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Xenobiotica
the fate of foreign compounds in biological systems
Volume 31, 2001 - Issue 8-9
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Research Article

Assessment of drug-drug interactions: concepts and approaches

Pages 499-538 | Published online: 22 Sep 2008

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Ragini Vuppugalla, Yueping Zhang, Shu Chang, A. David Rodrigues & Punit H. Marathe. (2012) Impact of nonlinear midazolam pharmacokinetics on the magnitude of the midazolam-ketoconazole interaction in rats. Xenobiotica 42:11, pages 1058-1068.
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G. G. Gibson, N. J. Plant, K. E. Swales, A. Ayrton & W. El-Sankary. (2002) Receptor-dependent transcriptional activation of cytochrome P4503A genes: induction mechanisms, species differences and interindividual variation in man. Xenobiotica 32:3, pages 165-206.
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HONGBING WANG & WEN XIE. 2022. Drug Metabolism Handbook. Drug Metabolism Handbook 427 464 .
Oliver Scherf-Clavel. (2022) Drug–Drug Interactions With Over-The-Counter Medicines: Mind the Unprescribed. Therapeutic Drug Monitoring 44:2, pages 253-274.
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Anne N. Nafziger & Joseph S. BertinoJrJr. 2018. Drug Interactions in Infectious Diseases: Mechanisms and Models of Drug Interactions. Drug Interactions in Infectious Diseases: Mechanisms and Models of Drug Interactions 259 284 .
Stéphane Mouly, Célia Lloret-Linares, Pierre-Olivier Sellier, Damien Sene & J.-F. Bergmann. (2017) Is the clinical relevance of drug-food and drug-herb interactions limited to grapefruit juice and Saint-John’s Wort?. Pharmacological Research 118, pages 82-92.
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Alexander V. LyubimovStéphane Mouly, Isabel Spriet, Joost Wauters, Pieter Annaert, Christophe Meune & Jean‐François Bergmann. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions 1 48 .
Vaishali Sahasrabudhe, Tong Zhu, Alfin Vaz & Susanna Tse. (2015) Drug Metabolism and Drug Interactions: Potential Application to Antituberculosis Drugs. Journal of Infectious Diseases 211:suppl 3, pages S107-S114.
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Laurent P. Rivory. 2014. Handbook of Anticancer Pharmacokinetics and Pharmacodynamics. Handbook of Anticancer Pharmacokinetics and Pharmacodynamics 351 371 .
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Lijun Zhu, Xiaoshan Yang, Juan Zhou, Lan Tang, Bijun Xia, Ming Hu, Fuyuan Zhou & Zhongqiu Liu. (2013) The exposure of highly toxic aconitine does not significantly impact the activity and expression of cytochrome P450 3A in rats determined by a novel ultra performance liquid chromatography–tandem mass spectrometric method of a specific probe buspirone. Food and Chemical Toxicology 51, pages 396-403.
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Verònica Ventura, Josep Solà, Concepción Peraire, Françoise Brée & Rosendo Obach. (2012) In Vitro Evaluation of the Interaction Potential of Irosustat with Drug-Metabolizing Enzymes. Drug Metabolism and Disposition 40:7, pages 1268-1278.
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Takushi Kanazu, Norihito Sato, Kyoko Kadono, Akira Touchi, Yuri Takeda, Yoshitaka Yamaguchi & Takahiko Baba. (2012) Investigation of drug-drug interaction via mechanism-based inhibition of cytochrome P450 3A by macrolides in dexamethasone-treated female rats. Biopharmaceutics & Drug Disposition 33:4, pages 195-206.
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Sheila Annie Peters. 2012. Physiologically‐Based Pharmacokinetic (PBPK) Modeling and Simulations. Physiologically‐Based Pharmacokinetic (PBPK) Modeling and Simulations 183 207 .
T.-M. Hu & W. L. Hayton. (2011) Architecture of the drug-drug interaction network. Journal of Clinical Pharmacy and Therapeutics 36:2, pages 135-143.
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Anne N. Nafziger, Joseph S. BertinoJr.Jr. & Joseph S. BertinoJr.Jr.. 2011. Drug Interactions in Infectious Diseases. Drug Interactions in Infectious Diseases 631 653 .
Cuyue Tang & Thomayant Prueksaritanont. (2010) Use of In Vivo Animal Models to Assess Pharmacokinetic Drug-Drug Interactions. Pharmaceutical Research 27:9, pages 1772-1787.
