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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 48, 2018 - Issue 5
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Original Articles

Synthesis, biological evaluation, and molecular docking study of pyridine clubbed 1,3,4-oxadiazoles as potential antituberculars

N. C. DesaiDivision of Medicinal Chemistry, Department of Chemistry (DST-FIST Sponsored), Maharaja Krishnakumarsinhji Bhavnagar University, Bhavnagar, IndiaCorrespondence[email protected]
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,
Amit TrivediDivision of Medicinal Chemistry, Department of Chemistry (DST-FIST Sponsored), Maharaja Krishnakumarsinhji Bhavnagar University, Bhavnagar, IndiaView further author information
,
Hardik SomaniDivision of Medicinal Chemistry, Department of Chemistry (DST-FIST Sponsored), Maharaja Krishnakumarsinhji Bhavnagar University, Bhavnagar, IndiaView further author information
,
Krunalsinh A. JadejaDivision of Medicinal Chemistry, Department of Chemistry (DST-FIST Sponsored), Maharaja Krishnakumarsinhji Bhavnagar University, Bhavnagar, IndiaView further author information
,
Darshita VajaDivision of Medicinal Chemistry, Department of Chemistry (DST-FIST Sponsored), Maharaja Krishnakumarsinhji Bhavnagar University, Bhavnagar, IndiaView further author information
,
Laxman NawaleCSIR-National Chemical Laboratory, Combi Chem-Bio Resource Centre, Pune, IndiaView further author information
,
Vijay M. KhedkarDepartment of Pharmaceutical Chemistry, Shri Vile Parle Kelavani Mandal’s Institute of Pharmacy, Mumbai, IndiaView further author information
&
Dhiman SarkarCSIR-National Chemical Laboratory, Combi Chem-Bio Resource Centre, Pune, IndiaView further author information
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Pages 524-540 | Received 22 Sep 2017, Published online: 30 Jan 2018

Citations (20)

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Bharti P. Koli, Rambhau P. Gore & Pravin R. Malasane. (2023) Green and efficient three-component synthesis of novel isoniazid pyrazoles, molecular docking, antioxidant and antitubercular evaluation. Synthetic Communications 53:18, pages 1506-1519.
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Nisheeth C. Desai, Kashyap R. Wadekar, Harsh K. Mehta, Unnat P. Pandit & Vijay M. Khedkar. (2023) Design, Synthesis, Antibacterial Activity and in Silico Studies of Novel Quinolone Fused with Triazine, Thiadiazole and Oxadiazole Heterocycles. Polycyclic Aromatic Compounds 43:1, pages 154-166.
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Nisheeth C. Desai, Dharmpalsinh J. Jadeja & Vijay M. Khedkar. (2022) Design, synthesis, antimicrobial activity and in silico molecular docking studies of some sulfur containing pyrazole-pyridine hybrids. Phosphorus, Sulfur, and Silicon and the Related Elements 197:12, pages 1226-1237.
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Jyothis Devasia, Aatika Nizam & Vasantha V. L.. (2022) Azole-Based Antibacterial Agents: A Review on Multistep Synthesis Strategies and Biology. Polycyclic Aromatic Compounds 42:8, pages 5474-5495.
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Nisheeth Desai, Niraj Shihory, Ashvinkumar Khasiya, Unnat Pandit & Vijay Khedkar. (2021) Quinazoline clubbed thiazole and 1,3,4-oxadiazole heterocycles: synthesis, characterization, antibacterial evaluation, and molecular docking studies. Phosphorus, Sulfur, and Silicon and the Related Elements 196:6, pages 569-577.
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Articles from other publishers (15)

