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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 37, 2007 - Issue 15
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Original Articles

α,α‐Dibromoketones: A Superior Alternative to α‐Bromoketones in Hantzsch Thiazole Synthesis

Richa Prakash Department of Chemistry, Kurukshetra University, Kurukshetra, Haryana, India
,
Ajay Kumar Department of Chemistry, Kurukshetra University, Kurukshetra, Haryana, India
,
Ranjana Aggarwal Department of Chemistry, Kurukshetra University, Kurukshetra, Haryana, India
,
Om Prakash Department of Chemistry, Kurukshetra University, Kurukshetra, Haryana, IndiaCorrespondence[email protected]
&
S. P. Singh Department of Chemistry, Kurukshetra University, Kurukshetra, Haryana, India
Pages 2501-2505 | Received 12 Dec 2006, Published online: 09 Aug 2007

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Sameh R. Elgogary, Emad M. El‑Telbani & Rizk E. Khidre. (2023) Synthesis, Molecular Docking, and Antitumor Evaluation of Some New Pyrazole, Pyridine, and Thiazole Derivatives Incorporating Sulfonamide Residue. Polycyclic Aromatic Compounds 43:9, pages 7769-7782.
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Loveena Arora, Richa Prakash & Rashmi Pundeer. (2019) Developments in the synthesis of α,α-dibromoacetophenones and related compounds. Synthetic Communications 49:12, pages 1486-1507.
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Alaa A. Hassan, Shaaban K. Mohamed, Nasr K. Mohamed, Kamal M.A. El-Shaieb, Ahmed T. Abdel-Aziz, Joel T. Mague & Mehmet Akkurt. (2016) Facile and convenient synthesis of 2,4-disubstituted and 2,3,4-trisubstituted 1,3-thiazoles. Journal of Sulfur Chemistry 37:2, pages 162-175.
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Ranjana Aggarwal, Sunil Kumar & Shiv P. Singh. (2012) Sodium carbonate-mediated facile synthesis of 4-substituted-2-(3,5-dimethylpyrazol-1-yl)thiazoles under solvent-free conditions. Journal of Sulfur Chemistry 33:5, pages 521-525.
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Ajay Kumar, Poonam Lohan & Om Prakash. (2012) Selective Bromination of Dehydroacetic Acid with N-Bromosuccinimide. Synthetic Communications 42:18, pages 2739-2747.
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Articles from other publishers (20)

