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Xenobiotica
the fate of foreign compounds in biological systems
Volume 36, 2006 - Issue 1
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Research Article

Metabolism of 3-chloro-4-fluoroaniline in rat using [14C]-radiolabelling, 19F-NMR spectroscopy, HPLC-MS/MS, HPLC-ICPMS and HPLC-NMR

C. J. Duckett Biological Chemistry, Division of Biomedical Sciences, Imperial College, London, UK
,
J. C. Lindon Biological Chemistry, Division of Biomedical Sciences, Imperial College, London, UK
,
H. Walker GV Instruments, Atlas Park, Simonsway, Manchester, UK
,
F. Abou-Shakra GV Instruments, Atlas Park, Simonsway, Manchester, UK
,
I. D. Wilson Department of Drug Metabolism and Pharmacokinetics, AstraZeneca, Mereside, Alderley Park, Macclesfield, UK
&
J. K. Nicholson Biological Chemistry, Division of Biomedical Sciences, Imperial College, London, UK
Pages 59-77 | Received 30 Aug 2005, Published online: 22 Sep 2008

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David Pearson, Maxime Garnier, Alexandre Luneau, Alexander David James & Markus Walles. (2019) 19F-NMR-based determination of the absorption, metabolism and excretion of the oral phosphatidylinositol-3-kinase (PI3K) delta inhibitor leniolisib (CDZ173) in healthy volunteers. Xenobiotica 49:8, pages 953-960.
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Catherine Duckett, Michael McCullagh, Christopher Smith & Ian D Wilson. (2015) The metabolism of 4-bromoaniline in the bile-cannulated rat: application of ICPMS (79/81Br), HPLC-ICPMS & HPLC-oaTOFMS. Xenobiotica 45:8, pages 672-680.
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Toby J. Athersuch, Ian D. Wilson, Hector C. Keun & John C. Lindon. (2013) Development of quantitative structure-metabolism (QSMR) relationships for substituted anilines based on computational chemistry. Xenobiotica 43:9, pages 792-802.
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Fred van Heuveln, Henri Meijering & Jaap Wieling. (2012) Inductively Coupled Plasma-Ms in Drug Development: Bioanalytical Aspects And Applications. Bioanalysis 4:15, pages 1933-1965.
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Pat Wright. (2011) Metabolite identification by mass spectrometry: forty years of evolution. Xenobiotica 41:8, pages 670-686.
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Gordon J Dear, Claire Beaumont, Andrew Roberts, Bianca Squillaci, Steve Thomas, Mike Nash & Donna Fraser. (2011) Approaches for The Rapid Identification of Drug Metabolites in Early Clinical Studies. Bioanalysis 3:2, pages 197-213.
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Angus NR Nedderman & Pat Wright. (2010) Looking Back Through the MIST: A Perspective of Evolving Strategies and Key Focus Areas for Metabolite Safety Analysis. Bioanalysis 2:7, pages 1235-1248.
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T. J. Athersuch, J. Castro-Perez, C. Rodgers, J. K. Nicholson & I. D. Wilson. (2010) UPLC-MS, HPLC-radiometric, and NMR-spectroscopic studies on the metabolic fate of 3-fluoro-[U-14C]-aniline in the bile-cannulated rat. Xenobiotica 40:7, pages 510-523.
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Pat Wright, Zhuang Miao & Barclay Shilliday. (2009) Metabolite Quantitation: Detector Technology and MIST Implications. Bioanalysis 1:4, pages 831-845.
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Götz Schlotterbeck & Simona M Ceccarelli. (2009) LC–SPE–NMR–MS: A Total Analysis System for Bioanalysis. Bioanalysis 1:3, pages 549-559.
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Bente Gammelgaard, Helle Rüsz Hansen, Stefan Stürup & Charlotte Møller. (2008) The use of inductively coupled plasma mass spectrometry as a detector in drug metabolism studies. Expert Opinion on Drug Metabolism & Toxicology 4:9, pages 1187-1207.
