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Xenobiotica
the fate of foreign compounds in biological systems
Volume 38, 2008 - Issue 9
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Research Article

Strategies to prevent N-acetyltransferase-mediated metabolism in a series of piperazine-containing pyrazalopyrimidine compounds

J. Rawal Pharmacokinetics, Dynamics and Metabolism, PGRD, Pfizer Ltd, Sandwich, UK
,
R. Jones Pharmacokinetics, Dynamics and Metabolism, PGRD, Pfizer Ltd, Sandwich, UK
,
A. Payne Pharmacokinetics, Dynamics and Metabolism, PGRD, Pfizer Ltd, Sandwich, UK
&
I. Gardner Pharmacokinetics, Dynamics and Metabolism, PGRD, Pfizer Ltd, Sandwich, UK
Pages 1219-1239 | Received 07 Apr 2008, Accepted 04 Jul 2008, Published online: 11 Aug 2008

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Jayaprakasam Bolleddula, Kevin DeMent, James P. Driscoll, Philip Worboys, Patrick J. Brassil & David L. Bourdet. (2014) Biotransformation and bioactivation reactions of alicyclic amines in drug molecules. Drug Metabolism Reviews 46:3, pages 379-419.
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Articles from other publishers (5)

Yurong Lai, Xiaoyan Chu, Li Di, Wei Gao, Yingying Guo, Xingrong Liu, Chuang Lu, Jialin Mao, Hong Shen, Huaping Tang, Cindy Q. Xia, Lei Zhang & Xinxin Ding. (2022) Recent advances in the translation of drug metabolism and pharmacokinetics science for drug discovery and development. Acta Pharmaceutica Sinica B 12:6, pages 2751-2777.
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Nathalie Rioux, Lorna H. Mitchell, Philip Tiller, Katie Plant, Joanne Shaw, Kerry Frost, Scott Ribich, Mikel P. Moyer, Robert A. Copeland, Richard Chesworth & Nigel J. Waters. (2015) Structural and Kinetic Characterization of a Novel N -acetylated Aliphatic Amine Metabolite of the PRMT Inhibitor, EPZ011652 . Drug Metabolism and Disposition 43:7, pages 936-943.
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Robert J. Weikert. 2012. Designing Multi-Target Drugs. Designing Multi-Target Drugs 270 289 .
Q. Sun, T. W. Harper, E. A. Dierks, L. Zhang, S. Chang, A. D. Rodrigues & P. Marathe. (2011) 1-Aminobenzotriazole, a Known Cytochrome P450 Inhibitor, Is a Substrate and Inhibitor of N -Acetyltransferase . Drug Metabolism and Disposition 39:9, pages 1674-1679.
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David S. Carter, Hai-Ying Cai, Eun Kyung Lee, Pravin S. Iyer, Matthew C. Lucas, Ralf Roetz, Ryan C. Schoenfeld & Robert J. Weikert. (2010) 2-Substituted N-aryl piperazines as novel triple reuptake inhibitors for the treatment of depression. Bioorganic & Medicinal Chemistry Letters 20:13, pages 3941-3945.
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