Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 32, 2002 - Issue 2
93
Views
15
CrossRef citations to date
0
Altmetric
Research Article

Absorption, metabolism and excretion of 4-chloro-2-methylphenoxyacetic acid (MCPA) in rat and dog

, , , &
Pages 153-163 | Published online: 22 Sep 2008

References

  • BELLET, E. M., VAN RAVENZWAAY, B., PIGOTT, G. and LEEMING, N., 1999, Chronic dietary toxicity and oncogenicity evaluation of MCPA in rodents. Regulatory Toxicology and Pharmacology, 30, 223–232.
  • BRAUNLICH, H., BERNHARDT, H. and BERNHARDT, I., 1989, Renal handling of 2-methy1-4-chlorophenoxyacetic acid (MCPA) in rats. Journal of Applied Toxicology, 9, 255–258.
  • CHANG, J., 1992, Dissociation of MCPA-DMA in water. Unpublished; DP Barcode D182938, Battelle, Columbus, OH.
  • CHERKOFSKY, S. C., 1995, 1-Aminocyclopanecarboxylic acid: mouse to man interspecies pharmacokinetic comparisons and allometric relationships. Journal of Pharmaceutical Science, 84, 1231–1235.
  • EMUDIANUGHE, T. S., CALDWELL, J., SINCLAIR, K. A. and SMITH, R. L., 1983, Species differences in the metabolic conjugation of colfibric acid and colfibrate in laboratory animals and man. Drug Metabolism and Disposition, 11, 97–102.
  • ERNE, K., 1966, Distribution and elimination of chlorinated phenoxy-acetic acids in animals. Ada Veterinica Scandinavka, 7, 240–256.
  • FERNANDO, T. R. and KOK, R., 1993, Hydrolysis of [14C]-MCPA-2-EHE to MCPA-acid in a soil/water system. Unpublished Study No. 5C920064; DP Barcode D189442, Battelle, Columbus, OH.
  • GELBKE, H. P. and HELLWIG, J., 1986, Acute inhalation toxicity LCso 4 hours (rat) dust aerosol study of
  • MCPA. Unpublished, BASF Aktiengesellschaft, Ludwigshafen am Rhein, Germany.
  • HELLWIG, J., DECKARDT, K., HASENOEHRL, J. and HILDEBRAND, B. 1986. Report on the study of the toxicity of MCPA in Beagle dogs after 12-month administration in the diet. Unpublished, BASF Aktiengesellschaft, Ludwigshafen am Rhein, Germany.
  • HOOK, J. B., CARDONA, R., OSBORN, J. L. and BAILE, M. D., 1976, The renal handling of 2,4,5-trichlorophenoxy-acetic acid in the dog. Food and Cosmetic Toxicology, 14, 19–23.
  • KIRSCH, P. and HILDEBRAND, B., 1983a, Report on the study of the acute oral toxicity in rats of MCPA. Unpublished, BASF Aktiengesellschaft, Ludwigshafen am Rhein, Germany.
  • KIRSCH, P. and HILDEBRAND, B., 1983b, Report on the study of the acute dermal toxicity in rats of MCPA. Unpublished, BASF Aktiengesellschaft, Ludwigshafen am Rhein, Germany.
  • KIRSCH, P. and HILDEBRAND, B., 1 983c, Report on the study of the irritation to the intact and abraided dorsal skin of the white rabbit based on draize of MCPA. Unpublished, BASF Aktiengesellschaft, Ludwigshafen am Rhein, Germany.
  • KIRSCH, P. and HILDEBRAND, B., 1983d, Report on the study of the irritation to the eye of the white rabbit based on draize of MCPA. Unpublished, BASF Aktiengesellschaft, Ludwigshafen am Rhein, Germany.
  • LA I., 1993, Hydrolysis of [14C]-MCPA-2-EHE in buffered aqueous solutions. Unpublished Study No. SC910087, DP Barcode D189760; Battelle, Columbus, OH.
  • MCPA TASK FORCE III, 2002, Unpublished document. c/o the Technical Chairman, 7474 Creedmoor Rd., N.C., 27613, USA.
  • MIKI, S., MOSBACH, H., COHEN, B. I., MIKAMI, T., INFANTE, R., AVYAD, N. and MCSHERRY, C. K., 1993, Metabolism of 0-muricholic acid in the hamster and prairie dog. Journal of Lipid Research, 34, 1709–1716.
  • MILLER, J. H. and MORRIS, L. L., 1982, Mechanisms of organic acid and monosaccharide transport in the kidney of the brush-tailed possum. Australian Journal of Biological Science, 35, 363–372.
  • PIPER, W. N., ROSE, J. Q., LENG, M. L. and GEHRING, P. J., 1973, The fate of 2,4,5-trichlorophenoxy acetic acid following oral administration to rats and dogs. Toxicology and Applied Pharmacology, 26, 339–401.
  • REUZEL, P. G. J., VAN DER HEIMEN, C. A. and VAN OOSTRUM, E. C. M., 1980, Subchronic (13-week) oral toxicity study of MCPA in Beagle dogs. Unpublished; TNO Central Institute for Nutrition and Food Research, Zeist, The Netherlands.
  • TIMCHALK, C. and NOLAN, R. L., 1997, Pharmacokinetics of tricopyr in the beagle dog and rhesus monkey: perspective on the reduced capacity of dogs to excrete this organic acid relative to the rat. Toxicology and Applied Pharmacology, 144, 268–278

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.