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Risto O. Juvonen, Mira Ahinko, Juhani Huuskonen, Hannu Raunio & Olli T. Pentikäinen. (2019) Development of new Coumarin-based profluorescent substrates for human cytochrome P450 enzymes. Xenobiotica 49:9, pages 1015-1024.
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Yannick Parmentier, Corinne Pothier, Nicola Hewitt, Ludwig Vincent, Fabrice Caradec, Jia Liu, Feifei Lin, Marie-Michèle Trancart, Fabrice Guillet, Belkacem Bouaita, Christophe Chesne & Bernard Walther. (2019) Direct and quantitative evaluation of the major human CYP contribution (fmCYP) to drug clearance using the in vitro Silensomes™ model. Xenobiotica 49:1, pages 22-35.
Read now
Read now
Chin Eng Ong, Yan Pan, Joon Wah Mak & Rusli Ismail. (2013)
In vitro approaches to investigate cytochrome P450 activities: update on current status and their applicability. Expert Opinion on Drug Metabolism & Toxicology 9:9, pages 1097-1113.
Read now
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Liyue Huang, April Chen, John Roberts, Brett Janosky, Xuhai Be, Loren Berry & Min-Hwa Jasmine Lin. (2012) Use of uptake intrinsic clearance from attached rat hepatocytes to predict hepatic clearance for poorly permeable compounds. Xenobiotica 42:9, pages 830-840.
Read now
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G. I. Somers, A. J. Harris, M. K. Bayliss & J. B. Houston. (2007) The metabolism of the 5HT3 antagonists ondansetron, alosetron and GR87442 I: A comparison of and metabolism and enzyme kinetics in rat, dog and human hepatocytes, microsomes and recombinant human enzymes. Xenobiotica 37:8, pages 832-854.
Read now
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G. I. Somers, M. K. Bayliss & J. B. Houston. (2007) The metabolism of the 5HT3 antagonists, ondansetron, alosetron and GR87442 II: Investigation into the in vitro methods used to predict the in vivo hepatic clearance of ondansetron, alosetron and GR87442 in the rat, dog and human. Xenobiotica 37:8, pages 855-869.
Read now
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Yasuhiro Masubuchi & Toshiharu Horie. (2007) Toxicological Significance of Mechanism-Based Inactivation of Cytochrome P450 Enzymes by Drugs. Critical Reviews in Toxicology 37:5, pages 389-412.
Read now
Read now
James J Cali, Dongping Ma, Mary Sobol, Daniel J Simpson, Susan Frackman, Troy D Good, William J Daily & David Liu. (2006) Luminogenic cytochrome P450 assays. Expert Opinion on Drug Metabolism & Toxicology 2:4, pages 629-645.
Read now
Read now
C. Sams, J. Cocker & M. S. Lennard. (2004) Biotransformation of chlorpyrifos and diazinon by human liver microsomes and recombinant human cytochrome P450s (CYP). Xenobiotica 34:10, pages 861-873.
Read now
Read now
S. Marini, E. Grasso, V. Longo, P. Puccini, B. Riccardi & P. Giovanni Gervasi. (2003) 4-Biphenylaldehyde and 9-anthraldehyde: two fluorescent substrates for determining P450 enzyme activities in rat and human. Xenobiotica 33:1, pages 1-11.
Read now
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Slobodan Rendic. (2002) Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metabolism Reviews 34:1-2, pages 83-448.
Read now
Read now
Z. Yan, G. W. Caldwell, W. N. Wu, L. A. McKown, B. Rafferty, W. Jones & J. A. Masucci. (2002) In vitro identification of metabolic pathways and cytochrome P450 enzymes involved in the metabolism of etoperidone. Xenobiotica 32:11, pages 949-962.
Read now
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G. J. Pass & S. McLean. (2002) Inhibition of the microsomal metabolism of 1,8-cineole in the common brushtail possum (Trichosurus vulpecula) by terpenes and other chemicals. Xenobiotica 32:12, pages 1109-1126.
Read now
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Articles from other publishers (96)
Ziru Dai, Yue Wu, Yuan Xiong, Jingjing Wu, Min Wang, Xiao Sun, Xinxin Ding, Ling Yang, Xiaobo Sun & Guangbo Ge. (2023) CYP1A inhibitors: Recent progress, current challenges, and future perspectives. Medicinal Research Reviews 44:1, pages 169-234.
Crossref
Crossref
Orphélie Lootens, Marthe De Boevre, Elke Gasthuys, Jan Van Bocxlaer, An Vermeulen & Sarah De Saeger. (2022) Unravelling the pharmacokinetics of aflatoxin B1: In vitro determination of Michaelis–Menten constants, intrinsic clearance and the metabolic contribution of CYP1A2 and CYP3A4 in pooled human liver microsomes. Frontiers in Microbiology 13.
