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Original Article

Soluble urokinase receptor is elevated in cerebrospinal fluid from patients with purulent meningitis and is associated with fatal outcome

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Pages 14-19 | Received 02 Jun 2003, Accepted 13 Oct 2003, Published online: 08 Jul 2009

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Read on this site (6)

Thor A. Skovsted, Eva Rabing Brix Petersen, Maj-Britt Fruekilde, Andreas Kristian Pedersen, Tomasz Pielak & Jesper Eugen-Olsen. (2020) Validation of suPAR turbidimetric assay on Cobas® (c502 and c702) and comparison to suPAR ELISA. Scandinavian Journal of Clinical and Laboratory Investigation 80:4, pages 327-335.
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Melis Sirinoglu, Ahmet Soysal, Ayşe Karaaslan, Eda Kepenekli Kadayifci, Ismail Cinel, Ahmet Koç, Gülnur Tokuç, Ali Yaman, Goncagül Haklar, Önder Şirikçi, Serap Turan, Gülşen Altınkanat Gelmez, Güner Söyletir & Mustafa Bakır. (2016) The diagnostic value of soluble urokinase plasminogen activator receptor compared with C-reactive protein and procalcitonin in children with febrile neutropenia. Pediatric Hematology and Oncology 33:3, pages 200-208.
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Aziz Gumus, Nejat Altintas, Halit Cinarka, Aynur Kirbas, Muge Hazıroglu, Mevlut Karatas & Unal Sahin. (2015) Soluble urokinase-type plasminogen activator receptor is a novel biomarker predicting acute exacerbation in COPD. International Journal of Chronic Obstructive Pulmonary Disease 10, pages 357-365.
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Mary Sandquist & Hector R Wong. (2014) Biomarkers of sepsis and their potential value in diagnosis, prognosis and treatment. Expert Review of Clinical Immunology 10:10, pages 1349-1356.
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Gergely Toldi, Balázs Szalay, Gabriella Bekő, Márta Bocskai, Magdolna Deák, László Kovács, Barna Vásárhelyi & Attila Balog. (2012) Plasma soluble urokinase plasminogen activator receptor (suPAR) levels in systemic lupus erythematosus. Biomarkers 17:8, pages 758-763.
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Manuela Nebuloni, Paola Cinque, Nicolai Sidenius, Angelita Ferri, Eleonora Lauri, Elisabetta Omodeo-Zorini, Pietro Zerbi & Luca Vago. (2009) Expression of the urokinase plasminogen activator receptor (uPAR) and its ligand (uPA) in brain tissues of human immunodeficiency virus patients with opportunistic cerebral diseases. Journal of Neurovirology 15:1, pages 99-107.
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Articles from other publishers (48)

