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Xenobiotica
the fate of foreign compounds in biological systems
Volume 38, 2008 - Issue 5
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Research Article

In vitro drug–drug interaction studies with febuxostat, a novel non-purine selective inhibitor of xanthine oxidase: plasma protein binding, identification of metabolic enzymes and cytochrome P450 inhibition

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Pages 496-510 | Received 28 Nov 2007, Accepted 21 Jan 2008, Published online: 22 Sep 2008

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Read on this site (7)

Saraswathisreeram Pranush Kumar, Deeki Doma Sherpa, Amit Kumar Sahu, Tarang Jadav, Rakesh Kumar Tekade & Pinaki Sengupta. (2021) Innovation in Bioanalytical Strategies and in vitro Drug–drug Interaction Study Approaches in Drug Discovery. Bioanalysis 13:6, pages 513-532.
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Fawzy A El-Yazbi, Omayma A Amin, Eman I El-Kimary, Essam F Khamis, Sameh E Younis, Mohammed A W Elkhatib & Ahmed F El-Yazbi. (2019) A Novel HPLC-DAD Method for Simultaneous Determination of Febuxostat and Diclofenac in Biological Samples: Pharmacokinetic Outcomes. Bioanalysis 11:1, pages 41-54.
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Sandra Pamela Chinchilla, Irati Urionaguena & Fernando Perez-Ruiz. (2016) Febuxostat for the chronic management of hyperuricemia in patients with gout. Expert Review of Clinical Pharmacology 9:5, pages 665-673.
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Harmanjot K Grewal, Joseph R Martinez & Luis R Espinoza. (2014) Febuxostat: drug review and update. Expert Opinion on Drug Metabolism & Toxicology 10:5, pages 747-758.
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Kapendra Sahu, Anees A Siddiqui, Mohammad Shaharyar & Sachin Malik. (2014) Pharmacokinetic interaction between febuxostat and morin in rats. Expert Opinion on Drug Metabolism & Toxicology 10:3, pages 307-312.
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Lada Beara-Lasic, Michael H Pillinger & David S Goldfarb. (2010) Advances in the management of gout: Critical appraisal of febuxostat in the control of hyperuricemia. International Journal of Nephrology and Renovascular Disease 3, pages 1-10.
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Miao Hu & Brian Tomlinson. (2008) Febuxostat in the management of hyperuricemia and chronic gout: a review. Therapeutics and Clinical Risk Management 4:6, pages 1209-1220.
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Jeong-Eun Yu, Byoung Hoon You, Mingoo Bae, Seung Yon Han, Kiwon Jung & Young Hee Choi. (2023) Evaluation of Pharmacokinetic Feasibility of Febuxostat/L-pyroglutamic Acid Cocrystals in Rats and Mice. Pharmaceutics 15:8, pages 2167.
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Bishoy Kamel, Garry G. Graham, Sophie L. Stocker, Zhixin Liu, Kenneth M. Williams, Jane E. Carland, Kevin D. Pile & Richard O. Day. (2020) A pharmacokinetic‐pharmacodynamic study of a single dose of febuxostat in healthy subjects. British Journal of Clinical Pharmacology 86:12, pages 2486-2496.
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Dong-Gyun Han, Kyu-Sang Kim, Seong-Wook Seo, Young Mee Baek, Yunjin Jung, Dae-Duk Kim & In-Soo Yoon. (2020) A sensitive HPLC-FL method to simultaneously determine febuxostat and diclofenac in rat plasma: assessment of metabolic drug interactions in vitro and in vivo . Analytical Methods 12:16, pages 2166-2175.
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Kenji Ikemura, Shun-ichi Hiramatsu, Yuri Shinogi, Yusuke Nakatani, Isao Tawara, Takuya Iwamoto, Naoyuki Katayama & Masahiro Okuda. (2019) Concomitant febuxostat enhances methotrexate-induced hepatotoxicity by inhibiting breast cancer resistance protein. Scientific Reports 9:1.
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Vicky Tai, Tony R. Merriman & Nicola Dalbeth. (2019) Genetic advances in gout: potential applications in clinical practice. Current Opinion in Rheumatology 31:2, pages 144-151.
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Jesse Hall, Michael Gillen, Xiaojuan Yang & Zancong Shen. (2018) Pharmacokinetics, Pharmacodynamics, and Tolerability of Concomitant Administration of Verinurad and Febuxostat in Healthy Male Volunteers. Clinical Pharmacology in Drug Development 8:2, pages 179-187.
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Eeunyoung AhnSunggun LeeHan-Na LeeSeung-Geun LeeMin Wook So. (2019) Comparison of Efficacy and Safety of Febuxostat in Gout Patients with Chronic Kidney Disease Stage 3 and Stage 4/5. Journal of Rheumatic Diseases 26:2, pages 118.
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M. S. Petrova, М. M. Musiychuk & V. I. Mazurov. (2018) The current treatment strategy for gouty arthritis. Modern Rheumatology Journal 12:3, pages 70-75.
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Satoshi Yamaori, Noriyuki Araki, Mio Shionoiri, Kurumi Ikehata, Shinobu Kamijo, Shigeru Ohmori & Kazuhito Watanabe. (2018) A Specific Probe Substrate for Evaluation of CYP4A11 Activity in Human Tissue Microsomes and a Highly Selective CYP4A11 Inhibitor: Luciferin-4A and Epalrestat. Journal of Pharmacology and Experimental Therapeutics 366:3, pages 446-457.
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Meihua Lin, Jian Liu, Huili Zhou, Minglan Wu, Duo Lv, Yujie Huang, Yunliang Zheng, Jianzhong Shentu & Lihua Wu. (2017) Effects of UDP-glucuronosyltransferase (UGT) polymorphisms on the pharmacokinetics of febuxostat in healthy Chinese volunteers. Drug Metabolism and Pharmacokinetics 32:1, pages 77-84.
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Huiru Xie, Zhijun Wang, Ke Deng, Xuehua Jiang, Ling Wang & Guoyu Lv. (2014) An HPLC–MS/MS method for simultaneous determination of the active metabolites of febuxostat (67M-1, 67M-2 and 67M-4) in human plasma. Journal of Chromatography B 970, pages 24-30.
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Lisa K. Stamp & Peter T. Chapman. (2014) Urate-Lowering Therapy: Current Options and Future Prospects for Elderly Patients with Gout. Drugs & Aging 31:11, pages 777-786.
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