Advanced search
Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 33, 2003 - Issue 12
Submit an article Journal homepage
166
Views
28
CrossRef citations to date
0
Altmetric
Research Article

S-oxidation of S-methyl-esonarimod by flavin-containing monooxygenases in human liver microsomes

N. Ohmi Department of Drug Metabolism, Research Center, Taisho Pharmaceutical Co., Ltd, 403, Yoshino-cho 1-chome, Kita-ku, Saitama-shi, Saitama 331-9530, JapanCorrespondence[email protected]
,
H. Yoshida Department of Drug Metabolism, Research Center, Taisho Pharmaceutical Co., Ltd, 403, Yoshino-cho 1-chome, Kita-ku, Saitama-shi, Saitama 331-9530, Japan
,
H. Endo Department of Drug Metabolism, Research Center, Taisho Pharmaceutical Co., Ltd, 403, Yoshino-cho 1-chome, Kita-ku, Saitama-shi, Saitama 331-9530, Japan
,
M. Hasegawa Department of Drug Metabolism, Research Center, Taisho Pharmaceutical Co., Ltd, 403, Yoshino-cho 1-chome, Kita-ku, Saitama-shi, Saitama 331-9530, Japan
,
M. Akimoto Department of Drug Metabolism, Research Center, Taisho Pharmaceutical Co., Ltd, 403, Yoshino-cho 1-chome, Kita-ku, Saitama-shi, Saitama 331-9530, Japan
&
S. Higuchi Department of Drug Metabolism, Research Center, Taisho Pharmaceutical Co., Ltd, 403, Yoshino-cho 1-chome, Kita-ku, Saitama-shi, Saitama 331-9530, Japan
Pages 1221-1231 | Received 02 May 2003, Published online: 22 Sep 2008

Citations (28)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (4)

Kaori Matsumoto, Tetsuya Hasegawa, Kosuke Ohara, Tomoyo Kamei, Junichi Koyanagi & Masayuki Akimoto. (2021) Role of human flavin-containing monooxygenase (FMO) 5 in the metabolism of nabumetone: Baeyer–Villiger oxidation in the activation of the intermediate metabolite, 3-hydroxy nabumetone, to the active metabolite, 6-methoxy-2-naphthylacetic acid in vitro. Xenobiotica 51:2, pages 155-166.
Read now
Kaori Matsumoto, Tetsuya Hasegawa, Kosuke Ohara, Chihiro Takei, Tomoyo Kamei, Junichi Koyanagi, Tamiko Takahashi & Masayuki Akimoto. (2020) A metabolic pathway for the prodrug nabumetone to the pharmacologically active metabolite, 6-methoxy-2-naphthylacetic acid (6-MNA) by non-cytochrome P450 enzymes. Xenobiotica 50:7, pages 783-792.
Read now
Ian R. Phillips & Elizabeth A. Shephard. (2020) Flavin-containing monooxygenase 3 (FMO3): genetic variants and their consequences for drug metabolism and disease. Xenobiotica 50:1, pages 19-33.
Read now
Ian R. Phillips & Elizabeth A. Shephard. (2017) Drug metabolism by flavin-containing monooxygenases of human and mouse. Expert Opinion on Drug Metabolism & Toxicology 13:2, pages 167-181.
Read now

Articles from other publishers (24)