Crossref
Crossref
Aditya R. Kumar, Gabriela I. Patilea-Vrana, Olena Anoshchenko & Jashvant D. Unadkat. (2022)
Characterizing and Quantifying Extrahepatic Metabolism of (−)-Δ
9
-Tetrahydrocannabinol (THC) and Its Psychoactive Metabolite, (±)-11-Hydroxy-Δ
9
-THC (11-OH-THC)
. Drug Metabolism and Disposition 50:6, pages 734-740.
Crossref
Crossref
Tingting Zhao, Yanwei Chen, Dalong Wang, Liyan Wang, Peipei Dong, Shan Zhao, Changyuan Wang, Qiang Meng, Huijun Sun, Kexin Liu & Jingjing Wu. (2021) Identifying the Dominant Contribution of Human Cytochrome P450 2J2 to the Metabolism of Rivaroxaban, an Oral Anticoagulant. Cardiovascular Drugs and Therapy 36:1, pages 121-129.
Crossref
Crossref
Florian Klomp, Christoph Wenzel, Marek Drozdzik & Stefan Oswald. (2020) Drug–Drug Interactions Involving Intestinal and Hepatic CYP1A Enzymes. Pharmaceutics 12:12, pages 1201.
Crossref
Crossref
Kunjie Li, Xingjie Guo, Feng Qin, Zhili Xiong, Longshan Zhao & Jia Yu. (2018) Identification of the cytochrome P450 enzymes involved in the oxidative metabolism of trantinterol using ultra high-performance liquid chromatography coupled with tandem mass spectrometry. RSC Advances 8:60, pages 34764-34772.
Crossref
Crossref
M. Cataldi. 2017. Reference Module in Biomedical Sciences. Reference Module in Biomedical Sciences.
S. V. Nikulin, E. A. Tonevitsky & A. A. Poloznikov. (2017) Effect of ketoconazole on the transport and metabolism of drugs in the human liver cell model. Russian Chemical Bulletin 66:1, pages 150-155.
Crossref
Crossref
Mili Mandal, Carol R. Gardner, Richard Sun, Hyejeong Choi, Sonali Lad, Vladimir Mishin, Jeffrey D. Laskin & Debra L. Laskin. (2016) The spleen as an extramedullary source of inflammatory cells responding to acetaminophen-induced liver injury. Toxicology and Applied Pharmacology 304, pages 110-120.
Crossref
Crossref
Stephen Nesnow. 2016. Toxicogenomics in Predictive Carcinogenicity. Toxicogenomics in Predictive Carcinogenicity
280
351
.
Janne T. Backman, Anne M. Filppula, Mikko Niemi & Pertti J. Neuvonen. (2015) Role of Cytochrome P450 2C8 in Drug Metabolism and Interactions. Pharmacological Reviews 68:1, pages 168-241.
Crossref
Crossref
Guolin Shen, Cheng Wang, Lili Zhou, Lei Li, Huiming Chen, Wenlian Yu & Haishan Li. (2015) CYP450 Enzyme-Mediated Metabolism of TCAS and Its Inhibitory and Induced Effects on Metabolized Enzymes in Vitro. International Journal of Environmental Research and Public Health 12:9, pages 10783-10793.
Crossref
Crossref
David J. Greenblatt & Jerold S. Harmatz. (2015) Ritonavir is the best alternative to ketoconazole as an index inhibitor of cytochrome P450-3A in drug-drug interaction studies. British Journal of Clinical Pharmacology 80:3, pages 342-350.
Crossref
Crossref
Nga Ting Colette Chiu, Emma S. Tomlinson Guns, Hans Adomat, William Jia & Subrata Deb. (2014)
Identification of human cytochrome P450 enzymes involved in the hepatic and intestinal biotransformation of 20(
S
)-protopanaxadiol
. Biopharmaceutics & Drug Disposition 35:2, pages 104-118.
Crossref
Crossref
Seetha Ramasamy, Lik Kiew & Lip Chung. (2014) Inhibition of Human Cytochrome P450 Enzymes by Bacopa monnieri Standardized Extract and Constituents. Molecules 19:2, pages 2588-2601.
Crossref
Crossref
Emmelie Björklund, Therése N. L. Larsson, Stig O. P. Jacobsson & Christopher J. Fowler. (2014) Ketoconazole Inhibits the Cellular Uptake of Anandamide via Inhibition of FAAH at Pharmacologically Relevant Concentrations. PLoS ONE 9:1, pages e87542.
