exchanger NHE3 Resulting in Intestinal Water Loss. Frontiers in Physiology 13.
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Vishwas Mishra, Avipsa Bose, Shashi Kiran, Sanghita Banerjee, Idrees A. Shah, Pooja Chaukimath, Mudasir M. Reshi, Swarna Srinivas, Anaxee Barman & Sandhya S. Visweswariah. (2021) Gut-associated cGMP mediates colitis and dysbiosis in a mouse model of an activating mutation in GUCY2C . Journal of Experimental Medicine 218:11.
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Pawel R. Kiela, Hua Xu & Fayez K. Ghishan. 2020. Studies of Epithelial Transporters and Ion Channels. Studies of Epithelial Transporters and Ion Channels 125 209 .
Mrinalini C. Rao. 2011. Comprehensive Physiology. Comprehensive Physiology 947 1023 .
Peijian He, Abedul Haque, Songbai Lin, Fabio Cominelli & C. Chris Yun. (2018) Inhibition of autotaxin alleviates inflammation and increases the expression of sodium-dependent glucose cotransporter 1 and Na + /H + exchanger 3 in SAMP1/Fc mice . American Journal of Physiology-Gastrointestinal and Liver Physiology 315:5, pages G762-G771.
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Christy A. Harrison, Daniel Laubitz, Christina L. Ohland, Monica T. Midura-Kiela, Karuna Patil, David G. Besselsen, Deepa R. Jamwal, Christian Jobin, Fayez K. Ghishan & Pawel R. Kiela. (2018) Microbial dysbiosis associated with impaired intestinal Na+/H+ exchange accelerates and exacerbates colitis in ex-germ free mice. Mucosal Immunology 11:5, pages 1329-1341.
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Henrike Lenzen, Jiajie Qian, Michael P Manns, Ursula Seidler & Anne Jörns. (2018) Restoration of mucosal integrity and epithelial transport function by concomitant anti-TNFα treatment in chronic DSS-induced colitis. Journal of Molecular Medicine 96:8, pages 831-843.
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Irshad A. Sheikh, Rana Ammoury & Fayez K. Ghishan. 2018. Physiology of the Gastrointestinal Tract. Physiology of the Gastrointestinal Tract 1669 1687 .
Michael A. Gurney, Daniel Laubitz, Fayez K. Ghishan & Pawel R. Kiela. (2017) Pathophysiology of Intestinal Na+/H+ Exchange. Cellular and Molecular Gastroenterology and Hepatology 3:1, pages 27-40.
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Thomas Müller, Insha Rasool, Peter Heinz-Erian, Eva Mildenberger, Christian Hülstrunk, Andreas Müller, Laurent Michaud, Bart G P Koot, Antje Ballauff, Julia Vodopiutz, Stefan Rosipal, Britt-Sabina Petersen, Andre Franke, Irene Fuchs, Heiko Witt, Heinz Zoller, Andreas R Janecke & Sandhya S Visweswariah. (2016) Congenital secretory diarrhoea caused by activating germline mutations in GUCY2C . Gut 65:8, pages 1306-1313.
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Daniel Laubitz, Christy A. Harrison, Monica T. Midura-Kiela, Rajalakshmy Ramalingam, Claire B. Larmonier, John H. Chase, J. Gregory Caporaso, David G. Besselsen, Fayez K. Ghishan & Pawel R. Kiela. (2016) Reduced Epithelial Na+/H+ Exchange Drives Gut Microbial Dysbiosis and Promotes Inflammatory Response in T Cell-Mediated Murine Colitis. PLOS ONE 11:4, pages e0152044.
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Diogo Magalhães, José Miguel Cabral, Patrício Soares-da-Silva & Fernando Magro. (2016) Role of epithelial ion transports in inflammatory bowel disease. American Journal of Physiology-Gastrointestinal and Liver Physiology 310:7, pages G460-G476.