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Hongbing Wang & wen xie. 2010. Pharmaceutical Sciences Encyclopedia. Pharmaceutical Sciences Encyclopedia 1 30 .
Frédéric Y. Bois. (2010) Physiologically Based Modelling and Prediction of Drug Interactions. Basic & Clinical Pharmacology & Toxicology 106:3, pages 154-161.
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Thorsten Lehr, Alexander Staab, Dirk Trommeshauser, Hans Guenter Schaefer & Charlotte Kloft. (2010) Semi-Mechanistic Population Pharmacokinetic Drug-Drug Interaction Modelling of a Long Half-Life Substrate and Itraconazole. Clinical Pharmacokinetics 49:1, pages 53-66.
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Thomayant Prueksaritanont. 2010. Enzyme- and Transporter-Based Drug-Drug Interactions. Enzyme- and Transporter-Based Drug-Drug Interactions 283 297 .
Xiangming Guan. 2009. Evaluation of Drug Candidates for Preclinical Development. Evaluation of Drug Candidates for Preclinical Development 109 133 .
Tonika Bohnert & Liang‐Shang Gan. 2009. Enzyme Inhibition in Drug Discovery and Development. Enzyme Inhibition in Drug Discovery and Development 91 176 .
Trevor N. Johnson, Thomas Kerbusch, Barry Jones, Geoffrey T. Tucker, Amin Rostami‐Hodjegan & Peter A. Milligan. (2009) Assessing the efficiency of mixed effects modelling in quantifying metabolism based drug–drug interactions: using in vitro data as an aid to assess study power . Pharmaceutical Statistics 8:3, pages 186-202.
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Stéphane Mouly, Christophe Meune & Jean-François Bergmann. (2009) Mini-series: I. Basic science. Uncertainty and inaccuracy of predicting CYP-mediated in vivo drug interactions in the ICU from in vitro models: focus on CYP3A4. Intensive Care Medicine 35:3, pages 417-429.
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Hongbing Wang & Wen Xie. 2009. Drug Metabolism Handbook. Drug Metabolism Handbook 449 478 .
Jinhan He & Wen Xie. 2009. 87 116 .
Stefanie D. Krämer & Bernard Testa. (2008) The Biochemistry of Drug Metabolism – An Introduction. Chemistry & Biodiversity 5:12, pages 2465-2578.
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Jie Zhou, Yonggong Zhai & Wen Xie. 2008. Antitargets. Antitargets 293 316 .
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Thomayant Prueksaritanont, Chunze Li, Cuyue Tang, Yuhsin Kuo, Kristie Strong-Basalyga & Brian Carr. (2006) Rifampin Induces the in Vitro Oxidative Metabolism, but Not the in Vivo Clearance of Diclofenac in Rhesus Monkeys. Drug Metabolism and Disposition 34:11, pages 1806-1810.
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Bernard Testa & Stefanie D. Krämer. (2006) The Biochemistry of Drug Metabolism – An Introduction. Chemistry & Biodiversity 3:10, pages 1053-1101.
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Thomayant Prueksaritanont, Yuhsin Kuo, Cuyue Tang, Chunze Li, Yue Qiu, Bing Lu, Kristie Strong-Basalyga, Karen Richards, Brian Carr & Jiunn H. Lin. (2006) In Vitro and in Vivo CYP3A64 Induction and Inhibition Studies in Rhesus Monkeys: A Preclinical Approach for CYP3A-Mediated Drug Interaction Studies. Drug Metabolism and Disposition 34:9, pages 1546-1555.
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Delphine Jouin, Nadège Blanchard, Eliane Alexandre, Frédéric Delobel, Pascale David-Pierson, Thierry Lavé, Daniel Jaeck, Lysiane Richert & Philippe Coassolo. (2006) Cryopreserved human hepatocytes in suspension are a convenient high throughput tool for the prediction of metabolic clearance. European Journal of Pharmaceutics and Biopharmaceutics 63:3, pages 347-355.
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Stuart McLean & Alan J. Duncan. (2006) Pharmacological Perspectives on the Detoxification of Plant Secondary Metabolites: Implications for Ingestive Behavior of Herbivores. Journal of Chemical Ecology 32:6, pages 1213-1228.
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Gregor Zlokarnik, Peter D.J. Grootenhuis & John B. Watson. (2005) High throughput P450 inhibition screens in early drug discovery. Drug Discovery Today 10:21, pages 1443-1450.
