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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 36, 2006 - Issue 16
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Original Articles

Efficient Green Procedure for the Knoevenagel Condensation under Solvent‐Free Conditions

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Pages 2407-2412 | Received 19 Jan 2006, Published online: 22 Sep 2006

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Read on this site (12)

Sharmil N. Anjirwala, Parnas S. Parmar & Saurabh K. Patel. (2022) Synthetic protocols for non-fused pyrimidines. Synthetic Communications 52:22, pages 2079-2121.
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Hongyuan Yang, Tengfei Zhang & Qing Liu. (2019) Eggshell waste as an eco-friendly and low-cost catalyst for the synthesis of α, β-unsaturated compounds. Toxicological & Environmental Chemistry 101:9-10, pages 451-462.
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Saléha Bakhta, Youssef Kabri, Maxime D. Crozet, Bellara Nedjar-Kolli & Patrice Vanelle. (2019) Synthesis of new substituted imidazo[1,2-a]pyridinylpropenenitriles through sequential one-pot Suzuki–Miyaura/Knoevenagel reactions in aqueous medium. Synthetic Communications 49:19, pages 2561-2571.
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Qing Liu & Hong-Mei Ai. (2012) Sodium Benzoate as a Green, Efficient, and Recyclable Catalyst for Knoevenagel Condensation. Synthetic Communications 42:20, pages 3004-3010.
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M.B. Deshmukh, SureshS. Patil, S.D. Jadhav & P.B. Pawar. (2012) Green Approach for Knoevenagel Condensation of Aromatic Aldehydes with Active Methylene Group. Synthetic Communications 42:8, pages 1177-1183.
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Nora M. Rateb. (2011) Synthesis and reactions of 4-trifluoromethyl-3-cyano pyridine-2(1H)-thione/one derivatives. Journal of Sulfur Chemistry 32:6, pages 611-622.
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H. Eshghi, S. Damavandi & G.H. Zohuri. (2011) Efficient One-Pot Synthesis of 2-Amino-4H-chromenes Catalyzed by Ferric Hydrogen Sulfate and Zr-Based Catalysts of FI. Synthesis and Reactivity in Inorganic, Metal-Organic, and Nano-Metal Chemistry 41:9, pages 1067-1073.
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Liangce Rong, Hongxia Han, Hong Jiang & Shujiang Tu. (2008) Efficient NaOH-Catalyzed Reaction of Aromatic Aldehyde, Cyclic Ketones, and Malononitrile Under Solvent-Free Conditions Using a Grinding Method. Synthetic Communications 38:20, pages 3530-3542.
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Liangce Rong, Hongxia Han, Suhui Wang & Qiya Zhuang. (2008) Efficient Synthesis of Polysubstituted Pyridine under Solvent‐free Conditions without Using Any Catalysts. Synthetic Communications 38:11, pages 1808-1814.
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Liangce Rong, Hongxia Han, Hong Jiang, Daqing Shi & Shujiang Tu. (2008) One‐Pot Synthesis of 4,6‐Diaryl‐2‐oxo‐1,2‐dihydropyridine‐3‐carbonitriles via Three‐Component Cyclocondensation under Solvent‐Free Conditions. Synthetic Communications 38:2, pages 217-224.
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Liangce Rong, Hongxia Han, Fang Yang, Hao Yao, Hong Jiang & Shujiang Tu. (2007) Efficient One‐Pot Synthesis of 2‐Amino‐4,6‐diarylbenzene‐1,3‐dicarbonitrile under Solvent‐Free Conditions. Synthetic Communications 37:21, pages 3767-3772.
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Articles from other publishers (32)