Atul Kakar, Sangeeta Choudhury, Ved Chaturvedi, Shikhar Tripathi, Pooja Rani Rajput & Rizwana Hasan. (2024) Utility of sUPAR as a Novel Biomarker for Stratifying Rheumatoid Arthritis Patients in Remission. Annals of Rheumatology and Autoimmunity 4:1, pages 14-18.
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Syeda Tayyaba Rehan, Hassan ul Hussain, Eman Ali, Kanwal Ashok Kumar, Shehroze Tabassum, Muhammad Hasanain, Asim Shaikh, Gibran Ali, Zohaib Yousaf & Muhammad Sohaib Asghar. (2023) Role of soluble urokinase type plasminogen activator receptor (suPAR) in predicting mortality, readmission, length of stay and discharge in emergency patients: A systematic review and meta analysis. Medicine 102:45, pages e35718.
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Huriye Erbak Yılmaz, Saliha Aksun, Süleyman Günay, Ferhan Elmalı & Cem Çekiç. (2023) Evaluation of plasma soluble urokinase plasminogen activator receptor (SuPAR) levels in ulcerative colitis. Arab Journal of Gastroenterology 24:3, pages 175-179.
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Veselina Stefanova, Valerie M. Crowley, Andrea M. Weckman & Kevin C. Kain. (2022) suPAR to Risk-Stratify Patients With Malaria. Frontiers in Immunology 13.
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Tomasz Skalec, Barbara Adamik, Katarzyna Kobylinska & Waldemar Gozdzik. (2022) Soluble Urokinase-Type Plasminogen Activator Receptor Levels as a Predictor of Kidney Replacement Therapy in Septic Patients with Acute Kidney Injury: An Observational Study. Journal of Clinical Medicine 11:6, pages 1717.
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Tobias P. Schmidt, Walid Albanna, Miriam Weiss, Michael Veldeman, Catharina Conzen, Omid Nikoubashman, Christian Blume, Daniel S. Kluger, Hans Clusmann, Sven H. Loosen & Gerrit A. Schubert. (2022) The Role of Soluble Urokinase Plasminogen Activator Receptor (suPAR) in the Context of Aneurysmal Subarachnoid Hemorrhage (aSAH)—A Prospective Observational Study. Frontiers in Neurology 13.
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Line Jee Hartmann Rasmussen, Jens Emil Vang Petersen & Jesper Eugen-Olsen. (2021) Soluble Urokinase Plasminogen Activator Receptor (suPAR) as a Biomarker of Systemic Chronic Inflammation. Frontiers in Immunology 12.
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Kadir KÜÇÜKCERAN, Omer KARASAHİN, Orhan DELİCE, Ali BATUR, Sibel İBA YILMAZ, Engin ŞEBİN & Mahmut ŞENYURT. (2021) The Diagnostic Value of Soluble Urokinase Plasminogen Activator Receptor in Crimean-Congo Hemorrhagic Fever Disease in Emergency DepartmentAcil Serviste Kırım Kongo Kanamalı Ateş Hastalığında Soluble Ürokinaz Plazminojen Aktivatör Reseptörünün Tanısal Değeri. Düzce Tıp Fakültesi Dergisi 23:1, pages 15-19.
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İsmail Taşdemir, Huriye Erbak Yılmaz, Figen Narin & Mehmet Sağlam. (2020) Assessment of saliva and gingival crevicular fluid soluble urokinase plasminogen activator receptor (suPAR), galectin‐1, and TNF‐α levels in periodontal health and disease. Journal of Periodontal Research 55:5, pages 622-630.
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Jens Emil Vang Petersen, Thomas Kallemose, Karen D Barton, Avshalom Caspi & Line Jee Hartmann Rasmussen. (2020) Soluble urokinase plasminogen activator receptor (suPAR) as a prognostic marker of mortality in healthy, general and patient populations: protocol for a systematic review and meta-analysis. BMJ Open 10:7, pages e036125.
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Jan Simon Scharrenberg, Ayla Yagdiran, Julia Brinkmann, Maik Brune, Jan Siewe, Norma Jung & Esther Mahabir. (2019) The diagnostic value of soluble urokinase-type plasminogen activator receptor (suPAR) for the discrimination of vertebral osteomyelitis and degenerative diseases of the spine. Journal of Orthopaedic Surgery and Research 14:1.
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Dan Chen, Xiaoling Wu, Junhui Yang & Li Yu. (2019) Serum plasminogen activator urokinase receptor predicts elevated risk of acute respiratory distress syndrome in patients with sepsis and is positively associated with disease severity, inflammation and mortality. Experimental and Therapeutic Medicine.
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Peter Polzik, Olav Grøndal, Juliette Tavenier, Martin B. Madsen, Ove Andersen, Morten Hedetoft & Ole Hyldegaard. (2019) SuPAR correlates with mortality and clinical severity in patients with necrotizing soft-tissue infections: results from a prospective, observational cohort study. Scientific Reports 9:1.
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Ding Long, Yujun Wang, Hui Wang, Xiaoling Wu & Li Yu. (2019) Correlation of Serum and Ascitic Fluid Soluble Form Urokinase Plasminogen Activator Receptor Levels With Patient Complications, Disease Severity, Inflammatory Markers, and Prognosis in Patients With Severe Acute Pancreatitis. Pancreas 48:3, pages 335-342.
