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Behzad Elyasi, Mohsen Zhaleh, Komail Amini, Hossein Zhaleh, Masoumeh Khanahmadi, Rouholah Moradi & Nastaran Kazemi. (2020) Chemical Characterization and Suppressor Potent of Juglans regia Essential Oil on Tramadol-Induced Cell Death. Journal of Essential Oil Bearing Plants 23:4, pages 849-861.
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Joomi Lee, Hee-Doo Yoo, Jung-Woo Bae, Sooyeun Lee & Kwang-Hee Shin. (2019) Population pharmacokinetic analysis of tramadol and O-desmethyltramadol with genetic polymorphism of CYP2D6. Drug Design, Development and Therapy 13, pages 1751-1761.
Read now
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Joana Barbosa, Juliana Faria, Odília Queirós, Roxana Moreira, Félix Carvalho & Ricardo Jorge Dinis-Oliveira. (2016) Comparative metabolism of tramadol and tapentadol: a toxicological perspective. Drug Metabolism Reviews 48:4, pages 577-592.
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Xiao Zhou & Ji Liu. (2015) Fluorescence detection of tramadol in healthy Chinese volunteers by high-performance liquid chromatography and bioequivalence assessment. Drug Design, Development and Therapy 9, pages 1225-1231.
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Nuggehally R. Srinivas. (2015) Differential Consequences of Tramadol in Overdosing: Dilemma of a Polymorphic Cytochrome P450 2D6–Mediated Substrate. Journal of Pain & Palliative Care Pharmacotherapy 29:3, pages 272-275.
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Joseph V Pergolizzi$suffix/text()$suffix/text(), Robert Taylor$suffix/text()$suffix/text() & Robert B Raffa. (2011) Extended-release formulations of tramadol in the treatment of chronic pain. Expert Opinion on Pharmacotherapy 12:11, pages 1757-1768.
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N. D. Forsberg, R. Rodriguez-Proteau, L. Ma, J. Morré, J. M. Christensen, C. S. Maier, J. J. Jenkins & K. A. Anderson. (2011) Organophosphorus pesticide degradation product in vitro metabolic stability and time-course uptake and elimination in rats following oral and intravenous dosing. Xenobiotica 41:5, pages 422-429.
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Consalvo Mattia & Flaminia Coluzzi. (2006) Once-daily tramadol in rheumatological pain. Expert Opinion on Pharmacotherapy 7:13, pages 1811-1823.
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W. N. Wu, L. A. McKown, E. E. Codd & R. B. Raffa. (2006) Metabolism of two analgesic agents, tramadol-n-oxide and tramadol, in specific pathogen-free and axenic mice. Xenobiotica 36:6, pages 551-565.
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Articles from other publishers (84)
Mahmood Mahajna, Rami Abu Fanne, Mahmoud Odeh, Matitiahu Berkovitch, Elias Tannous, Sara Eyal, Shlomo Vinker, Ilan Green & Ilan Matok. (2024) Influence of cytochrome P450 2D6*10/*10 genotype on the risk for tramadol associated adverse effects: a retrospective cohort study. Frontiers in Pharmacology 15.
Crossref
Crossref
Su-su Bao, Peng-fei Tang, Nan-yong Gao, Zhong-xiang Xiao, Jian-chang Qian, Long Zheng, Guo-xin Hu & Huan-hai Xu. (2023) Effect of apatinib on the pharmacokinetics of tramadol and O-desmethyltramadol in rats. PeerJ 11, pages e16051.
Crossref
Crossref
J. Barakji, S. K. Korang, J. B. Feinberg, M. Maagaard, O. Mathiesen, C. Gluud & J. C. Jakobsen. (2023) Tramadol for chronic pain in adults: protocol for a systematic review with meta-analysis and trial sequential analysis of randomised clinical trials. Systematic Reviews 12:1.
Crossref
Crossref
Varsha Chauhan, Manu Sharma, Abhishek Tiwari, Varsha Tiwari, Manish Kumar, Tarun Virmani, Girish Kumar, Najla Altwaijry, Omkulthom Al kamaly, Asmaa Saleh & Abdulsalam Alhalmi. (2023) Development and Validation of Liquid Chromatography-Tandem Mass Spectrometry Method for Simultaneous Determination of Tramadol and Its Phase I and II Metabolites in Human Urine. Separations 10:6, pages 365.
