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Research Article

Ursodeoxycholic Acid Increases the Activities of Alkaline Sphingomyelinase and Caspase-3 in the Rat Colon

Pages 915-920 | Published online: 08 Jul 2009

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Rui-Dong Duan. (2006) Phospholipid signals and intestinal carcinogenesis. Scandinavian Journal of Food and Nutrition 50:sup2, pages 45-53.
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Tomasz Charytoniuk, Ewa Harasim-Symbor, Agnieszka Polak, Krzysztof Drygalski, Klaudia Berk, Adrian Chabowski & Karolina Konstantynowicz-Nowicka. (2019) Influence of Resveratrol on Sphingolipid Metabolism in Hepatocellular Carcinoma Cells in Lipid Overload State. Anti-Cancer Agents in Medicinal Chemistry 19:1, pages 121-129.
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Wan-Kyu Ko, Seong Jun Kim, Min-Jae Jo, Hyemin Choi, Donghyun Lee, Il Keun Kwon, Soo-Hong Lee, In-Bo Han & Seil Sohn. (2018) Ursodeoxycholic Acid Inhibits Inflammatory Responses and Promotes Functional Recovery After Spinal Cord Injury in Rats. Molecular Neurobiology 56:1, pages 267-277.
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Rui-Dong Duan. (2018) Alkaline sphingomyelinase (NPP7) in hepatobiliary diseases: A field that needs to be closely studied. World Journal of Hepatology 10:2, pages 246-253.
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Prajna Shanbhogue & Yusuf A. Hannun. 2020. Lipid Signaling in Human Diseases. Lipid Signaling in Human Diseases 19 47 .
Hideki Furuya, Songhwa Choi, Lina M. Obeid, Toshihiko Kawamori & Ashley J. Snider. 2015. Bioactive Sphingolipids in Cancer Biology and Therapy. Bioactive Sphingolipids in Cancer Biology and Therapy 141 159 .
Mónica García-Barros, Nicolas Coant & Ashley J. Snider. 2015. Intestinal Tumorigenesis. Intestinal Tumorigenesis 257 286 .
Mónica García-Barros, Nicolas Coant, Jean-Philip Truman, Ashley J. Snider & Yusuf A. Hannun. (2014) Sphingolipids in colon cancer. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1841:5, pages 773-782.
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Chiara Mencarelli & Pilar Martinez–Martinez. (2012) Ceramide function in the brain: when a slight tilt is enough. Cellular and Molecular Life Sciences 70:2, pages 181-203.
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Yao Zhang, Yajun Cheng, Gert H. Hansen, Lise-Lotte Niels-Christiansen, Frank Koentgen, Lena Ohlsson, Åke Nilsson & Rui-Dong Duan. (2011) Crucial role of alkaline sphingomyelinase in sphingomyelin digestion: a study on enzyme knockout mice. Journal of Lipid Research 52:4, pages 771-781.
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Nikos J. Tsagarakis, Ioannis Drygiannakis, Antonis G. Batistakis, George Kolios & Elias A. Kouroumalis. (2010) A concentration-dependent effect of ursodeoxycholate on apoptosis and caspases activities of HepG2 hepatocellular carcinoma cells. European Journal of Pharmacology 640:1-3, pages 1-7.
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Yajun Cheng, Fuli Liu, Jun Wu, Yao Zhang, Åke Nilsson & Rui‐Dong Duan. (2009) Ezetimibe Inhibits Expression of Acid Sphingomyelinase in Liver and Intestine. Lipids 44:10, pages 897-906.
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Y Cheng, J Wu, E Hertervig, S Lindgren, D Duan, Å Nilsson & R-D Duan. (2007) Identification of aberrant forms of alkaline sphingomyelinase (NPP7) associated with human liver tumorigenesis. British Journal of Cancer 97:10, pages 1441-1448.
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Rui‐Dong Duan. (2007) Sphingomyelinase and ceramidase in the intestinal tract. European Journal of Lipid Science and Technology 109:10, pages 987-993.
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R.D. Duan, H.J. Verkade, Y. Cheng, R. Havinga & Å. Nilsson. (2007) Effects of bile diversion in rats on intestinal sphingomyelinases and ceramidase. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1771:2, pages 196-201.
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Fuli Liu, Yajun Cheng, Jun Wu, Horst-Dietmar Tauschel & Rui-Dong Duan. (2006) Ursodeoxycholic acid differentially affects three types of sphingomyelinase in human colon cancer Caco 2 cells. Cancer Letters 235:1, pages 141-146.
