Citations (94)
Keep up to date with the latest research on this topic with citation updates for this article.
Read on this site (17)
Rebecca Allison, Asha Guraka, Isaac Thom Shawa, Gyan Tripathi, Wolfgang Moritz & Ali Kermanizadeh. (2023) Drug induced liver injury – a 2023 update. Journal of Toxicology and Environmental Health, Part B 26:8, pages 442-467.
Read now
Read now
Shotaro Uehara, Norie Murayama, Yuichiro Higuchi, Nao Yoneda, Hiroshi Yamazaki & Hiroshi Suemizu. (2022) Comparison of mouse and human cytochrome P450 mediated-drug metabolising activities in hepatic and extrahepatic microsomes. Xenobiotica 52:3, pages 229-239.
Read now
Read now
Weijia Han & Zhongping Duan. (2021) Different drug metabolism behavior between species in drug-induced hepatotoxicity: limitations and novel resolutions. Toxin Reviews 40:4, pages 420-431.
Read now
Read now
Jaydeep Yadav, Mehdi El Hassani, Jasleen Sodhi, Volker M. Lauschke, Jessica H. Hartman & Laura E. Russell. (2021) Recent developments in in vitro and in vivo models for improved translation of preclinical pharmacokinetics and pharmacodynamics data. Drug Metabolism Reviews 53:2, pages 207-233.
Read now
Read now
Xianbao Shi, Shuman Yang, Gang Zhang, Yonggui Song, Dan Su, Yali Liu, Feng Guo, Lina Shan & Jiqun Cai. (2016) The different metabolism of morusin in various species and its potent inhibition against UDP-glucuronosyltransferase (UGT) and cytochrome p450 (CYP450) enzymes. Xenobiotica 46:5, pages 467-476.
Read now
Read now
Haruka Nishimuta, Tetsuya Nakagawa, Naruaki Nomura & Masashi Yabuki. (2013) Species differences in hepatic and intestinal metabolic activities for 43 human cytochrome P450 substrates between humans and rats or dogs. Xenobiotica 43:11, pages 948-955.
Read now
Read now
Tuomas Rahikainen, Merja R. Häkkinen, Moshe Finel, Markku Pasanen & Risto O. Juvonen. (2013) A high throughput assay for the glucuronidation of 7-hydroxy-4-trifluoromethylcoumarin by recombinant human UDP-glucuronosyltransferases and liver microsomes. Xenobiotica 43:10, pages 853-861.
Read now
Read now
Marilyn N. Martinez, Leposava Antonovic, Michael Court, Mauro Dacasto, Johanna Fink-Gremmels, Butch Kukanich, Chuck Locuson, Katrina Mealey, Michael J. Myers & Lauren Trepanier. (2013) Challenges in exploring the cytochrome P450 system as a source of variation in canine drug pharmacokinetics. Drug Metabolism Reviews 45:2, pages 218-230.
Read now
Read now
Lorenz R. Rhomberg, Julie E. Goodman, Warren G. Foster, Christopher J. Borgert & Glen Van Der Kraak. (2012) A critique of the European Commission Document, “State of the Art Assessment of Endocrine Disrupters”. Critical Reviews in Toxicology 42:6, pages 465-473.
Read now
Read now
Christian Riebeling, Katrin Hayess, Annelieke K. Peters, Margino Steemans, Horst Spielmann, Andreas Luch & Andrea E. M. Seiler. (2012) Assaying embryotoxicity in the test tube: Current limitations of the embryonic stem cell test (EST) challenging its applicability domain. Critical Reviews in Toxicology 42:5, pages 443-464.
Read now
Read now
Y. L. Song, W. H. Jing, H. Y. Zhao, R. Yan, P. T. Li & Y. T. Wang. (2012) Stereoselective metabolism of (±)-praeruptorin A, a calcium channel blocker from Peucedani Radix, in pooled liver microsomes of rats and humans. Xenobiotica 42:3, pages 231-237.
Read now
Read now
Anders Winbladh, Bergthor Björnsson, Lena Trulsson, Linda Bojmar, Tommy Sundqvist, Per Gullstrand & Per Sandström. (2012) N-acetyl cysteine improves glycogenesis after segmental liver ischemia and reperfusion injury in pigs. Scandinavian Journal of Gastroenterology 47:2, pages 225-236.
