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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 40, 2010 - Issue 8
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Original Articles

Efficient, Green, Solvent-Free Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones via Biginelli Reaction Catalyzed by Cu(NO3)2·3H2O

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Pages 1115-1122 | Received 01 Mar 2009, Published online: 12 Mar 2010

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Tayebeh Jazinizadeh, Afshin Yazdani-Elah-Abadi, Malek Taher Maghsoodlou & Reza Heydari. (2020) CeCl3-Catalyzed a Highly Efficient and Eco-friendly Synthesis of New and Densely Functionalized Thiazolo[3,2-a]Pyrimidins via Biginelli-type Reaction. Polycyclic Aromatic Compounds 40:3, pages 732-742.
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Emin Garibov, Parham Taslimi, Afsun Sujayev, Zeynebe Bingol, Songul Çetinkaya, İlhami Gulçin, Sukru Beydemir, Vagif Farzaliyev, Saleh H. Alwasel & Claudiu T. Supuran. (2016) Synthesis of 4,5-disubstituted-2-thioxo-1,2,3,4-tetrahydropyrimidines and investigation of their acetylcholinesterase, butyrylcholinesterase, carbonic anhydrase I/II inhibitory and antioxidant activities. Journal of Enzyme Inhibition and Medicinal Chemistry 31:sup3, pages 1-9.
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Li-Qin Kang, Dong-Yuan Jin & Yue-Qin Cai. (2013) Silica-Supported Ionic Liquid Si-[SbSipim][PF6]: An Efficient Catalyst for the Synthesis of 3,4-Dihydropyrimidine-2-(1H)-ones. Synthetic Communications 43:14, pages 1896-1901.
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S.V. Rashmi, N.C. Sandhya, B. Raghava, M.N. Kumara, K. Mantelingu & K.S. Rangappa. (2012) Trifluoroethanol as a Metal-Free, Homogeneous, and Recyclable Medium for the Efficient One-Pot Synthesis of Dihydropyrimidones. Synthetic Communications 42:3, pages 424-433.
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Articles from other publishers (21)