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Åke Nilsson & Rui-Dong Duan. (2006) Absorption and lipoprotein transport of sphingomyelin. Journal of Lipid Research 47:1, pages 154-171.
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E. Hertervig. 2006. Colitis: Diagnosis and Therapeutic Strategies. Colitis: Diagnosis and Therapeutic Strategies 205 219 .
Jun Wu, Yajun Cheng, Bo A.G. Jönsson, Åke Nilsson & Rui-Dong Duan. (2005) Acid sphingomyelinase is induced by butyrate but does not initiate the anticancer effect of butyrate in HT29 and HepG2 cells. Journal of Lipid Research 46:9, pages 1944-1952.
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Luisa Di Marzio, Alfredo Di Leo, Benedetta Cinque, Donatella Fanini, Alessio Agnifili, Pasquale Berloco, Michele Linsalata, Dionigi Lorusso, Michele Barone, Claudio De Simone & Maria Grazia Cifone. (2005) Detection of Alkaline Sphingomyelinase Activity in Human Stool: Proposed Role as a New Diagnostic and Prognostic Marker of Colorectal Cancer. Cancer Epidemiology, Biomarkers & Prevention 14:4, pages 856-862.
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Carlos M. Palmeira & Anabela P. Rolo. (2004) Mitochondrially-mediated toxicity of bile acids. Toxicology 203:1-3, pages 1-15.
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Yajun Cheng, Lena Ohlsson & Rui-Dong Duan. (2007) Psyllium and fat in diets differentially affect the activities and expressions of colonic sphingomyelinases and caspase in mice. British Journal of Nutrition 91:5, pages 715-723.
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Erik Hertervig, Åke Nilsson, Mef Nilbert & Rui-Dong Duan. (2003) Reduction in alkaline sphingomyelinase in colorectal tumorigenesis is not related to the APC gene mutation. International Journal of Colorectal Disease 18:4, pages 309-313.
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Rui-Dong Duan, Yajun Cheng, Gert Hansen, Erik Hertervig, Jian-Jun Liu, Ingvar Syk, Hans Sjo¨stro¨m & Åke Nilsson. (2003) Purification, localization, and expression of human intestinal alkaline sphingomyelinase. Journal of Lipid Research 44:6, pages 1241-1250.
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Bernard Szuhaj & Willem van NieuwenhuyzenAke Nilsson, Rui-Dong Duan & Erik Hertervig. 2003. Nutrition and Biochemistry of Phospholipids. Nutrition and Biochemistry of Phospholipids.
Jan Lillienau, Yajun Cheng, Åke Nilsson & Rui-Dong Duan. (2003) Development of intestinal alkaline sphingomyelinase in rat fetus and newborn rat. Lipids 38:5, pages 545-549.
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Liping Yang, Marja Mutanen, Yajun Cheng & Rui-Dong Duan. (2002) Effects of red meat and fiber in high fat diet on activities of sphingomyelinase, ceramidase and caspase-3 in rat colonic mucosa. The Journal of Nutritional Biochemistry 13:8, pages 499-504.
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Urban Sjöqvist, Erik Hertervig, Åke Nilsson, Rui-Dong Duan, Åke Öst, Bernhard Tribukait & Robert Löfberg. (2002) Chronic Colitis Is Associated With a Reduction of Mucosal Alkaline Sphingomyelinase Activity. Inflammatory Bowel Diseases 8:4, pages 258-263.
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Liang Qiao, Adly Yacoub, Elaine Studer, Seema Gupta, Xin Yan Pei, Steven Grant, Philip B. Hylemon & Paul Dent. (2002) Inhibition of the MAPK and PI3K pathways enhances UDCA-induced apoptosis in primary rodent hepatocytes. Hepatology 35:4, pages 779-789.
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Tomio Narisawa, Yoko Fukaura, Naomi Takeba & Keiko Nakai. (2005) Chemoprevention of N‐Methylnitrosourea‐induced Colon Carcinogenesis by Ursodeoxycholic Acid‐5‐aminosalicylic Acid Conjugate in F344 Rats. Japanese Journal of Cancer Research 93:2, pages 143-150.
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Yajun Cheng, Åke Nilsson, Elisabeth Tömquist & Rui-Dong Duan. (2002) Purification, characterization, and expression of rat intestinal alkaline sphingomyelinase. Journal of Lipid Research 43:2, pages 316-324.
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Liping Yang, Marja Mutanen, Yajun Cheng & Rui-Dong Duan. (2002) Effects of Fat, Beef and Fiber in Diets on Activities of Sphingomyelinase, Ceramidase and Caspase-3 in Rat Colonic Mucosa. Medical Principles and Practice 11:3, pages 150-156.
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