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Xenobiotica
the fate of foreign compounds in biological systems
Volume 37, 2007 - Issue 7
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Research Article

Disposition of desloratadine in healthy volunteers

R. Ramanathan Schering-Plough Research Institute, Kenilworth, NJ, USA
,
L. Reyderman Schering-Plough Research Institute, Kenilworth, NJ, USA
,
A.-D. Su Schering-Plough Research Institute, Kenilworth, NJ, USA
,
N. Alvarez Schering-Plough Research Institute, Kenilworth, NJ, USA
,
S. K. Chowdhury Schering-Plough Research Institute, Kenilworth, NJ, USA
,
K. B. Alton Schering-Plough Research Institute, Kenilworth, NJ, USA
,
M. A. Wirth Schering-Plough Research Institute, Kenilworth, NJ, USA
,
R. P. Clement Schering-Plough Research Institute, Kenilworth, NJ, USA
,
P. Statkevich Schering-Plough Research Institute, Kenilworth, NJ, USA
&
J. E. Patrick Schering-Plough Research Institute, Kenilworth, NJ, USA
 show all
Pages 770-787 | Received 02 Apr 2007, Accepted 21 May 2007, Published online: 22 Sep 2008

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Shotaro Uehara, Nao Yoneda, Yuichiro Higuchi, Hiroshi Yamazaki & Hiroshi Suemizu. (2020) Metabolism of desloratadine by chimeric TK-NOG mice transplanted with human hepatocytes. Xenobiotica 50:6, pages 733-740.
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Jean-Marie Nicolas, Pascal Espie & Mathieu Molimard. (2009) Gender and interindividual variability in pharmacokinetics. Drug Metabolism Reviews 41:3, pages 408-421.
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Shu-Feng Zhou, Jun-Ping Liu & Balram Chowbay. (2009) Polymorphism of human cytochrome P450 enzymes and its clinical impact. Drug Metabolism Reviews 41:2, pages 89-295.
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Articles from other publishers (23)