Crossref
Crossref
Dmitri R. DavydovNadezhda Y. DavydovaElena V. SinevaIrina KufarevaJames R. Halpert. (2013) Pivotal role of P450–P450 interactions in CYP3A4 allostery: the case of α-naphthoflavone. Biochemical Journal 453:2, pages 219-230.
Crossref
Crossref
Stephen Nesnow. (2013) Integration of toxicological approaches with “omic” and related technologies to elucidate mechanisms of carcinogenic action: Propiconazole, an example. Cancer Letters 334:1, pages 20-27.
Crossref
Crossref
Alexander V. LyubimovKristopher W. Krausz & Harry V. Gelboin. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions
1
20
.
Carol R. Gardner, Pamela Hankey, Vladimir Mishin, Mary Francis, Shan Yu, Jeffrey D. Laskin & Debra L. Laskin. (2012) Regulation of alternative macrophage activation in the liver following acetaminophen intoxication by stem cell-derived tyrosine kinase. Toxicology and Applied Pharmacology 262:2, pages 139-148.
Crossref
Crossref
David E. Moody. 2012. Handbook of Drug Interactions. Handbook of Drug Interactions
25
116
.
Peter McAnulty, Anthony Dayan, Niels-Christian Ganderup & Kenneth Hastings. 2011. The Minipig in Biomedical Research. The Minipig in Biomedical Research
143
158
.
Stephen Nesnow, Rachel D. Grindstaff, Guy Lambert, William T. Padgett, Maribel Bruno, Yue Ge, Pei-Jen Chen, Charles E. Wood & Lynea Murphy. (2011) Propiconazole increases reactive oxygen species levels in mouse hepatic cells in culture and in mouse liver by a cytochrome P450 enzyme mediated process. Chemico-Biological Interactions 194:1, pages 79-89.
Crossref
Crossref
Haizheng Hong, Hong Su, Li Ma, Ming Yao, Ramaswamy A. Iyer, W. Griffith Humphreys & Lisa J. Christopher. (2011) In Vitro Characterization of the Metabolic Pathways and Cytochrome P450 Inhibition and Induction Potential of BMS-690514, an ErbB/Vascular Endothelial Growth Factor Receptor Inhibitor. Drug Metabolism and Disposition 39:9, pages 1658-1667.
Crossref
Crossref
C-C Peng, I Templeton, K E Thummel, C Davis, K L Kunze & N Isoherranen. (2011) Evaluation of 6β-Hydroxycortisol, 6β-Hydroxycortisone, and a Combination of the Two as Endogenous Probes for Inhibition of CYP3A4 In Vivo. Clinical Pharmacology & Therapeutics 89:6, pages 888-895.
Crossref
Crossref
Steven W. Louie & Magang Shou. 2011. Mass Spectrometry in Drug Metabolism and Disposition. Mass Spectrometry in Drug Metabolism and Disposition
83
149
.
Kevin M. Marks, Eun Sun Park, Alexander Arefolov, Katie Russo, Keiko Ishihara, Jennifer E. Ring, Jon Clardy, Astrid S. Clarke & Henry E. Pelish. (2011) The Selectivity of Austocystin D Arises from Cell-Line-Specific Drug Activation by Cytochrome P450 Enzymes. Journal of Natural Products 74:4, pages 567-573.
Crossref
Crossref
Siamak Cyrus Khojasteh, Saileta Prabhu, Jane R. Kenny, Jason S. Halladay & Anthony Y. H. Lu. (2011) Chemical inhibitors of cytochrome P450 isoforms in human liver microsomes: a re-evaluation of P450 isoform selectivity. European Journal of Drug Metabolism and Pharmacokinetics 36:1, pages 1-16.
Crossref
Crossref
Haruka Nishimuta, Kimihiko Sato, Yasuyuki Mizuki, Masashi Yabuki & Setsuko Komuro. (2010) Prediction of the Intestinal First-Pass Metabolism of CYP3A Substrates in Humans Using Cynomolgus Monkeys. Drug Metabolism and Disposition 38:11, pages 1967-1975.
Crossref
Crossref
Lin Zhou, Suresh B. Naraharisetti, Li Liu, Honggang Wang, Yvonne S. Lin, Nina Isoherranen, Jashvant D. Unadkat, Mary F. Hebert & Qingcheng Mao. (2010) Contributions of human cytochrome P450 enzymes to glyburide metabolism. Biopharmaceutics & Drug Disposition 31:4, pages 228-242.
Crossref
Crossref
Nicholas Seneca, Sami S. Zoghbi, H. Umesha Shetty, Edward Tuan, Pavitra Kannan, Andrew Taku, Robert B. Innis & Victor W. Pike. (2010) Effects of ketoconazole on the biodistribution and metabolism of [11C]loperamide and [11C]N-desmethyl-loperamide in wild-type and P-gp knockout mice. Nuclear Medicine and Biology 37:3, pages 335-345.