Read now
Read now
K.A. Landskroner, P. Hess & A. Treiber. (2011) Surgical and pharmacological animal models used in drug metabolism and pharmacokinetics. Xenobiotica 41:8, pages 687-700.
Read now
Read now
D. K. Sevior, J. Hokkanen, A. Tolonen, K. Abass, L. Tursas, O. Pelkonen & J. T. Ahokas. (2010) Rapid screening of commercially available herbal products for the inhibition of major human hepatic cytochrome P450 enzymes using the N-in-one cocktail. Xenobiotica 40:4, pages 245-254.
Read now
Read now
Khaled Abass, Miia Turpeinen & Olavi Pelkonen. (2009) An evaluation of the cytochrome P450 inhibition potential of selected pesticides in human hepatic microsomes. Journal of Environmental Science and Health, Part B 44:6, pages 553-563.
Read now
Read now
Olavi Pelkonen, Ari Tolonen, Timo Korjamo, Miia Turpeinen & Hannu Raunio. (2009) From Known Knowns to Known Unknowns: Predicting in Vivo Drug Metabolites. Bioanalysis 1:2, pages 393-414.
Read now
Read now
J. E. Laine, S. Auriola, M. Pasanen & R. O. Juvonen. (2009) Acetaminophen bioactivation by human cytochrome P450 enzymes and animal microsomes. Xenobiotica 39:1, pages 11-21.
Read now
Read now
Articles from other publishers (77)
Kristin Beirow, Christian Schmidt, Britta Jürgen, Rabea Schlüter, Thomas Schweder & Patrick J. Bednarski. (2023)
Investigation of TGF‐
α
‐overexpressing mouse hepatocytes (TAMH) cultured as spheroids for use in hepatotoxicity screening of drug candidates
. Journal of Applied Toxicology 44:2, pages 272-286.
Crossref
Crossref
Raja S. Settivari, Austin Martini, Sanjeeva Wijeyesakere, Abigail Toltin & Mathew J. LeBaron. 2024. A Comprehensive Guide to Toxicology in Nonclinical Drug Development. A Comprehensive Guide to Toxicology in Nonclinical Drug Development
977
1015
.
Paula Ichinose, María Victoria Miró, Karen Larsen, Carlos Lanusse, Adrián Lifschitz & Guillermo Virkel. (2022) Medication with fenbendazole in feed: plasma concentrations and effects on hepatic xenobiotic metabolizing enzymes in swine. Veterinary Research Communications 47:2, pages 803-815.
Crossref
Crossref
B Rochat, E Paus, C Maitre & P Baumann. (2023) Citalopram in vitro metabolism in a beagle dog: A role for CYP2D15 in the production of toxic didesmethylcitalopram?. Veterinární medicína 68:4, pages 135-144.
Crossref
Crossref
Artitaya Thiengsusuk, Tullayakorn Plengsuriyakarn & Kesara Na-Bangchang. (2023) Modulatory Effects of Atractylodin and β-Eudesmol on Human Cytochrome P450 Enzymes: Potential Drug-Drug Interactions. Molecules 28:7, pages 3140.
Crossref
Crossref
Manon C. Bouwmeester, Yu Tao, Susana Proença, Frank G. van Steenbeek, Roos-Anne Samsom, Sandra M. Nijmeijer, Theo Sinnige, Luc J. W. van der Laan, Juliette Legler, Kerstin Schneeberger, Nynke I. Kramer & Bart Spee. (2023) Drug Metabolism of Hepatocyte-like Organoids and Their Applicability in In Vitro Toxicity Testing. Molecules 28:2, pages 621.
Crossref
Crossref
M. V. Miroshnikov, K. T. Sultanova, M. N. Makarova & V. G. Makarov. (2022) A comparative review of the activity of enzymes of the cytochrome P450 system in humans and laboratory animals. Prognostic value of preclinical models in vivo. Translational Medicine 9:5, pages 44-77.
Crossref
Crossref
Fernando Ezquer, Ya-Lin Huang & Marcelo Ezquer. (2022) New Perspectives to Improve Mesenchymal Stem Cell Therapies for Drug-Induced Liver Injury. International Journal of Molecular Sciences 23:5, pages 2669.