Crossref
Crossref
R. Manasfi, D. Tadić, O. Gomez, S. Perez & S. Chiron. (2022) Persistence of N-oxides transformation products of tertiary amine drugs at lab and field studies.. Chemosphere 309, pages 136661.
Crossref
Crossref
Romain Magny, Nicolas Auzeil, Bertrand Lefrère, Bruno Mégarbane, Pascal Houzé & Laurence Labat. (2022) Molecular Network-Based Identification of Tramadol Metabolites in a Fatal Tramadol Poisoning. Metabolites 12:7, pages 665.
Crossref
Crossref
O. Yoo, E.K.Y. Tang, M.N. Nguyen, S. Salman, A.J. Hua, B.S. von Ungern Sternberg & L.Y. Lim. (2021) HPLC-UV assay of tramadol and O-desmethyltramadol in human plasma containing other drugs potentially co-administered to participants in a paediatric population pharmacokinetic study. Journal of Chromatography B 1184, pages 122971.
Crossref
Crossref
Samaneh Nakhaee, Christopher Hoyte, Richard C. Dart, Masoumeh Askari, Roland J. Lamarine & Omid Mehrpour. (2021) A review on tramadol toxicity: mechanism of action, clinical presentation, and treatment. Forensic Toxicology 39:2, pages 293-310.
Crossref
Crossref
Douglas M. McMillan, Ahmed A. El-Sherbeni, Janielle Richards & Rachel F. Tyndale. (2020) Centrally administered CYP2D inhibitors increase oral tramadol analgesia in rats. Brain Research Bulletin 164, pages 400-406.
Crossref
Crossref
Amitava Dasgupta. 2020. Fighting the Opioid Epidemic. Fighting the Opioid Epidemic
17
41
.
John A. Zebala, Shawn L. Searle, Lynn R. Webster, Matt S. Johnson, Aaron D. Schuler, Dean Y. Maeda & Stuart J. Kahn. (2019) Desmetramadol Has the Safety and Analgesic Profile of Tramadol Without Its Metabolic Liabilities: Consecutive Randomized, Double-Blind, Placebo- and Active Comparator-Controlled Trials. The Journal of Pain 20:10, pages 1218-1235.
Crossref
Crossref
Valeria Romanucci, Antonietta Siciliano, Emilia Galdiero, Marco Guida, Giovanni Luongo, Renato Liguori, Giovanni Di Fabio, Lucio Previtera & Armando Zarrelli. (2019) Disinfection by-Products and Ecotoxic Risk Associated with Hypochlorite Treatment of Tramadol. Molecules 24:4, pages 693.
Crossref
Crossref
Joseph Massarella, Jay Ariyawansa, Jaya Natarajan, Stephan Francke, Thomas Murtaugh, Byron DeLemos, Subusola Vaughan & Sergio Fonseca. (2018) Tramadol Hydrochloride at Steady State Lacks Clinically Relevant QTc Interval Increases in Healthy Adults. Clinical Pharmacology in Drug Development 8:1, pages 95-106.
Crossref
Crossref
Ahsan F. Bairam, Mohammed I. Rasool, Fatemah A. Alherz, Maryam S. Abunnaja, Amal A. El Daibani, Katsuhisa Kurogi & Ming-Cheh Liu. (2018) Effects of human SULT1A3/SULT1A4 genetic polymorphisms on the sulfation of acetaminophen and opioid drugs by the cytosolic sulfotransferase SULT1A3. Archives of Biochemistry and Biophysics 648, pages 44-52.
Crossref
Crossref
Rumi Tanoue, Luigi Margiotta-Casaluci, Belinda Huerta, Tamsin J. Runnalls, Kei Nomiyama, Tatsuya Kunisue, Shinsuke Tanabe & John P. Sumpter. (2017) Uptake and Metabolism of Human Pharmaceuticals by Fish: A Case Study with the Opioid Analgesic Tramadol. Environmental Science & Technology 51:21, pages 12825-12835.
