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Xenobiotica
the fate of foreign compounds in biological systems
Volume 32, 2002 - Issue 5
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Research Article

Metabolism of the analgesic drug ULTRAM ® (tramadol hydrochloride) in humans: API-MS and MS/MS characterization of metabolites

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Pages 411-425 | Published online: 22 Sep 2008

References

  • ABEL, S. R., 1995, Tramadol: an alternative analgesic to traditional opioids and NSAIDs. Journal Pharmaceutical Care in Pain and Symptom Control, 3, 5–29.
  • DAYER, P., DESMEULES, J. and COLLART, L., 1997, Pharmacologie du tramadol. Drugs, 53 (suppl. 2), 18–24.
  • FLICK, K., FRANKUS, E. and FRIDERICKS, E., 1978, Studies on chemical structure and analgesic activity of phenyl substituted aminomethylcyclohexanols. Arzneim-ForschlDrug Research, 28, 107–113.
  • FLOI-m', L., AREND, I., CoGAL, A., RICHTER, W. and SIMON, W., 1978, Klinische prufung der abhangigkeitsentwicklung nach langzeitapplikation von tramadol. Arzneim-ForschlDrug Research, 28, 213–217.
  • FRANKUS, E., FRIDERICKS, E., KIM, S. M. and OSTERLOH, G., 1978, On separation of isomers, structural elucidation and pharmacological characterization of 1-(m-methoxypheny1)-2-(dimethylamino-methyl)-cyclohexan-1-ol. Arzneim-ForschlDrug Research, 28, 114–121.
  • FRIDERICKS, E., FELGENHAUER, F., JONSCHAAP, P. and OSTERLOH, G., 1978, Pharmakologische untersuchungen zur analgesie, abhangigkeits und toleranzen-twicklung von tramadol, einem stark wirkenden analgetikum. Arzneim-ForschlDrug Research, 28, 122–134.
  • HILLS, J. F., Liao, S. and NAYAK, R. K., 1992, The effect of food on the bioavailability of tramadol. 1992 AAPS Eastern Regional Meeting, abst 32.
  • LEE, R. C., McTAvisit, D. and SORKIN, E. M., 1993, Tramadol, a preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in acute and chronic pain states. Drugs, 46, 313–340.
  • LIAO, S., HILL, J. F. and NAYAK, R. K., Pharmacokinetics of tramadol following single and multiple oral doses in man. 1992 AAPS Annual Meeting, abst PPDM 8206; Pharmaceutical. Research, 9 (suppl. 1), 308.
  • LINTZ, W. and BESKE R., 1986, Determination of tramadol in human serum by capillary gas chromatography with nitrogen-selective detection. Journal of Chromatography, 377, 213–220.
  • LINTZ, W., ERLACIN, S., FRANKUS, E. and URAGG, H., 1981, Metabolismus von tramadol bei mensch und tier. Arzneim-ForschlDrug Research, 31, 1932–1943.
  • PAAR, W. D., FRANKUS, P. and DENGLER, H. J., 1992, The metabolism of tramadol by human liver microsomes. Clinical Investigation, 70, 708–710.
  • PAAR, W. D., POCHE, S., GERLO, J. and DENGLER, H. J., 1993, In vivo investigation of the metabolism of tramadol - further evidence for 0-demethylation polymorphism. Naunyn-Schmiedeberg's Archives of Pharmacology, 347 (suppl. R39), 154.
  • RAFFA, R. B., FRIDERICHS, E., REIMANN, W., SHANK, R. P., CODD, E. E. and VAUGHT, J. L., 1992, Opioid and nonopioid components independently contribute to the mechanism of action of tramadol, an 'atypical' opioid analgesic. Journal of Pharmacology and Experimental Therapeutics, 260, 275–285.
  • RAFFA, R. B., FRIDERICHS, E., REIMANN, W., SHANK, R. P., CODD, E. E., VAUGHT, J. L., JACOBY, H. I. and SELVE, N., 1993, Complementary and synergistic antinociceptive interaction between the enantiomers of tramadol. Journal of Pharmacology and Experimental Therapeutics, 267, 331–340.
  • RAFFA, R. B., NAYAK, R. K. and Liao, S., 1995, The mechanism(s) of action and pharmacokinetics of tramadol. Reviews in Contemporary Pharmacotherapeutics, 6, 485–497.
  • SUBRAHMANYAM, V., RENWICK A. B., WALTERS D. G., YOUNG P. J., PRICE R. J., TONELLI A. P. and LAKE, B. G., 2001, Identification of cytochrome p-450 isoforms responsible for cis-tramadol metabolism in human liver microsomes. Drug Metabolism and Disposition, 29, 1146–1155.
  • SUNSHINE, A., 1994, New clinical experience with tramadol. Drugs, 47 (suppl. 1), 8–18.
  • WU, W. N., DESAI, D., McKowN, L. A., GAUTHIER, A. D., JoNEs, W. J., TAKACS, A. R., SCOTT, L., SORGI, K. L. and RAFFA, R. B., 1997a, Metabolism of Ultram® (tramadol) in the dog. In ISSX Proceedings of the 6th European ISSX Meeting, 11, 160 (abst).
  • WU, W. N., McKowN, L. A., JONES, W. J., GAUTHIER, A. D. and TwitAcs, A. R., 1997b, Metabolism of Ultram® (tramadol) in the rat. In ISSX Proceedings of the 8th North American ISSX Meeting, 12, 107 (abst).
  • WU, W. N., Liao, S., McKowN, L. A. and TAKACS, A. R., 1997c, Metabolism of Ultram® (tramadol) in the human. ISSX Proceedings of the 6th European ISSX Meeting, 11, 159 (abst).
  • WU, W. N., McKowN, L. A., GAUTHIER, A. D., JONES. W. J. and RAFFA, R. B., 2001, Metabolism of the analgesic drug, tramadol hydrochloride, in rats and dogs. Xenobiotica, 31, 423–441.

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