Kerstin Scheurrell, Inês C. B. Martins, Claire Murray & Franziska Emmerling. (2023) Exploring the role of solvent polarity in mechanochemical Knoevenagel condensation: in situ investigation and isolation of reaction intermediates . Physical Chemistry Chemical Physics 25:35, pages 23637-23644.
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Xiaoqing Lv, Shengjun Liu, Yu Guo, Lijiu Gao, Liming Zhao, Jinpeng Zhang & Liangce Rong. (2023) Meerwein Arylation of Aryl(alkyl)idenemalononitriles and Diazonium Salts for the Synthesis of 2-(Aryl(alkyl)/arylmethylene)malononitrile Derivatives. The Journal of Organic Chemistry 88:17, pages 12421-12431.
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Ghobad Mansouri, Mino Abdizad, Amir Reza Abbasi & Sobhan Rezayati. (2022) Efficient and green one‐pot synthesis of Knoevenagel condensation catalyzed nano metal–organic frameworks in water. Applied Organometallic Chemistry 36:12.
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Fatemeh Kalantari, Sobhan Rezayati, Ali Ramazani, Hamideh Aghahosseini, Katarzyna Ślepokura & Tadeusz Lis. (2022) Proline-Cu Complex Based 1,3,5-Triazine Coated on Fe 3 O 4 Magnetic Nanoparticles: A Nanocatalyst for the Knoevenagel Condensation of Aldehyde with Malononitrile . ACS Applied Nano Materials 5:2, pages 1783-1797.
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Sourav Chakraborty, Abhijit Rudra Paul & Swapan Majumdar. (2022) Base and metal free true recyclable medium for Knoevenagel condensation reaction in SDS-ionic liquid-aqueous miceller composite system. Results in Chemistry 4, pages 100294.
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Anuradha Thakur, Kamalpreet Kaur, Praveen Sharma, Ramit Singla, Sandeep Singh & Vikas Jaitak. (2021) Synthesis, In vitro, and Docking Analysis of C-3 Substituted Coumarin Analogues as Anticancer Agents. Current Computer-Aided Drug Design 17:2, pages 161-172.
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Arup Datta. (2020) Bismuth (III) Triflate: A Mild, Efficient Promoter for the Synthesis of Trisubstituted Alkenes through Knoevenagel Condensation. Oriental Journal Of Chemistry 36:05, pages 843-849.
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Biswa Mohan Sahoo & Bimal Krishna Banik. 2020. Green Approaches in Medicinal Chemistry for Sustainable Drug Design. Green Approaches in Medicinal Chemistry for Sustainable Drug Design 523 548 .
Ziyang Gao, Hongyuan Yang & Qing Liu. (2019) Natural Seashell Waste as an Efficient and Low‐Cost Catalyst for the Synthesis of Arylmethylenemalonitriles. CLEAN – Soil, Air, Water 47:10.
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Sahil Arora, Gaurav Joshi, Sourav Kalra, Aabid Abdullah Wani, Prasad V. Bharatam, Pradeep Kumar & Raj Kumar. (2019) Knoevenagel/Tandem Knoevenagel and Michael Adducts of Cyclohexane-1,3-dione and Aryl Aldehydes: Synthesis, DFT Studies, Xanthine Oxidase Inhibitory Potential, and Molecular Modeling. ACS Omega 4:3, pages 4604-4614.
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Aliyeh Feghhi, Reihaneh Malakooti, Sadeq Malakooti & Nasrin Hooshmand. (2019) Easy Scale‐Up Synthesis of Mo 8 O 26 (C 5 H 6 N) 4 .H 2 O Hybrid with a Rectangular Prism Morphology and Its Application as an Efficient and Highly Recyclable Bi‐functional Catalyst for Knoevenagel Condensations . ChemistrySelect 4:9, pages 2551-2561.
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Hongyuan Yang, Hao Dong, Tengfei Zhang, Qi Zhang, Guangwei Zhang, Peng Wang & Qing Liu. (2018) Calcined Dolomite: An Efficient and Recyclable Catalyst for Synthesis of α, β-Unsaturated Carbonyl Compounds. Catalysis Letters 149:3, pages 778-787.
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Muhammad Naveed Javed, Shoaib Muhammad, Imran Ali Hashmi, Ahmed Bari, Syed Ghulam Musharraf & Firdous Imran Ali. (2018) Newly designed pyridine and piperidine based Ionic Liquids: Aggregation behavior in ESI-MS and catalytic activity in C C bond formation reactions. Journal of Molecular Liquids 272, pages 84-91.
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Stipe Lukin, Martina Tireli, Ivor Lončarić, Dajana Barišić, Primož Šket, Domagoj Vrsaljko, Marco di Michiel, Janez Plavec, Krunoslav Užarević & Ivan Halasz. (2018) Mechanochemical carbon–carbon bond formation that proceeds via a cocrystal intermediate . Chemical Communications 54:94, pages 13216-13219.
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Lakshmi Narayanan Jayalakshmi, Ayyanar Karuppasamy, Kesavan Stalindurai, Ramar Sivaramakarthikeyan, Vellasamy Devadoss & Chennan Ramalingan. (2015) Straightforward syntheses of nitriles, acrylates, and acrylamides in aqueous propan-1,2-diol: a catalyst free and waste free methodology. Tetrahedron Letters 56:28, pages 4207-4210.