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Mohsen Hanifeh, Romy M. Heilmann, Satu Sankari, Minna M. Rajamäki, Laura Mäkitalo, Pernilla Syrjä, Susanne Kilpinen, Jan S. Suchodolski, Jörg M. Steiner & Thomas Spillmann. (2015) S100A12 concentrations and myeloperoxidase activity in the intestinal mucosa of healthy dogs. BMC Veterinary Research 11:1.
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Shubha Priyamvada, Rochelle Gomes, Ravinder K. Gill, Seema Saksena, Waddah A. Alrefai & Pradeep K. Dudeja. (2015) Mechanisms Underlying Dysregulation of Electrolyte Absorption in Inflammatory Bowel Disease–Associated Diarrhea. Inflammatory Bowel Diseases 21:12, pages 2926-2935.
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Fayez K. Ghishan & Pawel R. Kiela. (2014) Epithelial Transport in Inflammatory Bowel Diseases. Inflammatory Bowel Diseases, pages 1.
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Claire B. LarmonierDaniel Laubitz, Faihza M. HillKareem W. ShehabLeszek Lipinski, Monica T. Midura-KielaRita-Marie T. McFaddenRajalakshmy RamalingamKareem A. HassanMarcin Golebiewski, David G. BesselsenFayez K. GhishanPawel R. Kiela. (2013) Reduced colonic microbial diversity is associated with colitis in NHE3-deficient mice. American Journal of Physiology-Gastrointestinal and Liver Physiology 305:10, pages G667-G677.
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Aliya C. Roginiel, Daniel L. Kohut, Sumanpreet KaurAhmad M. A. SalehTheresa WeberPeter GeibelHarmeet SinghJohn P. Geibel. (2013) Effect of NSAIDs on Na + /H + exchanger activity in rat colonic crypts . American Journal of Physiology-Cell Physiology 305:5, pages C512-C518.
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José Miguel Cabral, Patrício Soares-da-Silva & Fernando Magro. (2013) Short- and Long-Term Regulation of Intestinal Na + /H + Exchange Activity Associated with TLR2 Receptor Activation Is Independent of Nuclear Factor- κ B Signaling . Journal of Pharmacology and Experimental Therapeutics 346:3, pages 453-464.
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Jorge Elías Torres-López, Crystell Guadalupe Guzmán-Priego, Héctor Isaac Rocha-González & Vinicio Granados-Soto. (2013) Role of NHE1 in Nociception. Pain Research and Treatment 2013, pages 1-8.
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Henrike Lenzen, Maria Lünnemann, Andre Bleich, Michael P. Manns, Ursula Seidler & Anne Jörns. (2012) Downregulation of the NHE3-Binding PDZ-Adaptor Protein PDZK1 Expression during Cytokine-Induced Inflammation in Interleukin-10–Deficient Mice. PLoS ONE 7:7, pages e40657.
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Iqbal Siddique & Islam Khan. (2011) Mechanism of Regulation of Na-H Exchanger in Inflammatory Bowel Disease: Role of TLR-4 Signaling Mechanism. Digestive Diseases and Sciences 56:6, pages 1656-1662.
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Sunil Yeruva, Klaudia Farkas, Jessica Hubricht, Katja Rode, Brigitte Riederer, Oliver Bachmann, Ayhan Cinar, Zoltán Rakonczay, Tamás Molnár, Ferenc Nagy, Jochen Wedemeyer, Michael Manns, Dirk Raddatz, Mark W. Musch, Eugene B. Chang, Péter Hegyi & Ursula Seidler. (2010) Preserved Na+/H+ exchanger isoform 3 expression and localization, but decreased NHE3 function indicate regulatory sodium transport defect in ulcerative colitis†. Inflammatory Bowel Diseases 16:7, pages 1149-1161.
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Pawel R. Kiela, Daniel Laubitz, Claire B. Larmonier, Monica T. Midura–Kiela, Maciej A. Lipko, Nona Janikashvili, Aiping Bai, Robert Thurston & Fayez K. Ghishan. (2009) Changes in Mucosal Homeostasis Predispose NHE3 Knockout Mice to Increased Susceptibility to DSS-Induced Epithelial Injury. Gastroenterology 137:3, pages 965-975.e10.
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