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Xenobiotica
the fate of foreign compounds in biological systems
Volume 31, 2001 - Issue 11
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Research Article

Preclinical pharmacokinetics of SB-203580, a potent inhibitor of p38 mitogen-activated protein kinase

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Pages 783-797 | Published online: 22 Sep 2008

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Bin Sun, Hong Zhang, Yue Dong, Liyu Zhao, Jun Han & Min Liu. (2019) Evaluation of the combination mode and features of p38 MAPK inhibitors: construction of different pharmacophore models and molecular docking. Molecular Simulation 45:12, pages 975-984.
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Sarawut Kumphune, Sirirat Surinkaew, Siriporn C. Chattipakorn & Nipon Chattipakorn. (2015) Inhibition of p38 MAPK activation protects cardiac mitochondria from ischemia/reperfusion injury. Pharmaceutical Biology 53:12, pages 1831-1841.
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Tae Kyung HYUN, Libor HAVLICEK, Miroslav STRNAD & Thomas ROITSCH. (2010) Trisubstituted Purines Are Useful Tools for Developing Potent Plant Mitogen-Activated Protein Kinase Inhibitors. Bioscience, Biotechnology, and Biochemistry 74:3, pages 553-557.
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Articles from other publishers (14)

MirHojjat Khorasanizadeh, Mahsa Eskian, Erwin W. Gelfand & Nima Rezaei. (2017) Mitogen-activated protein kinases as therapeutic targets for asthma. Pharmacology & Therapeutics 174, pages 112-126.
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Kazuhiko Shirota, Makoto Kaneko, Makoto Sasaki, Kouichi Minato, Akira Fujikata, Shuji Ohta, Akihiro Hisaka & Hiroshi Suzuki. (2015) Analysis of the Disposition of a Novel p38 MAPK Inhibitor, AKP-001, and Its Metabolites in Rats with a Simple Physiologically Based Pharmacokinetic Model. Drug Metabolism and Disposition 43:2, pages 217-226.
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Sirirat Surinkaew, Sarawut Kumphune, Siriporn Chattipakorn & Nipon Chattipakorn. (2013) Inhibition of p38 MAPK During Ischemia, But Not Reperfusion, Effectively Attenuates Fatal Arrhythmia in Ischemia/Reperfusion Heart. Journal of Cardiovascular Pharmacology 61:2, pages 133-141.
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María Dolores Martín-de-Saavedra, Laura del Barrio, Noelia Cañas, Javier Egea, Silvia Lorrio, Eulàlia Montell, Josep Vergés, Antonio G. García & Manuela G. López. (2011) Chondroitin sulfate reduces cell death of rat hippocampal slices subjected to oxygen and glucose deprivation by inhibiting p38, NFκB and iNOS. Neurochemistry International 58:6, pages 676-683.
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Jason K. Stuart, Steven P. Bisch, Matilde Leon-Ponte, Jin Hayatsu, Delfina M. Mazzuca, Saman Maleki Vareki & S.M. Mansour Haeryfar. (2010) Negative modulation of invariant natural killer T cell responses to glycolipid antigens by p38 MAP kinase. International Immunopharmacology 10:9, pages 1068-1076.
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Santos M. Nicolau, Javier Egea, Manuela G. López & Antonio G. García. (2010) Mitochondrial Na+/Ca2+ exchanger, a new target for neuroprotection in rat hippocampal slices. Biochemical and Biophysical Research Communications 400:1, pages 140-144.
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Shomita S. Mathew, Megan P. Della Selva & April D. Burch. (2009) Modification and Reorganization of the Cytoprotective Cellular Chaperone Hsp27 during Herpes Simplex Virus Type 1 Infection. Journal of Virology 83:18, pages 9304-9312.
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Jorge H. Limón-Pacheco, Norma A. Hernández, María L. Fanjul-Moles & María E. Gonsebatt. (2007) Glutathione depletion activates mitogen-activated protein kinase (MAPK) pathways that display organ-specific responses and brain protection in mice. Free Radical Biology and Medicine 43:9, pages 1335-1347.
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Bernd Kammerer, Holger Scheible, Wolfgang Albrecht, Christoph H. Gleiter & Stefan Laufer. (2007) Pharmacokinetics of ML3403 ({4-[5-(4-Fluorophenyl)-2-methylsulfanyl-3 H -imidazol-4-yl]-pyridin-2-yl}-(1-phenylethyl)-amine), a 4-Pyridinylimidazole-Type p38 Mitogen-Activated Protein Kinase Inhibitor . Drug Metabolism and Disposition 35:6, pages 875-883.
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Marta Massip-Salcedo, Araní Casillas-Ramirez, Rosah Franco-Gou, Ramón Bartrons, Ismail Ben Mosbah, Anna Serafin, Joan Roselló-Catafau & Carmen Peralta. (2006) Heat Shock Proteins and Mitogen-activated Protein Kinases in Steatotic Livers Undergoing Ischemia-Reperfusion: Some Answers. The American Journal of Pathology 168:5, pages 1474-1485.
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V. K. Yadav & R. Medhamurthy. (2006) Dynamic Changes in Mitogen-Activated Protein Kinase (MAPK) Activities in the Corpus Luteum of the Bonnet Monkey (Macaca radiata) during Development, Induced Luteolysis, and Simulated Early Pregnancy: A Role for p38 MAPK in the Regulation of Luteal Function. Endocrinology 147:4, pages 2018-2027.
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I Ringshausen, T Dechow, F Schneller, K Weick, M Oelsner, C Peschel & T Decker. (2004) Constitutive activation of the MAPkinase p38 is critical for MMP-9 production and survival of B-CLL cells on bone marrow stromal cells. Leukemia 18:12, pages 1964-1970.
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Keith W. Ward & Leonard M. Azzarano. (2004) Preclinical Pharmacokinetic Properties of the P-Glycoprotein Inhibitor GF120918A (HCl salt of GF120918, 9,10-Dihydro-5-methoxy-9-oxo- N -[4-[2-(1,2,3,4-tetrahydro-6,7-dimethoxy-2-isoquinolinyl)ethyl]phenyl]-4-acridine-carboxamide) in the Mouse, Rat, Dog, and Monkey . Journal of Pharmacology and Experimental Therapeutics 310:2, pages 703-709.
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Robert Newton & Neil Holden. (2003) Inhibitors of p38 Mitogen-Activated Protein Kinase. BioDrugs 17:2, pages 113-129.
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