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Pratyush Kumar, Atul Kakar, Atul Gogia & NIamatullah Waziri. (2019) Evaluation of soluble urokinase-type plasminogen activator receptor (suPAR) quick test for triage in the emergency department. Journal of Family Medicine and Primary Care 8:12, pages 3871.
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Melis Şirinoğlu, Ahmet Soysal, Ayşe Karaaslan, Eda Kepenekli Kadayifci, Nilüfer Yalındağ-Öztürk, İsmail Cinel, Ali Yaman, Goncagül Haklar, Önder Şirikci, Serap Turan, Gülşen Altınkanat Gelmez, Güner Söyletir & Mustafa Bakır. (2017) The diagnostic value of soluble urokinase plasminogen activator receptor (suPAR) compared to C-reactive protein (CRP) and procalcitonin (PCT) in children with systemic inflammatory response syndrome (SIRS). Journal of Infection and Chemotherapy 23:1, pages 17-22.
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Andreas Kronbichler, Moin A. Saleem, Björn Meijers & Jae Il Shin. (2016) Soluble Urokinase Receptors in Focal Segmental Glomerulosclerosis: A Review on the Scientific Point of View. Journal of Immunology Research 2016, pages 1-14.
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Ivo Casagranda, Chiara Vendramin, Tiziana Callegari, Matteo Vidali, Alessandra Calabresi, Giovanna Ferrandu, Gianfranco Cervellin, Mario Cavazza, Giuseppe Lippi, Isabella Zanotti, Sophie Negro, Andrea Rocchetti & Carlo Arfini. (2015) Usefulness of suPAR in the risk stratification of patients with sepsis admitted to the emergency department. Internal and Emergency Medicine 10:6, pages 725-730.
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Waldemar Gozdzik, Barbara Adamik, Anna Gozdzik, Maciej Rachwalik, Wojciech Kustrzycki & Andrzej Kübler. (2014) Unchanged Plasma Levels of the Soluble Urokinase Plasminogen Activator Receptor in Elective Coronary Artery Bypass Graft Surgery Patients and Cardiopulmonary Bypass Use. PLoS ONE 9:6, pages e98923.
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Katia Donadello, Sabino Scolletta, Fabio Silvio Taccone, Cecilia Covajes, Cristina Santonocito, Diego Orbegozo Cortes, Daiva Grazulyte, Leonardo Gottin & Jean-Louis Vincent. (2014) Soluble urokinase–type plasminogen activator receptor as a prognostic biomarker in critically ill patients. Journal of Critical Care 29:1, pages 144-149.
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Thomas H. HauptThomas KallemoseSteen LadelundLine J. H. RasmussenChristian W. ThorballOve AndersenCharlotta PisingerJesper Eugen-Olsen. (2014) Risk Factors Associated with Serum Levels of the Inflammatory Biomarker Soluble Urokinase Plasminogen Activator Receptor in a General Population. Biomarker Insights 9, pages BMI.S19876.
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A. Wrotek, K. Pawlik & T. Jackowska. 2013. Neurobiology of Respiration. Neurobiology of Respiration 329 334 .
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R. Uusitalo‐Seppälä, R. Huttunen, M. Tarkka, J. Aittoniemi, P. Koskinen, A. Leino, T. Vahlberg & E. M. Rintala. (2012) Soluble urokinase‐type plasminogen activator receptor in patients with suspected infection in the emergency room: a prospective cohort study. Journal of Internal Medicine 272:3, pages 247-256.
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R. Huttunen, J. Syrjänen, R. Vuento, M. Hurme, H. Huhtala, J. Laine, T. Pessi & J. Aittoniemi. (2011) Plasma level of soluble urokinase-type plasminogen activator receptor as a predictor of disease severity and case fatality in patients with bacteraemia: a prospective cohort study. Journal of Internal Medicine 270:1, pages 32-40.
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E. Haastrup, J. Andersen, S. R. Ostrowski, G. Høyer‐Hansen, N. Jacobsen, C. Heilmann, H. Ullum & K. Müller. (2011) Soluble Urokinase Plasminogen Activator Receptor During Allogeneic Stem Cell Transplantation. Scandinavian Journal of Immunology 73:4, pages 325-329.
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K. Kofoed, J. Eugen-Olsen, J. Petersen, K. Larsen & O. Andersen. (2008) Predicting mortality in patients with systemic inflammatory response syndrome: an evaluation of two prognostic models, two soluble receptors, and a macrophage migration inhibitory factor. European Journal of Clinical Microbiology & Infectious Diseases 27:5, pages 375-383.
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Nathalie Beaufort, Dominique Leduc, Jean-Claude Rousselle, Abdelkader Namane, Michel Chignard & Dominique Pidard. (2004) Plasmin cleaves the juxtamembrane domain and releases truncated species of the urokinase receptor (CD87) from human bronchial epithelial cells. FEBS Letters 574:1-3, pages 89-94.
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