Crossref
Crossref
Haonan Li, Yalong Wang, Mengxian Zhang, Hong Wang, Along Cui, Jianguo Zhao, Weizhi Ji & Ye-Guang Chen. (2021) Establishment of porcine and monkey colonic organoids for drug toxicity study. Cell Regeneration 10:1.
Crossref
Crossref
Patrick Indorf, Andreas Patzak & Falk‐Bach Lichtenberger. (2021) Drug metabolism in animal models and humans: Translational aspects and chances for individual therapy. Acta Physiologica 233:4.
Crossref
Crossref
Ning Ding, Syunsuke Yamamoto, Ikumi Chisaki, Miyu Nakayama, Shin-ichi Matsumoto & Hideki Hirabayashi. (2021) Utility of Göttingen minipigs for the prediction of human pharmacokinetic profiles after intravenous drug administration. Drug Metabolism and Pharmacokinetics 41, pages 100408.
Crossref
Crossref
Yannan Ding, Honghong Ma, Yasha Xu, Feng Yang, Yi Li, Fuguo Shi & Yuanfu Lu. (2021) Potentiation of flutamide-induced hepatotoxicity in mice by Xian-Ling-Gu-Bao through induction of CYP1A2. Journal of Ethnopharmacology 278, pages 114299.
Crossref
Crossref
Mona Mansouri & Nic D. Leipzig. (2021)
Advances in removing mass transport limitations for more physiologically relevant
in vitro
3D cell constructs
. Biophysics Reviews 2:2.
Crossref
Crossref
Nadja Walle, Frederike Nordmeier, Adrian A. Doerr, Benjamin Peters, Matthias W. Laschke, Michael D. Menger, Peter H. Schmidt, Markus R. Meyer & Nadine Schaefer. (2020)
Comparison of
in vitro
and
in vivo
models for the elucidation of metabolic patterns of 7‐azaindole‐derived synthetic cannabinoids exemplified using cumyl‐5F‐P7AICA
. Drug Testing and Analysis 13:1, pages 74-90.
Crossref
Crossref
Yong-Wook Son, Ha-Ni Choi, Jeong-Hwan Che, Byeong-Cheol Kang & Jun-Won Yun. (2020) Advances in selecting appropriate non-rodent species for regulatory toxicology research: Policy, ethical, and experimental considerations. Regulatory Toxicology and Pharmacology 116, pages 104757.
Crossref
Crossref
Frederike Nordmeier, Adrian Doerr, Matthias W. Laschke, Michael D. Menger, Peter H. Schmidt, Nadine Schaefer & Markus R. Meyer. (2020) Are pigs a suitable animal model for in vivo metabolism studies of new psychoactive substances? A comparison study using different in vitro/in vivo tools and U-47700 as model drug. Toxicology Letters 329, pages 12-19.
Crossref
Crossref
Anders Bork Davidsen, Marie Mardal, Sys Stybe Johansen, Petur Weihe Dalsgaard & Kristian Linnet. (2020) In vitro and in vivo metabolism and detection of 3‐HO‐PCP, a synthetic phencyclidine, in human samples and pooled human hepatocytes using high resolution mass spectrometry. Drug Testing and Analysis 12:7, pages 987-993.
Crossref
Crossref
James C. Fuscoe, Vikrant Vijay, Joseph P. Hanig, Tao Han, Lijun Ren, James J. Greenhaw, Richard D. Beger, Lisa M. Pence & Qiang Shi. (2020) Hepatic Transcript Profiles of Cytochrome P450 Genes Predict Sex Differences in Drug Metabolism. Drug Metabolism and Disposition 48:6, pages 447-458.
Crossref
Crossref
Seiichi Ishida. 2020. Organ-on-a-chip. Organ-on-a-chip
181
213
.
Frederike Nordmeier, Lilian H. J. Richter, Peter H. Schmidt, Nadine Schaefer & Markus R. Meyer. (2019) Studies on the in vitro and in vivo metabolism of the synthetic opioids U-51754, U-47931E, and methoxyacetylfentanyl using hyphenated high-resolution mass spectrometry. Scientific Reports 9:1.
