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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 44, 2014 - Issue 7
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Original Articles

Metal-Free, One-Pot, Rapid Synthesis of Tetrahydropyridines Using Acetic Acid as Solvent and Catalyst at Room Temperature

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Pages 943-953 | Received 26 Feb 2013, Published online: 24 Feb 2014

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Faiza Saleem, Fariha Shamim, Musa Özil, Nimet Baltaş, Uzma Salar, Sajda Ashraf, Zaheer Ul-Haq, Muhammad Taha, Mehwish Solangi & Khalid Mohammed Khan. (2023) Multicomponent Diastereoselective Synthesis of Tetrahydropyridines As α-amylase and α-glucosidase Enzymes Inhibitors. Future Medicinal Chemistry 15:15, pages 1343-1368.
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Indah Raya, Mahmoud Kandeel, Forat H. Alsultany, Usama S. Altimari & Surendar Aravindhan. (2023) Fabrication and Characterization of a Novel and Efficient Zinc Nanomagnetic Catalyst for Multicomponent Synthesis of Heterocycles. Polycyclic Aromatic Compounds 43:6, pages 5591-5606.
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Saade Abdalkareem Jasim, Ziyadulla Eshmamatovich Zhumanov, Maria Jade Catalan Opulencia, Mustafa M. Kadhim, Thulfeqar Ahmed Hamza, Shaymaa Abed Hussein, Himanshu Sharma & Ali Thaeer Hammid. (2023) Tribromide Immobilized on Amino-Functionalized Magnetic Nanoparticles: A Active Magnetically Recoverable Catalyst for the Synthesis of Heterocycles. Polycyclic Aromatic Compounds 43:5, pages 4750-4767.
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Somayeh Sattari Alamdar, Naser Foroughifar, Masoumeh Shahi & Ebrahim Balali. (2023) Synthesis, Biological Activitiy and DFT Study of New Azaphenalene Derivatives. Polycyclic Aromatic Compounds 43:5, pages 4354-4370.
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Ajeet A. Yelwande, Madhukar E. Navgire, Manoj Palve, Harshal S. Patil, Mazahar Farooqui & Jaysing M. Dinore. (2022) One-pot multicomponent synthesis approach for tetrahydropyridines using polyaniline-zirconium oxide composites. Synthetic Communications 52:7, pages 1039-1049.
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Maryam Shokoohian, Nourallah Hazeri, Malek Taher Maghsoodlou & Mojtaba Lashkari. (2022) Design and Synthesis, Antimicrobial Activities of 1,2,4-Triazine Derivatives as Representation of a New Hetrocyclic System. Polycyclic Aromatic Compounds 42:1, pages 1-12.
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Kandula Madhu Kumar Reddy, Kotha Peddanna, Mavallur Varalakshmi, Nemallapudi Bakthavatchala Reddy, Gundala Sravya, Grigory V. Zyryanov & Cirandur Suresh Reddy. (2019) Ceric ammonium nitrate (CAN) catalyzed synthesis and α-glucosidase activity of some novel tetrahydropyridine phosphonate derivatives. Phosphorus, Sulfur, and Silicon and the Related Elements 194:8, pages 812-819.
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Maryam Aghamohammadsadegh, Abdolhamid Bamoniri & Bi Bi Fatemeh Mirjalili. Nano-γ-Al2O3/Sb(V) as an effective catalyst for the synthesis of highly substituted tetrahydropyridines under ultrasonic or thermal conditions. Inorganic and Nano-Metal Chemistry 0:0, pages 1-12.
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Articles from other publishers (20)