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E. Monteagudo, S. Pesci, M. Taliani, F. Fiore, A. Petrocchi, E. Nizi, M. Rowley, R. Laufer & V. Summa. (2007) Studies of metabolism and disposition of potent human immunodeficiency virus (HIV) integrase inhibitors using 19F-NMR spectroscopy. Xenobiotica 37:9, pages 1000-1012.
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B. Kammerer, H. Scheible, G. Zurek, M. Godejohann, K.-P. Zeller, C. H. Gleiter, W. Albrecht & S. Laufer. (2007) In vitro metabolite identification of ML3403, a 4-pyridinylimidazole-type p38 MAP kinase inhibitor by LC-Qq-TOF-MS and LC-SPE-cryo-NMR/MS. Xenobiotica 37:3, pages 280-297.
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T. J. Athersuch, C. J. Duckett, J. Castro-Perez, C. Rodgers, J. K. Nicholson & I. D. Wilson. (2007) Metabolism of [14C]-5-chloro-1,3-benzodioxol-4-amine in male Wistar-derived rats following intraperitoneal administration. Xenobiotica 37:1, pages 44-58.
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Gabriele Sabbioni. (2017) Hemoglobin Adducts and Urinary Metabolites of Arylamines and Nitroarenes. Chemical Research in Toxicology 30:10, pages 1733-1766.
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J. Giner Martínez-Sierra, O. Galilea San Blas, J.M. Marchante Gayón & J.I. García Alonso. (2015) Sulfur analysis by inductively coupled plasma-mass spectrometry: A review. Spectrochimica Acta Part B: Atomic Spectroscopy 108, pages 35-52.
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Abdul E. Mutlib. 2014. Handbook of Metabolic Pathways of Xenobiotics. Handbook of Metabolic Pathways of Xenobiotics 1 31 .
Abdul Mutlib, Robert Espina, James Atherton, Jianyao Wang, Rasmy Talaat, JoAnn Scatina & Appavu Chandrasekaran. (2012) Alternate Strategies to Obtain Mass Balance without the Use of Radiolabeled Compounds: Application of Quantitative Fluorine ( 19 F) Nuclear Magnetic Resonance (NMR) Spectroscopy in Metabolism Studies . Chemical Research in Toxicology 25:3, pages 572-583.
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Devi Datt JoshiDevi Datt Joshi. 2012. Herbal Drugs and Fingerprints. Herbal Drugs and Fingerprints 61 81 .
James S. McKenzie, James A. Donarski, Julie C. Wilson & Adrian J. Charlton. (2011) Analysis of complex mixtures using high-resolution nuclear magnetic resonance spectroscopy and chemometrics. Progress in Nuclear Magnetic Resonance Spectroscopy 59:4, pages 336-359.
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Abdul Mutlib, Robert Espina, Karthick Vishwanathan, Kathlene Babalola, Zecheng Chen, Christoph Dehnhardt, Aranapakam Venkatesan, Tarek Mansour, Inder Chaudhary, Rasmy Talaat & JoAnn Scatina. (2011) Application of Quantitative NMR in Pharmacological Evaluation of Biologically Generated Metabolites: Implications in Drug Discovery. Drug Metabolism and Disposition 39:1, pages 106-116.
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Ian D. Wilson. 2011. Metabolic Profiling. Metabolic Profiling 173 190 .
M. Holčapek, L. Kolářová & M. Nobilis. (2008) High-performance liquid chromatography–tandem mass spectrometry in the identification and determination of phase I and phase II drug metabolites. Analytical and Bioanalytical Chemistry 391:1, pages 59-78.
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Jian‐Xin Yu, Weina Cui, Dawen Zhao & Ralph P. Mason. 2008. Fluorine and Health. Fluorine and Health 197 276 .
Toby J. Athersuch, Jeremy K. Nicholson & Ian D. Wilson. (2007) Isotopic enrichment enhancement in metabonomic analysis of UPLC–MS data sets. Journal of Labelled Compounds and Radiopharmaceuticals 50:5-6, pages 303-307.
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Bente Gammelgaard & Berit Packert Jensen. (2007) Application of inductively coupled plasma mass spectrometry in drug metabolism studies. Journal of Analytical Atomic Spectrometry 22:3, pages 235.
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. (2006) Current literature in mass spectrometry. Journal of Mass Spectrometry 41:12, pages 1654-1665.
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