Crossref
Crossref
Yvonne Chang, Lisbeth K. Siddens, Lauren K. Heine, David A. Sampson, Zhen Yu, Kay A. Fischer, Christiane V. Löhr & Susan C. Tilton. (2019) Comparative mechanisms of PAH toxicity by benzo[a]pyrene and dibenzo[def,p]chrysene in primary human bronchial epithelial cells cultured at air-liquid interface. Toxicology and Applied Pharmacology 379, pages 114644.
Crossref
Crossref
Wim Schelstraete, Laura De Clerck, Elisabeth Govaert, Joske Millecam, Mathias Devreese, Dieter Deforce, Jan Van Bocxlaer & Siska Croubels. (2019) Characterization of Porcine Hepatic and Intestinal Drug Metabolizing CYP450: Comparison with Human Orthologues from A Quantitative, Activity and Selectivity Perspective. Scientific Reports 9:1.
Crossref
Crossref
Mitchell R. McGill & Hartmut Jaeschke. (2019) Animal models of drug-induced liver injury. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1865:5, pages 1031-1039.
Crossref
Crossref
Wim Schelstraete, Mathias Devreese & Siska Croubels. (2019) Impact of Subacute Exposure to T-2 Toxin and Zearalenone on the Pharmacokinetics of Midazolam as CYP3A Probe Drug in a Porcine Animal Model: A Pilot Study. Frontiers in Pharmacology 10.
Crossref
Crossref
Marina Massaro, Gabriella Buscemi, Luca Arista, Giuseppa Biddeci, Giuseppe Cavallaro, Francesca D’Anna, Francesco Di Blasi, Angelo Ferrante, Giuseppe Lazzara, Carla Rizzo, Gaetano Spinelli, Thomas Ullrich & Serena Riela. (2018) Multifunctional Carrier Based on Halloysite/Laponite Hybrid Hydrogel for Kartogenin Delivery. ACS Medicinal Chemistry Letters 10:4, pages 419-424.
Crossref
Crossref
Chang Seon Ryu, Young Jae Choi, Hyo Seon Nam, Jang Su Jeon, Taeyoon Jung, Ji-Eun Park, Seong-Jin Choi, Kyuhong Lee, Moo-Yeol Lee & Sang Kyum Kim. (2019) Short-term regulation of the hepatic activities of cytochrome P450 and glutathione S-transferase by nose-only cigarette smoke exposure in mice. Food and Chemical Toxicology 125, pages 182-189.
Crossref
Crossref
Fashe Muluneh, Merja R. Häkkinen, Rami El‐Dairi, Markku Pasanen & Risto O. Juvonen. (2018)
New glutathione conjugate of pyrrolizidine alkaloids produced by human cytosolic enzyme‐dependent reactions
in vitro
. Rapid Communications in Mass Spectrometry 32:16, pages 1344-1352.
Crossref
Crossref
Stephanie C. Piekos, Liming Chen, Pengcheng Wang, Jian Shi, Sharon Yaqoob, Hao-Jie Zhu, Xiaochao Ma & Xiao-bo Zhong. (2018) Consequences of Phenytoin Exposure on Hepatic Cytochrome P450 Expression during Postnatal Liver Maturation in Mice. Drug Metabolism and Disposition 46:8, pages 1241-1250.
Crossref
Crossref
Takafumi Ueyama, Saori Tsuji, Takemi Sugiyama & Masako Tada. (2017) Fluorometric evaluation of CYP3A4 expression using improved transgenic HepaRG cells carrying a dual-colour reporter for CYP3A4 and CYP3A7. Scientific Reports 7:1.
Crossref
Crossref
R.S. Settivari, J.C. Rowlands, D.M. Wilson, S.M. Arnold & P.J. Spencer. 2017. A Comprehensive Guide to Toxicology in Nonclinical Drug Development. A Comprehensive Guide to Toxicology in Nonclinical Drug Development
843
873
.
Yinghua Ma, Weiwei Xie, Tingting Tian, Yiran Jin, Huijun Xu, Kerong Zhang & Yingfeng Du. (2016) Identification and comparative oridonin metabolism in different species liver microsomes by using UPLC-Triple-TOF-MS/MS and PCA. Analytical Biochemistry 511, pages 61-73.
