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Xenobiotica
the fate of foreign compounds in biological systems
Volume 34, 2004 - Issue 6
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Research Article

Pharmacokinetics of two major hydroxylated polychlorinated biphenyl metabolites with specific retention in rat blood

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Pages 581-589 | Received 20 Feb 2004, Published online: 22 Sep 2008

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Read on this site (5)

Michael W. Duffel & Hans-Joachim Lehmler. (2024) Complex roles for sulfation in the toxicities of polychlorinated biphenyls. Critical Reviews in Toxicology 54:2, pages 92-122.
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Fabian A. Grimm, Dingfei Hu, Izabela Kania-Korwel, Hans-Joachim Lehmler, Gabriele Ludewig, Keri C. Hornbuckle, Michael W. Duffel, Åke Bergman & Larry W. Robertson. (2015) Metabolism and metabolites of polychlorinated biphenyls. Critical Reviews in Toxicology 45:3, pages 245-272.
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P. Ruiz, E. Myshkin, P. Quigley, O. Faroon, J.S. Wheeler, M.M. Mumtaz & R.J. Brennan. (2013) Assessment of hydroxylated metabolites of polychlorinated biphenyls as potential xenoestrogens: a QSAR comparative analysis∗ . SAR and QSAR in Environmental Research 24:5, pages 393-416.
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Articles from other publishers (27)