Crossref
Crossref
Byron DeLemos, Henry M. Richards, Joris Vandenbossche, Jay Ariyawansa, Jaya Natarajan, Binu Alexander, Tage Ramakrishna, Thomas Murtaugh & Hans‐Jürgen Stahlberg. (2017) Safety, Tolerability, and Pharmacokinetics of Therapeutic and Supratherapeutic Doses of Tramadol Hydrochloride in Healthy Adults: A Randomized, Double‐Blind, Placebo‐Controlled Multiple‐Ascending‐Dose Study. Clinical Pharmacology in Drug Development 6:6, pages 592-603.
Crossref
Crossref
Mohammed I. Rasool, Ahsan F. Bairam, Katsuhisa Kurogi & Ming-Cheh Liu. (2017) On the sulfation of O -desmethyltramadol by human cytosolic sulfotransferases. Pharmacological Reports 69:5, pages 953-958.
Crossref
Crossref
Nesreen Moustafa Omar & Mohammed Amin Mohammed. (2017) The impact of black seed oil on tramadol-induced hepatotoxicity: Immunohistochemical and ultrastructural study. Acta Histochemica 119:5, pages 543-554.
Crossref
Crossref
Behjat Sheikholeslami, Mahdi Gholami, Hoda Lavasani & Mohammadreza Rouini. (2016) Evaluation of the route dependency of the pharmacokinetics and neuro-pharmacokinetics of tramadol and its main metabolites in rats. European Journal of Pharmaceutical Sciences 92, pages 55-63.
Crossref
Crossref
Ibrahim A. Abdel-Hamid, Karl-Erik Andersson, Marcel D. Waldinger & Tarek H. Anis. (2016) Tramadol Abuse and Sexual Function. Sexual Medicine Reviews 4:3, pages 235-246.
Crossref
Crossref
Wataru Matsuura, Erika Kageyama, Shinichi Harada & Shogo Tokuyama. (2016) Unique action mechanisms of tramadol in global cerebral ischemia-induced mechanical allodynia. NeuroReport 27:9, pages 699-704.
Crossref
Crossref
Μ. Αntonopoulou, D. Hela & I. Konstantinou. (2016) Photocatalytic degradation kinetics, mechanism and ecotoxicity assessment of tramadol metabolites in aqueous TiO 2 suspensions. Science of The Total Environment 545-546, pages 476-485.
Crossref
Crossref
H. K. Knych, E. P. Steffey, A. M. White & D. S. McKemie. (2014)
Effects of age on the pharmacokinetics of tramadol and its active metabolite,
O
‐desmethyltramadol following intravenous administration to foals
. Equine Veterinary Journal 48:1, pages 65-71.
Crossref
Crossref
Behjat Sheikholeslami, Bardia Jamali & Mohammadreza Rouini. 2016. Neuropathology of Drug Addictions and Substance Misuse. Neuropathology of Drug Addictions and Substance Misuse
407
416
.
Huybrecht T’jollyn, Jan Snoeys, An Vermeulen, Robin Michelet, Filip Cuyckens, Geert Mannens, Achiel Van Peer, Pieter Annaert, Karel Allegaert, Jan Van Bocxlaer & Koen Boussery. (2015) Physiologically Based Pharmacokinetic Predictions of Tramadol Exposure Throughout Pediatric Life: an Analysis of the Different Clearance Contributors with Emphasis on CYP2D6 Maturation. The AAPS Journal 17:6, pages 1376-1387.
Crossref
Crossref
Davide Seripa, Paola Latina, Andrea Fontana, Carolina Gravina, Monia Lattanzi, Maria Savino, Antonietta P. Gallo, Giuseppe Melchionda, Stefano A. Santini, Maurizio Margaglione, Massimiliano Copetti, Lazzaro di Mauro, Francesco Panza, Antonio Greco & Alberto Pilotto. (2015) Role of CYP2D6 Polymorphisms in the Outcome of Postoperative Pain Treatment. Pain Medicine 16:10, pages 2012-2023.
Crossref
Crossref
K. R. Kelly, B. H. Pypendop & K. L. Christe. (2014)
Pharmacokinetics of tramadol following intravenous and oral administration in male rhesus macaques (
Macaca mulatta
)
. Journal of Veterinary Pharmacology and Therapeutics 38:4, pages 375-382.
Crossref
Crossref
Tuukka Saarikoski, Teijo I. Saari, Nora M. Hagelberg, Janne T. Backman, Pertti J. Neuvonen, Mika Scheinin, Klaus T. Olkkola & Kari Laine. (2015) Effects of terbinafine and itraconazole on the pharmacokinetics of orally administered tramadol. European Journal of Clinical Pharmacology 71:3, pages 321-327.