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Marcella Martignoni, Ruben de Kanter, Anna Moscone, Pietro Grossi & Mario Monshouwer. (2004) Lack of strain-related differences in drug metabolism and efflux transporter characteristics between CD-1 and athymic nude mice. Cancer Chemotherapy and Pharmacology 55:2, pages 129-135.
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S. Polak, J. Brandys & A. Mendyk. (2005) Neural System for in silico Drug-Drug Interaction Screening. Neural System for in silico Drug-Drug Interaction Screening.
Haibiao Gong, Michael W. Sinz, Yan Feng, Taosheng Chen, Raman Venkataramanan & Wen Xie. 2005. Phase II Conjugation Enzymes and Transport Systems. Phase II Conjugation Enzymes and Transport Systems 598 618 .
Adam G. STAINESPavel SINDELAR, Michael W. H. COUGHTRIEBrian BURCHELL. (2004) Farnesol is glucuronidated in human liver, kidney and intestine in vitro , and is a novel substrate for UGT2B7 and UGT1A1 . Biochemical Journal 384:3, pages 637-645.
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D. K. Walker. (2004) The use of pharmacokinetic and pharmacodynamic data in the assessment of drug safety in early drug development. British Journal of Clinical Pharmacology 58:6, pages 601-608.
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Stanislav Micuda, Lucie Mundlova, Eva Anzenbacherova, Pavel Anzenbacher, Jaroslav Chladek, Leos Fuksa & Jirina Martinkova. (2004) Inhibitory effects of memantine on human cytochrome P450 activities: prediction of in vivo drug interactions. European Journal of Clinical Pharmacology 60:8, pages 583-589.
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Tommy B. Andersson, Eva Bredberg, Hans Ericsson & Helena Sjöberg. (2004) AN EVALUATION OF THE IN VITRO METABOLISM DATA FOR PREDICTING THE CLEARANCE AND DRUG-DRUG INTERACTION POTENTIAL OF CYP2C9 SUBSTRATES. Drug Metabolism and Disposition 32:7, pages 715-721.
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Hannah M. Jones, David Hallifax & J. Brian Houston. (2004) QUANTITATIVE PREDICTION OF THE IN VIVO INHIBITION OF DIAZEPAM METABOLISM BY OMEPRAZOLE USING RAT LIVER MICROSOMES AND HEPATOCYTES. Drug Metabolism and Disposition 32:5, pages 572-580.
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Mohamed El Mouelhi, Dan J. Worley, Barbara Kuzmak, Anthony J. Destefano & Gary A. Thompson. (2013) Influence of Azimilide on CYP2C19‐Mediated Metabolism. The Journal of Clinical Pharmacology 44:4, pages 373-378.
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Hiroyuki YAMAZAKI, Hideki FUJINO, Mizuho KANAZAWA, Taro TAMAKI, Fumiyasu SATO, Mikio SUZUKI & Masaki KITAHARA. (2004) Pharmacological and pharmacokinetic features and clinical effects of pitavastatin (Livalo Tablet®). Folia Pharmacologica Japonica 123:5, pages 349-362.
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Laurent P. Rivory. 2004. Handbook of Anticancer Pharmacokinetics and Pharmacodynamics. Handbook of Anticancer Pharmacokinetics and Pharmacodynamics 245 266 .
Michael W. Sinz. 2004. Applications of Pharmacokinetic Principles in Drug Development. Applications of Pharmacokinetic Principles in Drug Development 75 132 .
Pierre Kremers. (2003) In vitro Tests for Predicting Drug‐Drug Interactions: The Need for Validated Procedures . Pharmacology & Toxicology 91:5, pages 209-217.
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Carl J. Fichtenbaum & John G. Gerber. (2002) Interactions Between Antiretroviral Drugs and Drugs Used for the Therapy of the Metabolic Complications Encountered During HIV Infection. Clinical Pharmacokinetics 41:14, pages 1195-1211.
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Takashi Matsubara. (2002) Safety Evaluation and Drug Development based on Biological Fate of Drugs —Efforts Made to Overcome Drug Interaction in Drug Development—. Drug Metabolism and Pharmacokinetics 17:5, pages 379-394.
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Tamihide Matsunaga, Shigeru Ohmori, Mikiko Ishida, Yasuko Sakamoto, Hiromitsu Nakasa & Mitsukazu Kitada. (2002) Molecular Cloning of Monkey CYP2C43 cDNA and Expression in Yeast. Drug Metabolism and Pharmacokinetics 17:2, pages 117-124.
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