Crossref
Crossref
Christoph E. Hagemeyer, Carolin Bürck, Ricarda Schwab, Rolf Knoth & Ralf P. Meyer. (2010) 7-Benzyloxyresorufin-O-dealkylase activity as a marker for measuring cytochrome P450 CYP3A induction in mouse liver. Analytical Biochemistry 398:1, pages 104-111.
Crossref
Crossref
Olga L. Zharikova, Valentina M. Fokina, Tatiana N. Nanovskaya, Ronald A. Hill, Donald R. Mattison, Gary D.V. Hankins & Mahmoud S. Ahmed. (2009) Identification of the major human hepatic and placental enzymes responsible for the biotransformation of glyburide. Biochemical Pharmacology 78:12, pages 1483-1490.
Crossref
Crossref
Takaki Toda, Erik Eliasson, Birgitta Ask, Nobuo Inotsume & Anders Rane. (2009) Roles of Different CYP Enzymes in the Formation of Specific Fluvastatin Metabolites by Human Liver Microsomes. Basic & Clinical Pharmacology & Toxicology 105:5, pages 327-332.
Crossref
Crossref
Marta Kot & Władysława A. Daniel. (2009) Effect of diethyldithiocarbamate (DDC) and ticlopidine on CYP1A2 activity and caffeine metabolism: an in vitro comparative study with human cDNA-expressed CYP1A2 and liver microsomes. Pharmacological Reports 61:6, pages 1216-1220.
Crossref
Crossref
Onur Dagliyan, I. Halil Kavakli & Metin Turkay. (2009)
Classification of Cytochrome P450 Inhibitors with Respect to Binding Free Energy and pIC
50
Using Common Molecular Descriptors
. Journal of Chemical Information and Modeling 49:10, pages 2403-2411.
Crossref
Crossref
Ralf Peter Meyer, Marcel Gehlhaus, Ricarda Schwab, Carolin Bürck, Rolf Knoth & Christoph Eugen Hagemeyer. (2009) Concordant up-regulation of cytochrome P450 Cyp3a11, testosterone oxidation and androgen receptor expression in mouse brain after xenobiotic treatment. Journal of Neurochemistry 109:2, pages 670-681.
Crossref
Crossref
Chiara GiannarelliAgostino VirdisFerdinando De NegriArmando MagagnaEmiliano DurantiAntonio SalvettiStefano Taddei. (2009) Effect of Sulfaphenazole on Tissue Plasminogen Activator Release in Normotensive Subjects and Hypertensive Patients. Circulation 119:12, pages 1625-1633.
Crossref
Crossref
Kazunobu Aoyama, Kouichi Yoshinari, Hye-Ji Kim, Kiyoshi Nagata & Yasushi Yamazoe. (2009) Simultaneous Expression of Plural Forms of Human Cytochrome P450 at Desired Ratios in HepG2 Cells: Adenovirus-mediated Tool for Cytochrome P450 Reconstitution. Drug Metabolism and Pharmacokinetics 24:3, pages 209-217.
Crossref
Crossref
Pei-Jen Chen, William T. Padgett, Tanya Moore, Witold Winnik, Guy R. Lambert, Sheau-Fung Thai, Susan D. Hester & Stephen Nesnow. (2009) Three conazoles increase hepatic microsomal retinoic acid metabolism and decrease mouse hepatic retinoic acid levels in vivo. Toxicology and Applied Pharmacology 234:2, pages 143-155.
Crossref
Crossref
Kazuhiro Shiizaki, Seiichiroh Ohsako, Masanobu Kawanishi & Takashi Yagi. (2008) Omeprazole Alleviates Benzo[a]pyrene Cytotoxicity by Inhibition of CYP1A1 Activity in Human and Mouse Hepatoma Cells. Basic & Clinical Pharmacology & Toxicology 103:5, pages 468-475.
Crossref
Crossref
D. Pekthong, H. Martin, C. Abadie, A. Bonet, B. Heyd, G. Mantion & L. Richert. (2008) Differential inhibition of rat and human hepatic cytochrome P450 by Andrographis paniculata extract and andrographolide. Journal of Ethnopharmacology 115:3, pages 432-440.
Crossref
Crossref
Kedar Purnapatre, Sunil K. Khattar & Kulvinder Singh Saini. (2008) Cytochrome P450s in the development of target-based anticancer drugs. Cancer Letters 259:1, pages 1-15.