Crossref
Crossref
Floriane Lignet, Eva Sherbetjian, Nicole Kratochwil, Russell Jones, Claudia Suenderhauf, Michael B. Otteneder, Thomas Singer & Neil Parrott. (2016) Characterization of Pharmacokinetics in the Göttingen Minipig with Reference Human Drugs: An In Vitro and In Vivo Approach. Pharmaceutical Research 33:10, pages 2565-2579.
Crossref
Crossref
Jouko Uusitalo, Miia Turpeinen, Ari Tolonen, Pasi Koskimies, Risto Lammintausta & Olavi Pelkonen. (2016)
Metabolism and metabolite profiles
in vitro
and
in vivo
of ospemifene in humans and preclinical species
. Drug Metabolism and Personalized Therapy 31:1, pages 35-40.
Crossref
Crossref
Natalia Moskaleva, Alexander Moysa, Svetlana Novikova, Olga Tikhonova, Victor Zgoda & Alexander Archakov. (2015) Spaceflight Effects on Cytochrome P450 Content in Mouse Liver. PLOS ONE 10:11, pages e0142374.
Crossref
Crossref
Toni Lassila, Timo Rousu, Sampo Mattila, Christophe Chesné, Olavi Pelkonen, Miia Turpeinen & Ari Tolonen. (2015) Formation of GSH-trapped reactive metabolites in human liver microsomes, S9 fraction, HepaRG-cells, and human hepatocytes. Journal of Pharmaceutical and Biomedical Analysis 115, pages 345-351.
Crossref
Crossref
Muluneh M. Fashe, Risto O. Juvonen, Aleksanteri Petsalo, Juha Räsänen & Markku Pasanen. (2015)
Species-Specific Differences in the
in Vitro
Metabolism of Lasiocarpine
. Chemical Research in Toxicology 28:10, pages 2034-2044.
Crossref
Crossref
Yicong Bian, Qingqing Yao, Haitao Shang, Jinxiu Lei, Haihong Hu, Kenan Guo, Huidi Jiang, Lushan Yu, Hong Wei & Su Zeng. (2015) Expression of Bama Minipig and Human CYP3A Enzymes: Comparison of the Catalytic Characteristics with Each Other and Their Liver Microsomes. Drug Metabolism and Disposition 43:9, pages 1336-1340.
Crossref
Crossref
Mark Johnson, Shayne Gad & Christopher Kemper. 2015. Animal Models in Toxicology, Third Edition. Animal Models in Toxicology, Third Edition
153
283
.
Lars Dalgaard. (2015) Comparison of minipig, dog, monkey and human drug metabolism and disposition. Journal of Pharmacological and Toxicological Methods 74, pages 80-92.
Crossref
Crossref
Sang Yoon Lee, Ji-Yoon Lee, Young-Mi Kim, Sang Kyum Kim & Soo Jin Oh. (2015) Expression of hepatic cytochrome P450s and UDP-glucuronosyltransferases in PXR and CAR double humanized mice treated with rifampicin. Toxicology Letters 235:2, pages 107-115.
Crossref
Crossref
Toni Lassila, Sampo Mattila, Miia Turpeinen & Ari Tolonen. (2015) Glutathione trapping of reactive drug metabolites produced by biomimetic metalloporphyrin catalysts. Rapid Communications in Mass Spectrometry 29:6, pages 521-532.
Crossref
Crossref
Sixun Guo, Yan Liu, Zhiping Lin, Sheng Tai, Shuo Yin & Gaofeng Liu. (2014) Effects of Eleutheroside B and Eleutheroside E on activity of cytochrome P450 in rat liver microsomes. BMC Complementary and Alternative Medicine 14:1.
Crossref
Crossref
Jarrod Bailey, Michelle Thew & Michael Balls. (2014) An Analysis of the Use of Animal Models in Predicting Human Toxicology and Drug Safety. Alternatives to Laboratory Animals 42:3, pages 181-199.
Crossref
Crossref
Erik Sjögren, Bertil Abrahamsson, Patrick Augustijns, Dieter Becker, Michael B. Bolger, Marcus Brewster, Joachim Brouwers, Talia Flanagan, Matthew Harwood, Christian Heinen, René Holm, Hans-Paul Juretschke, Marlies Kubbinga, Anders Lindahl, Viera Lukacova, Uwe Münster, Sibylle Neuhoff, Mai Anh Nguyen, Achiel van Peer, Christos Reppas, Amin Rostami Hodjegan, Christer Tannergren, Werner Weitschies, Clive Wilson, Patricia Zane, Hans Lennernäs & Peter Langguth. (2014) In vivo methods for drug absorption – Comparative physiologies, model selection, correlations with in vitro methods (IVIVC), and applications for formulation/API/excipient characterization including food effects. European Journal of Pharmaceutical Sciences 57, pages 99-151.