Crossref
Crossref
Omar Alharbi, Yun Xu & Royston Goodacre. (2015) Detection and quantification of the opioid tramadol in urine using surface enhanced Raman scattering. The Analyst 140:17, pages 5965-5970.
Crossref
Crossref
Souvik Kusari, Simplice Joel N. Tatsimo, Sebastian Zühlke, Ferdinand M. Talontsi, Simeon Fogue Kouam & Michael Spiteller. (2014) Tramadol—A True Natural Product?. Angewandte Chemie International Edition 53:45, pages 12073-12076.
Crossref
Crossref
Souvik Kusari, Simplice Joel N. Tatsimo, Sebastian Zühlke, Ferdinand M. Talontsi, Simeon Fogue Kouam & Michael Spiteller. (2014) Tramadol—A True Natural Product?. Angewandte Chemie 126:45, pages 12269-12272.
Crossref
Crossref
Pierluigi Marzuillo, Lorenzo Calligaris & Egidio Barbi. (2014) Tramadol can selectively manage moderate pain in children following European advice limiting codeine use. Acta Paediatrica 103:11, pages 1110-1116.
Crossref
Crossref
Nina Brvar, Tatjana Mateović-Rojnik & Iztok Grabnar. (2014) Population pharmacokinetic modelling of tramadol using inverse Gaussian function for the assessment of drug absorption from prolonged and immediate release formulations. International Journal of Pharmaceutics 473:1-2, pages 170-178.
Crossref
Crossref
Yenny Indrawirawan & Trudi McAlees. (2014) Tramadol toxicity in a cat: case report and literature review of serotonin syndrome. Journal of Feline Medicine and Surgery 16:7, pages 572-578.
Crossref
Crossref
Steven P. Stanos, Mark D. Tyburski & Sagar S. Parikh. 2014. Practical Management of Pain. Practical Management of Pain
508
529.e6
.
Nuggehally R Srinivas. (2013) Commentary on: “study of the pharmacokinetic changes of tramadol in diabetic rats” is the handicapped renal pathway in DMIS contributing for the increased bioavailability of tramadol?. DARU Journal of Pharmaceutical Sciences 21:1.
Crossref
Crossref
Hoda Lavasani, Behjat Sheikholeslami, Yalda H Ardakani, Mohammad Abdollahi, Lida Hakemi & Mohammad-Reza Rouini. (2013) Study of the pharmacokinetic changes of Tramadol in diabetic rats. DARU Journal of Pharmaceutical Sciences 21:1.
Crossref
Crossref
Rasmus Steen Pedersen, Per Damkier, Mette Marie Hougaard Christensen & Kim Brosen. (2013) A cytochrome P450 phenotyping cocktail causing unexpected adverse reactions in female volunteers. European Journal of Clinical Pharmacology 69:12, pages 1997-1999.
Crossref
Crossref
H. K. Knych, C. R. Corado, D. S. McKemie, E. Scholtz & R. Sams. (2012) Pharmacokinetics and pharmacodynamics of tramadol in horses following oral administration. Journal of Veterinary Pharmacology and Therapeutics 36:4, pages 389-398.
Crossref
Crossref
Sandra Pinho, Ana Oliveira, Isabel Costa, Carla Alexandra Gouveia, Félix Carvalho, Roxana Falcão Moreira & Ricardo Jorge Dinis‐Oliveira. (2013)
Simultaneous quantification of tramadol and
O
‐desmethyltramadol in hair samples by gas chromatography–electron impact/mass spectrometry
. Biomedical Chromatography 27:8, pages 1003-1011.
Crossref
Crossref
Junho Jeon, Denise Kurth, Roman Ashauer & Juliane Hollender. (2013) Comparative Toxicokinetics of Organic Micropollutants in Freshwater Crustaceans. Environmental Science & Technology, pages 130712083046004.
Crossref
Crossref
Nunziata Barbera, Marco Fisichella, Andrea Bosco, Francesca Indorato, Giorgio Spadaro & Guido Romano. (2013) A suicidal poisoning due to tramadol. A metabolic approach to death investigation. Journal of Forensic and Legal Medicine 20:5, pages 555-558.
