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Xenobiotica
the fate of foreign compounds in biological systems
Volume 33, 2003 - Issue 2
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Research Article

Pharmacokinetics and tissue distribution of the nonadecapeptide Moli1901 in rats and mice

M. J. Mcnulty GlaxoSmithKline, Inc., Research Triangle Park, NC 27709, USA
,
R. H. Hutabarat GlaxoSmithKline, Inc., Research Triangle Park, NC 27709, USA
,
J. W. A. Findlay GlaxoSmithKline, Inc., Research Triangle Park, NC 27709, USA
,
K. Devereux GlaxoSmithKline, Inc., Research Triangle Park, NC 27709, USA
,
V. C. Knick GlaxoSmithKline, Inc., Research Triangle Park, NC 27709, USA
,
R. J. Harvey GlaxoSmithKline, Inc., Research Triangle Park, NC 27709, USA
&
L. Molina MoliChem R& Inc., Chapel Hill, NC 27514, USA
 show all
Pages 197-210 | Published online: 22 Sep 2008

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Stephanie Kate Sandiford. (2020) An overview of lantibiotic biosynthetic machinery promiscuity and its impact on antimicrobial discovery. Expert Opinion on Drug Discovery 15:3, pages 373-382.
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Stephanie Kate Sandiford. (2019) Current developments in lantibiotic discovery for treating Clostridium difficile infection. Expert Opinion on Drug Discovery 14:1, pages 71-79.
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Auke Johan van Heel, Manuel Montalban-Lopez & Oscar P Kuipers. (2011) Evaluating the feasibility of lantibiotics as an alternative therapy against bacterial infections in humans. Expert Opinion on Drug Metabolism & Toxicology 7:6, pages 675-680.
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Articles from other publishers (12)

Ernst Eber, Maria Trawinska-Bartnicka, Dorota Sands, Gabriel Bellon, Uwe Mellies, Katalin Bolbás, Serena Quattrucci, Henryk Mazurek, Rudolf Widmann, Christian Schoergenhofer, Bernd Jilma & Felix Ratjen. (2021) Aerosolized lancovutide in adolescents (≥12 years) and adults with cystic fibrosis – a randomized trial. Journal of Cystic Fibrosis 20:1, pages 61-67.
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Daniel S. Nielsen, Nicholas E. Shepherd, Weijun Xu, Andrew J. Lucke, Martin J. Stoermer & David P. Fairlie. (2017) Orally Absorbed Cyclic Peptides. Chemical Reviews 117:12, pages 8094-8128.
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Lindsay M. Repka, Jonathan R. Chekan, Satish K. Nair & Wilfred A. van der Donk. (2017) Mechanistic Understanding of Lanthipeptide Biosynthetic Enzymes. Chemical Reviews 117:8, pages 5457-5520.
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Elvis Legala Ongey, Hüseyin Yassi, Stephan Pflugmacher & Peter Neubauer. (2017) Pharmacological and pharmacokinetic properties of lanthipeptides undergoing clinical studies. Biotechnology Letters 39:4, pages 473-482.
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Neha Garg, Yuki Goto, Ting Chen & Wilfred A. van der Donk. (2016) Characterization of the stereochemical configuration of lanthionines formed by the lanthipeptide synthetase GeoM. Biopolymers 106:6, pages 834-842.
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IGOR OLIYNYK, GEORGIA VARELOGIANNI, GODFRIED M. ROOMANS & MARIE JOHANNESSON. (2010) Effect of duramycin on chloride transport and intracellular calcium concentration in cystic fibrosis and non‐cystic fibrosis epithelia. APMIS 118:12, pages 982-990.
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Ilka Steiner, Peter Errhalt, Klaus Kubesch, Marianne Hubner, Marion Holy, Martin Bauer, Markus Müller, Sabine Hinterberger, Rudolf Widmann, Daniel Mascher, Michael Freissmuth & Meinhard Kneussl. (2008) Pulmonary pharmacokinetics and safety of nebulized duramycin in healthy male volunteers. Naunyn-Schmiedeberg's Archives of Pharmacology 378:3, pages 323-333.
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Scott H. Donaldson. (2008) Hydrator therapies for cystic fibrosis lung disease. Pediatric Pulmonology 43:S9, pages S18-S23.
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Eva Zebedin, Xaver Koenig, Miroslav Radenkovic, Halyna Pankevych, Hannes Todt, Michael Freissmuth & Karlheinz Hilber. (2008) Effects of duramycin on cardiac voltage-gated ion channels. Naunyn-Schmiedeberg's Archives of Pharmacology 377:1, pages 87-100.
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Hartmut Grasemann, Florian Stehling, Helmut Brunar, Rudolf Widmann, Terry W. Laliberte, Luis Molina, Gerd Döring & Felix Ratjen. (2007) Inhalation of Moli1901 in Patients With Cystic Fibrosis. Chest 131:5, pages 1461-1466.
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D.E. Rickert, K. Dingley, E. Ubick, K.J. Dix & L. Molina. (2005) Determination of the tissue distribution and excretion by accelerator mass spectrometry of the nonadecapeptide 14C-Moli1901 in beagle dogs after intratracheal instillation. Chemico-Biological Interactions 155:1-2, pages 55-61.
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Pamela L. Zeitlin, Michael P. Boyle, William B. Guggino & Luis Molina. (2004) A Phase I Trial of Intranasal Moli1901 for Cystic Fibrosis. Chest 125:1, pages 143-149.
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