Xenobiotica, Volume 31, Issue 8-9 (2001)

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Xenobiotica, Volume 31, Issue 8-9 (2001)

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Editorial

Editorial
The Drug Metabolism Discussion Group in 2001
Peter Andrew, Phillip Jeffrey, Simon Roberts, Don Walker & Richard Weaver
Pages: 457-458
Published online: 22 Sep 2008
CitationforThe Drug Metabolism Discussion Group in 2001 | PDF (84.6 KB)
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Comment

Article Commentary
The long, hard road: drug metabolism in the lifetime of the DMDG
D. A. Smith
Pages: 459-467
Published online: 22 Sep 2008
AbstractforThe long, hard road: drug metabolism in the lifetime of the DMDG | References | PDF (190.5 KB)
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Research Article

Article
Role of transport proteins in drug absorption, distribution and excretion
A. Ayrton & P. Morgan
Pages: 469-497
Published online: 22 Sep 2008
AbstractforRole of transport proteins in drug absorption, distribution and excretion | References | PDF (431.3 KB)
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Article
Assessment of drug-drug interactions: concepts and approaches
R. J. Weaver
Pages: 499-538
Published online: 22 Sep 2008
AbstractforAssessment of drug-drug interactions: concepts and approaches | References | PDF (513.1 KB)
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Article
Implications and consequences of enzyme induction on preclinical and clinical drug development
P. D. Worboys & D. J. Carlile
Pages: 539-556
Published online: 22 Sep 2008
AbstractforImplications and consequences of enzyme induction on preclinical and clinical drug development | References | PDF (307 KB)
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Article
High-throughput screening approaches for investigating drug metabolism and pharmacokinetics
S. A. Roberts
Pages: 557-589
Published online: 22 Sep 2008
AbstractforHigh-throughput screening approaches for investigating drug metabolism and pharmacokinetics | References | PDF (437.3 KB)
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Article
Utility of metabolic stability screening: comparison of in vitro and in vivo clearance
S. E. Clarke & P. Jeffrey
Pages: 591-598
Published online: 22 Sep 2008
AbstractforUtility of metabolic stability screening: comparison of in vitro and in vivo clearance | References | PDF (921.2 KB)
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Article
Quantitative analysis of pharmaceuticals in biological fluids using high-performance liquid chromatography coupled to mass spectrometry: a review
R. S. Plumb, G. J. Dear, D. N. Mallett, D. M. Higton, S. Pleasance & R. A. Biddlecombe
Pages: 599-617
Published online: 22 Sep 2008
AbstractforQuantitative analysis of pharmaceuticals in biological fluids using high-performance liquid chromatography coupled to mass spectrometry: a review | References | PDF (609.8 KB)
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Article
Accelerator mass spectrometry (AMS): recent experience of its use in a clinical study and the potential future of the technique
G. Young, W. Ellis, J. Ayrton, E. Hussey & B. Adamkiewicz
Pages: 619-632
Published online: 22 Sep 2008
AbstractforAccelerator mass spectrometry (AMS): recent experience of its use in a clinical study and the potential future of the technique | References | PDF (378.2 KB)
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Article
Pharmacokinetic/pharmacodynamic assessment of the effects of E4031, cisapride, terfenadine and terodiline on monophasic action potential duration in dog
R. Webster, G. Allan, K. Anto-Awuakye, A. Harrison, T. Kidd, D. Leishman, J. Phipps & D. Walker
Pages: 633-650
Published online: 22 Sep 2008
AbstractforPharmacokinetic/pharmacodynamic assessment of the effects of E4031, cisapride, terfenadine and terodiline on monophasic action potential duration in dog | References | PDF (322.6 KB)
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Article
Pharmacokinetics and metabolism of a selective PDE5 inhibitor (UK-343,664) in rat and dog
D. K. Walker, K. C. Beaumont, P. Comby, K. M. Evans, J. I. Gedge, R. C. Halliday, S. J. Roffey & P. A. Wright
Pages: 651-664
Published online: 22 Sep 2008
AbstractforPharmacokinetics and metabolism of a selective PDE5 inhibitor (UK-343,664) in rat and dog | References | PDF (334.6 KB)
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Article
Potential role for P-glycoprotein in the nonproportional pharmacokinetics of UK-343,664 in man
S. Abel, K. C. Beaumont, C. L. Crespi, M. D. Eva, L. Fox, R. Hyland, B. C. Jones, G. J. Muirhead, D. A. Smith, R. F. Venn & D. K. Walker
Pages: 665-676
Published online: 22 Sep 2008
AbstractforPotential role for P-glycoprotein in the nonproportional pharmacokinetics of UK-343,664 in man | References | PDF (294.9 KB)
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Article
Pharmacokinetics of the novel, high-affinity and selective dopamine D3 receptor antagonist SB-277011 in rat, dog and monkey: in vitro/in vivo correlation and the role of aldehyde oxidase
N. E. Austin, S. J. Baldwin, L. Cutler, N. Deeks, P. J. Kelly, M. Nash, C. E. Shardlow, G. Stemp, K. Thewlis, A. Ayrton & P. Jeffrey
Pages: 677-686
Published online: 22 Sep 2008
AbstractforPharmacokinetics of the novel, high-affinity and selective dopamine D3 receptor antagonist SB-277011 in rat, dog and monkey: in vitro/in vivo correlation and the role of aldehyde oxidase | References | PDF (286.2 KB)
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