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Xenobiotica
the fate of foreign compounds in biological systems
Volume 32, 2002 - Issue 2
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Research Article

Absorption, metabolism and excretion of 4-chloro-2-methylphenoxyacetic acid (MCPA) in rat and dog

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Pages 153-163 | Published online: 22 Sep 2008

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Alex Gledhill, Rachael Bowen, Michael Bartels, Andrew Bond, Git Chung, Colin Brown, Keith Pye & Tarang Vora. (2022) The chlorophenoxy herbicide MCPA: a mechanistic basis for the observed differences in toxicological profile in humans and rats versus dogs. Xenobiotica 52:5, pages 498-510.
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B. Van Ravenzwaay, T. D. Hardwick, D. Needham, S. Pethen & G. J. Lappin. (2003) Comparative metabolism of 2,4-dichlorophenoxyacetic acid (2,4-D) in rat and dog. Xenobiotica 33:8, pages 805-821.
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Articles from other publishers (13)

Christian Skonberg & Jørgen Olsen. (2023) A review of the synthesis, bioanalysis, and chemical reactivity of xenobiotic acyl-coenzyme a thioesters. Medicinal Chemistry Research.
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Wenjing Song, Yanjian Wan, Ying Jiang, Zhengdan Liu & Qi Wang. (2021) Urinary concentrations of 2,4-D in repeated samples from 0–7 year old healthy children in central and south China. Chemosphere 267, pages 129225.
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Klintean Wunnapuk, Xin Liu, Glenda C. Gobe, Zoltan H. Endre, Philip W. Peake, Jeffrey E. Grice, Michael S. Roberts & Nicholas A. Buckley. (2014) Kidney biomarkers in MCPA-induced acute kidney injury in rats: Reduced clearance enhances early biomarker performance. Toxicology Letters 225:3, pages 467-478.
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Barbara A. Wetmore, John F. Wambaugh, Stephen S. Ferguson, Lili Li, Harvey J. ClewellIIIIII, Richard S. Judson, Kimberly Freeman, Wenjun Bao, Mark A. Sochaski, Tzu-Ming Chu, Michael B. Black, Eric Healy, Brittany Allen, Melvin E. Andersen, Russell D. Wolfinger & Russell S. Thomas. (2013) Relative Impact of Incorporating Pharmacokinetics on Predicting In Vivo Hazard and Mode of Action from High-Throughput In Vitro Toxicity Assays. Toxicological Sciences 132:2, pages 327-346.
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Katherine von Stackelberg. (2013) A Systematic Review of Carcinogenic Outcomes and Potential Mechanisms from Exposure to 2,4-D and MCPA in the Environment. Journal of Toxicology 2013, pages 1-53.
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B. van Ravenzwaay, M. Herold, H. Kamp, M.D. Kapp, E. Fabian, R. Looser, G. Krennrich, W. Mellert, A. Prokoudine, V. Strauss, T. Walk & J. Wiemer. (2012) Metabolomics: A tool for early detection of toxicological effects and an opportunity for biology based grouping of chemicals—From QSAR to QBAR. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 746:2, pages 144-150.
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Osamu Kimura, Kensuke Tsukagoshi, Moriaki Hayasaka & Tetsuya Endo. (2012) Transepithelial Transport of 4‐Chloro‐2‐Methylphenoxyacetic Acid (MCPA) across Human Intestinal C aco‐2 Cell Monolayers . Basic & Clinical Pharmacology & Toxicology 110:6, pages 530-536.
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Osamu Kimura, Kensuke Tsukagoshi, Moriaki Hayasaka & Tetsuya Endo. (2011) Uptake of triclopyr (3,5,6-trichloro-2-pyridinyloxyacetic acid) and dicamba (3,6-dichloro-2-methoxybenzoic acid) from the apical membranes of the human intestinal Caco-2 cells. Archives of Toxicology 86:1, pages 55-61.
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Osamu Kimura, Yuichi Kotaki, Naoya Hamaue, Koichi Haraguchi & Tetsuya Endo. (2011) Transcellular transport of domoic acid across intestinal Caco-2 cell monolayers. Food and Chemical Toxicology 49:9, pages 2167-2171.
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Bernard Testa & Stefanie D. Krämer. (2008) The Biochemistry of Drug Metabolism – An Introduction. Chemistry & Biodiversity 5:11, pages 2171-2336.
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Osamu Kimura, Kensuke Tsukagoshi & Tetsuya Endo. (2008) Uptake of 4-chloro-2-methylphenoxyacetic acid (MCPA) from the apical membrane of Caco-2 cells by the monocarboxylic acid transporter. Toxicology and Applied Pharmacology 227:3, pages 325-330.
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Christian H. Lindh, Margareta Littorin, Åsa Amilon & Bo A. G. Jönsson. (2008) Analysis of phenoxyacetic acid herbicides as biomarkers in human urine using liquid chromatography/triple quadrupole mass spectrometry. Rapid Communications in Mass Spectrometry 22:2, pages 143-150.
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B. van Ravenzwaay, Geoff Pigott & E. Leibold. (2004) Absorption, distribution, metabolism and excretion of 4-chloro-2-methylphenoxyacetic acid (MCPA) in rats. Food and Chemical Toxicology 42:1, pages 115-125.
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