Anjaneyulu Bendi, Priyanka Yadav, Komal Saini, Anirudh Singh Bhathiwal & Neera Raghav. (2024) A Comprehensive Examination of Heterocyclic Scaffold Chemistry for Antitubercular Activity. Chemistry & Biodiversity.
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Yannan Zhu, Fang Bo, Xuying Wang, Qianxi Jiang, Qiuyun Li, Zhongfei Han, Yi-Ning Wang & Gang Qi. (2024) Construction of 1,3,4-oxadiazolines bearing CF 3 -quaternary centers via amino-assisted [3 + 2] cycloadditions . Organic & Biomolecular Chemistry 22:7, pages 1391-1394.
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Nisheeth Desai, Dharmpalsinh Jadeja, Jahnvi Monapara, Saroj Kumar Panda, Malay Kumar Rana & Bharti Dave. (2023) Design, synthesis, antimicrobial activity, DFT, and molecular docking studies of pyridine‐pyrazole‐based dihydro‐1,3,4‐oxadiazoles against various bacterial and fungal targets. Journal of Biochemical and Molecular Toxicology 37:8.
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Mayursinh Zala, Jwalant J. Vora & Vijay M. Khedkar. (2023) Synthesis, Characterization, Antitubercular Activity, and Molecular Docking Studies of Pyrazolylpyrazoline-Clubbed Triazole and Tetrazole Hybrids. ACS Omega 8:23, pages 20262-20271.
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Nisheeth C. Desai, Jahnvi D. Monapara, Aratiba M. Jethawa & Unnat Pandit. 2023. Recent Developments in the Synthesis and Applications of Pyridines. Recent Developments in the Synthesis and Applications of Pyridines 253 298 .
Nisheeth Desai, Jahnvi Monapara, Aratiba Jethawa, Vijay Khedkar & Bapurao Shingate. (2022) Oxadiazole: A highly versatile scaffold in drug discovery. Archiv der Pharmazie 355:9.
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Nisheeth C. Desai, Kandarp Bhatt, Dharmpalsinh J. Jadeja, Harsh K. Mehta, Vijay M. Khedkar & Dhiman Sarkar. (2021) Conventional and microwave‐assisted organic synthesis of novel antimycobacterial agents bearing furan and pyridine hybrids. Drug Development Research 83:2, pages 416-431.
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Alexander V. Aksenov, Nikita K. Kirilov, Nicolai A. Aksenov, Nikolai A. Arutiunov, Dmitrii A. Aksenov & Michael Rubin. (2022) Electrophilically activated nitroalkanes in the synthesis of substituted 1,3,4-oxadiazoles from amino acid derivatives. Chemistry of Heterocyclic Compounds 58:1, pages 32-36.
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Nisheeth C. Desai, Kandarp Bhatt, Jahnvi Monapara, Unnat Pandit & Vijay M. Khedkar. (2021) Conventional and Microwave-Assisted Synthesis, Antitubercular Activity, and Molecular Docking Studies of Pyrazole and Oxadiazole Hybrids. ACS Omega 6:42, pages 28270-28284.
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Nisheeth C. Desai, Hasit V. Vaghani, Aratiba M. Jethawa & Vijay M. Khedkar. (2021) In silico molecular docking studies of oxadiazole and pyrimidine bearing heterocyclic compounds as potential antimicrobial agents. Archiv der Pharmazie 354:10.
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Hesham A. Shamsel-Din & Mohamed A. Gizawy. (2021) A novel dipeptide coupled with pyrazine-oxadiazole derivative as a potential antitubercular agent: Synthesis, radioiodination and bioevaluation. Applied Radiation and Isotopes 173, pages 109719.
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Teresa Glomb & Piotr Świątek. (2021) Antimicrobial Activity of 1,3,4-Oxadiazole Derivatives. International Journal of Molecular Sciences 22:13, pages 6979.
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Periyan Durairaju, Chinnasamy Umarani, Jothi Ramalingam Rajabather, Amer M. Alanazi, Govindasami Periyasami & Lee D. Wilson. (2021) Synthesis and Characterization of Pyridine-Grafted Copolymers of Acrylic Acid–Styrene Derivatives for Antimicrobial and Fluorescence Applications. Micromachines 12:6, pages 672.
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Narendra Singh Chundawat, Gajanan S. Shanbhag & Narendra Pal Singh Chauhan. (2020) Chemical synthesis and molecular modeling of novel substituted N-1,3-benzoxazol-2yl benzene sulfonamides as inhibitors of inhA enzyme and Mycobacterium tuberculosis growth. Journal of the Iranian Chemical Society 18:4, pages 903-920.
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Suparna S. De, Mihir P. Khambete & Mariam S. Degani. (2019) Oxadiazole scaffolds in anti-tuberculosis drug discovery. Bioorganic & Medicinal Chemistry Letters 29:16, pages 1999-2007.
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