Behjat Pouramiri, Khadijeh Rabiei, Mohammad Hadi Meshkatalsadat & Mohsen Rashidi. (2023) Saccharin based ionic liquid: Novel and recyclable catalyst for eco-friendly mechanosynthesis of Biginelli and Hantzcsh heterocycles under solvent-free conditions. Journal of Molecular Structure 1292, pages 136013.
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Selvi Arumugam, Nangan Senthilkumar, Natesan Thirumalaivasan, Govindaraj Dharman, Saravanan Pandiaraj, Mostafizur Rahaman, Manikandan Palaniappan, Rubiga Muthusami, Tamiliniyaa Manogaran, Lavanya Mari, Kuppusamy Kanagaraj, Rajakumar Govindasamy & Rajavel Rangappan. (2023) Heterogenous copper(II) schiff-base complex immobilized mesoporous silica catalyst for multicomponent biginelli reaction. Journal of Organometallic Chemistry 998, pages 122804.
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Waquar Ahsan. 2023. Dihydropyrimidinones as Potent Anticancer Agents. Dihydropyrimidinones as Potent Anticancer Agents 17 38 .
E. S. Filatova, O. V. Fedorova, I. G. Ovchinnikova, K. A. Chistyakov, G. L. Rusinov & V. N. Charushin. (2022) Stereoselective synthesis of dihydropyrimidinethione podand in the presence of l-proline or 4-hydroxy-l-proline and metal nitrates. Russian Chemical Bulletin 71:7, pages 1506-1513.
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Sourav Handique & Priyanka Sharma. (2022) One pot three components solvent free synthesis of 4-substituted phenyl-2-(sulfanyl/oxo) pyrimidine-5-carboxylate derivatives. Results in Chemistry 4, pages 100411.
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Ehsan Valiey, Mohammad G. Dekamin & Zahra Alirezvani. (2021) Sulfamic acid pyromellitic diamide-functionalized MCM-41 as a multifunctional hybrid catalyst for melting-assisted solvent-free synthesis of bioactive 3,4-dihydropyrimidin-2-(1H)-ones. Scientific Reports 11:1.
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Simran Harsh, Sanjay Kumar, Rohit Sharma, Yogesh Kumar & Rupesh Kumar. (2020) Chlorophyll triggered one-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones via photo induced electron transfer reaction. Arabian Journal of Chemistry 13:3, pages 4720-4730.
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Robert Pawłowski, Ewelina Zaorska, Sebastian Staszko & Anna Szadkowska. (2018) Copper(I)-catalyzed multicomponent reactions in sustainable media. Applied Organometallic Chemistry 32:4, pages e4256.
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Zahra Nasresfahani & Mohammad Zaman Kassaee. (2017) Cu(II) immobilized on mesoporous organosilica as an efficient and reusable nanocatalyst for one‐pot Biginelli reaction under solvent‐free conditions. Applied Organometallic Chemistry 32:2.
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Jovana Muškinja, Nenad Janković, Zoran Ratković, Goran Bogdanović & Zorica Bugarčić. (2016) Vanillic aldehydes for the one-pot synthesis of novel 2-oxo-1,2,3,4-tetrahydropyrimidines. Molecular Diversity 20:3, pages 591-604.
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M. Hajjami & E. Ghiasbeygi. (2016) First catalyst- and solvent-free synthesis of 3,4-dihydropyrimidin-2(1H)-ones and -thiones. Russian Journal of Organic Chemistry 52:3, pages 429-432.
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Chetan K. Khatri, Deelip S. Rekunge & Ganesh U. Chaturbhuj. (2016) Sulfated polyborate: a new and eco-friendly catalyst for one-pot multi-component synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones via Biginelli reaction. New Journal of Chemistry 40:12, pages 10412-10417.
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Rong Liang-Ce, Yunyun Zha, Sheng Xia, Linlin Ji, Jing Zhang & Peijun Cai. (2016) An Efficient and Facile Synthesis of 5-(Thiophene-2-carbonyl)-6-(trifluoromethyl)-tetrahydro-pyrimidin-2(1 H )-one and 6-(Thiophen-2-yl)-4,5-dihydropyrimidin-2(1 H )-one from Same Substrates Under Different Conditions . Journal of Heterocyclic Chemistry 53:1, pages 56-63.
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K. Aswin, S. Sheik Mansoor, K. Logaiya & S.P.N. Sudhan. (2014) Triphenylphosphine: An efficient catalyst for the synthesis of 4,6-diphenyl-3,4-dihydropyrimidine-2(1H)-thione under thermal conditions. Journal of King Saud University - Science 26:2, pages 141-148.
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Natália Aparecida Liberto, Sarah de Paiva Silva, Ângelo de Fátima & Sergio Antonio Fernandes. (2013) β-Cyclodextrin-assisted synthesis of Biginelli adducts under solvent-free conditions. Tetrahedron 69:38, pages 8245-8249.
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Nicolò Prosa, Raphaël Turgis, Riccardo Piccardi & Marie-Christine Scherrmann. (2012) Soluble Polymer-Supported Flow Synthesis: A Green Process for the Preparation of Heterocycles. European Journal of Organic Chemistry 2012:11, pages 2188-2200.
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Kawaljit Singh & Kamaljit Singh. 2012. 223 308 .
DHANAJI V JAWALE, UMESH R PRATAP, APARNA A MULAY, JYOTIRLING R MALI & RAMRAO A MANE. (2011) Synthesis of New dihydropyrimidinones catalysed by dicationic ionic liquid. Journal of Chemical Sciences 123:5, pages 645-655.
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Razieh Fazaeli, Hamid Aliyan, Foroogh Mohammadifar, Amir Abbas Zamani & Mohammad Javad Bagi. (2011) One-pot Synthesis of Dihydropyrimidinones Using Polyoxometalate Tri-supported Transition Metal Complexes. Journal of the Korean Chemical Society 55:4, pages 666-672.
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Ganesh Chandra Nandi, Subhasis Samai & Maya Shankar Singh. (2010) Biginelli and Hantzsch-Type Reactions Leading to Highly Functionalized Dihydropyrimidinone, Thiocoumarin, and Pyridopyrimidinone Frameworks via Ring Annulation with β-Oxodithioesters. The Journal of Organic Chemistry 75:22, pages 7785-7795.
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Dong-Chao Wang, Hai-Ming Guo & Gui-Rong Qu. (2010) ChemInform Abstract: Efficient, Green, Solvent-Free Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones via Biginelli Reaction Catalyzed by Cu(NO3)2·3H2O.. ChemInform 41:38, pages no-no.
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