Shotaro Uehara, Hiroshi Suemizu & Hiroshi Yamazaki. 2022. Pharmacology and Toxicology of Cytochrome P450 – 60th Anniversary. Pharmacology and Toxicology of Cytochrome P450 – 60th Anniversary 307 328 .
Suguru Kato, Abhi Shah, Mihaela Plesescu, Yoshinari Miyata, Jayaprakasam Bolleddula, Swapan Chowdhury & Xiaochun Zhu. (2020) Prediction of Human Disproportionate and Biliary Excreted Metabolites Using Chimeric Mice with Humanized Liver. Drug Metabolism and Disposition 48:10, pages 934-943.
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Zhongyang Shi, Chenguang Wang & Changquan Calvin Sun. (2020) Molecular Origin of the Distinct Tabletability of Loratadine and Desloratadine: Role of the Bonding Area – Bonding Strength Interplay. Pharmaceutical Research 37:7.
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Katja Berginc, Nadica Sibinovska, Simon Žakelj, Jurij Trontelj & Igor Legen. (2020) Biopharmaceutical classification of desloratadine – not all drugs are classified the easy way. Acta Pharmaceutica 70:2, pages 131-144.
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Matti K. Itkonen, Aleksi Tornio, Mikko Neuvonen, Pertti J. Neuvonen, Mikko Niemi & Janne T. Backman. (2019) Clopidogrel and Gemfibrozil Strongly Inhibit the CYP2C8-Dependent Formation of 3-Hydroxydesloratadine and Increase Desloratadine Exposure In Humans. Drug Metabolism and Disposition 47:4, pages 377-385.
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R.E. White. 2017. Comprehensive Medicinal Chemistry III. Comprehensive Medicinal Chemistry III 1 33 .
Jörg Täubel, Georg Ferber, Sara Fernandes, Ulrike Lorch, Eva Santamaría & Iñaki Izquierdo. (2016) Pharmacokinetics, Safety and Cognitive Function Profile of Rupatadine 10, 20 and 40 mg in Healthy Japanese Subjects: A Randomised Placebo-Controlled Trial. PLOS ONE 11:9, pages e0163020.
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Shufeng Zhou. 2016. Cytochrome P450 2D6. Cytochrome P450 2D6 139 288 .
Ting Wang, Kun Zhang, Tingting Li, Lin He, Huiru Xie, Xuehua Jiang & Ling Wang. (2015) Prevalence of Desloratadine Slow-metabolizer Phenotype and Food-dependent Pharmacokinetics of Desloratadine in Healthy Chinese Volunteers. Clinical Drug Investigation 35:12, pages 807-813.
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Faraz Kazmi, Phyllis Yerino, Joanna E. Barbara & Andrew Parkinson. (2015) Further Characterization of the Metabolism of Desloratadine and Its Cytochrome P450 and UDP-glucuronosyltransferase Inhibition Potential: Identification of Desloratadine as a Relatively Selective UGT2B10 Inhibitor. Drug Metabolism and Disposition 43:9, pages 1294-1302.
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X Han, SK Quinney, Z Wang, P Zhang, J Duke, Z Desta, JS Elmendorf, DA Flockhart & L Li. (2015) Identification and Mechanistic Investigation of Drug–Drug Interactions Associated With Myopathy: A Translational Approach. Clinical Pharmacology & Therapeutics 98:3, pages 321-327.
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Faraz Kazmi, Joanna E. Barbara, Phyllis Yerino & Andrew Parkinson. (2015) A Long-Standing Mystery Solved: The Formation of 3-Hydroxydesloratadine Is Catalyzed by CYP2C8 But Prior Glucuronidation of Desloratadine by UDP-Glucuronosyltransferase 2B10 Is an Obligatory Requirement. Drug Metabolism and Disposition 43:4, pages 523-533.
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Lyndsee Baumann-Birkbeck, Gary D. Grant, Shailendra Anoopkumar-Dukie & Justin J. Kavanagh. (2014) Drowsiness and motor responses to consecutive daily doses of promethazine and loratadine. Clinical Neurophysiology 125:12, pages 2390-2396.
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Natasha Penner. 2014. Handbook of Metabolic Pathways of Xenobiotics. Handbook of Metabolic Pathways of Xenobiotics 1 3 .
R. Scott Obach. (2013) Pharmacologically Active Drug Metabolites: Impact on Drug Discovery and Pharmacotherapy. Pharmacological Reviews 65:2, pages 578-640.
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Alexander V. LyubimovSilvi A. Chacko, Ragu Ramanathan, W. Griffith Humphreys & Jonathan L. Josephs. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions 1 38 .
Nancy Hakooz & Isam I. Salem. (2012) Prevalence of desloratadine poor metabolizer phenotype in healthy Jordanian males. Biopharmaceutics & Drug Disposition 33:1, pages 15-21.
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Lan Gao, Jing Li, Claudia Kasserra, Qi Song, Ali Arjomand, David Hesk & Swapan K Chowdhury. (2011) Precision and Accuracy in the Quantitative Analysis of Biological Samples by Accelerator Mass Spectrometry: Application in Microdose Absolute Bioavailability Studies. Analytical Chemistry 83:14, pages 5607-5616.
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Shu-Feng Zhou. (2009) Polymorphism of Human Cytochrome P450 2D6 and Its Clinical Significance. Clinical Pharmacokinetics 48:12, pages 761-804.
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Ragu Ramanathan, S Çömezoglu & W Humphreys. 2009. Using Mass Spectrometry for Drug Metabolism Studies, Second Edition. Using Mass Spectrometry for Drug Metabolism Studies, Second Edition 127 203 .
Guodong Chen, Ibrahim Daaro, Birendra N. Pramanik & John J. Piwinski. (2009) Structural characterization of in vitro rat liver microsomal metabolites of antihistamine desloratadine using LTQ-Orbitrap hybrid mass spectrometer in combination with online hydrogen/deuterium exchange HR-LC/MS . Journal of Mass Spectrometry 44:2, pages 203-213.
Crossref
Petia A. Shipkova, Jonathan L. Josephs & Mark Sanders. 2008. Mass Spectrometry in Drug Metabolism and Pharmacokinetics. Mass Spectrometry in Drug Metabolism and Pharmacokinetics 191 221 .
Dil M. Ramanathan & Richard M. Lelacheur. 2008. Mass Spectrometry in Drug Metabolism and Pharmacokinetics. Mass Spectrometry in Drug Metabolism and Pharmacokinetics 1 85 .

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