Crossref
Crossref
Tuukka Saarikoski, Teijo I. Saari, Nora M. Hagelberg, Mikko Neuvonen, Pertti J. Neuvonen, Mika Scheinin, Klaus T. Olkkola & Kari Laine. (2012) Rifampicin markedly decreases the exposure to oral and intravenous tramadol. European Journal of Clinical Pharmacology 69:6, pages 1293-1301.
Crossref
Crossref
Shanna Babalonis, Michelle R. Lofwall, Paul A. Nuzzo, Anthony J. Siegel & Sharon L. Walsh. (2013) Abuse liability and reinforcing efficacy of oral tramadol in humans. Drug and Alcohol Dependence 129:1-2, pages 116-124.
Crossref
Crossref
Nora M. Hagelberg, Tuukka Saarikoski, Teijo I. Saari, Mikko Neuvonen, Pertti J. Neuvonen, Miia Turpeinen, Mika Scheinin, Kari Laine & Klaus T. Olkkola. (2012) Ticlopidine inhibits both O-demethylation and renal clearance of tramadol, increasing the exposure to it, but itraconazole has no marked effect on the ticlopidine-tramadol interaction. European Journal of Clinical Pharmacology 69:4, pages 867-875.
Crossref
Crossref
Junho Jeon, Denise Kurth & Juliane Hollender. (2013) Biotransformation Pathways of Biocides and Pharmaceuticals in Freshwater Crustaceans Based on Structure Elucidation of Metabolites Using High Resolution Mass Spectrometry. Chemical Research in Toxicology 26:3, pages 313-324.
Crossref
Crossref
D.-Y. Xia, Y.-H. Wang, T. Guo, X. L. Li, X. Y. Su & L. S. Zhao. (2012) Pharmacokinetics of tramadol in a diverse healthy Chinese population. Journal of Clinical Pharmacy and Therapeutics 37:5, pages 599-603.
Crossref
Crossref
C. Narjoz, C. Moreau, P. Beaune & M. -A. Loriot. (2011) Intérêt clinique de la pharmacogénétique : anticiper les toxicités et mieux prédire l’efficacité des médicamentsClinical utility of pharmacogenetics for predicting drug efficacy and toxicity. Réanimation 21:S2, pages 354-362.
Crossref
Crossref
Bridget B. Baker, Kurt K. Sladky & Stephen M. Johnson. (2011) Evaluation of the analgesic effects of oral and subcutaneous tramadol administration in red-eared slider turtles. Journal of the American Veterinary Medical Association 238:2, pages 220-227.
Crossref
Crossref
Päivi Lehtonen, Taina Sten, Olli Aitio, Mika Kurkela, Katariina Vuorensola, Moshe Finel & Risto Kostiainen. (2010) Glucuronidation of racemic O-desmethyltramadol, the active metabolite of tramadol. European Journal of Pharmaceutical Sciences 41:3-4, pages 523-530.
Crossref
Crossref
G. Saccomanni, S. Del Carlo, M. Giorgi, C. Manera, A. Saba & M. Macchia. (2010) Determination of tramadol and metabolites by HPLC-FL and HPLC–MS/MS in urine of dogs. Journal of Pharmaceutical and Biomedical Analysis 53:2, pages 194-199.
Crossref
Crossref
Lukáš Chytil, Olga Matoušková, Olga Černá, Pavla Pokorná, Václav Vobruba, František Perlík & Ondřej Slanař. (2010) Enantiomeric determination of tramadol and O-desmethyltramadol in human plasma by fast liquid chromatographic technique coupled with mass spectrometric detection. Journal of Chromatography B 878:3-4, pages 481-486.
Crossref
Crossref
M. Giorgi, S. Del Carlo, G. Saccomanni, B. Łebkowska-Wieruszewska & C. J. Kowalski. (2009) Pharmacokinetic and urine profile of tramadol and its major metabolites following oral immediate release capsules administration in dogs. Veterinary Research Communications 33:8, pages 875-885.
Crossref
Crossref
Shu-Feng Zhou. (2009) Polymorphism of Human Cytochrome P450 2D6 and Its Clinical Significance. Clinical Pharmacokinetics 48:11, pages 689-723.