Crossref
Crossref
Els Van Peer, Evy Verbueken, Moayad Saad, Christophe Casteleyn, Chris Van Ginneken & Steven Van Cruchten. (2013)
Ontogeny of
CYP
3
A
and
P
‐Glycoprotein in the Liver and the Small Intestine of the Göttingen Minipig: An Immunohistochemical Evaluation
. Basic & Clinical Pharmacology & Toxicology 114:5, pages 387-394.
Crossref
Crossref
Peter L Pontoppidan, René L Shen, Bodil L Petersen, Thomas Thymann, Carsten Heilmann, Klaus Müller & Per T Sangild. (2013) Intestinal response to myeloablative chemotherapy in piglets. Experimental Biology and Medicine 239:1, pages 94-104.
Crossref
Crossref
Khaled Abass, Petri Reponen, Sampo Mattila, Arja Rautio & Olavi Pelkonen. (2014) Comparative metabolism of benfuracarb in in vitro mammalian hepatic microsomes model and its implications for chemical risk assessment. Toxicology Letters 224:2, pages 290-299.
Crossref
Crossref
Olavi Pelkonen, Jorma T. Ahokas, Jukka Hakkola & Miia Turpeinen. 2014. In Vitro Toxicology Systems. In Vitro Toxicology Systems
501
519
.
Terhi Lehtinen, Ari Tolonen, Miia Turpeinen, Jouko Uusitalo, Jouni Vuorinen, Risto Lammintausta, Olavi Pelkonen & Mika Scheinin. (2013) Effects of cytochrome P450 inhibitors and inducers on the metabolism and pharmacokinetics of ospemifene. Biopharmaceutics & Drug Disposition 34:7, pages 387-395.
Crossref
Crossref
Míriam Cristina Sakuragui Matuo, Rafael Teruiti de Oliveira Takamoto, Irene Satiko Kikuchi & Terezinha de Jesus Andreoli Pinto. (2013)
Effect of bixin and norbixin on the expression of cytochrome P450 in Hep
G
2 cell line
. Cell Biology International 37:8, pages 843-848.
Crossref
Crossref
Miia Turpeinen, Jouko Uusitalo, Terhi Lehtinen, Marita Kailajärvi, Olavi Pelkonen, Jouni Vuorinen, Pasi Tapanainen, Camilla Stjernschantz, Risto Lammintausta & Mika Scheinin. (2013) Effects of Ospemifene on Drug Metabolism Mediated by Cytochrome P450 Enzymes in Humans in Vitro and in Vivo. International Journal of Molecular Sciences 14:7, pages 14064-14075.
Crossref
Crossref
Edward W. Carney & Raja Settivari. 2013. A Comprehensive Guide to Toxicology in Preclinical Drug Development. A Comprehensive Guide to Toxicology in Preclinical Drug Development
777
806
.
Niels Christian Ganderup, Warren Harvey, Jens Thing Mortensen & Wafa Harrouk. (2012) The Minipig as Nonrodent Species in Toxicology—Where Are We Now?. International Journal of Toxicology 31:6, pages 507-528.
Crossref
Crossref
Stephanie Haller, Franz Schuler, Stanley E. Lazic, Dalila Bachir-Cherif, Stefanie D. Krämer, Neil J. Parrott, Guido Steiner & Sara Belli. (2012) Expression Profiles of Metabolic Enzymes and Drug Transporters in the Liver and along the Intestine of Beagle Dogs. Drug Metabolism and Disposition 40:8, pages 1603-1611.
Crossref
Crossref
Kevin L. Salyers & Yang Xu. 2012. ADME‐Enabling Technologies in Drug Design and Development. ADME‐Enabling Technologies in Drug Design and Development
253
276
.
