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Xenobiotica
the fate of foreign compounds in biological systems
Volume 36, 2006 - Issue 9
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Original

Metabolism of myclobutanil and triadimefon by human and rat cytochrome P450 enzymes and liver microsomes

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Pages 793-806 | Received 04 Apr 2006, Accepted 23 May 2006, Published online: 11 Aug 2009

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Barbara Maino, Simona Paparone, Cinzia Severini, Maria Teresa Ciotti, Velia D’agata, Pietro Calissano & Sebastiano Cavallaro. (2017) Drug target identification at the crossroad of neuronal apoptosis and survival. Expert Opinion on Drug Discovery 12:3, pages 249-259.
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ChristopherS. Mazur, JohnF. Kenneke, Caroline Tebes-Stevens, MilesS. Okino & JohnC. Lipscomb. (2007) In Vitro Metabolism of the Fungicide and Environmental Contaminant trans-bromuconazole and Implications for Risk Assessment. Journal of Toxicology and Environmental Health, Part A 70:14, pages 1241-1250.
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G. Sun, R. D. Grindstaff, S.-F. Thai, G. R. Lambert, D. B. Tully, D. J. Dix & S. Nesnow. (2007) Induction of cytochrome P450 enzymes in rat liver by two conazoles, myclobutanil and triadimefon. Xenobiotica 37:2, pages 180-193.
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Susan Ritger Crowell, W. Matthew Henderson, John F. Kenneke & Jeffrey W. Fisher. (2011) Development and application of a physiologically based pharmacokinetic model for triadimefon and its metabolite triadimenol in rats and humans. Toxicology Letters 205:2, pages 154-162.
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Susan R. Crowell, W. Matthew Henderson, Jeffrey W. Fisher & John F. Kenneke. (2010) Gender and species differences in triadimefon metabolism by rodent hepatic microsomes. Toxicology Letters 193:1, pages 101-107.
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Ernest Hodgson. 2010. Hayes' Handbook of Pesticide Toxicology. Hayes' Handbook of Pesticide Toxicology 941 959 .
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Christopher S. Mazur, John F. Kenneke, Michael-Rock Goldsmith & Cather Brown. (2009) Contrasting Influence of NADPH and a NADPH-Regenerating System on the Metabolism of Carbonyl-Containing Compounds in Hepatic Microsomes. Drug Metabolism and Disposition 37:9, pages 1801-1805.
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Amber K. Goetz & David J. Dix. (2009) Mode of Action for Reproductive and Hepatic Toxicity Inferred from a Genomic Study of Triazole Antifungals. Toxicological Sciences 110:2, pages 449-462.
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John F. Kenneke, Christopher S. Mazur, Susan E. Ritger & Thomas J. Sack. (2008) Mechanistic Investigation of the Noncytochrome P450-Mediated Metabolism of Triadimefon to Triadimenol in Hepatic Microsomes. Chemical Research in Toxicology 21:10, pages 1997-2004.
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Christopher S. Mazur & John F. Kenneke. (2007) Cross-Species Comparison of Conazole Fungicide Metabolites Using Rat and Rainbow Trout (Onchorhynchus mykiss) Hepatic Microsomes and Purified Human CYP 3A4. Environmental Science & Technology 42:3, pages 947-954.
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Amber K. Goetz, Hongzu Ren, Judith E. Schmid, Chad R. Blystone, Inthirany Thillainadarajah, Deborah S. Best, Harriette P. Nichols, Lillian F. Strader, Douglas C. Wolf, Michael G. Narotsky, John C. Rockett & David J. Dix. (2007) Disruption of Testosterone Homeostasis as a Mode of Action for the Reproductive Toxicity of Triazole Fungicides in the Male Rat. Toxicological Sciences 95:1, pages 227-239.
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