CARL DAVIS. 2022. Drug Metabolism Handbook. Drug Metabolism Handbook 527 552 .
Slobodan P. Rendić, Rachel D. Crouch & F. Peter Guengerich. (2022) Roles of selected non-P450 human oxidoreductase enzymes in protective and toxic effects of chemicals: review and compilation of reactions. Archives of Toxicology 96:8, pages 2145-2246.
Crossref
Xiaoyan Pang, Chongzhuang Tang, Runcong Guo & Xiaoyan Chen. (2022) Non-cytochrome P450 enzymes involved in the oxidative metabolism of xenobiotics: Focus on the regulation of gene expression and enzyme activity. Pharmacology & Therapeutics 233, pages 108020.
Crossref
Gianluca Catucci, Gianfranco Gilardi & Sheila J. Sadeghi. 2022. Comprehensive Pharmacology. Comprehensive Pharmacology 509 562 .
Min Chen, Baozhang Guan, Haiman Xu, Fangjun Yu, Tianpeng Zhang & Baojian Wu. (2019) The Molecular Mechanism Regulating Diurnal Rhythm of Flavin-Containing Monooxygenase 5 in Mouse Liver. Drug Metabolism and Disposition 47:11, pages 1333-1342.
Crossref
Tong Zhang, Ping Yang, Jianchang Wei, Wanglin Li, Junbin Zhong, Huacui Chen & Jie Cao. (2018) Overexpression of flavin-containing monooxygenase 5 predicts poor prognosis in patients with colorectal cancer. Oncology Letters.
Crossref
J.R. Cashman. 2018. Comprehensive Toxicology. Comprehensive Toxicology 87 125 .
Flora Scott, Sandra G. Gonzalez Malagon, Brett A. O’Brien, Diede Fennema, Sunil Veeravalli, Clarissa R. Coveney, Ian R. Phillips & Elizabeth A. Shephard. (2017) Identification of Flavin-Containing Monooxygenase 5 (FMO5) as a Regulator of Glucose Homeostasis and a Potential Sensor of Gut Bacteria. Drug Metabolism and Disposition 45:9, pages 982-989.
Crossref
Chien-wei Fu & Thy-Hou Lin. (2017) Predicting the Metabolic Sites by Flavin-Containing Monooxygenase on Drug Molecules Using SVM Classification on Computed Quantum Mechanics and Circular Fingerprints Molecular Descriptors. PLOS ONE 12:1, pages e0169910.
Crossref
Filippo Fiorentini, Martina Geier, Claudia Binda, Margit Winkler, Kurt Faber, Mélanie Hall & Andrea Mattevi. (2016) Biocatalytic Characterization of Human FMO5: Unearthing Baeyer–Villiger Reactions in Humans. ACS Chemical Biology 11:4, pages 1039-1048.
Crossref
Sandra G. Gonzalez Malagon, Anna N. Melidoni, Diana Hernandez, Bilal A. Omar, Lyndsey Houseman, Sunil Veeravalli, Flora Scott, Dorsa Varshavi, Jeremy Everett, Yugo Tsuchiya, John F. Timms, Ian R. Phillips & Elizabeth A. Shephard. (2015) The phenotype of a knockout mouse identifies flavin-containing monooxygenase 5 (FMO5) as a regulator of metabolic ageing. Biochemical Pharmacology 96:3, pages 267-277.
Crossref
Gabriele Cruciani, Aurora Valeri, Laura Goracci, Roberto Maria Pellegrino, Federica Buonerba & Massimo Baroni. (2014) Flavin Monooxygenase Metabolism: Why Medicinal Chemists Should Matter. Journal of Medicinal Chemistry 57:14, pages 6183-6196.
Crossref
Alexander V. LyubimovMurali Subramanian & Timothy S. Tracy. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions 1 27 .
Meike S. Motika, Jun Zhang, Erik C. Ralph, Mary A. Dwyer & John R. Cashman. (2012) pH dependence on functional activity of human and mouse flavin-containing monooxygenase 5. Biochemical Pharmacology 83:7, pages 962-968.
Crossref
DaCheng Hao & PeiGen Xiao. (2011) Prediction of sites under adaptive evolution in flavin-containing monooxygenases: Selection pattern revisited. Chinese Science Bulletin 56:12, pages 1246-1255.
Crossref
W. George Lai, Nadia Farah, George A. Moniz & Y. Nancy Wong. (2011) A Baeyer-Villiger Oxidation Specifically Catalyzed by Human Flavin-Containing Monooxygenase 5. Drug Metabolism and Disposition 39:1, pages 61-70.
Crossref
Carl D. Davis & A. David Rodrigues. 2010. Pharmaceutical Sciences Encyclopedia. Pharmaceutical Sciences Encyclopedia 1 58 .
J.R. Cashman & M.S. Motika. 2010. Comprehensive Toxicology. Comprehensive Toxicology 77 110 .
Da Cheng Hao, Shi Lin Chen, Jun Mu & Pei Gen Xiao. (2009) Molecular phylogeny, long-term evolution, and functional divergence of flavin-containing monooxygenases. Genetica 137:2, pages 173-187.
Crossref
Carl D. Davis & A. David Rodrigues. 2009. Drug Metabolism Handbook. Drug Metabolism Handbook 391 447 .
Jun Zhang, Matt A. Cerny, Matt Lawson, Ruzbeh Mosadeghi & John R. Cashman. (2007) Functional activity of the mouse flavin‐containing monooxygenase forms 1, 3, and 5. Journal of Biochemical and Molecular Toxicology 21:4, pages 206-215.
Crossref
John R. CashmanJun Zhang. (2006) HUMAN FLAVIN-CONTAINING MONOOXYGENASES. Annual Review of Pharmacology and Toxicology 46:1, pages 65-100.
Crossref
Jun Zhang & John R. Cashman. (2006) QUANTITATIVE ANALYSIS OF FMO GENE mRNA LEVELS IN HUMAN TISSUES . Drug Metabolism and Disposition 34:1, pages 19-26.
Crossref
Sharon K. Krueger & David E. Williams. (2005) Mammalian flavin-containing monooxygenases: structure/function, genetic polymorphisms and role in drug metabolism. Pharmacology & Therapeutics 106:3, pages 357-387.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.