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Xenobiotica
the fate of foreign compounds in biological systems
Volume 33, 2003 - Issue 2
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Research Article

Pharmacokinetics and tissue distribution of the nonadecapeptide Moli1901 in rats and mice

M. J. Mcnulty GlaxoSmithKline, Inc., Research Triangle Park, NC 27709, USA
,
R. H. Hutabarat GlaxoSmithKline, Inc., Research Triangle Park, NC 27709, USA
,
J. W. A. Findlay GlaxoSmithKline, Inc., Research Triangle Park, NC 27709, USA
,
K. Devereux GlaxoSmithKline, Inc., Research Triangle Park, NC 27709, USA
,
V. C. Knick GlaxoSmithKline, Inc., Research Triangle Park, NC 27709, USA
,
R. J. Harvey GlaxoSmithKline, Inc., Research Triangle Park, NC 27709, USA
&
L. Molina MoliChem R& Inc., Chapel Hill, NC 27514, USA
 show all
Pages 197-210 | Published online: 22 Sep 2008

References

  • CLOUTIER, M. M., GUERNSEY, L., MATTES, P. and KOEPPEN, B., 1990, Duramycin enhances chloride secretion in airway epithelium. American Journal of Physiology, 259, C450—C454.
  • CLOUTIER, M. M., GUERNSEY, L. and SHA'AFI, R. I., 1993, Duramycin increases intracellular calcium in airway epithelium. Membrane Biochemistry, 10, 107–118.
  • DODOO, A. N. O., BANSAL, S., BARLOW, D. J., BENNET, E. C., HIDER, R. C., LANSLEY, A. B., LAWRENCE, M. J. and MARRIOTT, C., 2000, Systemic investigations of the influence of molecular structure on the transport of peptides across cultured alveolar cell monolayers. Pharmaceutical Research, 17, 7–14.
  • FRITSCH, P. and MASSE, R., 1992, Overview of pulmonary alveolar macrophage renewal in normal rats and during different pathological processes. Environmental Health Perspectives, 97, 59–67.
  • GATTO, L. A., 1993, Cholinergic and adrenergic stimulation of mucociliary transport in the rat trachea. Respiration Physiology, 92, 209–217.
  • HAYASHI, F., NAGASHIMA, K., TERUI, Y., KAWAMURA, Y., MATSUMOTO, K. and ITAZAKI, H., 1990, THE STRUCTURE OF PA48009: THE REVISED STRUCTURE OF DURAMYCIN. Journal of Antibiotics, 43, 1421–1430.
  • HENKE, D. C., STUTTS, M. J., HARVEY, R. and MOLINA, L., 1998, Bioelectric and fluid transport effects of the nonadecapeptide 2622U90 (duramycin) in normal human cystic fibrosis airway epithelium and canine airways. Pediatric Pulmonology, suppl. 17, 238.
  • KNOWLES, M. R., CLARKE, L. L. and BOUCHER, R. C., 1991, Activation by extracellular nucleotides of chloride secretion in the airway epithelia of patients with cystic fibrosis. New England Journal of Medicine, 325, 533–538.
  • MARKI, F., HANNI, E., FREDENHAGEN, A. and VAN OOSTRUM, J., 1991, Mode of action of the lanthionine-containing peptide antibiotics duramycin, duramycin B and C, and cinnamycin as indirect inhibitors of phospholipase A2. Biochemical Pharmacology, 42, 2027–2035.
  • MCNULTY, M. J., HUTABARAT, R. M., HARVEY, R. and MOLINA, L., 1997, The disposition of the nonadecapeptide, duramycin, in the beagle dog after inhalation exposure. ISSX Proceedings, 12, 123.
  • MOLINA Y VEDIA, L., STUTTS, M. J., BOUCHER, R. C. and HENKE, D. C., 1996, Method of treating retained pulmonary secretions. US Patent 5,512,269.
  • NAVARRO, J, CHABOT, J, SHERRILL, K, ANEJA, R, ZAHLER, S. A. and RACKER, E., 1985, Interaction of duramycin with artificial and natural membranes. Biochemistry, 24, 4645–4650.
  • PATTON, J. S. and PLATZ, R. M., 1992, Routes of delivery: case studies. Pulmonary delivery of peptides and proteins for systemic action. Advanced Drug Delivery Reviews, 8, 179–196.
  • ROBERTS, M., HLADKY, S. B., PICKLES, R. J. and CUTHBERT, A. W., 1991, Stimulation of sodium transport by duramycin in cultured human colonic epithelia. Journal of Pharmacology and Experimental Therapeutics, 259, 1050–1058.
  • SHOTVVELL, O. L., STODOLA, F. H., MICHAEL, W. R., LINDENFELSER, L. A., DWORSCHACK, R. G. and PRIDHAM, T. G., 1958, Antibiotics against plant disease III. Duramycin, a new antibiotic from Streptomyces cinnamomeus forma azacoluta. Journal of the American Chemical Society, 80, 3912–3914.
  • SOKOLOVE, P. M., WESTPHAL, P. A., RESTER, M. B., WIERWILLE, R. and SIKORA-VANMETER, K., 1989, Duramycin effects on the structure and function of heart mitochondria. I. Structural alterations and changes in membrane permeability. Biochimica et Biophysica Acta, 983, 15–22.
  • STONE, D. K., XIE, S.-S. and RACKER, E., 1984, Inhibition of clathrin-coated vesicle acidification by duramycin. Journal of Biological Chemistry, 259: 2701–2703.
  • TASK GROUP ON MUCOACTIVE DRUGS, 1994, Special report: Recommendations for guidelines on clinical trials of mucoactive drugs in chronic bronchitis and chromic obstructive pulmonary disease. Chest, 106, 1532–1537.
  • ZEITLIN, P., GUGGINO, W. and MOLINA, L., 1998, Activation by the nonadecapeptide 2622U90 (duramycin) of chloride secretion in healthy volunteers and patients with cystic fibrosis. Pediatric Pulmonology, suppl. 17, 277–278.

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