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Xenobiotica
the fate of foreign compounds in biological systems
Volume 32, 2002 - Issue 11
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Research Article

In vitro biotransformation of 2,6,9-trisubstituted purine-derived cyclin-dependent kinase inhibitor bohemine by mouse liver microsomes

M. Rypka Department of Pathological Physiology, Medical Faculty, Palacký University, Olomouc, Czech Republic
,
J. Veselý Institute of Nuclear Medicine, Medical Faculty I, Charles University, Prague, Czech Republic
,
Z. Chmela Department of Analytical Chemistry, Faculty of Natural Science, Palacký University, Olomouc, Czech Republic
,
D. Riegrová Institute of Experimental Botany, Academy of Science, Prague, Czech Republic
,
K. Červenková Department of Nuclear Medicine, University Hospital in Olomouc, Czech Republic
,
L. Havlíček Department of Analytical Chemistry, Faculty of Natural Science, Palacký University, Olomouc, Czech Republic
,
K. Lemr Department of Pathological Physiology, Medical Faculty, Palacký University, Olomouc, Czech Republic
,
J. Hanuš Institute of Nuclear Medicine, Medical Faculty I, Charles University, Prague, Czech Republic
,
B. Černý Department of Analytical Chemistry, Faculty of Natural Science, Palacký University, Olomouc, Czech Republic
,
J. Lukeš Institute of Experimental Botany, Academy of Science, Prague, Czech Republic
&
K. Michalíková Department of Nuclear Medicine, University Hospital in Olomouc, Czech Republic
 show all
Pages 1017-1031 | Published online: 22 Sep 2008

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Eun Sook Jeong, Gabin Kim, Daeun Yim, Kyung-Sik Moon, Su-Jun Lee, Jae-Gook Shin & Dong Hyun Kim. (2018) Identification and characterization of amiodarone metabolites in rats using UPLC–ESI-QTOFMS-based untargeted metabolomics approach. Journal of Toxicology and Environmental Health, Part A 81:12, pages 481-492.
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Articles from other publishers (7)

Iva Dolečková, Michal Česnek, Martin Dračinský, Jiří Brynda, Jiří Voller, Zlatko Janeba & Vladimír Kryštof. (2013) Synthesis and biological evaluation of guanidino analogues of roscovitine. European Journal of Medicinal Chemistry 62, pages 443-452.
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Marek Zatloukal, Radek Jorda, Tomáš Gucký, Eva Řezníčková, Jiří Voller, Tomáš Pospíšil, Veronika Malínková, Helena Adamcová, Vladimír Kryštof & Miroslav Strnad. (2013) Synthesis and in vitro biological evaluation of 2,6,9-trisubstituted purines targeting multiple cyclin-dependent kinases. European Journal of Medicinal Chemistry 61, pages 61-72.
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Michal Karady, Ondřej Novák, Aleš Horna , Miroslav Strnad & Karel Doležal. (2011) High Performance Liquid Chromatography-Electrochemistry-Electrospray Ionization Mass Spectrometry (HPLC/EC/ESI-MS) for Detection and Characterization of Roscovitine Oxidation Products. Electroanalysis 23:12, pages 2898-2905.
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Hana PospíŠilová, Marek Šebela, Ondřej Novák & Ivo Frébort. (2008) Hydrolytic cleavage of N 6-substituted adenine derivatives by eukaryotic adenine and adenosine deaminases . Bioscience Reports 28:6, pages 335-347.
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Steven J. McClue & Iain Stuart. (2008) Metabolism of the Trisubstituted Purine Cyclin-Dependent Kinase Inhibitor Seliciclib ( R -Roscovitine) in Vitro and in Vivo . Drug Metabolism and Disposition 36:3, pages 561-570.
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Michal Česnek, Milena Masojídková, Antonín Holý, Veronika Šolínová, Dušan Koval & Václav Kašička. (2006) Synthesis and Properties of 2-Guanidinopurines. Collection of Czechoslovak Chemical Communications 71:9, pages 1303-1319.
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Bernard P. Nutley, Florence I. Raynaud, Stuart C. Wilson, Peter M. Fischer, Angela Hayes, Phyllis M. Goddard, Steven J. McClue, Michael Jarman, David P. Lane & Paul Workman. (2005) Metabolism and pharmacokinetics of the cyclin-dependent kinase inhibitor R -roscovitine in the mouse . Molecular Cancer Therapeutics 4:1, pages 125-139.
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