Crossref
Crossref
Wojciech Leppert. (2009) Tramadol as an analgesic for mild to moderate cancer pain. Pharmacological Reports 61:6, pages 978-992.
Crossref
Crossref
Liming Shao, Fengjiang Wang, Michael C. Hewitt & Timothy J. Barberich. (2009) μ-Opioid/5-HT4 dual pharmacologically active agents—Efforts towards an effective opioid analgesic with less GI and respiratory side effects (Part I). Bioorganic & Medicinal Chemistry Letters 19:19, pages 5679-5683.
Crossref
Crossref
Lukáš Chytil, Martin Štícha, Olga Matoušková, František Perlík & Ondřej Slanař. (2009) Enatiomeric determination of tramadol and O-desmethyltramadol in human urine by gas chromatography–mass spectrometry. Journal of Chromatography B 877:20-21, pages 1937-1942.
Crossref
Crossref
Marinella De Leo, Mario Giorgi, Giuseppe Saccomanni, Clementina Manera & Alessandra Braca. (2008) Evaluation of tramadol and its main metabolites in horse plasma by high‐performance liquid chromatography/fluorescence and liquid chromatography/electrospray ionization tandem mass spectrometry techniques. Rapid Communications in Mass Spectrometry 23:2, pages 228-236.
Crossref
Crossref
David J. Skinner, Jonathan Epstein & Marco Pappagallo. 2009. Current Therapy in Pain. Current Therapy in Pain
508
512
.
F. Di Patti, D. Fanelli, R.S. Pedersen, C. Giuliani & F. Torricelli. (2008) Modelling the pharmacokinetics of tramadol: On the difference between CYP2D6 extensive and poor metabolizers. Journal of Theoretical Biology 254:3, pages 568-574.
Crossref
Crossref
Robert B. Raffa & Dennis J. StoneJr.Jr.. (2008) Unexceptional Seizure Potential of Tramadol or Its Enantiomers or Metabolites in Mice. Journal of Pharmacology and Experimental Therapeutics 325:2, pages 500-506.
Crossref
Crossref
R. B. Raffa. (2008) Basic pharmacology relevant to drug abuse assessment: tramadol as example. Journal of Clinical Pharmacy and Therapeutics 33:2, pages 101-108.
Crossref
Crossref
Liming Shao, Michael Hewitt, Thomas P. Jerussi, Frank Wu, Scott Malcolm, Paul Grover, Kevin Fang, Patrick Koch, Chris Senanayake, Nandkumar Bhongle, Seth Ribe, Roger Bakale & Mark Currie. (2008) In vitro and in vivo evaluation of O-alkyl derivatives of tramadol. Bioorganic & Medicinal Chemistry Letters 18:5, pages 1674-1680.
Crossref
Crossref
Y. SHILO, M. BRITZI, B. EYTAN, T. LIFSCHITZ, S. SOBACK & A. STEINMAN. (2007) Pharmacokinetics of tramadol in horses after intravenous, intramuscular and oral administration. Journal of Veterinary Pharmacology and Therapeutics 31:1, pages 60-65.
Crossref
Crossref
Maciej J. Bogusz. 2008. Forensic Science. Forensic Science
3
72
.
Steven P. Stanos & Mark D. Tyburski. 2008. Raj's Practical Management of Pain. Raj's Practical Management of Pain
613
641
.
Mohammad‐Reza Rouini, Mahmoud Ghazi‐Khansari, Yalda H. Ardakani, Zahra Dasian & Hoda Lavasani. (2008) A disposition kinetic study of tramadol in rat perfused liver. Biopharmaceutics & Drug Disposition 29:4, pages 231-235.
Crossref
Crossref
Mario Giorgi, Giulio Soldani, Clementina Manera, PierLuigi Ferrarini, Micaela Sgorbini & Giuseppe Saccomanni. (2007) Pharmacokinetics of Tramadol and its Metabolites M1, M2 and M5 in Horses Following Intravenous, Immediate Release (Fasted/Fed) and Sustained Release Single Dose Administration. Journal of Equine Veterinary Science 27:11, pages 481-488.
Crossref
Crossref
Reza Mehvar, Katherine Elliott, Ridhi Parasrampuria & Okponanabofa Eradiri. (2007) Stereospecific high-performance liquid chromatographic analysis of tramadol and its O-demethylated (M1) and N,O-demethylated (M5) metabolites in human plasma. Journal of Chromatography B 852:1-2, pages 152-159.