Crossref
Crossref
Ahmed Kousba, Richard Soll, Shiyin Yee & Michael Martin. (2007)
Cyclic Conversion of the Novel Src Kinase Inhibitor [7-(2,6-Dichloro-phenyl)-5-methyl-benzo[1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine (TG100435) and Its
N
-Oxide Metabolite by Flavin-Containing Monoxygenases and Cytochrome P450 Reductase
. Drug Metabolism and Disposition 35:12, pages 2242-2251.
Crossref
Crossref
Michael D. Cameron, Jason Wright, Christopher B. Black & Naidong Ye. (2007) In Vitro Prediction and in Vivo Verification of Enantioselective Human Tofisopam Metabolite Profiles. Drug Metabolism and Disposition 35:10, pages 1894-1902.
Crossref
Crossref
Negar Gharavi, Somayeh Sattari, Anooshirvan Shayeganpour, Ayman O.S. El‐Kadi & Dion R. Brocks. (2006) The stereoselective metabolism of halofantrine to desbutylhalofantrine in the rat: Evidence of tissue‐specific enantioselectivity in microsomal metabolism. Chirality 19:1, pages 22-33.
Crossref
Crossref
Stacey L. Polsky-Fisher, Hong Cao, Ping Lu & Christopher R. Gibson. (2006) EFFECT OF CYTOCHROMES P450 CHEMICAL INHIBITORS AND MONOCLONAL ANTIBODIES ON HUMAN LIVER MICROSOMAL ESTERASE ACTIVITY. Drug Metabolism and Disposition 34:8, pages 1361-1366.
Crossref
Crossref
Anima Ghosal, Swapan K. Chowdhury, Wei Tong, Neil Hapangama, Yuan Yuan, Ai-Duen Su & Shmuel Zbaida. (2006) IDENTIFICATION OF HUMAN LIVER CYTOCHROME P450 ENZYMES RESPONSIBLE FOR THE METABOLISM OF LONAFARNIB (SARASAR). Drug Metabolism and Disposition 34:4, pages 628-635.
Crossref
Crossref
Harry V. Gelboin & Kristopher Krausz. (2006) Monoclonal Antibodies and Multifunctional Cytochrome P450: Drug Metabolism as Paradigm. The Journal of Clinical Pharmacology 46:3, pages 353-372.
Crossref
Crossref
Yan Chang, David E. Moody & Elinore F. McCance-Katz. (2006) NOVEL METABOLITES OF BUPRENORPHINE DETECTED IN HUMAN LIVER MICROSOMES AND HUMAN URINE. Drug Metabolism and Disposition 34:3, pages 440-448.
Crossref
Crossref
J. VriensG. OwsianikB. FisslthalerM. SuzukiA. JanssensT. VoetsC. MorisseauB.D. HammockI. FlemingR. BusseB. Nilius. (2005)
Modulation of the Ca
2
Permeable Cation Channel TRPV4 by Cytochrome P450 Epoxygenases in Vascular Endothelium
. Circulation Research 97:9, pages 908-915.
Crossref
Crossref
Ping Lu, Suresh B. Singh, Brian A. Carr, Yulin Fang, Cathie Dong Xiang, Thomas H. Rushmore, A. David Rodrigues & Magang Shou. (2005) Selective Inhibition of Dog Hepatic CYP2B11 and CYP3A12. Journal of Pharmacology and Experimental Therapeutics 313:2, pages 518-528.
Crossref
Crossref
Margaret O. James, Zhen Lou, Laura Rowland-Faux & Malin C. Celander. (2005) Properties and regional expression of a CYP3A-like protein in channel catfish intestine. Aquatic Toxicology 72:4, pages 361-371.
Crossref
Crossref
S. Bhoopathy, B. Xin, S.E. Unger & H.T. Karnes. (2005) A novel incubation direct injection LC/MS/MS technique for in vitro drug metabolism screening studies involving the CYP 2D6 and the CYP 3A4 isozymes. Journal of Pharmaceutical and Biomedical Analysis 37:4, pages 739-749.
Crossref
Crossref
Theresa Mariero Klees, Pamela Sheffels, Ola Dale & Evan D. Kharasch. (2005) METABOLISM OF ALFENTANIL BY CYTOCHROME P4503A (CYP3A) ENZYMES. Drug Metabolism and Disposition 33:3, pages 303-311.
Crossref
Crossref
Ram P. Gupta, You Ai He, Kennerly S. Patrick, James R. Halpert & Norman H. Bell. (2005) CYP3A4 Is a Vitamin D-24- and 25-Hydroxylase: Analysis of Structure Function by Site-Directed Mutagenesis. The Journal of Clinical Endocrinology & Metabolism 90:2, pages 1210-1219.