Munmee Goswami, Pooja Paul, Chayan Pandya, Ridahunlang Nongkhlaw, Arup Dutta, Jyothi Kumari, Dharmarajan Sriram, Akella Sivaramakrishna & Rishanlang Nongkhlaw. (2024) Photocatalytic activity of Rose Bengal encapsulated in zeolitic imidazolate framework-8 (RB@ZIF-8): an innovative approach for the one pot synthesis of highly functionalized tetrahydropyridines and study of their anti-tubercular activity. Catalysis Science & Technology.
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Eman A. Ahmed, Ahmed Khodairy, Mahmoud Abd El Aleem Ali Ali El-Remaily & Abdelraheem M. Ahmed. (2023) One-Step, Low-Cost, Operator-Friendly, and Scalable Procedure to Synthetize Novel Tetrazolopyrimidinylbenzopyran-2-ones by Benign Protocol. Current Organic Chemistry 26:24, pages 2214-2222.
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Ramasamy Duraisamy, Prashantha Nagaraja, Aatika Nizam, N. Venugopala Katharigatta, Honnappa Nagarajaiah, M. B. Madhusudana Reddy & Dhakshnamurthy Thirumalai. (2023) A Facile One‐Pot Solvent‐Free Synthesis, in Vitro and in Silico Studies of a Series of Tetrahydropyridine Derivatives as Breast Cancer Inhibitors. ChemistrySelect 8:43.
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Merangmenla Aier, Firdaus Rahaman Gayen & Amrit Puzari. (2023) A facile synthesis of sterically hindered tetrahydropyridine derivatives: The role of 2-Picolinic acid based 1D Copper (II) coordination polymer. Journal of Organometallic Chemistry 993, pages 122712.
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S. Geetha, A. Thangamani, R. Valliappan, S. Vedanayaki & A. Ganapathi. (2020) Sulfated titania (TiO2-SO42−) as an efficient and reusable solid acid catalyst for the multi-component synthesis of highly functionalized piperidines. Chemical Data Collections 30, pages 100565.
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Rajneesh P. Sharma, Usha K. Verma & Kamal K. Kapoor. (2020) TAPSO** : A Highly Efficient and Ecofriendly Catalyst for the Synthesis of α‐ Aminophosphonates and Tetrahydropyridines **3‐[N‐Tris(hydroxymethyl)methylamino]‐2‐hydroxypropanesulfonic acid . ChemistrySelect 5:20, pages 6016-6022.
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Kiran N. Patil, Rohan A. Mane, Sandip B. Jadhav, Mansing M. Mane & Vasant B. Helavi. (2019) One pot multicomponent synthesis of highly functionalized tetrahydropyridine using copper (II) triflate as catalyst and their anti-inflammatory activity. Chemical Data Collections 21, pages 100233.
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Marimuthu Ponram, Umamahesh Balijapalli, Baskaran Sambath, Sathiyanarayanan Kulathu Iyer, Kranthiraja Kakaraparthi, Giridhar Thota, Venkatachalapathy Bakthavachalam, Ravichandran Cingaram, Jin Sung-Ho & Karthikeyan Natesan Sundaramurthy. (2019) Inkjet-printed phosphorescent Iridium(III) complex based paper sensor for highly selective detection of Hg2+. Dyes and Pigments 163, pages 176-182.
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Gurpreet Kaur, Mamta Devi, Anjana Kumari, Rekha Devi & Bubun Banerjee. (2018) One‐Pot Pseudo Five Component Synthesis of Biologically Relevant 1,2,6‐Triaryl‐4‐arylamino‐piperidine‐3‐ene‐3‐ carboxylates: A Decade Update. ChemistrySelect 3:34, pages 9892-9910.
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Mustafa Hussain, Jianhui Liu, Zhipeng Zhang, Mengwei Hu, Yang Li & Xiangting Min. (2018) Green Synthesis and Theoretical Study of β‐Amino Esters via PPh 3 ‐Catalyzed Mannich Reaction . ChemistrySelect 3:31, pages 8787-8792.
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M. Musawwer Khan, Sarfaraz Khan, Saigal & Subash C. Sahoo. (2018) Efficient and Eco‐Friendly One‐Pot Synthesis of Functionalized Furan‐2‐one, Pyrrol‐2‐one, and Tetrahydropyridine Using Lemon Juice as a Biodegradable Catalyst. ChemistrySelect 3:5, pages 1371-1380.
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Cheng-Wei Lü, Jia-Jing Wang, Fei Li, Shi-Jun Yu & Yue An. (2017) Efficient synthesis of 2-amino-3-cyano-4H-pyran derivatives via a non-catalytic one-pot three-component reaction. Research on Chemical Intermediates 44:2, pages 1035-1043.
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Ali Maleki, Abbas Ali Jafari & Somayeh Yousefi. (2017) MgFe2O4/cellulose/SO3H nanocomposite: a new biopolymer-based nanocatalyst for one-pot multicomponent syntheses of polysubstituted tetrahydropyridines and dihydropyrimidinones. Journal of the Iranian Chemical Society 14:8, pages 1801-1813.
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Annah Gupta, Ramneet Kaur, Deepika Singh & Kamal K. Kapoor. (2017) Graphene oxide: A carbocatalyst for the one-pot multicomponent synthesis of highly functionalized tetrahydropyridines. Tetrahedron Letters 58:26, pages 2583-2587.
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V. Palermo, A. Sathicq, N. Liberto, S. Fernandes, P. Langer, J. Jios & G. Romanelli. (2016) Calix[n]arenes: active organocatalysts for the synthesis of densely functionalized piperidines by one-pot multicomponent procedure. Tetrahedron Letters 57:19, pages 2049-2054.
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Mir Rasul Mousavi, Hadigheh Gharari, Malek Taher Maghsoodlou & Nourallah Hazeri. (2015) Acetic acid-promoted eco-friendly one-pot pseudo six-component synthesis of bis-spiro-substituted piperidines. Research on Chemical Intermediates 42:4, pages 3875-3886.
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Md. Musawwer Khan, Sarfaraz Khan, Saigal Saigal & Safia Iqbal. (2016) Recent developments in multicomponent synthesis of structurally diversified tetrahydropyridines. RSC Advances 6:48, pages 42045-42061.
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Md. Musawwer Khan, Sarfaraz Khan, Safia Iqbal, Saigal Saigal & Raveed Yousuf. (2016) Synthesis of functionalized dihydro-2-oxypyrroles and tetrahydropyridines using 2,6-pyridinedicarboxylic acid as an efficient and mild organocatalyst. New Journal of Chemistry 40:9, pages 7504-7512.
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Mohsen Abbasi. (2015) Design, preparation and characterization of a new ionic liquid, 1,3-disulfonic acid benzimidazolium chloride, as an efficient and recyclable catalyst for the synthesis of tetrahydropyridine under solvent-free conditions. RSC Advances 5:83, pages 67405-67411.
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Umamahesh Balijapalli, Sathishkumar Munusamy, Karthikeyan Natesan Sundaramoorthy & Sathiyanarayanan Kulathu Iyer. (2014) ChemInform Abstract: Metal‐Free, One‐Pot, Rapid Synthesis of Tetrahydropyridines Using Acetic Acid as Solvent and Catalyst at Room Temperature. ChemInform 45:33.
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