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Xenobiotica
the fate of foreign compounds in biological systems
Volume 34, 2004 - Issue 10
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Research Article

Metabolic disposition of gefitinib, an epidermal growth factor receptor tyrosine kinase inhibitor, in rat, dog and man

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Pages 917-934 | Received 28 Jun 2004, Published online: 22 Sep 2008

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Billy J. Molloy, Adam King, Lauren G. Mullin, Lee A. Gethings, Robert Riley, Robert S. Plumb & Ian D. Wilson. (2021) Rapid determination of the pharmacokinetics and metabolic fate of gefitinib in the mouse using a combination of UPLC/MS/MS, UPLC/QToF/MS, and ion mobility (IM)-enabled UPLC/QToF/MS. Xenobiotica 51:4, pages 434-446.
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Toshihiro Sato, Hajime Ito, Ayaka Hirata, Takaaki Abe, Nariyasu Mano & Hiroaki Yamaguchi. (2018) Interactions of crizotinib and gefitinib with organic anion-transporting polypeptides (OATP)1B1, OATP1B3 and OATP2B1: gefitinib shows contradictory interaction with OATP1B3. Xenobiotica 48:1, pages 73-78.
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D. McKillop, S. P. Guy, M. P. Spence, J. Kendrew, J. V. Kemp, N. Bushby, P. G. Wood, S. Barnett & M. Hutchison. (2006) Minimal contribution of desmethyl-gefitinib, the major human plasma metabolite of gefitinib, to epidermal growth factor receptor (EGFR)-mediated tumour growth inhibition. Xenobiotica 36:1, pages 29-39.
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