Crossref
Crossref
Evan D Kharasch, Dale Whittington, Christine Hoffer, Kevin Krudys, Keith Craig, Paolo Vicini, Pam Sheffels & Bojan Lalovic. (2005) Paradoxical Role of Cytochrome P450 3A in the Bioactivation and Clinical Effects of Levo-??-Acetylmethadol. Clinical Pharmacokinetics 44:7, pages 731-751.
Crossref
Crossref
Toshifumi ShiragaZenzaburo TozukaRika IshimuraAkio KawamuraAkira Kagayama. (2005) Identification of Cytochrome P450 Enzymes Involved in the Metabolism of FK228, a Potent Histone Deacetylase Inhibitor, in Human Liver Microsomes. Biological and Pharmaceutical Bulletin 28:1, pages 124-129.
Crossref
Crossref
Bang-ning Yu, Chen-Hui Luo, Dan Wang, An Wang, Zhi Li, Wei Zhang, Wei Mo & Hong-Hao Zhou. (2004) CYP2C9 allele variants in Chinese hypertension patients and healthy controls. Clinica Chimica Acta 348:1-2, pages 57-61.
Crossref
Crossref
Kyoung-Ah Kim, Jaegul Chung, Dong-Hae Jung & Ji-Young Park. (2004) Identification of cytochrome P450 isoforms involved in the metabolism of loperamide in human liver microsomes. European Journal of Clinical Pharmacology 60:8, pages 575-581.
Crossref
Crossref
Hiroyuki Hichiya, Shino Kuramoto, Shigeo Yamamoto, Sumio Shinoda, Nobumitsu Hanioka, Shizuo Narimatsu, Kazuo Asaoka, Atsuro Miyata, Shinichi Iwata, Masahiro Nomoto, Tetsuo Satoh, Kimio Kiryu, Nobuhiko Ueda, Shinsaku Naito, Geoffrey T. Tucker & S.Wynne Ellis. (2004) Cloning and functional expression of a novel marmoset cytochrome P450 2D enzyme, CYP2D30: comparison with the known marmoset CYP2D19. Biochemical Pharmacology 68:1, pages 165-175.
Crossref
Crossref
Bennett Ma, Raju Subramanian, Michael L. Schrag, A. David Rodrigues & Cuyue Tang. (2004)
CYTOCHROME P450 2C8 (CYP2C8)-MEDIATED HYDROXYLATION OF AN ENDOTHELIN ET
A
RECEPTOR ANTAGONIST IN HUMAN LIVER MICROSOMES
. Drug Metabolism and Disposition 32:5, pages 473-478.
Crossref
Crossref
Katalin Monostory, Eszter Hazai & László Vereczkey. (2004) Inhibition of cytochrome P450 enzymes participating in p-nitrophenol hydroxylation by drugs known as CYP2E1 inhibitors. Chemico-Biological Interactions 147:3, pages 331-340.
Crossref
Crossref
Howard G. Shertzer, Corey D. Clay, Mary Beth Genter, Scott N. Schneider, Daniel W. Nebert & Timothy P. Dalton. (2004) CYP1A2 protects against reactive oxygen production in mouse liver microsomes. Free Radical Biology and Medicine 36:5, pages 605-617.
Crossref
Crossref
Masashi Mise, Seiji Yadera, Michiaki Matsuda, Takanori Hashizume, Satoshi Matsumoto, Yoshiaki Terauchi & Toshihiko Fujii. (2004) POLYMORPHIC EXPRESSION OF CYP1A2 LEADING TO INTERINDIVIDUAL VARIABILITY IN METABOLISM OF A NOVEL BENZODIAZEPINE RECEPTOR PARTIAL INVERSE AGONIST IN DOGS. Drug Metabolism and Disposition 32:2, pages 240-245.
Crossref
Crossref
Stephan FichtlschererStefanie DimmelerSusanne BreuerRudi BusseAndreas M. ZeiherIngrid Fleming. (2004) Inhibition of Cytochrome P450 2C9 Improves Endothelium-Dependent, Nitric Oxide–Mediated Vasodilatation in Patients With Coronary Artery Disease. Circulation 109:2, pages 178-183.
Crossref
Crossref
Toshifumi ShiragaToshiro NiwaYasuo Ohno & Akira Kagayama. (2004) Interindividual Variability in 2-Hydroxylation, 3-Sulfation, and 3-Glucuronidation of Ethynylestradiol in Human Liver. Biological and Pharmaceutical Bulletin 27:12, pages 1900-1906.