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Lakshmi Narayanan Jayalakshmi, Ayyanar Karuppasamy, Kesavan Stalindurai, Ramar Sivaramakarthikeyan, Vellasamy Devadoss & Chennan Ramalingan. (2015) A Mechanochemical Approach for the Construction of Carbon–Carbon Double Bonds: Efficient Syntheses of Aryl/Heteroaryl/Aliphatic Acrylates and Nitriles. Catalysis Letters 145:6, pages 1322-1330.
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Fengxia Zhu, Xiaojun Sun, Fengwen Lou, Litao An & Pusu Zhao. (2015) Facile One-Pot Synthesis of Amine-Functionalized Mesoporous Silica Nanospheres for Water-Medium Knoevenagel Reaction Under Microwave Irradiation. Catalysis Letters 145:4, pages 1072-1079.
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Hesamaldin Mahmoudi & Reihaneh Malakooti. (2014) Mn-grafted imine-functionalized mesoporous SBA-15 as an efficient catalyst for Knoevenagel condensation under mild conditions. Reaction Kinetics, Mechanisms and Catalysis 113:1, pages 241-255.
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Rammohan Pal & Taradas Sarkar. (2014) Visible Light Induced Knoevenagel Condensation Catalyzed by Starfruit Juice of <i>Averrhoa carambola</i>. International Journal of Organic Chemistry 04:02, pages 106-115.
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Mohd Bismillah Ansari, Mst. Nargis Parvin & Sang-Eon Park. (2013) Microwave-assisted Knoevenagel condensation in aqueous over triazine-based microporous network. Research on Chemical Intermediates 40:1, pages 67-75.
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T. Asefa, A. V. Biradar, S. Das & R. Silva. 2013. Nanocatalysis Synthesis and Applications. Nanocatalysis Synthesis and Applications 221 249 .
SURESH PATIL, SWATI D JADHAV & M B DESHMUKH. (2013) Calcined eggshell (CES): An efficient natural catalyst for Knoevenagel condensation under aqueous condition. Journal of Chemical Sciences 125:4, pages 851-857.
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Reihaneh Malakooti, Hesamaldin Mahmoudi, Rahele Hosseinabadi, Srebri Petrov & Andrea Migliori. (2013) Facile synthesis of pure non-monoclinic zirconia nanoparticles and their catalytic activity investigations for Knoevenagel condensation. RSC Advances 3:44, pages 22353.
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Naraparaju Swathi, Thirumurthy Durai Ananda Kumar, Chavali Venkata Satya Subrahmanyam & Kota Satyanarayana. (2013) Synthesis and in silico drug likeness evaluation of N,5-disubstituted-1,3-thiazolidine-2,4-dione analogues. Journal of Pharmacy Research 6:1, pages 107-111.
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Mohd Bismillah Ansari, Hailian Jin, Mst. Nargis Parvin & Sang-Eon Park. (2012) Mesoporous carbon nitride as a metal-free base catalyst in the microwave assisted Knoevenagel condensation of ethylcyanoacetate with aromatic aldehydes. Catalysis Today 185:1, pages 211-216.
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Pedro Verdía, Francisco Santamarta & Emilia Tojo. (2011) Knoevenagel Reaction in [MMIm][MSO4]: Synthesis of Coumarins. Molecules 16:6, pages 4379-4388.
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An-Guo Ying, Li-Min Wang, Le-Le Wang, Xin-Zhi Chen & Wei-Dong Ye. (2010) Green and Efficient Knoevenagel Condensation Catalysed by a DBU Based ionic Liquid in Water. Journal of Chemical Research 34:1, pages 30-33.
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. (2009) Silica Supported Ammonium Acetate: An Efficient and Recyclable Heterogeneous Catalyst for Knoevenagel Condensation between Adehydes or Ketones and Active Methylene Group in Liquid Phase. Bulletin of the Korean Chemical Society 30:10, pages 2419-2421.
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Liangce Rong, Haiying Wang, Jingwen Shi, Fang Yang, Hao Yao, Shuajiang Tu & Daqing Shi. (2009) An efficient and facile procedure for the synthesis of 4,6‐diaryl‐2(1 H )‐pyridones under solvent‐free conditions . Journal of Heterocyclic Chemistry 44:6, pages 1505-1508.
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Belén Rodríguez, Angelika Bruckmann, Toni Rantanen & Carsten Bolm. (2007) Solvent‐Free Carbon‐Carbon Bond Formations in Ball Mills. Advanced Synthesis & Catalysis 349:14-15, pages 2213-2233.
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Liangce Rong, Xiaoyue Li, Haiying Wang, Daqing Shi, Shujiang Tu & Qiya Zhuang. (2007) Efficient Green Procedure for the Knoevenagel Condensation under Solvent‐Free Conditions.. ChemInform 38:6.
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Liangce Rong, Xiaoyue Li, Haiying Wang, Daqing Shi & Shujiang Tu. (2006) An Efficient and Facile Synthesis of 2-Amino-4,6-diarylbenzene-1,3-dicarbonitrile and 1,2-Dihydro-2-oxo-4,6-diarylpyridine-3-carbonitrile under Solvent-free Conditions. Chemistry Letters 35:11, pages 1314-1315.
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