Xenobiotica, Volume 34, Issue 6 (2004)

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Xenobiotica, Volume 34, Issue 6 (2004)

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Research Article

Article
Quantitative structure-activity relationships within a homologous series of 7-alkoxyresorufins exhibiting activity towards CYP1A and CYP2B enzymes: molecular modelling studies on key members of the resorufin series with CYP2C5-derived models of human CYP1A1, CYP1A2, CYP2B6 and CYP3A4
David F. V. Lewis, Brian G. Lake & M. Dickins
Pages: 501-513
Published online: 22 Sep 2008
AbstractforQuantitative structure-activity relationships within a homologous series of 7-alkoxyresorufins exhibiting activity towards CYP1A and CYP2B enzymes: molecular modelling studies on key members of the resorufin series with CYP2C5-derived models of human CYP1A1, CYP1A2, CYP2B6 and CYP3A4 | References | PDF (642.6 KB)
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Article
Molecular modelling of CYP2A enzymes: application to metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)
J. R. Jalas, M. Seetharaman, S. S. Hecht & S. E. Murphy
Pages: 515-533
Published online: 22 Sep 2008
AbstractforMolecular modelling of CYP2A enzymes: application to metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) | References | PDF (830.5 KB)
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Article
In vitro assessment of intestinal permeability and hepatic metabolism of 4′-bromoflavone, a promising cancer chemopreventive agent
Y. Li, S. Grubjesic, D. Nikolic, D. Zhu, J. W. Kosmeder, R. M. Moriarty, J. M. Pezzuto & R. B. Van Breemen
Pages: 535-547
Published online: 22 Sep 2008
AbstractforIn vitro assessment of intestinal permeability and hepatic metabolism of 4′-bromoflavone, a promising cancer chemopreventive agent | References | PDF (332.5 KB)
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Article
Homology modelling of CYP3A4 from the CYP2C5 crystallographic template: analysis of typical CYP3A4 substrate interactions
D. F. V. Lewis, B. G. Lake, M. Dickins & P. S. Goldfarb
Pages: 549-569
Published online: 22 Sep 2008
AbstractforHomology modelling of CYP3A4 from the CYP2C5 crystallographic template: analysis of typical CYP3A4 substrate interactions | References | PDF (2.2 MB)
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Article
Prediction of clinical pharmacokinetic parameters of linezolid using animal data by allometric scaling: applicability for the development of novel oxazolidinones
R. K. Bhamidipati, P. V. Dravid, R. Mullangi & N. R. Srinivas
Pages: 571-579
Published online: 22 Sep 2008
AbstractforPrediction of clinical pharmacokinetic parameters of linezolid using animal data by allometric scaling: applicability for the development of novel oxazolidinones | References | PDF (100.3 KB)
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Article
Pharmacokinetics of two major hydroxylated polychlorinated biphenyl metabolites with specific retention in rat blood
T. Malmberg, J. Hoogstraate, Å Bergman & E. Klasson Wehler
Pages: 581-589
Published online: 22 Sep 2008
AbstractforPharmacokinetics of two major hydroxylated polychlorinated biphenyl metabolites with specific retention in rat blood | References | PDF (110.4 KB)
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Article
Metabolism of the antineoplastic and immunosuppressive drug 2-CdA (Leustatin®) in animals and humans
W. N. Wu, L. A. Mckown, M. D. Moyer & W. Cheung
Pages: 591-606
Published online: 22 Sep 2008
AbstractforMetabolism of the antineoplastic and immunosuppressive drug 2-CdA (Leustatin®) in animals and humans | References | PDF (909.6 KB)
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