Crossref
Crossref
Ondřej Slanař, Milan Nobilis, Jaroslav Kvétina, Olga Matoušková, Jeffrey R. Idle & František Perlík. (2007) Pharmacokinetics of tramadol is affected by MDR1 polymorphism C3435T. European Journal of Clinical Pharmacology 63:4, pages 419-421.
Crossref
Crossref
Ridhi Parasrampuria, Ragini Vuppugalla, Katherine Elliott & Reza Mehvar. (2006)
Route‐dependent stereoselective pharmacokinetics of tramadol and its active
O
‐demethylated metabolite in rats
. Chirality 19:3, pages 190-196.
Crossref
Crossref
Bernard Testa & Stefanie D. Krämer. (2007) The Biochemistry of Drug Metabolism – An Introduction. Chemistry & Biodiversity 4:3, pages 257-405.
Crossref
Crossref
M. GIORGI, G. SACCOMANNI, M. R. DANIELLO, C. MANERA, G. SOLDANI, P. L. FERRARINI & M. GIUSIANI. (2006)
D13
In vitro
metabolism of tramadol in horses: preliminary data
. Journal of Veterinary Pharmacology and Therapeutics 29:s1, pages 124-124.
Crossref
Crossref
Kati S. Hakala, Risto Kostiainen & Raimo A. Ketola. (2006) Feasibility of different mass spectrometric techniques and programs for automated metabolite profiling of tramadol in human urine. Rapid Communications in Mass Spectrometry 20:14, pages 2081-2090.
Crossref
Crossref
Rasmus Steen Pedersen, Per Damkier & Kim Brøsen. (2006) Enantioselective pharmacokinetics of tramadol in CYP2D6 extensive and poor metabolizers. European Journal of Clinical Pharmacology 62:7, pages 513-521.
Crossref
Crossref
Liming Shao, Craig Abolin, Michael C. Hewitt, Patrick Koch & Mark Varney. (2006) Derivatives of tramadol for increased duration of effect. Bioorganic & Medicinal Chemistry Letters 16:3, pages 691-694.
Crossref
Crossref
Karel Allegaert, M. Rayyan, J. De Hoon, D. Tibboel, R. Verbesselt, G. Naulaers, J. N. Anker & H. Devlieger. (2006) Contribution of Glucuronidation to Tramadol Disposition in Early Neonatal Life. Basic & Clinical Pharmacology & Toxicology 98:1, pages 110-112.
Crossref
Crossref
Bernard Testa, Anne-Loyse Balmat, Anthony Long & Philip Judson. (2005) Predicting Drug Metabolism - An Evaluation of the Expert SystemMETEOR. Chemistry & Biodiversity 2:7, pages 872-885.
Crossref
Crossref
Wojciech Leppert & Jacek Łuczak. (2004) The role of tramadol in cancer pain treatment—a review. Supportive Care in Cancer 13:1, pages 5-17.
Crossref
Crossref
Päivi Lehtonen, Heli Siren, Ilkka Ojanperä & Risto Kostiainen. (2004) Migration behaviour and separation of tramadol metabolites and diastereomeric separation of tramadol glucuronides by capillary electrophoresis. Journal of Chromatography A 1041:1-2, pages 227-234.
Crossref
Crossref
Stefan Grond & Armin Sablotzki. (2004) Clinical Pharmacology of Tramadol. Clinical Pharmacokinetics 43:13, pages 879-923.
Crossref
Crossref
Z. Yan & G. W. Caldwell. (2003) Metabolic assessment in liver microsomes by co-activating cytochrome P450s and UDP-glycosyltransferases. European Journal of Drug Metabolism and Pharmacokinetics 28:3, pages 223-232.
Crossref
Crossref
. (2002) Current literature in mass spectrometry. Journal of Mass Spectrometry 37:10, pages 1096-1103.
Crossref
Crossref
W. N. Wu, L. A. McKown, E. E. Codd & R. B. Raffa. (2002) In vitro metabolism of the analgesic agent, tramadol-N-oxide, in mouse, rat, and human. European Journal of Drug Metabolism and Pharmacokinetics 27:3, pages 193-197.
Crossref
Crossref