Debashish Mishra, Dineshwori Chanu Loukrakpam, Smriti Rekha Neog, Debojit Hazarika & Prodeep Phukan. (2022) A Switchable Protocol for Selective Synthesis of gem ‐Dibromo Compounds and Amides from Ketoximes using TsNBr 2 . ChemistrySelect 7:44.
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Alaa M. Alqahtani & Abrar A. Bayazeed. (2021) Synthesis and antiproliferative activity studies of new functionalized pyridine linked thiazole derivatives. Arabian Journal of Chemistry 14:1, pages 102914.
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Santu Sadhukhan, Jampani Santhi & Beeraiah Baire. (2020) The α,α‐Dihalocarbonyl Building Blocks: An Avenue for New Reaction Development in Organic Synthesis. Chemistry – A European Journal 26:32, pages 7145-7175.
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Vijay Kiran, Radhika Joshi & Rashmi Pundeer. (2020) α,α‐Dibromoketone precursors in the synthesis of some new thiazole derivatives: Thiazol‐2‐yl hydrazonobutanoates, thiazol‐2‐yl pyrazole‐4‐carboxylates and acids. Journal of Heterocyclic Chemistry 57:5, pages 2173-2183.
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Jitander K. Kapoor, Richa Prakash, Ajay Kumar, Deepika Saini & Loveena Arora. (2018) Selective Synthesis of 3-(α,α-Dibromoacetyl)-4-hydroxy-6-methyl-2 H -pyran-2-one as an Excellent Precursor for the Synthesis of 2-Substituted 4-(4-Hydroxy-6-methyl-2 H -2-oxopyran-3-yl)thiazoles as Antimicrobial and Antifungal Agents . Journal of Heterocyclic Chemistry 55:4, pages 899-906.
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S Arshadi, E Vessally, L Edjlali, R Hosseinzadeh-Khanmiri & E Ghorbani-Kalhor. (2017) N- Propargylamines: versatile building blocks in the construction of thiazole cores . Beilstein Journal of Organic Chemistry 13, pages 625-638.
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Ping Wu, Senhan Xu, Hao Xu, Haiyan Hu & Wei Zhang. (2017) One-pot syntheses of α,α-dibromoacetophenones from aromatic alkenes with 1,3-dibromo-5,5-dimethylhydantoin. Tetrahedron Letters 58:7, pages 618-621.
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Hakan Tahtaci, Mustafa Er, Tuncay Karakurt & Abdurrahman Onaran. (2017) Synthesis, Structural Characterization, and Biological Evaluation of Novel Substituted 1,3-Thiazole Derivatives Containing Schiff Bases. Journal of Heterocyclic Chemistry 54:1, pages 183-193.
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Tatiana Guzzo, Andrea Aramini, Samuele Lillini, Ridvan Nepravishta, Maurizio Paci & Alessandra Topai. (2015) The 15N induced isotope shift as an effective tool for the structure elucidation of 2,4 and 2,5 di-substituted thiazoles. Tetrahedron Letters 56:30, pages 4455-4458.
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A. S. Bunev, Yu. O. Trushkova, G. I. Ostapenko, V. E. Statsyuk & A. S. Peregudov. (2014) Synthesis of 4-(1Н-1,2,3-Triazol-4-Yl)-1,3-Thiazole-2-Amine Derivatives. Chemistry of Heterocyclic Compounds 50:7, pages 1027-1031.
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Marco Pieroni, Baojie Wan, Sanghyun Cho, Scott G. Franzblau & Gabriele Costantino. (2014) Design, synthesis and investigation on the structure–activity relationships of N-substituted 2-aminothiazole derivatives as antitubercular agents. European Journal of Medicinal Chemistry 72, pages 26-34.
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Rashmi Pundeer, Vijay Kiran, Richa Prakash, Sushma, Subhash C. Bhatia, Chetan Sharma & Kamal R. Aneja. (2011) α,α-Dibromoacetophenones mediated synthesis of some new 7H-7-alkoxy-3-alkyl/phenyl-6-aryl-s-triazolo[3,4-b][1,3,4]thiadiazines and their antimicrobial evaluation. Medicinal Chemistry Research 21:12, pages 4043-4052.
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Seung-Hwa Baek, Nak-Jeong Kim, Seong-Hwan Kim, Kwang-Hwa Park, Kyung-Chae Jeong, Bae-Keun Park & Nam-Sook Kang. (2012) Inhibitory Effect of 4-Aryl 2-Substituted Aniline-thiazole Analogs on Growth of Human Prostate Cancer LNCap Cells. Bulletin of the Korean Chemical Society 33:1, pages 111-114.
Crossref
Om Prakash, Deepak K. Aneja, Khalid Hussain, Poonam Lohan, Pooja Ranjan, Sanjiv Arora, Chetan Sharma & Kamal R. Aneja. (2011) Synthesis and biological evaluation of dihydroindeno and indeno [1,2-e] [1,2,4]triazolo [3,4-b] [1,3,4]thiadiazines as antimicrobial agents. European Journal of Medicinal Chemistry 46:10, pages 5065-5073.
Crossref
. 2011. Name Reactions in Heterocyclic Chemistry II. Name Reactions in Heterocyclic Chemistry II 515 650 .
. 2011. Name Reactions in Heterocyclic Chemistry II. Name Reactions in Heterocyclic Chemistry II 259 336 .
Michael Schnürch, Birgit Waldner, Karlheinz Hilber & Marko D. Mihovilovic. (2011) Synthesis of 5-arylated N-arylthiazole-2-amines as potential skeletal muscle cell differentiation promoters. Bioorganic & Medicinal Chemistry Letters 21:7, pages 2149-2154.
Crossref
Michael Schnürch, Ather Farooq Khan, Marko D. Mihovilovic & Peter Stanetty. (2009) Polyarylated Thiazoles via a Combined Halogen Dance - Cross-Coupling Strategy. European Journal of Organic Chemistry 2009:19, pages 3228-3236.
Crossref
Yong-Jin Wu & Bingwei V. Yang. 2009. A critical review of the 2007 literature preceded by two chapters on current heterocyclic topics. A critical review of the 2007 literature preceded by two chapters on current heterocyclic topics 220 252 .
Richa Prakash, Ajay Kumar, Ranjana Aggarwal, Om Prakash & S. P. Singh. (2007) ChemInform Abstract: α,α‐Dibromoketones: A Superior Alternative to α‐Bromoketones in Hantzsch Thiazole Synthesis.. ChemInform 39:1.
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