Mei Mei, Jian-Qing Ruan, Wen-Jin Wu, Rui-Na Zhou, Jacky Pui-Cheong Lei, Hai-Yu Zhao, Ru Yan & Yi-Tao Wang. (2012)
In Vitro Pharmacokinetic Characterization of Mulberroside A, the Main Polyhydroxylated Stilbene in Mulberry (
Morus alba
L.), and Its Bacterial Metabolite Oxyresveratrol in Traditional Oral Use
. Journal of Agricultural and Food Chemistry 60:9, pages 2299-2308.
Crossref
Crossref
Soo Jin Oh, Jong Min Choi, Kang Uk Yun, Jung Min Oh, Hui Chan Kwak, Jin-Gyo Oh, Kye Sook Lee, Bong-Hee Kim, Tae-Hwe Heo & Sang Kyum Kim. (2012) Hepatic expression of cytochrome P450 in type 2 diabetic Goto–Kakizaki rats. Chemico-Biological Interactions 195:3, pages 173-179.
Crossref
Crossref
Alexander V. LyubimovJoshua G. DeKeyser & Magang Shou. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions
1
38
.
Imen Ayed-Boussema, Jean-Marc Pascussi, Patrick Maurel, Hassen Bacha & Wafa Hassen. (2011) Effect of Aflatoxin B1 on Nuclear Receptors PXR, CAR, and AhR and Their Target Cytochromes P450 mRNA Expression in Primary Cultures of Human Hepatocytes. International Journal of Toxicology 31:1, pages 86-93.
Crossref
Crossref
Sang Yoon Lee, Soo Jin Oh, Kang Uk Yun, Hwan Mook Kim, Bong-Hee Kim, Kiho Lee & Sang Kyum Kim. (2011) Expression of hepatic and ovarian cytochrome P450 during estrous cycle in rats. Archives of Toxicology 86:1, pages 75-85.
Crossref
Crossref
Shotaro Uehara, Norie Murayama, Yasuharu Nakanishi, Darryl C. Zeldin, Hiroshi Yamazaki & Yasuhiro Uno. (2011) Immunochemical Detection of Cytochrome P450 Enzymes in Liver Microsomes of 27 Cynomolgus Monkeys. Journal of Pharmacology and Experimental Therapeutics 339:2, pages 654-661.
Crossref
Crossref
Merja R. Häkkinen, Jaana E. Laine, Risto O. Juvonen, Seppo Auriola, Jukka Häyrinen & Markku Pasanen. (2011) 2′-Deoxyguanosine as a surrogate trapping agent for DNA reactive drug metabolites. Toxicology Letters 207:1, pages 34-41.
Crossref
Crossref
Sarah Adler, David Basketter, Stuart Creton, Olavi Pelkonen, Jan van Benthem, Valérie Zuang, Klaus Ejner Andersen, Alexandre Angers-Loustau, Aynur Aptula, Anna Bal-Price, Emilio Benfenati, Ulrike Bernauer, Jos Bessems, Frederic Y. Bois, Alan Boobis, Esther Brandon, Susanne Bremer, Thomas Broschard, Silvia Casati, Sandra Coecke, Raffaella Corvi, Mark Cronin, George Daston, Wolfgang Dekant, Susan Felter, Elise Grignard, Ursula Gundert-Remy, Tuula Heinonen, Ian Kimber, Jos Kleinjans, Hannu Komulainen, Reinhard Kreiling, Joachim Kreysa, Sofia Batista Leite, George Loizou, Gavin Maxwell, Paolo Mazzatorta, Sharon Munn, Stefan Pfuhler, Pascal Phrakonkham, Aldert Piersma, Albrecht Poth, Pilar Prieto, Guillermo Repetto, Vera Rogiers, Greet Schoeters, Michael Schwarz, Rositsa Serafimova, Hanna Tähti, Emanuela Testai, Joost van Delft, Henk van Loveren, Mathieu Vinken, Andrew Worth & José-Manuel Zaldivar. (2011) Alternative (non-animal) methods for cosmetics testing: current status and future prospects—2010. Archives of Toxicology 85:5, pages 367-485.
Crossref
Crossref
Yue‐Lin Song, Ru Yan, Wang‐Hui Jing, Hai‐Yu Zhao & Yi‐Tao Wang. (2011) Characterization of metabolism of (+)‐praeruptorin B and (+)‐praeruptorin E in human and rat liver microsomes by liquid chromatography coupled with ion trap mass spectrometry and time‐of‐flight mass spectrometry. Rapid Communications in Mass Spectrometry 25:6, pages 719-730.