Shuai Wang, Meng-Yuan Wang, Yong-Fu Shi, Feng Han, Hong-Li Ye, You-Qiong Cai, Di Wu, Liang-Liang Tian, Xuan Zhang & Yun-Yu Tang. (2022) Identification of 2,2′,4,5,5′-Pentachlorobiphenyl (PCB101) metabolites and their transmission characteristics in silver crucian carp (Carassius auratus gibelio). Environmental Pollution 307, pages 119583.
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Panithi Saktrakulkla, Xueshu Li, Andres Martinez, Hans-Joachim Lehmler & Keri C. Hornbuckle. (2022) Hydroxylated Polychlorinated Biphenyls Are Emerging Legacy Pollutants in Contaminated Sediments. Environmental Science & Technology 56:4, pages 2269-2278.
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Shengtao Ma, Guofa Ren, Xiangying Zeng, Zhiqiang Yu, Guoying Sheng & Jiamo Fu. (2017) Polychlorinated biphenyls and their hydroxylated metabolites in the serum of e-waste dismantling workers from eastern China. Environmental Geochemistry and Health 40:5, pages 1931-1940.
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Mari Ochiai, Midori Iida, Tetsuro Agusa, Kohki Takaguchi, Satoshi Fujii, Kei Nomiyama & Hisato Iwata. (2018) Effects of 4-Hydroxy-2,3,3′,4′,5-Pentachlorobiphenyl (4-OH-CB107) on Liver Transcriptome in Rats: Implication in the Disruption of Circadian Rhythm and Fatty Acid Metabolism. Toxicological Sciences 165:1, pages 118-130.
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Asahi Haijima, Ronny Lesmana, Noriaki Shimokawa, Izuki Amano, Yusuke Takatsuru & Noriyuki Koibuchi. (2017) Differential neurotoxic effects of <i>in utero</i> and lactational exposure to hydroxylated polychlorinated biphenyl (OH-PCB 106) on spontaneous locomotor activity and motor coordination in young adult male mice. The Journal of Toxicological Sciences 42:4, pages 407-416.
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Koichi Haraguchi, Yoshiko Ito, Masae Takagi, Yukiko Fujii, Kouji H. Harada & Akio Koizumi. (2016) Levels, profiles and dietary sources of hydroxylated PCBs and hydroxylated and methoxylated PBDEs in Japanese women serum samples. Environment International 97, pages 155-162.
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Danny Pauwels, Sanaz Pilehvar, Bart Geboes, Annick Hubin, Karolien De Wael & Tom Breugelmans. (2016) A new multisine-based impedimetric aptasensing platform. Electrochemistry Communications 71, pages 23-27.
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Hazuki Mizukawa, Kei Nomiyama, Tatsuya Kunisue, Michio X. Watanabe, Annamalai Subramanian, Hisato Iwata, Mayumi Ishizuka & Shinsuke Tanabe. (2015) Organohalogens and their hydroxylated metabolites in the blood of pigs from an open waste dumping site in south India: Association with hepatic cytochrome P450. Environmental Research 138, pages 255-263.
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Chiho Ohta, Koichi Haraguchi, Yoshihisa Kato, Tetsuya Endo, Osamu Kimura & Nobuyuki Koga. (2015) Distribution and excretion of 2,2′,3,4′,5,5′,6-heptachlorobiphenyl (CB187) and its metabolites in rats and guinea pigs. Chemosphere 118, pages 5-11.
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Aya Hisada, Kazuhisa Shimodaira, Takashi Okai, Kiyohiko Watanabe, Hiroaki Takemori, Takumi Takasuga, Maiko Koyama, Noriko Watanabe, Emiko Suzuki, Miyako Shirakawa, Yumiko Noda, Yoko Komine, Nagako Ariki, Nobumasa Kato & Jun Yoshinaga. (2014) Associations between levels of hydroxylated PCBs and PCBs in serum of pregnant women and blood thyroid hormone levels and body size of neonates. International Journal of Hygiene and Environmental Health 217:4-5, pages 546-553.
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Sanaz Pilehvar, Jahangir Ahmad Rather, Freddy Dardenne, Johan Robbens, Ronny Blust & Karolien De Wael. (2014) Carbon nanotubes based electrochemical aptasensing platform for the detection of hydroxylated polychlorinated biphenyl in human blood serum. Biosensors and Bioelectronics 54, pages 78-84.
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Aya Hisada, Kazuhisa Shimodaira, Takashi Okai, Kiyohiko Watanabe, Hiroaki Takemori, Takumi Takasuga, Yumiko Noda, Miyako Shirakawa, Nobumasa Kato & Jun Yoshinaga. (2012) Serum levels of hydroxylated PCBs, PCBs and thyroid hormone measures of Japanese pregnant women. Environmental Health and Preventive Medicine 18:3, pages 205-214.
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Anders Glynn, Maria Larsdotter, Marie Aune, Per Ola Darnerud, Rickard Bjerselius & Åke Bergman. (2011) Changes in serum concentrations of polychlorinated biphenyls (PCBs), hydroxylated PCB metabolites and pentachlorophenol during pregnancy. Chemosphere 83:2, pages 144-151.
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Arno C. GutlebPeter CenijnMartin van VelzenElisabeth LieErik RopstadJanneche Utne SkaareTina MalmbergÅke BergmanGeir W. GabrielsenJuliette Legler. (2010) In Vitro Assay Shows That PCB Metabolites Completely Saturate Thyroid Hormone Transport Capacity in Blood of Wild Polar Bears ( Ursus maritimus ) . Environmental Science & Technology 44:8, pages 3149-3154.
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June-Soo Park, Olga Ioanna Kalantzi, Dianne Kopec & Myrto Petreas. (2009) Polychlorinated biphenyls (PCBs) and their hydroxylated metabolites (OH-PCBs) in livers of harbor seals (Phoca vitulina) from San Francisco Bay, California and Gulf of Maine. Marine Environmental Research 67:3, pages 129-135.
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Tatsuya Kunisue & Shinsuke Tanabe. (2009) Hydroxylated polychlorinated biphenyls (OH-PCBs) in the blood of mammals and birds from Japan: Lower chlorinated OH-PCBs and profiles. Chemosphere 74:7, pages 950-961.
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Marte Braathen, Anne Skjetne Mortensen, Morten Sandvik, Janneche Utne Skåre & Augustine Arukwe. (2008) Estrogenic Effects of Selected Hydroxy Polychlorinated Biphenyl Congeners in Primary Culture of Atlantic Salmon (Salmo salar) Hepatocytes. Archives of Environmental Contamination and Toxicology 56:1, pages 111-122.
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Heli RouttiRobert J. LetcherAugustine ArukweBert van BavelNigel G. YoccozShaogang ChuGeir W. Gabrielsen. (2008) Biotransformation of PCBs in Relation to Phase I and II Xenobiotic-Metabolizing Enzyme Activities in Ringed Seals ( Phoca hispida ) from Svalbard and the Baltic Sea . Environmental Science & Technology 42:23, pages 8952-8958.
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Jonathan Verreault, Rune Dietz, Christian Sonne, Wouter A. Gebbink, Soheila Shahmiri & Robert J. Letcher. (2008) Comparative fate of organohalogen contaminants in two top carnivores in Greenland: Captive sledge dogs and wild polar bears. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 147:3, pages 306-315.
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Wouter A. GebbinkChristian SonneRune DietzMaja KirkegaardErik W. BornDerek C.G. MuirRobert J. Letcher. (2007) Target Tissue Selectivity and Burdens of Diverse Classes of Brominated and Chlorinated Contaminants in Polar Bears (Ursus maritimus) from East Greenland. Environmental Science & Technology 42:3, pages 752-759.
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Anne S. Mortensen, Marte Braathen, Morten Sandvik & Augustine Arukwe. (2007) Effects of hydroxy-polychlorinated biphenyl (OH-PCB) congeners on the xenobiotic biotransformation gene expression patterns in primary culture of Atlantic salmon (Salmo salar) hepatocytes. Ecotoxicology and Environmental Safety 68:3, pages 351-360.
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Kendrick Turner, Shifen Xu, Patrizia Pasini, Sapna Deo, Leonidas Bachas & Sylvia Daunert. (2007) Hydroxylated Polychlorinated Biphenyl Detection Based on a Genetically Engineered Bioluminescent Whole-Cell Sensing System. Analytical Chemistry 79:15, pages 5740-5745.
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J. Verreault, S. Shahmiri, G.W. Gabrielsen & R.J. Letcher. (2007) Organohalogen and metabolically-derived contaminants and associations with whole body constituents in Norwegian Arctic glaucous gulls. Environment International 33:6, pages 823-830.
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Seo-Hee You, Kelly J. Gauger, Ruby Bansal & R. Thomas Zoeller. (2006) 4-Hydroxy-PCB106 acts as a direct thyroid hormone receptor agonist in rat GH3 cells. Molecular and Cellular Endocrinology 257-258, pages 26-34.
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Lotta Hovander, Linda Linderholm, Maria Athanasiadou, Ioannis Athanassiadis, Anders Bignert, Britta Fängström, Anton Kocan, Jan Petrik, Tomas Trnovec & Åke Bergman. (2006) Levels of PCBs and Their Metabolites in the Serum of Residents of a Highly Contaminated Area in Eastern Slovakia. Environmental Science & Technology 40:12, pages 3696-3703.
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Britta Fängström, Lotta Hovander, Anders Bignert, Ioannis Athanassiadis, Linda Linderholm, Philippe Grandjean, Pál Weihe & Åke Bergman. (2005) Concentrations of Polybrominated Diphenyl Ethers, Polychlorinated Biphenyls, and Polychlorobiphenylols in Serum from Pregnant Faroese Women and Their Children 7 Years Later. Environmental Science & Technology 39:24, pages 9457-9463.
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. (2005) Opinion of the Scientific Panel on contaminants in the food chain [CONTAM] related to the presence of non dioxin-like polychlorinated biphenyls (PCB) in feed and food. EFSA Journal 3:11, pages 284.
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