Crossref
Crossref
David M. Stresser, Marc I. Broudy, Thuy Ho, Catherine E. Cargill, Andrew P. Blanchard, Raman Sharma, Andre A. Dandeneau, Joseph J. Goodwin, Stephanie D. Turner, John C. L. Erve, Christopher J. Patten, Shangara S. Dehal & Charles L. Crespi. (2004) HIGHLY SELECTIVE INHIBITION OF HUMAN CYP3A IN VITRO BY AZAMULIN AND EVIDENCE THAT INHIBITION IS IRREVERSIBLE. Drug Metabolism and Disposition 32:1, pages 105-112.
Crossref
Crossref
David E. Moody. 2004. Handbook of Drug Interactions. Handbook of Drug Interactions
3
88
.
??mit Yasar, Anna M Bennet, Erik Eliasson, Stefan Lundgren, Bj??rn Wiman, Ulf de Faire & Anders Rane. (2003) Allelic variants of cytochromes P450 2C modify the risk for acute myocardial infarction. Pharmacogenetics 13:12, pages 715-720.
Crossref
Crossref
Shin-Pei Yang, Theresa Medling & Gregory M. Raner. (2003) Cytochrome P450 expression and activities in rat, rabbit and bovine tongue. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 136:4, pages 297-308.
Crossref
Crossref
Dragoni Stefania, Bellik Lydia, Frosini Maria, Matteucci Giacomo, Sgaragli Giampietro & Valoti Massimo. (2003) Cytochrome P450-dependent metabolism of l-deprenyl in monkey (Cercopithecus aethiops) and C57BL/6 mouse brain microsomal preparations. Journal of Neurochemistry 86:5, pages 1174-1180.
Crossref
Crossref
Richard Weaver, Ken S. Graham, Iain G. Beattie & Rob J. Riley. (2003) CYTOCHROME P450 INHIBITION USING RECOMBINANT PROTEINS AND MASS SPECTROMETRY/MULTIPLE REACTION MONITORING TECHNOLOGY IN A CASSETTE INCUBATION. Drug Metabolism and Disposition 31:7, pages 955-966.
Crossref
Crossref
Michael A. Wynalda, J. Matthew Hutzler, Michael D. Koets, Terry Podoll & Larry C. Wienkers. (2003) IN VITRO METABOLISM OF CLINDAMYCIN IN HUMAN LIVER AND INTESTINAL MICROSOMES. Drug Metabolism and Disposition 31:7, pages 878-887.
Crossref
Crossref
Wenjiang Zhang, Yamini Ramamoorthy, Rachel F. Tyndale & Edward M. Sellers. (2003) INTERACTION OF BUPRENORPHINE AND ITS METABOLITE NORBUPRENORPHINE WITH CYTOCHROMES P450 IN VITRO. Drug Metabolism and Disposition 31:6, pages 768-772.
Crossref
Crossref
Balázs Dalmadi, János Leibinger, Szabolcs Szeberényi, Tı́mea Borbás, Sándor Farkas, Zsolt Szombathelyi & Károly Tihanyi. (2003) Identification of Metabolic Pathways Involved in the Biotransformation of Tolperisone by Human Microsomal Enzymes. Drug Metabolism and Disposition 31:5, pages 631-636.
Crossref
Crossref
Aleksandra Galetin, Stephen E. Clarke & J. Brian Houston. (2002) Quinidine and Haloperidol as Modifiers of CYP3A4 Activity: Multisite Kinetic Model Approach. Drug Metabolism and Disposition 30:12, pages 1512-1522.
Crossref
Crossref
Chyung S. Cook, Loren M. Berry, David H. Kim, Earl G. Burton, Jeremy D. Hribar & Liming Zhang. (2002) Involvement of CYP3A in the Metabolism of Eplerenone in Humans and Dogs: Differential Metabolism by CYP3A4 and CYP3A5. Drug Metabolism and Disposition 30:12, pages 1344-1351.
Crossref
Crossref
Eckhart Büssemaker, Christian Wallner, Beate Fisslthaler & Ingrid Fleming. (2009) The Na‐K‐ATPase is a target for an EDHF displaying characteristics similar to potassium ions in the porcine renal interlobar artery. British Journal of Pharmacology 137:5, pages 647-654.
Crossref
Crossref
Mette T. Skaanild & Christian Friis. (2008) Is Cytochrome P450 CYP2D Activity Present in Pig Liver?. Pharmacology & Toxicology 91:4, pages 198-203.
Crossref
Crossref
Janet K. Coller, Niels Krebsfaenger, Kathrin Klein, Karin Endrizzi, Renzo Wolbold, Thomas Lang, Andreas Nüssler, Peter Neuhaus, Ulrich M. Zanger, Michel Eichelbaum & Thomas E. Mürdter. (2002)
The influence of
CYP2B6
,
CYP2C9
and
CYP2D6
genotypes on the formation of the potent antioestrogen Z‐4‐hydroxy‐tamoxifen in human liver
. British Journal of Clinical Pharmacology 54:2, pages 157-167.