Crossref
Crossref
Juho Hokkanen, Ari Tolonen, Sampo Mattila & Miia Turpeinen. (2011) Metabolism of hyperforin, the active constituent of St. John's wort, in human liver microsomes. European Journal of Pharmaceutical Sciences 42:3, pages 273-284.
Crossref
Crossref
Thomas A. Baillie & Allan E. Rettie. (2011) Role of Biotransformation in Drug-Induced Toxicity: Influence of Intra- and Inter-Species Differences in Drug Metabolism. Drug Metabolism and Pharmacokinetics 26:1, pages 15-29.
Crossref
Crossref
Kang Uk Yun, Soo Jin Oh, Jung Min Oh, Keon Wook Kang, Chang-Seon Myung, Gyu Yong Song, Bong-Hee Kim & Sang Kyum Kim. (2010) Age-related changes in hepatic expression and activity of cytochrome P450 in male rats. Archives of Toxicology 84:12, pages 939-946.
Crossref
Crossref
Khaled Abass, Petri Reponen, Sampo Mattila & Olavi Pelkonen. (2010) Metabolism of carbosulfan II. Human interindividual variability in its in vitro hepatic biotransformation and the identification of the cytochrome P450 isoforms involved. Chemico-Biological Interactions 185:3, pages 163-173.
Crossref
Crossref
Marjo Volotinen, Timo Korjamo, Ari Tolonen, Miia Turpeinen, Olavi Pelkonen, Jukka Hakkola & Jukka Mäenpää. (2010) Effects of Selective Serotonin Reuptake Inhibitors on Timolol Metabolism in Human Liver Microsomes and Cryo‐Preserved Hepatocytes. Basic & Clinical Pharmacology & Toxicology 106:4, pages 302-309.
Crossref
Crossref
Sasitorn Aueviriyavit, Kaoru Kobayashi & Kan Chiba. (2010) Species Differences in Mechanism-Based Inactivation of CYP3A in Humans, Rats and Mice. Drug Metabolism and Pharmacokinetics 25:1, pages 93-100.
Crossref
Crossref
Mari Murtomaa, Pirkko Viitala, Juho Hokkanen, Olavi Pelkonen & Arja Rautio. (2010) Xenobiotic metabolism of bank vole (Myodes glareolus) exposed to PCDDs. Environmental Toxicology and Pharmacology 29:1, pages 19-23.
Crossref
Crossref
. 2009. General, Applied and Systems Toxicology. General, Applied and Systems Toxicology.
Khaled Abass, Petri Reponen, Sampo Mattila & Olavi Pelkonen. (2009) Metabolism of carbosulfan. I. Species differences in the in vitro biotransformation by mammalian hepatic microsomes including human. Chemico-Biological Interactions 181:2, pages 210-219.
Crossref
Crossref
Miia Turpeinen, Ari Tolonen, Christophe Chesne, André Guillouzo, Jouko Uusitalo & Olavi Pelkonen. (2009) Functional expression, inhibition and induction of CYP enzymes in HepaRG cells. Toxicology in Vitro 23:4, pages 748-753.
Crossref
Crossref
Charles W. Locuson, Brian T. Ethell, Michael Voice, David Lee & Kenneth L. Feenstra. (2009)
Evaluation of
Escherichia coli
Membrane Preparations of Canine CYP1A1, 2B11, 2C21, 2C41, 2D15, 3A12, and 3A26 with Coexpressed Canine Cytochrome P450 Reductase
. Drug Metabolism and Disposition 37:3, pages 457-461.
Crossref
Crossref
Stefanie D. Krämer & Bernard Testa. (2008) The Biochemistry of Drug Metabolism – An Introduction. Chemistry & Biodiversity 5:12, pages 2465-2578.
Crossref
Crossref
Divesh Aidasani, Matthew J. Zaya, Phyllis B. Malpas & Charles W. Locuson. (2008) In Vitro Drug-Drug Interaction Screens for Canine Veterinary Medicines: Evaluation of Cytochrome P450 Reversible Inhibition. Drug Metabolism and Disposition 36:8, pages 1512-1518.
Crossref
Crossref