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Xenobiotica
the fate of foreign compounds in biological systems
Volume 31, 2001 - Issue 8-9
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Research Article

Pharmacokinetics and metabolism of a selective PDE5 inhibitor (UK-343,664) in rat and dog

D. K. Walker Department of Drug Metabolism, Pfizer Global Research and Development, Sandwich CT13 9NJ, UK
,
K. C. Beaumont Department of Drug Metabolism, Pfizer Global Research and Development, Sandwich CT13 9NJ, UK
,
P. Comby Centre de Recherche Pfizer, BP 159, 37401 Amboise Cedex, France
,
K. M. Evans Department of Drug Metabolism, Pfizer Global Research and Development, Sandwich CT13 9NJ, UK
,
J. I. Gedge Department of Drug Metabolism, Pfizer Global Research and Development, Sandwich CT13 9NJ, UK
,
R. C. Halliday Department of Drug Metabolism, Pfizer Global Research and Development, Sandwich CT13 9NJ, UK
,
S. J. Roffey Department of Drug Metabolism, Pfizer Global Research and Development, Sandwich CT13 9NJ, UK
&
P. A. Wright Department of Drug Metabolism, Pfizer Global Research and Development, Sandwich CT13 9NJ, UK
 show all
Pages 651-664 | Published online: 22 Sep 2008

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M. C. Dumasia, L. Grainger & E. Houghton. (2002) Biotransformation of cyclizine in greyhounds. 1: identification and analysis of cyclizine and some basic metabolites in canine urine by gas chromatography-mass spectrometry. Xenobiotica 32:9, pages 795-807.
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Articles from other publishers (11)

Elaina M. Kenyon & Michael F. Hughes. 2024. Reference Module in Biomedical Sciences. Reference Module in Biomedical Sciences.
Terry P. Kenakin. 2022. A Pharmacology Primer. A Pharmacology Primer 307 357 .
Terry P. Kenakin. 2019. A Pharmacology Primer. A Pharmacology Primer 245 293 .
E.M. Kenyon & M.F. Hughes. 2018. Comprehensive Toxicology. Comprehensive Toxicology 98 111 .
Olga A.H. Reneerkens, Kris Rutten, Sven Akkerman, Arjan Blokland, Christopher L. Shaffer, Frank S. Menniti, Harry W.M. Steinbusch & Jos Prickaerts. (2012) Phosphodiesterase type 5 (PDE5) inhibition improves object recognition memory: Indications for central and peripheral mechanisms. Neurobiology of Learning and Memory 97:4, pages 370-379.
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Bilal S. Abuasal, Michael B. Bolger, Don K. WalkerAmal Kaddoumi. (2012) In Silico Modeling for the Nonlinear Absorption Kinetics of UK-343,664: A P-gp and CYP3A4 Substrate . Molecular Pharmaceutics 9:3, pages 492-504.
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Barbara Picconi, Vincenza Bagetta, Veronica Ghiglieri, Vincent Paillè, Massimiliano Di Filippo, Valentina Pendolino, Alessandro Tozzi, Carmela Giampà, Francesca R. Fusco, Carmelo Sgobio & Paolo Calabresi. (2011) Inhibition of phosphodiesterases rescues striatal long-term depression and reduces levodopa-induced dyskinesia. Brain 134:2, pages 375-387.
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E.M. Kenyon & M.F. Hughes. 2010. Comprehensive Toxicology. Comprehensive Toxicology 61 74 .
Dmitri Pissarnitski. (2005) Phosphodiesterase 5 (PDE 5) inhibitors for the treatment of male erectile disorder: Attaining selectivity versus PDE6. Medicinal Research Reviews 26:3, pages 369-395.
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Amal Kaddoumi, David Fleisher, Tycho Heimbach, Lilian Y. Li & Susan Cole. (2006) Factors influencing regional differences in intestinal absorption of UK-343,664 in rat: Possible role in dose-dependent pharmacokinetics. Journal of Pharmaceutical Sciences 95:2, pages 435-445.
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Toshihiro Wajima, Kazuya Fukumura, Yoshitaka Yano & Takayoshi Oguma. (2003) Prediction of Human Pharmacokinetics from Animal Data and Molecular Structural Parameters using Multivariate Regression Analysis: Oral Clearance. Journal of Pharmaceutical Sciences 92:12, pages 2427-2440.
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