Crossref
Crossref
Timothy J. Sontag & Robert S. Parker. (2002) Cytochrome P450 ω-Hydroxylase Pathway of Tocopherol Catabolism. Journal of Biological Chemistry 277:28, pages 25290-25296.
Crossref
Crossref
Qin Mei, Cuyue Tang, Yuh Lin, Thomas H. Rushmore & Magang Shou. (2002) Inhibition Kinetics of Monoclonal Antibodies against Cytochromes P450. Drug Metabolism and Disposition 30:6, pages 701-708.
Crossref
Crossref
Wenjiang Zhang, Yamini Ramamoorthy, Rachel F. Tyndale, Stanley D. Glick, Isabelle M. Maisonneuve, Martin E. Kuehne & Edward M. Sellers. (2002) Metabolism of 18-Methoxycoronaridine, an Ibogaine Analog, to 18-Hydroxycoronaridine by Genetically Variable CYP2C19. Drug Metabolism and Disposition 30:6, pages 663-669.
Crossref
Crossref
Wenjiang Zhang, Yamini Ramamoorthy, Tansel Kilicarslan, Helma Nolte, Rachel F. Tyndale & Edward M. Sellers. (2002) Inhibition of Cytochromes P450 by Antifungal Imidazole Derivatives. Drug Metabolism and Disposition 30:3, pages 314-318.
Crossref
Crossref
Chin B. Eap, Thierry Buclin & Pierre Baumann. (2002) Interindividual Variability of the Clinical Pharmacokinetics of Methadone. Clinical Pharmacokinetics 41:14, pages 1153-1193.
Crossref
Crossref
Richard J. Roman. (2002)
P
-450 Metabolites of Arachidonic Acid in the Control of Cardiovascular Function
. Physiological Reviews 82:1, pages 131-185.
Crossref
Crossref
Ingrid Fleming. (2001) Cytochrome P450 and Vascular Homeostasis. Circulation Research 89:9, pages 753-762.
Crossref
Crossref
Natalie J. Thatcher & Stephen Murray. (2001) Analysis of the glutathione conjugate of paracetamol in human liver microsomal fraction by liquid chromatography mass spectrometry. Biomedical Chromatography 15:6, pages 374-378.
Crossref
Crossref
Ole V. Olesen & Kristian Linnet. (2013) Contributions of Five Human Cytochrome P450 Isoforms to the N‐demethylation of Clozapine In Vitro at Low and High Concentrations. The Journal of Clinical Pharmacology 41:8, pages 823-832.
Crossref
Crossref
Jill R Cupp-Vickery, Carlos Garcia, Andy Hofacre & Kathleen McGee-Estrada. (2001) Ketoconazole-induced conformational changes in the active site of cytochrome P450eryF. Journal of Molecular Biology 311:1, pages 101-110.
Crossref
Crossref
Bruno Bournique, Nicole Lambert, Rachid Boukaiba & Michel Martinet. (2001)
In vitro
metabolism and drug interaction potential of a new highly potent anti‐cytomegalovirus molecule, CMV423 (2‐chloro 3‐pyridine 3‐yl 5,6,7,8‐tetrahydroindolizine 1‐carboxamide)
. British Journal of Clinical Pharmacology 52:1, pages 53-63.
Crossref
Crossref
N Hamaoka, Y Oda, I Hase & A Asada. (2001) Cytochrome P4502B6 and 2C9 do not metabolize midazolam: kinetic analysis and inhibition study with monoclonal antibodies. British Journal of Anaesthesia 86:4, pages 540-544.
Crossref
Crossref
Ingrid FlemingU. Ruth MichaelisDaniel BredenkötterBeate FisslthalerFaramarz DehghaniRalf P. BrandesRudi Busse. (2001) Endothelium-Derived Hyperpolarizing Factor Synthase (Cytochrome P450 2C9) Is a Functionally Significant Source of Reactive Oxygen Species in Coronary Arteries. Circulation Research 88:1, pages 44-51.
Crossref
Crossref
P. David Josephy, Sarah M. Batty & Darrell R. Boverhof. (2001)
Recombinant human P450 forms 1A1, 1A2, and 1B1 catalyze the bioactivation of heterocyclic amine mutagens in
Escherichia coli lacZ
strains
. Environmental and Molecular Mutagenesis 38:1, pages 12-18.
Crossref
Crossref
Ole V. Olesen & Kristian Linnet. (2008)
Identification of the human cytochrome P450 isoforms mediating
in vitro N
‐dealkylation of perphenazine
. British Journal of Clinical Pharmacology 50:6, pages 563-571.
Crossref
Crossref